产品简要
公司名称 :
Neuromab
产品类型 :
抗体
产品名称 :
GluN2B/NR2B谷氨酸受体
目录 :
75-097
规格 :
100微克
价格 :
269美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
N59/20
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 66
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Koster K, Francesconi W, Berton F, Alahmadi S, Srinivas R, Yoshii A. Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s6c
Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, et al. Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. Proc Natl Acad Sci U S A. 2018;115:2508-2513 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Wilkinson B, Li J, Coba M. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Sci Rep. 2017;7:5272 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 1d
Gross G, Straub C, Perez Sanchez J, Dempsey W, Junge J, Roberts R, et al. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016;13:673-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4e
Yang P, Leu D, Ye K, Srinivasan C, Fike J, Huang T. Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist. Exp Neurol. 2016;279:178-186 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Kim S, Kim T, Lee H, Kong Y, Kaang B. Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity. Korean J Physiol Pharmacol. 2015;19:515-22 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 2
McGuier N, Padula A, Mulholland P, Chandler L. Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens. Front Pharmacol. 2015;6:28 pubmed 出版商
  • 免疫印迹; 小鼠; 图 7
Lo S, Wang Y, Weber M, Larson J, Scearce Levie K, Sheng M. Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control. J Neurosci. 2015;35:2118-32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Portugal G, Al Hasani R, Fakira A, Gonzalez Romero J, Melyan Z, McCall J, et al. Hippocampal long-term potentiation is disrupted during expression and extinction but is restored after reinstatement of morphine place preference. J Neurosci. 2014;34:527-38 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:300
  • 免疫印迹; 小鼠; 1:1000
Hoy J, Haeger P, Constable J, Arias R, McCallum R, Kyweriga M, et al. Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions. J Neurosci. 2013;33:9364-84 pubmed 出版商
  • 免疫印迹; 大鼠
Murata Y, Constantine Paton M. Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway. J Neurosci. 2013;33:5040-52 pubmed 出版商
Gajardo I, Salazar C, Lopez Espíndola D, Estay C, Flores Muñoz C, Elgueta C, et al. Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice. Front Mol Neurosci. 2018;11:114 pubmed 出版商
Berg J, Lee C, Chen L, Galvan L, Cepeda C, Chen J, et al. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015;88:1173-1191 pubmed 出版商
Zollinger D, Chang K, Baalman K, Kim S, Rasband M. The Polarity Protein Pals1 Regulates Radial Sorting of Axons. J Neurosci. 2015;35:10474-84 pubmed 出版商
Chen N, Koopmans F, Gordon A, Paliukhovich I, Klaassen R, van der Schors R, et al. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. Biochim Biophys Acta. 2015;1854:827-33 pubmed 出版商
Chassefeyre R, Martínez Hernández J, Bertaso F, Bouquier N, Blot B, Laporte M, et al. Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B. J Neurosci. 2015;35:3155-73 pubmed 出版商
D Orsi B, Kilbride S, Chen G, Perez Alvarez S, Bonner H, Pfeiffer S, et al. Bax regulates neuronal Ca2+ homeostasis. J Neurosci. 2015;35:1706-22 pubmed 出版商
Neuner S, Wilmott L, Hope K, Hoffmann B, Chong J, Abramowitz J, et al. TRPC3 channels critically regulate hippocampal excitability and contextual fear memory. Behav Brain Res. 2015;281:69-77 pubmed 出版商
Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P. Controlling NMDA receptor subunit composition using ectopic retention signals. J Neurosci. 2014;34:16630-6 pubmed 出版商
McGuier N, Padula A, Lopez M, Woodward J, Mulholland P. Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice. Alcohol. 2015;49:21-7 pubmed 出版商
de Andrade G, Kunzelman L, Merrill M, Fuerst P. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. Mol Vis. 2014;20:1422-33 pubmed
Mellone M, Pelucchi S, Alberti L, Genazzani A, Di Luca M, Gardoni F. Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density. J Neurochem. 2015;132:159-68 pubmed 出版商
Bhattacharyya M, Battacharya M, Nandanoor A, Osman M, Kasinathan C, FREDERIKSE P. NMDA glutamate receptor NR1, NR2A and NR2B expression and NR2B Tyr-1472 phosphorylation in the lens. Neurochem Res. 2014;39:1825-32 pubmed 出版商
Kehoe L, Bellone C, De Roo M, Zandueta A, Dey P, Pérez Otaño I, et al. GluN3A promotes dendritic spine pruning and destabilization during postnatal development. J Neurosci. 2014;34:9213-21 pubmed 出版商
Neumann J, Dash Wagh S, Jüngling K, Tsai T, Meschkat M, Räk A, et al. Y-P30 promotes axonal growth by stabilizing growth cones. Brain Struct Funct. 2015;220:1935-50 pubmed 出版商
Trantham Davidson H, Burnett E, Gass J, Lopez M, Mulholland P, Centanni S, et al. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014;34:3706-18 pubmed 出版商
Li Q, Zheng S, Han A, Lin C, Stoilov P, Fu X, et al. The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. elife. 2014;3:e01201 pubmed 出版商
Gunn B, Cunningham L, Cooper M, Corteen N, Seifi M, Swinny J, et al. Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. J Neurosci. 2013;33:19534-54 pubmed 出版商
Fiuza M, González González I, Pérez Otaño I. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Proc Natl Acad Sci U S A. 2013;110:20807-12 pubmed 出版商
Kunda S, Cheriyan J, Hur M, Balsara R, Castellino F. Antagonist properties of Conus parius peptides on N-methyl-D-aspartate receptors and their effects on CREB signaling. PLoS ONE. 2013;8:e81405 pubmed 出版商
den Hartog C, Beckley J, Smothers T, Lench D, Holseberg Z, Fedarovich H, et al. Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. PLoS ONE. 2013;8:e80541 pubmed 出版商
Yuan T, Mameli M, O Connor E, Dey P, Verpelli C, Sala C, et al. Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. Neuron. 2013;80:1025-38 pubmed 出版商
Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed 出版商
Krüger J, Favaro P, Liu M, Kitlinska A, Huang X, Raabe M, et al. Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission. J Neurosci. 2013;33:15504-17 pubmed 出版商
Viviani B, Boraso M, Valero M, Gardoni F, Marco E, Llorente R, et al. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner. Brain Behav Immun. 2014;35:135-43 pubmed 出版商
Barcomb K, Coultrap S, Bayer K. Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol Pharmacol. 2013;84:834-43 pubmed 出版商
Gaier E, Miller M, Ralle M, Aryal D, Wetsel W, Mains R, et al. Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem. 2013;127:605-19 pubmed 出版商
Bonnet S, Akad D, Samaddar T, Liu Y, Huang X, Dong Y, et al. Synaptic state-dependent functional interplay between postsynaptic density-95 and synapse-associated protein 102. J Neurosci. 2013;33:13398-409 pubmed 出版商
Frühbeis C, Fröhlich D, Kuo W, Amphornrat J, Thilemann S, Saab A, et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013;11:e1001604 pubmed 出版商
Marco S, Giralt A, Petrovic M, Pouladi M, Mart nez Turrillas R, Mart nez Hern ndez J, et al. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med. 2013;19:1030-8 pubmed 出版商
Brigman J, Daut R, Wright T, Gunduz Cinar O, Graybeal C, Davis M, et al. GluN2B in corticostriatal circuits governs choice learning and choice shifting. Nat Neurosci. 2013;16:1101-10 pubmed 出版商
Chowdhury D, Marco S, Brooks I, Zandueta A, Rao Y, Haucke V, et al. Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors. J Neurosci. 2013;33:4151-64 pubmed 出版商
Di Filippo M, Chiasserini D, Gardoni F, Viviani B, Tozzi A, Giampà C, et al. Effects of central and peripheral inflammation on hippocampal synaptic plasticity. Neurobiol Dis. 2013;52:229-36 pubmed 出版商
Bagetta V, Sgobio C, Pendolino V, Del Papa G, Tozzi A, Ghiglieri V, et al. Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease. J Neurosci. 2012;32:17921-31 pubmed 出版商
Harraz M, Eacker S, Wang X, Dawson T, Dawson V. MicroRNA-223 is neuroprotective by targeting glutamate receptors. Proc Natl Acad Sci U S A. 2012;109:18962-7 pubmed 出版商
Mazzone C, Larese T, Kiraly D, Eipper B, Mains R. Analysis of kalirin-7 knockout mice reveals different effects in female mice. Mol Pharmacol. 2012;82:1241-9 pubmed 出版商
Zhang Y, Xiao X, Zhang X, Zhao Z, Zhang Y. Estrogen facilitates spinal cord synaptic transmission via membrane-bound estrogen receptors: implications for pain hypersensitivity. J Biol Chem. 2012;287:33268-81 pubmed
Xiao X, Yang Y, Zhang Y, Zhang X, Zhao Z, Zhang Y. Estrogen in the anterior cingulate cortex contributes to pain-related aversion. Cereb Cortex. 2013;23:2190-203 pubmed 出版商
Mulholland P, Jordan B, Chandler L. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons. Alcohol. 2012;46:569-76 pubmed 出版商
Wilke S, Hall B, Antonios J, DeNardo L, Otto S, Yuan B, et al. NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev. 2012;7:9 pubmed 出版商
Wang C, Held R, Chang S, Yang L, Delpire E, Ghosh A, et al. A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron. 2011;72:789-805 pubmed 出版商
Peng X, Kim J, Zhou Z, Fink D, Mata M. Neuronal Nogo-A regulates glutamate receptor subunit expression in hippocampal neurons. J Neurochem. 2011;119:1183-93 pubmed 出版商
Kiraly D, Lemtiri Chlieh F, Levine E, Mains R, Eipper B. Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. J Neurosci. 2011;31:12554-65 pubmed 出版商
Eipper Mains J, Kiraly D, Palakodeti D, Mains R, Eipper B, Graveley B. microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. RNA. 2011;17:1529-43 pubmed 出版商
Doherty F, Sladek C. NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D. Brain Res. 2011;1388:89-99 pubmed 出版商
Mains R, Kiraly D, Eipper Mains J, Ma X, Eipper B. Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. BMC Neurosci. 2011;12:20 pubmed 出版商
Fourgeaud L, Davenport C, Tyler C, Cheng T, Spencer M, Boulanger L. MHC class I modulates NMDA receptor function and AMPA receptor trafficking. Proc Natl Acad Sci U S A. 2010;107:22278-83 pubmed 出版商
Hsin H, Kim M, Wang C, Sheng M. Proline-rich tyrosine kinase 2 regulates hippocampal long-term depression. J Neurosci. 2010;30:11983-93 pubmed 出版商
Antion M, Christie L, Bond A, Dalva M, Contractor A. Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses. Mol Cell Neurosci. 2010;45:378-88 pubmed 出版商
Perez de Arce K, de Arce K, Varela Nallar L, Farias O, Cifuentes A, Bull P, et al. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. J Neurosci. 2010;30:3728-38 pubmed 出版商
Edbauer D, Neilson J, Foster K, Wang C, Seeburg D, Batterton M, et al. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron. 2010;65:373-84 pubmed 出版商
Longordo F, Kopp C, Mishina M, Lujan R, Lüthi A. NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss. J Neurosci. 2009;29:9026-41 pubmed 出版商
Gardoni F, Mauceri D, Malinverno M, Polli F, Costa C, Tozzi A, et al. Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression. J Neurosci. 2009;29:669-77 pubmed 出版商
Ghasemzadeh M, Vasudevan P, Mueller C. Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects. Pharmacol Biochem Behav. 2009;92:383-92 pubmed 出版商
Ghasemzadeh M, Mueller C, Vasudevan P. Behavioral sensitization to cocaine is associated with increased glutamate receptor trafficking to the postsynaptic density after extended withdrawal period. Neuroscience. 2009;159:414-26 pubmed 出版商
Ma X, Kiraly D, Gaier E, Wang Y, Kim E, Levine E, et al. Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008;28:12368-82 pubmed 出版商
产品信息
TargetType :
Receptors
靶标 :
GluN2B/NR2B谷氨酸受体
AccessionNum :
Q00960
克隆 :
N59/20
HumanGeneName :
GRIN2B
DataSheetFileName :
neuromab.ucdavis.edu/datasheet/N59_20.pdf
抗体亚型 :
IgG2a
ValidationT :
Pass
ValidationBrIB :
Pass
ValidationBrIHC :
Pass
ValidationKO :
Pass
目录 :
75-097
更多信息或购买 :
公司信息
Neuromab
PO Box 1560 Davis, CA 95617-1560
info@antibodiesinc.com
http://neuromab.ucdavis.edu
800-824-8540 530-758-4400
公司总部: 美国