产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
PINK1抗体
目录 :
BC100-494
规格 :
0.1 ml (also 0.025 ml)
价格 :
379美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
HH1/1784R
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, proximity ligation assay, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 132
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 大鼠; 1:50; 图 3a
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4, 7
Huang Y, Gu C, Wang Q, Xu L, Chen J, Zhou W, et al. The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury. FASEB J. 2020;34:2055-2074 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2b
Walsh T, van den Bosch M, Lewis K, Williams C, Poole A. Loss of the mitochondrial kinase PINK1 does not alter platelet function. Sci Rep. 2018;8:14377 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3e
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed 出版商
  • 免疫沉淀; 人类; 图 3g
  • 免疫细胞化学; 人类; 图 3h
  • 免疫印迹; 人类; 图 4a
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s20c
Wettengel J, Reautschnig P, Geisler S, Kahle P, Stafforst T. Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res. 2017;45:2797-2808 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed 出版商
  • proximity ligation assay; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed 出版商
Xing Y, Wei X, Liu Y, Wang M, Sui Z, Wang X, et al. Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway. Autophagy. 2021;:1-23 pubmed 出版商
Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, et al. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2021;:1-19 pubmed 出版商
Francelin C, Mitter S, Qian Q, Barodia S, Ip C, Qi X, et al. BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage. Antioxidants (Basel). 2021;10: pubmed 出版商
Uesugi R, Ishii S, Matsuura A, Itakura E. Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. J Biol Chem. 2021;297:101279 pubmed 出版商
Duan K, Gu Q, Petralia R, Wang Y, Panja D, Liu X, et al. Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience. Neuron. 2021;109:3793-3809.e8 pubmed 出版商
Cucarull B, Tutusaus A, Hernáez Alsina T, Garcia de Frutos P, Reig M, Colell A, et al. Antioxidants Threaten Multikinase Inhibitor Efficacy against Liver Cancer by Blocking Mitochondrial Reactive Oxygen Species. Antioxidants (Basel). 2021;10: pubmed 出版商
Baiano C, Job X, Santangelo G, Auvray M, Kirsch L. Interactions between interoception and perspective-taking: Current state of research and future directions. Neurosci Biobehav Rev. 2021;130:252-262 pubmed 出版商
Soman S, Tingle D, Dagda R, Torres M, Dagda M, Dagda R. Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation. J Neurosci Res. 2021;99:2134-2155 pubmed 出版商
Anzell A, Fogo G, Gurm Z, Raghunayakula S, Wider J, Maheras K, et al. Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons. Cell Death Dis. 2021;12:475 pubmed 出版商
Wang C, Liu K, Cao J, Wang L, Zhao Q, Li Z, et al. PINK1-mediated mitophagy maintains pluripotency through optineurin. Cell Prolif. 2021;54:e13034 pubmed 出版商
Wang B, Ye Y, Qian C, Zhang H, Mao H, Yao L, et al. Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease. Neural Regen Res. 2021;16:2521-2527 pubmed 出版商
Miyahara K, Takano N, Yamada Y, Kazama H, Tokuhisa M, Hino H, et al. BRCA1 degradation in response to mitochondrial damage in breast cancer cells. Sci Rep. 2021;11:8735 pubmed 出版商
Reddy A, Sawant N, Morton H, Kshirsagar S, Bunquin L, Yin X, et al. Selective serotonin reuptake inhibitor citalopram ameliorates cognitive decline and protects against amyloid beta-induced mitochondrial dynamics, biogenesis, autophagy, mitophagy and synaptic toxicities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2021;30:789-810 pubmed 出版商
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, et al. miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes. Life Sci. 2021;276:119415 pubmed 出版商
Roca Agujetas V, Barbero Camps E, de Dios C, Podlesniy P, Abadin X, Morales A, et al. Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease. Mol Neurodegener. 2021;16:15 pubmed 出版商
Wang H, Dou S, Zhu J, Shao Z, Wang C, Xu X, et al. Ghrelin protects against rotenone-induced cytotoxicity: Involvement of mitophagy and the AMPK/SIRT1/PGC1α pathway. Neuropeptides. 2021;87:102134 pubmed 出版商
Ragimbeau R, El Kebriti L, Sebti S, Fourgous E, Boulahtouf A, Arena G, et al. BAG6 promotes PINK1 signaling pathway and is essential for mitophagy. FASEB J. 2021;35:e21361 pubmed 出版商
Choi G, Lee H, Chae C, Cho J, Jung Y, Kim J, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun. 2021;12:487 pubmed 出版商
Vangrieken P, Al Nasiry S, Bast A, Leermakers P, Tulen C, Janssen G, et al. Hypoxia-induced mitochondrial abnormalities in cells of the placenta. PLoS ONE. 2021;16:e0245155 pubmed 出版商
Wu D, Zhang H, Wu Q, Li F, Wang Y, Liu S, et al. Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages. Life Sci. 2021;267:118941 pubmed 出版商
Uda M, Yoshihara T, Ichinoseki Sekine N, Baba T, Yoshioka T. Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS ONE. 2020;15:e0243660 pubmed 出版商
Ramakrishnan R, Bajbouj K, Hachim M, Mogas A, Mahboub B, Olivenstein R, et al. Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients. PLoS ONE. 2020;15:e0242695 pubmed 出版商
Yu X, Sun Y, Cai Q, Zhao X, Liu Z, Xue X, et al. Hyperoxia exposure arrests alveolarization in neonatal rats via PTEN‑induced putative kinase 1‑Parkin and Nip3‑like protein X‑mediated mitophagy disorders. Int J Mol Med. 2020;46:2126-2136 pubmed 出版商
Cheng G, Hardy M, Zielonka J, Weh K, Zielonka M, Boyle K, et al. Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells. Cancer Treat Res Commun. 2020;25:100210 pubmed 出版商
Zhang X, Griepentrog J, Zou B, Xu L, CYR A, Chambers L, et al. CaMKIV regulates mitochondrial dynamics during sepsis. Cell Calcium. 2020;92:102286 pubmed 出版商
Gu C, Li L, Huang Y, Qian D, Liu W, Zhang C, et al. Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting Oxidative Stress and Promoting Mitophagy. Oxid Med Cell Longev. 2020;2020:3549704 pubmed 出版商
Wang X, Feng L, Xin M, Hao Y, Wang X, Shang P, et al. Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis. Biomed Pharmacother. 2020;127:110125 pubmed 出版商
Verma M, Zhu J, Wang K, Chu C. Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1 (PINK1) via up-regulation of Bcl-2-associated athanogene 6 (BAG6). J Biol Chem. 2020;295:7865-7876 pubmed 出版商
Nikolaou P, Efentakis P, Qourah F, Femminò S, Makridakis M, Kanaki Z, et al. Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress. Antioxid Redox Signal. 2020;: pubmed 出版商
Sridevi Gurubaran I, Viiri J, Koskela A, Hyttinen J, Paterno J, Kis G, et al. Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model. Int J Mol Sci. 2020;21: pubmed 出版商
Bhupana J, Huang B, Liou G, Calkins M, Lin Chao S. Gas7 knockout affects PINK1 expression and mitochondrial dynamics in mouse cortical neurons. FASEB Bioadv. 2020;2:166-181 pubmed 出版商
Franco Iborra S, Plaza Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez Vicente M. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. 2020;:1-18 pubmed 出版商
Sarkar A, Stellrecht C, Vangapandu H, Ayres M, Kaipparettu B, Park J, et al. Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Haematologica. 2020;: pubmed 出版商
Igarashi R, Yamashita S, Yamashita T, Inoue K, Fukuda T, Fukuchi T, et al. Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. Sci Rep. 2020;10:1465 pubmed 出版商
Park S, Koh H. FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells. Food Chem Toxicol. 2020;137:111163 pubmed 出版商
Furlong R, O Keeffe G, O Neill C, Sullivan A. Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Neurosci Lett. 2020;720:134777 pubmed 出版商
Ren Y, Zhang B, Zhao X, Zhang Z. Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria. J Neurochem. 2020;: pubmed 出版商
Riis S, Murray J, O Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. Cells. 2020;9: pubmed 出版商
Qu F, Wang P, Zhang K, Shi Y, Li Y, Li C, et al. Manipulation of Mitophagy by "All-in-One" nanosensitizer augments sonodynamic glioma therapy. Autophagy. 2019;:1-23 pubmed 出版商
Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed 出版商
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, et al. USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. Autophagy. 2019;:1-11 pubmed 出版商
Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke A, et al. Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy. Am J Pathol. 2019;189:2061-2076 pubmed 出版商
Tomita K, Takashi Y, Ouchi Y, Kuwahara Y, Igarashi K, Nagasawa T, et al. Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA. Cancer Sci. 2019;110:2856-2866 pubmed 出版商
Guardia Laguarta C, Liu Y, Lauritzen K, Erdjument Bromage H, Martin B, Swayne T, et al. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. J Neurosci. 2019;39:7074-7085 pubmed 出版商
Martín Maestro P, Gargini R, Garcia E, Simon D, Avila J, García Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. J Alzheimers Dis. 2019;: pubmed 出版商
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254 pubmed 出版商
Martín Maestro P, Sproul A, Martínez H, Paquet D, Gerges M, Noggle S, et al. Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells. Mol Neurobiol. 2019;: pubmed 出版商
Yan C, Gong L, Chen L, Xu M, Abou Hamdan H, Tang M, et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 2019;:1-16 pubmed 出版商
Ganzleben I, He G, Günther C, Prigge E, Richter K, Rieker R, et al. PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis. Cell Mol Life Sci. 2019;: pubmed 出版商
Warnez Soulie J, Macia M, Lac S, Pecchi E, Bernard M, Bendahan D, et al. Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo. Physiol Rep. 2019;7:e14055 pubmed 出版商
Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019;10:2205 pubmed 出版商
Livingston M, Wang J, Zhou J, Wu G, Ganley I, Hill J, et al. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy. 2019;:1-21 pubmed 出版商
Audesse A, Dhakal S, Hassell L, Gardell Z, Nemtsova Y, Webb A. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet. 2019;15:e1008097 pubmed 出版商
Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, et al. LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy. 2019;:1-20 pubmed 出版商
Eid N, Ito Y, Horibe A, Otsuki Y, Kondo Y. Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy. Cells. 2019;8: pubmed 出版商
Park J, Lee D, Lee Y, Oh E, Bae K, Oh K, et al. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. Autophagy. 2019;:1-20 pubmed 出版商
Cairó M, Campderros L, Gavaldà Navarro A, Cereijo R, Delgado Anglés A, Quesada López T, et al. Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis. EMBO Rep. 2019;20: pubmed 出版商
Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed 出版商
Yakhine Diop S, Niso Santano M, Rodríguez Arribas M, Gómez Sánchez R, Martínez Chacón G, Uribe Carretero E, et al. Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients. Mol Neurobiol. 2019;56:2466-2481 pubmed 出版商
McWilliams T, Barini E, Pohjolan Pirhonen R, Brooks S, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8: pubmed 出版商
Kim H, Joe Y, Rah S, Kim S, Park S, Park J, et al. Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis. 2018;9:1060 pubmed 出版商
Civiletto G, Doğan S, Cerutti R, Fagiolari G, Moggio M, Lamperti C, et al. Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med. 2018;10: pubmed 出版商
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed 出版商
Sun X, Duan Y, Qin C, Li J, Duan G, Deng X, et al. Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy. Cell Death Dis. 2018;9:953 pubmed 出版商
Basso V, Marchesan E, Peggion C, Chakraborty J, von Stockum S, Giacomello M, et al. Regulation of ER-mitochondria contacts by Parkin via Mfn2. Pharmacol Res. 2018;138:43-56 pubmed 出版商
Thomas H, Zhang Y, Stefely J, Veiga S, Thomas G, Kozma S, et al. Mitochondrial Complex I Activity Is Required for Maximal Autophagy. Cell Rep. 2018;24:2404-2417.e8 pubmed 出版商
Xu G, Li T, Chen J, Li C, Zhao H, Yao C, et al. Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing. Autophagy. 2018;14:1818-1830 pubmed 出版商
Lizama B, Palubinsky A, Raveendran V, Moore A, Federspiel J, Codreanu S, et al. Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein. J Neurosci. 2018;38:6825-6840 pubmed 出版商
Marcassa E, Kallinos A, Jardine J, Rusilowicz Jones E, Martinez A, Kuehl S, et al. Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO Rep. 2018;19: pubmed 出版商
Sun Y, Yao X, Zhang Q, Zhu M, Liu Z, Ci B, et al. Beclin-1-Dependent Autophagy Protects the Heart During Sepsis. Circulation. 2018;: pubmed 出版商
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett. 2018;291:92-100 pubmed 出版商
Ausman J, Abbade J, Ermini L, Farrell A, Tagliaferro A, Post M, et al. Ceramide-induced BOK promotes mitochondrial fission in preeclampsia. Cell Death Dis. 2018;9:298 pubmed 出版商
Hawk M, Gorsuch C, Fagan P, Lee C, Kim S, Hamann J, et al. RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells. Nat Cell Biol. 2018;20:272-284 pubmed 出版商
Song Y, Du Y, Zou W, Luo Y, Zhang X, Fu J. Involvement of impaired autophagy and mitophagy in Neuro-2a cell damage under hypoxic and/or high-glucose conditions. Sci Rep. 2018;8:3301 pubmed 出版商
Biel T, Rao V. Mitochondrial dysfunction activates lysosomal-dependent mitophagy selectively in cancer cells. Oncotarget. 2018;9:995-1011 pubmed 出版商
Bueno M, Brands J, Voltz L, Fiedler K, Mays B, St Croix C, et al. ATF3 represses PINK1 gene transcription in lung epithelial cells to control mitochondrial homeostasis. Aging Cell. 2018;17: pubmed 出版商
Kumar A, Shaha C. SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation. Sci Rep. 2018;8:615 pubmed 出版商
Fiesel F, James E, Hudec R, Springer W. Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy. Oncotarget. 2017;8:106233-106248 pubmed 出版商
Yoo L, Chung K. The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. J Biol Chem. 2018;293:1286-1297 pubmed 出版商
Sorrentino V, Romani M, Mouchiroud L, Beck J, Zhang H, D Amico D, et al. Enhancing mitochondrial proteostasis reduces amyloid-? proteotoxicity. Nature. 2017;552:187-193 pubmed 出版商
Mizumura K, Justice M, Schweitzer K, Krishnan S, Bronova I, Berdyshev E, et al. Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J. 2017;: pubmed 出版商
Tang C, Han H, Yan M, Zhu S, Liu J, Liu Z, et al. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against Renal ischemia-reperfusion injury. Autophagy. 2017;:1-45 pubmed 出版商
Kravic B, Harbauer A, Romanello V, Simeone L, Vögtle F, Kaiser T, et al. In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy. 2018;14:311-335 pubmed 出版商
Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, et al. PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress. Nat Commun. 2017;8:1399 pubmed 出版商
Kim H, Ham S, Jo M, Lee G, Lee Y, Shin J, et al. CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation. Int J Mol Sci. 2017;18: pubmed 出版商
Mart n Maestro P, Gargini R, A Sproul A, Garc a E, Ant n L, Noggle S, et al. Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Front Mol Neurosci. 2017;10:291 pubmed 出版商
Bartolomé A, García Aguilar A, Asahara S, Kido Y, Guillen C, Pajvani U, et al. MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol. 2017;37: pubmed 出版商
Zhang C, Liu Z, Bunker E, Ramírez A, Lee S, Peng Y, et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response. J Biol Chem. 2017;292:15105-15120 pubmed 出版商
Ando M, Fiesel F, Hudec R, Caulfield T, Ogaki K, Górka Skoczylas P, et al. The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity. Mol Neurodegener. 2017;12:32 pubmed 出版商
Orr A, Rutaganira F, de Roulet D, Huang E, Hertz N, Shokat K, et al. Long-term oral kinetin does not protect against ?-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017;109:106-116 pubmed 出版商
Martinez A, Lectez B, Ramirez J, Popp O, Sutherland J, Urbé S, et al. Quantitative proteomic analysis of Parkin substrates in Drosophila neurons. Mol Neurodegener. 2017;12:29 pubmed 出版商
Gelmetti V, De Rosa P, Torosantucci L, Marini E, Romagnoli A, Di Rienzo M, et al. PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation. Autophagy. 2017;13:654-669 pubmed 出版商
Sato S, Furuya N. Induction of PINK1/Parkin-Mediated Mitophagy. Methods Mol Biol. 2018;1759:9-17 pubmed 出版商
Callegari S, Oeljeklaus S, Warscheid B, Dennerlein S, Thumm M, Rehling P, et al. Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects. Autophagy. 2017;13:201-211 pubmed 出版商
Jamil S, Hojabrpour P, Duronio V. The small molecule 2-phenylethynesulfonamide induces covalent modification of p53. Biochem Biophys Res Commun. 2017;482:154-158 pubmed 出版商
Wai T, Saita S, Nolte H, Müller S, König T, Richter Dennerlein R, et al. The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i-AAA protease YME1L. EMBO Rep. 2016;17:1844-1856 pubmed
Mannam P, Rauniyar N, Lam T, Luo R, Lee P, Srivastava A. MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. Free Radic Biol Med. 2016;101:102-115 pubmed 出版商
Zhang T, Xue L, Li L, Tang C, Wan Z, Wang R, et al. BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy. J Biol Chem. 2016;291:21616-21629 pubmed
Xu Y, Zhi F, Shao N, Wang R, Yang Y, Xia Y. Cytoprotection against Hypoxic and/or MPP? Injury: Effect of ?-Opioid Receptor Activation on Caspase 3. Int J Mol Sci. 2016;17: pubmed 出版商
Kim J, Fiesel F, Belmonte K, Hudec R, Wang W, Kim C, et al. miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1). Mol Neurodegener. 2016;11:55 pubmed 出版商
Berezhnov A, Soutar M, Fedotova E, Frolova M, Plun Favreau H, Zinchenko V, et al. Intracellular pH Modulates Autophagy and Mitophagy. J Biol Chem. 2016;291:8701-8 pubmed 出版商
Martín Maestro P, Gargini R, Perry G, Avila J, García Escudero V. PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease. Hum Mol Genet. 2016;25:792-806 pubmed 出版商
Qu D, Hage A, Don Carolis K, Huang E, Joselin A, Safarpour F, et al. BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. J Biol Chem. 2015;290:30441-52 pubmed 出版商
Fiesel F, Ando M, Hudec R, Hill A, Castanedes Casey M, Caulfield T, et al. (Patho-)physiological relevance of PINK1-dependent ubiquitin phosphorylation. EMBO Rep. 2015;16:1114-30 pubmed 出版商
Srivastava A, McGinniss J, Wong Y, Shinn A, Lam T, Lee P, et al. MKK3 deletion improves mitochondrial quality. Free Radic Biol Med. 2015;87:373-84 pubmed 出版商
Meissner C, Lorenz H, Hehn B, Lemberg M. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy. 2015;11:1484-98 pubmed 出版商
Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed 出版商
Peng M, Ostrovsky J, Kwon Y, Polyak E, Licata J, Tsukikawa M, et al. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease. Hum Mol Genet. 2015;24:4829-47 pubmed 出版商
Lim G, Chua D, Basil A, Chan H, Chai C, Arumugam T, et al. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. J Biol Chem. 2015;290:16882-93 pubmed 出版商
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed 出版商
Yue M, Hinkle K, Davies P, Trushina E, Fiesel F, Christenson T, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis. 2015;78:172-95 pubmed 出版商
Seillier M, Pouyet L, N Guessan P, Nollet M, Capo F, Guillaumond F, et al. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med. 2015;7:802-18 pubmed 出版商
Han J, Kang M, Kim K, Han P, Kim H, Ha J, et al. Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy. J Biol Chem. 2015;290:10325-35 pubmed 出版商
Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 2015;11:166-82 pubmed 出版商
Palubinsky A, Stankowski J, Kale A, Codreanu S, Singer R, Liebler D, et al. CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling. Antioxid Redox Signal. 2015;23:535-49 pubmed 出版商
Bueno M, Lai Y, Romero Y, Brands J, St Croix C, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125:521-38 pubmed 出版商
Aerts L, Craessaerts K, De Strooper B, Morais V. PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem. 2015;290:2798-811 pubmed 出版商
Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015;290:904-17 pubmed 出版商
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed 出版商
Rossin F, D Eletto M, Falasca L, Sepe S, Cocco S, Fimia G, et al. Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death Differ. 2015;22:408-18 pubmed 出版商
产品信息
品牌 :
Novus
master code :
BC100-494
SKU号 :
BC100-494
产品名称 :
PINK1抗体
描述 :
The PINK1 Antibody from BC100-494 is a bc100-494 antibody to . This antibody reacts with alzheimers research, autophagy, cardiovascular biology, dna repair, lipid and metabolism, mitochondrial markers, mitophagy, neurodegeneration, neuronal cell markers, neuroscience, protein kinase, signal transduction. The PINK1 Antibody has been validated for the following applications: Q9BXM7.
靶标 :
PINK1
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
PINK1 antibody was developed using a synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 果蝇, 兔
特异性 :
Human PINK1 Antibody will be reactive to isoform 2
理论上的分子量 :
62.7 kDa
基因符号 :
PINK1
accessionNumbers :
Q9BXM7
应用 :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Peptide ELISA, SDS-Page, Knockout Validated, Knockdown Validated
美元 :
379美元
别名 :
Anti-PINK1, BRPK, EC 2.7.11.1, FLJ27236, Mitochondrial, PARK6, Parkinson disease (autosomal recessive) 6, PINK1, PINK1 mouse, PINK1 polyclonal, protein kinase BRPK, PTEN Induced Kinase 1, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, serine/threonine-protein kinase PINK1, mitochondrial
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。