蛋白

重组人类IL-17A蛋白

ATGP3083

10微克

80美元

重组人类IL-17A蛋白

24-155aa

ATGP3083

NP_002181.1

IL17A, also known as Interleukin 17, is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation. It is produced by T-helper cells and is induced by IL23 which results in destructive tissue damage in delayed-type reactions. This protein is a 155 amino acid protein that is a disulfide-linked, homodimeric, secreted glycoprotein with a molecular mass of 35kDa. The structure of IL17A consists of a signal peptide of 23 amino acids followed by a 123 aa chain region characteristic of the IL17 family. An N-linked glycosylation site on the protein was first identified after purification of the protein revealed two bands, one at 15kDa and another at 20kDa. Recombinant human IL17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

白细胞介素17A, IL-17, IL-17A, 白细胞介素-17, CTLA8, 细胞毒性T淋巴细胞 蛋白8, 细胞毒性T淋巴细胞 丝氨酸酯酶8

0.25毫克/毫升(由布拉德福德Bradford检测确定)

液体。 磷酸盐缓冲液(pH值7.4)含20% 甘油, 1mM乙二胺四乙酸, 0.1mM苯甲基磺酰氟

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Yao Z, et al (1995) J Immunol. 155(12):5483-6.

> 90% by SDS-PAGE

The activity is determined by the IL-6 ELISA in a using NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 7 ng/ml.

SDS-PAGE, Bioactivity

人类

激素&细胞因子

15.9 kDa (138aa)

< 1 EU per 1ug of protein (determined by LAL method)

Human IL-17A stimulates IL-6 secretion of the NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 7 ng/ml.

GITIPRNPGC PNSEDKNFPR TVMVNLNIHN RNTNTNPKRS SDYYNRSTSP WNLHRNEDPE RYPSVIWEAK CRHLGCINAD GNVDYHMNSV PIQQEILVLR REPPHCPNSF RLEKILVSVG CTCVTPIVHH VA

多聚组氨酸标签

杆状病毒

Gly24

重组蛋白

Q16552

IL17A, 白细胞介素17A, CTLA8, IL-17, IL-17A, 白细胞介素-17, ATGP3083-10微克, ATGP3083-20微克, ATGP3083-50微克, ATGP3083-100微克, ATGP3083-250微克, ATGP3083-500微克, ATGP3083-1毫克, ATGP3083-10, ATGP3083-20, ATGP3083-50, ATGP3083-100, ATGP3083-250, ATGP3083-500, ATGP3083-1