出版应用/物种/样本/稀释 | 参考文献 |
---|
| Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed 出版商
|
| Mir R, Tonelli F, Lis P, MacArtney T, Polinski N, Martinez T, et al. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human. Biochem J. 2018;475:1861-1883 pubmed 出版商
|
| Purlyte E, Dhekne H, Sarhan A, Gomez R, Lis P, Wightman M, et al. Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. EMBO J. 2018;37:1-18 pubmed 出版商
|
| Fan Y, Howden A, Sarhan A, Lis P, Ito G, Martinez T, et al. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils. Biochem J. 2018;475:23-44 pubmed 出版商
|
| Kim M, Deng H, Wong Y, Siddique T, Krainc D. The Parkinson's disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking. Hum Mol Genet. 2017;26:729-741 pubmed 出版商
|
- 免疫组化基因敲除验证; 小鼠; 1:100-1:400; 图 3a
- 免疫印迹; 小鼠; 1:1000; 图 2a
| Dzamko N, Gysbers A, Bandopadhyay R, Bolliger M, Uchino A, Zhao Y, et al. LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies. Mov Disord. 2017;32:423-432 pubmed 出版商
|
- proximity ligation assay; 小鼠; 1:50; 图 6
- 免疫细胞化学; 小鼠; 1:50; 图 s5
| Choi I, Kim B, Byun J, Baik S, Huh Y, Kim J, et al. LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase. Nat Commun. 2015;6:8255 pubmed 出版商
|
- 免疫印迹; 人类; 图 1a,1e,1f,2a,2d,3a
| Zhao J, Molitor T, Langston J, Nichols R. LRRK2 dephosphorylation increases its ubiquitination. Biochem J. 2015;469:107-20 pubmed 出版商
|
- 免疫印迹基因敲除验证; 大鼠; 1:1000; 图 1
| Boddu R, Hull T, Bolisetty S, Hu X, Moehle M, Daher J, et al. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Hum Mol Genet. 2015;24:4078-93 pubmed 出版商
|
- 免疫印迹基因敲除验证; 大鼠; 图 5
- 免疫组化; 大鼠; 图 6
- 免疫细胞化学基因敲除验证; 小鼠; 图 s3
- 免疫印迹基因敲除验证; 小鼠; 图 1, s2
- 免疫沉淀; 小鼠; 图 2
- 免疫沉淀; 人类; 图 2
- 免疫印迹; 人类; 图 1
| Davies P, Hinkle K, Sukar N, Sepulveda B, Mesias R, Serrano G, et al. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. Biochem J. 2013;453:101-13 pubmed 出版商
|
| Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed 出版商
|
| Henry A, Aghamohammadzadeh S, Samaroo H, Chen Y, Mou K, Needle E, et al. Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression. Hum Mol Genet. 2015;24:6013-28 pubmed 出版商
|
| Fuji R, Flagella M, Baca M, Baptista M, Brodbeck J, Chan B, et al. Effect of selective LRRK2 kinase inhibition on nonhuman primate lung. Sci Transl Med. 2015;7:273ra15 pubmed 出版商
|
| Liu Z, Galemmo R, Fraser K, Moehle M, Sen S, Volpicelli Daley L, et al. Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. J Biol Chem. 2014;289:32937-51 pubmed 出版商
|
| Lee J, Tapias V, Di Maio R, Greenamyre J, Cannon J. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiol Aging. 2015;36:505-18 pubmed 出版商
|
| Gomez Suaga P, Rivero Ríos P, Fdez E, Blanca Ramírez M, Ferrer I, Aiastui A, et al. LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity. Hum Mol Genet. 2014;23:6779-96 pubmed 出版商
|
| Daher J, Volpicelli Daley L, Blackburn J, Moehle M, West A. Abrogation of ?-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. Proc Natl Acad Sci U S A. 2014;111:9289-94 pubmed 出版商
|
| Schapansky J, Nardozzi J, Felizia F, LaVoie M. Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. Hum Mol Genet. 2014;23:4201-14 pubmed 出版商
|
| West A, Cowell R, Daher J, Moehle M, Hinkle K, Melrose H, et al. Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. J Comp Neurol. 2014;522:2465-80 pubmed 出版商
|
| Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, et al. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS ONE. 2014;9:e85510 pubmed 出版商
|
| Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, et al. Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. Hum Mol Genet. 2014;23:2055-77 pubmed 出版商
|
| Yao C, Johnson W, Gao Y, Wang W, Zhang J, Deak M, et al. Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum Mol Genet. 2013;22:328-44 pubmed 出版商
|
| Gomez Suaga P, Luzón Toro B, Churamani D, Zhang L, Bloor Young D, Patel S, et al. Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet. 2012;21:511-25 pubmed 出版商
|