蛋白

重组人类v-erb-b2成红细胞白血病病毒致瘤基因2/Her2蛋白

ATGP3586

10微克

130美元

重组人类v-erb-b2成红细胞白血病病毒致瘤基因2/Her2蛋白

23-652aa

ATGP3586

NP_004439.2

ERBB2, also known as receptor tyrosine-protein kinase erbB-2 isoform, belongs to the epidermal growth factor (EGF) receptor family. It is an oncogene encoding a type 1 tyrosine kinase growth factor receptor. Its overexpression is associated with reduced disease free and overall survival. It is a predictor factor for poor response to chemotherapy and plays a key role in development, cell proliferation and differentiation. It is permanently coupled to phospholipase C gamma and involves tyrosine phosphorylation and activation of PLC gamma. It reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs. It results in cellular transformation and is associated with a variety of malignancy and breast, prostate, ovarian, lung cancers. Recombinant human ERBB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Receptor tyrosine-protein kinase erbB-2 isoform, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1

0.25毫克/毫升(由布拉德福德Bradford检测确定)

液体。 磷酸盐缓冲液(pH值7.4)含10% 甘油

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Hammam O., et al. (2014) J Egypt Soc Parasitol. 44:719-731.;; Zavalishina LE., et al. (2014) Arkh Patol. 76:22-27.

> 85% by SDS-PAGE

十二烷基磺酸钠-PAGE

人类

Cancer

70.4 kDa (638aa)

< 1 EU per 1ug of protein (determined by LAL method)

TQVCTGTDMK LRLPASPETH LDMLRHLYQG CQVVQGNLEL TYLPTNASLS FLQDIQEVQG YVLIAHNQVR QVPLQRLRIV RGTQLFEDNY ALAVLDNGDP LNNTTPVTGA SPGGLRELQL RSLTEILKGG VLIQRNPQLC YQDTILWKDI FHKNNQLALT LIDTNRSRAC HPCSPMCKGS RCWGESSEDC QSLTRTVCAG GCARCKGPLP TDCCHEQCAA GCTGPKHSDC LACLHFNHSG ICELHCPALV TYNTDTFESM PNPEGRYTFG ASCVTACPYN YLSTDVGSCT LVCPLHNQEV TAEDGTQRCE KCSKPCARVC YGLGMEHLRE VRAVTSANIQ EFAGCKKIFG SLAFLPESFD GDPASNTAPL QPEQLQVFET LEEITGYLYI SAWPDSLPDL SVFQNLQVIR GRILHNGAYS LTLQGLGISW LGLRSLRELG SGLALIHHNT HLCFVHTVPW DQLFRNPHQA LLHTANRPED ECVGEGLACH QLCARGHCWG PGPTQCVNCS QFLRGQECVE ECRVLQGLPR EYVNARHCLP CHPECQPQNG SVTCFGPEAD QCVACAHYKD PPFCVARCPS GVKPDLSYMP IWKFPDEEGA CQPCPINCTH SCVDLDDKGC PAEQRASPLT

多聚组氨酸标签

杆状病毒

Thr23

重组蛋白

P04626

ErbB2, Her2, Receptor tyrosine-protein kinase erbB-2 isoform, ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1,ATGP3586-10ug,ATGP3586-20ug,ATGP3586-50ug,ATGP3586-100ug,ATGP3586-250ug,ATGP3586-500ug,ATGP3586-1mg,ATGP3586-10,ATGP3586-20,ATGP3586-50,ATGP3586-100,ATGP3586-250,ATGP3586-500,ATGP3586-1