产品简要
公司名称 :
Nordic BioSite
产品类型 :
抗体
产品名称 :
PAX5
目录 :
BSH-7833-100
规格 :
100微升
价格 :
190美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
BS11
反应物种 :
人类
应用 :
免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
产品信息
目录代码 :
BSH-7833-100
产品名称 :
PAX5
产品类型 :
Antibodies, Primary
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
未共轭
克隆名称 :
BS11
规格 :
100微升
标价(美元) :
190美元
产品描述 :
Anti-PAX5, mouse monoclonal - Optibodies
背景 :
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
别名 :
BSAP
缓冲液 :
TRIS with 0.03% sodium azide, pH7,2
应用摘要 :
IHC-P,IHC-Fr
储存 :
存放在4℃
更多信息或购买 :
公司信息
Nordic BioSite
support-us@nordicbiosite.com
www.nordicbiosite.com