蛋白

Recombinant human FGF R2 beta (lllb) protein

ATGP3899

10微克

140美元

Recombinant human FGF R2 beta (lllb) protein

22-289aa

ATGP3899

NP_001138391

FGF R2 beta (lllb), also known as fibroblast growth factor receptor 2 isoform 9, is a member of the fibroblast growth factor receptor family. This protein has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Also, it is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Mutations in FGF R2 beta are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes: Apert syndrome, Antley-Bixler syndrome, Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome) and cancer. (e.g. Breast cancer, endometrial cancer and melanoma) Recombinant Human FGF R2 beta (lllb), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

FGF R2 beta, FGF R2b, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2, FGFR-2, K-sam ,Keratinocyte growth factor receptor

0.5mg/ml (determined by absorbance at 280nm)

液体。 磷酸盐缓冲液(pH值7.4)含10% 甘油

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Galzie Z., et al. (1997) Biochem. Cell Biol. 75:669-685.;;Ornitz DM., et al, (1996) J Biol Chem. 271:15292-15297.

> 95% by SDS-PAGE

十二烷基磺酸钠-PAGE

人类

生长因子

56.8 kDa (507aa)

< 1 EU per 1ug of protein (determined by LAL method)

RPSFSLVEDT TLEPEDAISS GDDEDDTDGA EDFVSENSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPMPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEADAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPGREKEI TASPDYLE

hIgG-His-Tag

杆状病毒

Arg22

重组蛋白

P21802

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