产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
PINK1 Antibody - BSA Free
目录 :
BC100-494
规格 :
0.1 ml (also 0.025 ml)
价格 :
469美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
HH1/1784R
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, proximity ligation assay, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 173
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 6f
  • 免疫印迹; 小鼠; 1:1000; 图 5c
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  • 免疫印迹; 人类; 1:3000; 图 3c
Choi G, Lee H, Chae C, Cho J, Jung Y, Kim J, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun. 2021;12:487 pubmed 出版商
  • 免疫印迹; 大鼠; 1:50; 图 3a
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, et al. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging (Albany NY). 2020;12:25035-25059 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4, 7
Huang Y, Gu C, Wang Q, Xu L, Chen J, Zhou W, et al. The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury. FASEB J. 2020;34:2055-2074 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2b
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  • 免疫印迹; 人类; 图 1a
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  • 免疫印迹; 小鼠; 1:1000; 图 2a
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3e
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
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  • 免疫沉淀; 人类; 图 3g
  • 免疫细胞化学; 人类; 图 3h
  • 免疫印迹; 人类; 图 4a
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  • 免疫印迹基因敲除验证; 人类; 图 s20c
Wettengel J, Reautschnig P, Geisler S, Kahle P, Stafforst T. Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res. 2017;45:2797-2808 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
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  • proximity ligation assay; 人类; 图 2
  • 免疫印迹; 人类; 图 1
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  • 免疫印迹; 人类; 图 3a
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Choi Y, Choi Y, Ko S, Cheon C, Kim T. Investigation of Molecular Mechanisms Involved in Sensitivity to the Anti-Cancer Activity of Costunolide in Breast Cancer Cells. Int J Mol Sci. 2023;24: pubmed 出版商
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Xie X, Yang Y, Wang Q, Liu H, Fang X, Li C, et al. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria. Cell Res. 2023;33:215-228 pubmed 出版商
Sharma N, Banerjee R, Davis R. Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2023;: pubmed 出版商
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Wang R, Santos J, Dufour J, Stephens E, Miranda J, Washburn R, et al. Ginger Root Extract Improves GI Health in Diabetic Rats by Improving Intestinal Integrity and Mitochondrial Function. Nutrients. 2022;14: pubmed 出版商
Kshirsagar S, Alvir R, Pradeepkiran J, Hindle A, Vijayan M, Ramasubramaniam B, et al. A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer's Disease. Cells. 2022;11: pubmed 出版商
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed 出版商
Nguyen J, Deering Rice C, Armstrong B, Massa C, Reilly C, Venosa A. Parenchymal and Inflammatory Cell Responses to Single and Repeated Ozone Exposure in Healthy and Surfactant Protein-C Mutant Lung. Toxicol Sci. 2022;189:107-123 pubmed 出版商
Duan P, Tan J, Miao Y, Zhang Q. PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in Albumin Overload-Induced Renal Tubular Cell Injury. Front Biosci (Landmark Ed). 2022;27:184 pubmed 出版商
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Yang L, Tao Y, Luo L, Zhang Y, Wang X, Meng X. Dengzhan Xixin injection derived from a traditional Chinese herb Erigeron breviscapus ameliorates cerebral ischemia/reperfusion injury in rats via modulation of mitophagy and mitochondrial apoptosis. J Ethnopharmacol. 2022;288:114988 pubmed 出版商
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Uesugi R, Ishii S, Matsuura A, Itakura E. Labeling and measuring stressed mitochondria using a PINK1-based ratiometric fluorescent sensor. J Biol Chem. 2021;297:101279 pubmed 出版商
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Franco Iborra S, Plaza Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez Vicente M. Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease. Autophagy. 2020;:1-18 pubmed 出版商
Sarkar A, Stellrecht C, Vangapandu H, Ayres M, Kaipparettu B, Park J, et al. Ataxia telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma. Haematologica. 2020;: pubmed 出版商
Igarashi R, Yamashita S, Yamashita T, Inoue K, Fukuda T, Fukuchi T, et al. Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1. Sci Rep. 2020;10:1465 pubmed 出版商
Park S, Koh H. FUNDC1 regulates receptor-mediated mitophagy independently of the PINK1/Parkin-dependent pathway in rotenone-treated SH-SY5Y cells. Food Chem Toxicol. 2020;137:111163 pubmed 出版商
Furlong R, O Keeffe G, O Neill C, Sullivan A. Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Neurosci Lett. 2020;720:134777 pubmed 出版商
Ren Y, Zhang B, Zhao X, Zhang Z. Resolvin D1 ameliorates cognitive impairment following traumatic brain injury via protecting astrocytic mitochondria. J Neurochem. 2020;: pubmed 出版商
Riis S, Murray J, O Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. Cells. 2020;9: pubmed 出版商
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Berndsen K, Lis P, Yeshaw W, Wawro P, Nirujogi R, Wightman M, et al. PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. elife. 2019;8: pubmed 出版商
Niu K, Fang H, Chen Z, Zhu Y, Tan Q, Wei D, et al. USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy. Autophagy. 2019;:1-11 pubmed 出版商
Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke A, et al. Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy. Am J Pathol. 2019;189:2061-2076 pubmed 出版商
Tomita K, Takashi Y, Ouchi Y, Kuwahara Y, Igarashi K, Nagasawa T, et al. Lipid peroxidation increases hydrogen peroxide permeability leading to cell death in cancer cell lines that lack mtDNA. Cancer Sci. 2019;110:2856-2866 pubmed 出版商
Guardia Laguarta C, Liu Y, Lauritzen K, Erdjument Bromage H, Martin B, Swayne T, et al. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. J Neurosci. 2019;39:7074-7085 pubmed 出版商
Martín Maestro P, Gargini R, Garcia E, Simon D, Avila J, García Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. J Alzheimers Dis. 2019;: pubmed 出版商
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产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
BC100-494
SKU号 :
BC100-494
产品名称 :
PINK1 Antibody - BSA Free
描述 :
The PINK1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to PINK1. This antibody reacts with human, mouse, rat, rabbit. The PINK1 Antibody - BSA Free has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Peptide ELISA, Electron Microscopy, SDS-Page, Knockout Validated, Knockdown Validated.
靶标 :
PINK1
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
PINK1 antibody was developed using a synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 兔
特异性 :
Human PINK1 Antibody will be reactive to isoform 2
理论上的分子量 :
62.7 kDa
基因符号 :
PINK1
accessionNumbers :
Q9BXM7
应用 :
Western Blot, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Peptide ELISA, Electron Microscopy, SDS-Page, Knockout Validated, Knockdown Validated
美元 :
469美元
别名 :
Anti-PINK1, BRPK, EC 2.7.11.1, FLJ27236, Mitochondrial, PARK6, Parkinson disease (autosomal recessive) 6, PINK1, PINK1 mouse, PINK1 polyclonal, protein kinase BRPK, PTEN Induced Kinase 1, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, serine/threonine-protein kinase PINK1, mitochondrial
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。