产品简要
公司名称 :
Nordic BioSite
产品类型 :
抗体
产品名称 :
EpCAM
目录 :
BSH-7402-100
规格 :
100微升
价格 :
190美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
BS14
反应物种 :
人类
应用 :
免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录代码 :
BSH-7402-100
产品名称 :
EpCAM
产品类型 :
Antibodies, Primary
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
BS14
规格 :
100微升
标价(美元) :
190美元
产品描述 :
Anti-EPCAM, mouse monoclonal - Optibodies
背景 :
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas. EPCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups, and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM, many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues, with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells. EpCAM expression has been reported to be a possible marker of early malignancy, with expression being increased in tumour cells, and de novo expression being seen in dysplastic squamous epithelium. This cell surface, glycosylated 40kD protein is highly expressed in the bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin.
别名 :
上皮细胞 细胞粘附分子
缓冲液 :
TRIS with 0.03% sodium azide, pH7,2
应用摘要 :
免疫组化-P
储存 :
存放在4℃
更多信息或购买 :
公司信息
Nordic BioSite
support-us@nordicbiosite.com
www.nordicbiosite.com