产品简要
公司名称 :
NKMAX
产品类型 :
抗体
产品名称 :
人类TDP-43/TARDBP抗体
目录 :
ATA0834
规格 :
50微升
价格 :
170美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
k1B8
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 流式细胞仪
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名 :
人类TDP-43/TARDBP抗体
目录号(SKU号) :
ATA0834
NCBI :
NP_031401
描述 :
TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
别称 :
焦油DNA结合蛋白, TDP-43, ALS10, 焦油DNA结合蛋白43, TDP43
浓度 :
1mg/ml (determined by BCA assay)
配方 :
Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
储存 :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
一般参考 :
Nicola JR, et al., (2008) PLoS Genet 4(9):e1000193.;; Kabashi E, et al., (2008) Nat Genet 40(5):572-574.;;Ou SH, et al., (1995) J Virol 69:3584-3596. ;;
ab宿主 :
小鼠
抗体亚型 :
IgG1 kappa
免疫原 :
重组人类TARDBP(1-260aa)纯化来自大肠杆菌
应用 :
酶联免疫吸附测定, 免疫印迹, 免疫组化, 流式细胞仪
WB Comment and Pic :
The cell lysates (20ug) was resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human TARDBP (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.;; Lane 1.: HeLa cell lysate;;
反应对象 :
人类
克隆编号 :
k1B8
Ab用途 :
The antibody has been tested by ELISA, Western blot, FACS and IHC analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.
FACS Comment and Pic :
Flow cytometry analysis of TARDBP in HeLa cells. The cell was stained with ATA0834 at 2-5ug for 1x10^6cells (red). A Goat anti mouse IgG (Alexa fluor 488) was used as the secondary antibody. Mouse monoclonal IgG was used as the isotype control (dark gray), cells without incubation with primary and secondary antibody was used as the negative control (light gray).
IHC Comment And Pic :
Paraffin embedded sections of human prostate cancer tissue were incubated with anti-human TARDBP(1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Paraffin embedded sections of human seminoma tissue were incubated with anti-human TARDBP(1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) {ATA0834-IHC1b.jpg}
抗原物种 :
人类
基因类别 :
Epigenomics (Transcription & Translation)
共轭 :
未共轭
Clonality Mono VS Poly :
单克隆
Ab纯化评论 :
By protein-G affinity chromatography
产品类型名 :
单克隆抗体
UniProt No. :
Q13148
内部搜索条款 :
TDP43, TARDBP, ATA0834-10微克, ATA0834-20微克, ATA0834-50微克, ATA0834-100微克, ATA0834-250微克, ATA0834-500微克, ATA0834-1毫克, ATA0834-10, ATA0834-20, ATA0834-50, ATA0834-100, ATA0834-250, ATA0834-500, ATA0834-1
更多信息或购买 :
公司信息
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com
82-31-8017-8114
公司总部: 韩国
NKMAX有限公司是一家生物技术公司,制造和供应独特的优质蛋白质和抗体以供应世界各地的研究人员和零售商。