蛋白

重组人类CD45蛋白

ATGP2577

4微克

80美元

重组人类CD45蛋白

1031-1251aa

ATGP2577

NP_002829.3

PTPRC, also known as CD45, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Recombinant human PTPRC protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Protein tyrosine phosphatase receptor type isoform 1, Protein tyrosine phosphatase, receptor type, isoform 1, LCA, LY5, B220, CD45, T200, GP180

0.25毫克/毫升(由布拉德福德Bradford检测确定)

液体。 20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含0.15M氯化钠, 10% 甘油, 1mM DTT

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Charbonneau H., et al. (1988) Proc. Natl. Acad. Sci. u.S.A. 85:7182-7186;; Wu L., et al. (2002) Mol. Cell. Biol. 22:2673-2686;;

> 90% by SDS-PAGE

十二烷基磺酸钠-PAGE

人类

干细胞

29.6 kDa (257aa) confirmed by MALDI-TOF

< 1 EU per 1ug of protein (determined by LAL method)

VMIA AQGPLKETIG DFWQMIFQRK VKVIVMLTEL KHGDQEICAQ YWGEGKQTYG DIEVDLKDTD KSSTYTLRVF ELRHSKRKDS RTVYQYQYTN WSVEQLPAEP KELISMIQVV KQKLPQKNSS EGNKHHKSTP LLIHCRDGSQ QTGIFCALLN LLESAETEEV VDIFQVVKAL RKARPGMVST FEQYQFLYDV IASTYPAQNG QVKKNNHQED KIEFDNE

多聚组氨酸标签

大肠杆菌

重组蛋白

P08575

CD45, Protein tyrosine phosphatase receptor type isoform 1, Protein tyrosine phosphatase, receptor type, isoform 1, LCA, LY5, B220, CD45, T200, GP180,ATGP2577-10ug,ATGP2577-20ug,ATGP2577-50ug,ATGP2577-100ug,ATGP2577-250ug,ATGP2577-500ug,ATGP2577-1mg,ATGP2577-10,ATGP2577-20,ATGP2577-50,ATGP2577-100,ATGP2577-250,ATGP2577-500,ATGP2577-1