产品简要
公司名称 :
Nordic BioSite
产品类型 :
抗体
产品名称 :
E钙粘蛋白
目录 :
BSH-7516-1
规格 :
1毫升
价格 :
550美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
BS38
反应物种 :
人类, 小鼠
应用 :
免疫组化-石蜡切片
更多信息或购买 :
Nordic BioSite 产品网页
产品信息
目录代码 :
BSH-7516-1
产品名称 :
E钙粘蛋白
产品类型 :
Antibodies, Primary
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
BS38
规格 :
1毫升
标价(美元) :
550美元
产品描述 :
Anti-E-Cadherin, mouse monoclonal - Optibodies
背景 :
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
别名 :
ECAD, CDH1
缓冲液 :
TRIS with 0.03% sodium azide, pH7,2
应用摘要 :
免疫组化-P
储存 :
存放在4℃
更多信息或购买 :
Nordic BioSite 产品网页
公司信息
Nordic BioSite
support-us@nordicbiosite.com
www.nordicbiosite.com