蛋白

Recombinant human Sepiapterin reductase/SPR protein

ATGP0288

20微克

80美元

Recombinant human Sepiapterin reductase/SPR protein

1-261aa

ATGP0288

NP_003115

Sepiapterin reductase (SPR) belongs to the short-chain dehydrogenase/reductase (SDR) family and also reduces various exogenous carbonyl compounds including phenylpropanedione. SPR is an essential enzyme for the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydrolases including tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. Defects in SPR cause DOPA-responsive dystonia defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Recombinant human SPR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.

SPR, Sepiapterin reductase, SDR38C1, Short chain dehydrogenase/reductase family 38C, member 1

0.5毫克/毫升(由布拉德福德Bradford检测确定)

液体。 20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)10% 甘油

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Tobin JE., et al. (2007). Brain Res. 30:42-7.;; Ohye T., et al. (1998). Biochem Biophys Res Commun. 251(2):597-602.;;

> 95% by SDS-PAGE

十二烷基磺酸钠-PAGE

人类

Redox Proteins

30.2 kDa (281aa) confirmed by MALDI-TOF

< 1 EU per 1ug of protein (determined by LAL method)

MGSSHHHHHH SSGLVPRGSH MEGGLGRAVC LLTGASRGFG RTLAPLLASL LSPGSVLVLS ARNDEALRQL EAELGAERSG LRVVRVPADL GAEAGLQQLL GALRELPRPK GLQRLLLINN AGSLGDVSKG FVDLSDSTQV NNYWALNLTS MLCLTSSVLK AFPDSPGLNR TVVNISSLCA LQPFKGWALY CAGKAARDML FQVLALEEPN VRVLNYAPGP LDTDMQQLAR ETSVDPDMRK GLQELKAKGK LVDCKVSAQK LLSLLEKDEF KSGAHVDFYD K

多聚组氨酸标签

大肠杆菌

重组蛋白

P35270

Sepiapterin reductase, SPR, Sepiapterin reductase.,ATGP0288-10ug,ATGP0288-20ug,ATGP0288-50ug,ATGP0288-100ug,ATGP0288-250ug,ATGP0288-500ug,ATGP0288-1mg,ATGP0288-10,ATGP0288-20,ATGP0288-50,ATGP0288-100,ATGP0288-250,ATGP0288-500,ATGP0288-1