产品简要
公司名称 :
Nordic BioSite
产品类型 :
抗体
产品名称 :
MLH1
目录 :
BSH-7208-100
规格 :
100微升
价格 :
190美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
BS29
反应物种 :
人类
应用 :
免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录代码 :
BSH-7208-100
产品名称 :
MLH1
产品类型 :
Antibodies, Primary
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
BS29
规格 :
100微升
标价(美元) :
190美元
产品描述 :
Anti-MLH1, mouse monoclonal - Optibodies
背景 :
DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.
别名 :
HNPCC
缓冲液 :
TRIS with 0.03% sodium azide, pH7,2
应用摘要 :
免疫组化-P
储存 :
存放在4℃
更多信息或购买 :
公司信息
Nordic BioSite
support-us@nordicbiosite.com
www.nordicbiosite.com