蛋白

重组人类载脂蛋白b-100

MBS967958

0.01毫克(大肠杆菌)

110美元

重组蛋白

重组人类载脂蛋白b-100

载脂蛋白b-100

载脂蛋白b-48;载脂蛋白B-48

载脂蛋白b-100;载脂蛋白b-100

载脂蛋白B

载脂蛋白B;载脂蛋白B-100;载脂蛋白B-48

APOB_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

28-127

4563

EEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPG
TADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGF
NPEGKALLKKTKNSEEFAAAMS

Greater than 90% as determined by SDS-PAGE.

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Species: Homo sapiens (Human)

Cardiovascular

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

Complete cDNA and derived protein sequence of human apolipoprotein B-100." Knott T.C., Wallis S.C., Powell L.M., Pease R.J., Lusis A.J., Blackhart B., McCarthy B.J., Mahley R.W., Levy-Wilson B., Scott J. Nucleic Acids Res. 14:7501-7503(1986)

105990532

NP_000375.2

NM_000384.2

P04114

13.19kD

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Chylomicron-mediated Lipid Transport Pathway (1270006); FOXA1 Transcription Factor Network Pathway (137979); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Hemostasis Pathway (1269340); LDL-mediated Lipid Transport Pathway (1270008); Lipid Digestion, Mobilization, And Transport Pathway (1270002); Lipoprotein Metabolism Pathway (1270005)

APOB: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Defects in APOB are a cause of familial hypobetalipoproteinemia type 1 (FHBL1). A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. Protein type: Secreted; Secreted, signal peptide; Carrier. Chromosomal Location of Human Ortholog: 2p24-p23. Cellular Component: actin cytoskeleton; cell soma; chylomicron; cytoplasm; cytosol; early endosome; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endosome membrane; extracellular region; extracellular space; Golgi apparatus; intracellular membrane-bound organelle; plasma membrane. Molecular Function: cholesterol transporter activity; heparin binding; low-density lipoprotein receptor binding; phospholipid binding; protein binding. Biological Process: artery morphogenesis; blood coagulation; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; fat-soluble vitamin metabolic process; fertilization; in utero embryonic development; leukocyte migration; lipoprotein biosynthetic process; lipoprotein catabolic process; lipoprotein metabolic process; lipoprotein transport; nervous system development; phototransduction, visible light; post-embryonic development; receptor-mediated endocytosis; regulation of cholesterol biosynthetic process; response to carbohydrate stimulus; response to lipopolysaccharide; response to selenium ion; response to virus; retinoid metabolic process; sperm motility; spermatogenesis; triacylglycerol catabolic process; triacylglycerol mobilization; vitamin metabolic process. Disease: Hypercholesterolemia, Autosomal Dominant, Type B; Hypobetalipoproteinemia, Familial, 1

0.01毫克(大肠杆菌)

110美元

0.05毫克(大肠杆菌)

190

0.2毫克(大肠杆菌)

460

0.5毫克(大肠杆菌)

750

0.05毫克(杆状病毒)

835