蛋白

重组人类S100-A8蛋白

ATGP3372

20微克

80美元

重组人类S100-A8蛋白

1-93aa

ATGP3372

NP_002955

S100A8, also known as S100A8 isoform d. S100A8 is a member of the S100 family, EF-hand superfamily of Calcium binding proteins. S100A8 protein is localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Altered expression of this protein is associated with the disease cystic fibrosis. Recombinant human S100A8, fused to His-tag at N-terminus, fused to Myc-tag at C-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8

1毫克/毫升(由布拉德福德Bradford检测确定)

液体。 20mM三羟甲基氨基甲烷氯化氢缓冲液(pH值8.0)含10% 甘油, 0.1M氯化钠

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Kerkhoff C., et al. (1998) Biochim. Biophys. 1448(2):200-11. ;; Nacken W., et al. (2003) Microsc Res Tech. 60(6):569-80.

> 90% by SDS-PAGE

十二烷基磺酸钠-PAGE

人类

Cancer

14.5 kDa (127aa) confirmed by MALDI-TOF

< 1 EU per 1ug of protein (determined by LAL method)

MGSSHHHHHH SSGLVPRGSH MGSHMLTELE KALNSIIDVY HKYSLIKGNF HAVYRDDLKK LLETECPQYI RKKGADVWFK ELDINTDGAV NFQEFLILVI KMGVAAHKKS HEESHKEEQK LISEEDL

His-Myc-Tag

大肠杆菌

重组蛋白

P05109

S100钙结合蛋白A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, ATGP3372-10微克, ATGP3372-20微克, ATGP3372-50微克, ATGP3372-100微克, ATGP3372-250微克, ATGP3372-500微克, ATGP3372-1毫克, ATGP3372-10, ATGP3372-20, ATGP3372-50, ATGP3372-100, ATGP3372-250, ATGP3372-500, ATGP3372-1

Kwon CH, et al. S100A8 and S100A9 promotes invasion and migration through p38 mitogen-activated protein kinase-dependent NF-κB activation in gastric cancer cells. (Mol Cells. 2013){https://pubmed.ncbi.nlm.nih.gov/23456298/};;Nishikawa Y, et al. Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts. (J Cell Physiol. 2017){https://pubmed.ncbi.nlm.nih.gov/27925202/}