产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
PINK1抗体
目录 :
BC100-494
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, proximity ligation assay, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 140
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 s2b
Walsh T, van den Bosch M, Lewis K, Williams C, Poole A. Loss of the mitochondrial kinase PINK1 does not alter platelet function. Sci Rep. 2018;8:14377 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation. Cell Death Differ. 2018;25:873-884 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Viana Huete V, Guillen C, García G, Fernandez S, García Aguilar A, Kahn C, et al. Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology. 2018;159:323-340 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3e
Xiao B, Goh J, Xiao L, Xian H, Lim K, Liou Y. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. 2017;292:16697-16708 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed 出版商
  • 免疫沉淀; 人类; 图 3g
  • 免疫细胞化学; 人类; 图 3h
  • 免疫印迹; 人类; 图 4a
Li G, Fu R, Shen H, Zhou J, Hu X, Liu Y, et al. Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels. Oncotarget. 2017;8:10359-10374 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s20c
Wettengel J, Reautschnig P, Geisler S, Kahle P, Stafforst T. Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. Nucleic Acids Res. 2017;45:2797-2808 pubmed 出版商
  • proximity ligation assay; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Akabane S, Matsuzaki K, Yamashita S, Arai K, Okatsu K, Kanki T, et al. Constitutive Activation of PINK1 Protein Leads to Proteasome-mediated and Non-apoptotic Cell Death Independently of Mitochondrial Autophagy. J Biol Chem. 2016;291:16162-74 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Ivankovic D, Chau K, Schapira A, Gegg M. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy. J Neurochem. 2016;136:388-402 pubmed 出版商
  • 免疫印迹; 人类
Park S, Choi S, Yoo S, Nah J, Jeong E, Kim H, et al. Pyruvate stimulates mitophagy via PINK1 stabilization. Cell Signal. 2015;27:1824-30 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫细胞化学; 人类; 图 5
  • 免疫印迹; 人类; 图 1
Lim G, Chua D, Basil A, Chan H, Chai C, Arumugam T, et al. Cytosolic PTEN-induced Putative Kinase 1 Is Stabilized by the NF-κB Pathway and Promotes Non-selective Mitophagy. J Biol Chem. 2015;290:16882-93 pubmed 出版商
  • 免疫沉淀; 人类; 1:1000; 图 1
  • 免疫细胞化学; 人类; 1:1000; 图 5
  • 免疫印迹; 人类
Okatsu K, Koyano F, Kimura M, Kosako H, Saeki Y, Tanaka K, et al. Phosphorylated ubiquitin chain is the genuine Parkin receptor. J Cell Biol. 2015;209:111-28 pubmed 出版商
  • 免疫印迹; 小鼠
Yue M, Hinkle K, Davies P, Trushina E, Fiesel F, Christenson T, et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice. Neurobiol Dis. 2015;78:172-95 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a, 5b, 5c
  • 免疫印迹; 人类
Seillier M, Pouyet L, N Guessan P, Nollet M, Capo F, Guillaumond F, et al. Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med. 2015;7:802-18 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2a
Zhang Q, Kuang H, Chen C, Yan J, Do Umehara H, Liu X, et al. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol. 2015;16:458-66 pubmed 出版商
  • 免疫印迹; 人类
Han J, Kang M, Kim K, Han P, Kim H, Ha J, et al. Nitric oxide induction of Parkin translocation in PTEN-induced putative kinase 1 (PINK1) deficiency: functional role of neuronal nitric oxide synthase during mitophagy. J Biol Chem. 2015;290:10325-35 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2f
Jabir M, Hopkins L, Ritchie N, Ullah I, Bayes H, Li D, et al. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 2015;11:166-82 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Palubinsky A, Stankowski J, Kale A, Codreanu S, Singer R, Liebler D, et al. CHIP Is an Essential Determinant of Neuronal Mitochondrial Stress Signaling. Antioxid Redox Signal. 2015;23:535-49 pubmed 出版商
  • 免疫印迹; 小鼠
Bueno M, Lai Y, Romero Y, Brands J, St Croix C, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Invest. 2015;125:521-38 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:50
Bifsha P, Yang J, Fisher R, Drouin J. Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra. PLoS Genet. 2014;10:e1004863 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1
Zhang C, Lee S, Peng Y, Bunker E, Shen C, Giaime E, et al. A chemical genetic approach to probe the function of PINK1 in regulating mitochondrial dynamics. Cell Res. 2015;25:394-7 pubmed 出版商
  • 免疫印迹; 人类
Shiba Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, et al. Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering. PLoS Genet. 2014;10:e1004861 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Lee S, Zhang C, Liu X. Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem. 2015;290:904-17 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1,000
  • 免疫印迹; 人类
Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy. J Biol Chem. 2014;289:33131-6 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 图 1a
  • 免疫细胞化学; 小鼠; 图 s2c
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Mizumura K, Cloonan S, Nakahira K, Bhashyam A, Cervo M, Kitada T, et al. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest. 2014;124:3987-4003 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Fiesel F, Moussaud Lamodière E, Ando M, Springer W. A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently. J Cell Sci. 2014;127:3488-504 pubmed 出版商
  • 免疫印迹; 人类
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, et al. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. Circulation. 2014;130:554-64 pubmed 出版商
  • 免疫印迹; 人类; 1:300
Choubey V, Cagalinec M, Liiv J, Safiulina D, Hickey M, Kuum M, et al. BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria. Autophagy. 2014;10:1105-19 pubmed 出版商
  • 免疫印迹; 人类
Patil K, Basak I, Lee S, Abdullah R, Larsen J, Møller S. PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons. J Neurosci Res. 2014;92:1167-77 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014;510:162-6 pubmed 出版商
  • 免疫印迹; 人类
Parganlija D, Klinkenberg M, Domínguez Bautista J, Hetzel M, Gispert S, Chimi M, et al. Loss of PINK1 impairs stress-induced autophagy and cell survival. PLoS ONE. 2014;9:e95288 pubmed 出版商
  • 免疫印迹; 人类
Kane L, Lazarou M, Fogel A, Li Y, Yamano K, Sarraf S, et al. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol. 2014;205:143-53 pubmed 出版商
  • 免疫印迹; 人类
McLelland G, Soubannier V, Chen C, McBride H, Fon E. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 2014;33:282-95 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Zhou Z, Refai F, Xie S, Ng S, Chan C, Ho P, et al. Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. Free Radic Biol Med. 2014;68:220-33 pubmed 出版商
  • 免疫印迹; 人类
Okatsu K, Uno M, Koyano F, Go E, Kimura M, Oka T, et al. A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. J Biol Chem. 2013;288:36372-84 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Gómez Sánchez R, Gegg M, Bravo San Pedro J, Niso Santano M, Alvarez Erviti L, Pizarro Estrella E, et al. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression. Neurobiol Dis. 2014;62:426-40 pubmed 出版商
  • 免疫印迹; 人类
Dagda R, Pien I, Wang R, Zhu J, Wang K, Callio J, et al. Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. J Neurochem. 2014;128:864-77 pubmed 出版商
  • 免疫印迹; 小鼠
Hoshino A, Mita Y, Okawa Y, Ariyoshi M, Iwai Kanai E, Ueyama T, et al. Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun. 2013;4:2308 pubmed 出版商
  • 免疫印迹; 人类
Murata H, Sakaguchi M, Kataoka K, Huh N. SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. Mol Biol Cell. 2013;24:2772-84 pubmed 出版商
  • 免疫印迹; 小鼠
Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, et al. Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem. 2013;288:22019-32 pubmed 出版商
  • 免疫印迹; 小鼠
Koyano F, Okatsu K, Ishigaki S, Fujioka Y, Kimura M, Sobue G, et al. The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons. Genes Cells. 2013;18:672-81 pubmed 出版商
  • 免疫印迹; 人类
Narendra D, Wang C, Youle R, Walker J. PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Hum Mol Genet. 2013;22:2572-89 pubmed 出版商
  • 免疫印迹; 小鼠
Saita S, Shirane M, Nakayama K. Selective escape of proteins from the mitochondria during mitophagy. Nat Commun. 2013;4:1410 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Song S, Jang S, Park J, Bang S, Choi S, Kwon K, et al. Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J Biol Chem. 2013;288:5660-72 pubmed 出版商
  • 免疫印迹; 小鼠
Shiba Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, et al. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep. 2012;2:1002 pubmed 出版商
  • 免疫细胞化学; 人类
Wood Kaczmar A, Deas E, Wood N, Abramov A. The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease. Adv Exp Med Biol. 2013;961:241-9 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, et al. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun. 2012;3:1016 pubmed 出版商
  • 免疫印迹; 人类
Kondapalli C, Kazlauskaite A, Zhang N, Woodroof H, Campbell D, Gourlay R, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012;2:120080 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Becker D, Richter J, Tocilescu M, Przedborski S, Voos W. Pink1 kinase and its membrane potential (Delta?)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem. 2012;287:22969-87 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Wang X, Winter D, Ashrafi G, Schlehe J, Wong Y, Selkoe D, et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 2011;147:893-906 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫组化; 小鼠
Mitsuhashi S, Hatakeyama H, Karahashi M, Koumura T, Nonaka I, Hayashi Y, et al. Muscle choline kinase beta defect causes mitochondrial dysfunction and increased mitophagy. Hum Mol Genet. 2011;20:3841-51 pubmed 出版商
  • 免疫印迹; 人类
Meissner C, Lorenz H, Weihofen A, Selkoe D, Lemberg M. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. J Neurochem. 2011;117:856-67 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Imai Y, Kanao T, Sawada T, Kobayashi Y, Moriwaki Y, Ishida Y, et al. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet. 2010;6:e1001229 pubmed 出版商
  • 免疫印迹; 人类
Kamp F, Exner N, Lutz A, Wender N, Hegermann J, Brunner B, et al. Inhibition of mitochondrial fusion by ?-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J. 2010;29:3571-89 pubmed 出版商
  • 免疫印迹; 人类
Geisler S, Holmström K, Treis A, Skujat D, Weber S, Fiesel F, et al. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. Autophagy. 2010;6:871-8 pubmed
  • 免疫印迹; 人类
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science. 2010;329:1215-8 pubmed 出版商
  • 免疫印迹; 小鼠
Irrcher I, Aleyasin H, Seifert E, Hewitt S, Chhabra S, Phillips M, et al. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet. 2010;19:3734-46 pubmed 出版商
  • 免疫印迹; 大鼠
Cui M, Tang X, Christian W, Yoon Y, Tieu K. Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem. 2010;285:11740-52 pubmed 出版商
Miyai T, Vasanth S, Melangath G, Deshpande N, Kumar V, Benischke A, et al. Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy. Am J Pathol. 2019;189:2061-2076 pubmed 出版商
Guardia Laguarta C, Liu Y, Lauritzen K, Erdjument Bromage H, Martin B, Swayne T, et al. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. J Neurosci. 2019;39:7074-7085 pubmed 出版商
Martín Maestro P, Gargini R, Garcia E, Simon D, Avila J, García Escudero V. Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease. J Alzheimers Dis. 2019;: pubmed 出版商
Martín Maestro P, Sproul A, Martínez H, Paquet D, Gerges M, Noggle S, et al. Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer's Disease iPSC-Derived Neural Stem Cells. Mol Neurobiol. 2019;: pubmed 出版商
Yan C, Gong L, Chen L, Xu M, Abou Hamdan H, Tang M, et al. PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 2019;:1-16 pubmed 出版商
Ganzleben I, He G, Günther C, Prigge E, Richter K, Rieker R, et al. PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis. Cell Mol Life Sci. 2019;: pubmed 出版商
Warnez Soulie J, Macia M, Lac S, Pecchi E, Bernard M, Bendahan D, et al. Tumor protein 53-induced nuclear protein 1 deficiency alters mouse gastrocnemius muscle function and bioenergetics in vivo. Physiol Rep. 2019;7:e14055 pubmed 出版商
Cheng G, Zhang Q, Pan J, Lee Y, Ouari O, Hardy M, et al. Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis. Nat Commun. 2019;10:2205 pubmed 出版商
Livingston M, Wang J, Zhou J, Wu G, Ganley I, Hill J, et al. Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys. Autophagy. 2019;:1-21 pubmed 出版商
Audesse A, Dhakal S, Hassell L, Gardell Z, Nemtsova Y, Webb A. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet. 2019;15:e1008097 pubmed 出版商
Wauters F, Cornelissen T, Imberechts D, Martin S, Koentjoro B, Sue C, et al. LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10. Autophagy. 2019;:1-20 pubmed 出版商
Eid N, Ito Y, Horibe A, Otsuki Y, Kondo Y. Ethanol-Induced Mitochondrial Damage in Sertoli Cells is Associated with Parkin Overexpression and Activation of Mitophagy. Cells. 2019;8: pubmed 出版商
Park J, Lee D, Lee Y, Oh E, Bae K, Oh K, et al. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. Autophagy. 2019;:1-20 pubmed 出版商
Cairó M, Campderros L, Gavaldà Navarro A, Cereijo R, Delgado Anglés A, Quesada López T, et al. Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis. EMBO Rep. 2019;20: pubmed 出版商
Park H, Chung K, An H, Gim J, Hong J, Woo H, et al. Parkin Promotes Mitophagic Cell Death in Adult Hippocampal Neural Stem Cells Following Insulin Withdrawal. Front Mol Neurosci. 2019;12:46 pubmed 出版商
Yakhine Diop S, Niso Santano M, Rodríguez Arribas M, Gómez Sánchez R, Martínez Chacón G, Uribe Carretero E, et al. Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients. Mol Neurobiol. 2019;56:2466-2481 pubmed 出版商
McWilliams T, Barini E, Pohjolan Pirhonen R, Brooks S, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8: pubmed 出版商
Kim H, Joe Y, Rah S, Kim S, Park S, Park J, et al. Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury. Cell Death Dis. 2018;9:1060 pubmed 出版商
Civiletto G, Doğan S, Cerutti R, Fagiolari G, Moggio M, Lamperti C, et al. Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med. 2018;10: pubmed 出版商
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed 出版商
Sun X, Duan Y, Qin C, Li J, Duan G, Deng X, et al. Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy. Cell Death Dis. 2018;9:953 pubmed 出版商
Basso V, Marchesan E, Peggion C, Chakraborty J, von Stockum S, Giacomello M, et al. Regulation of ER-mitochondria contacts by Parkin via Mfn2. Pharmacol Res. 2018;138:43-56 pubmed 出版商
Thomas H, Zhang Y, Stefely J, Veiga S, Thomas G, Kozma S, et al. Mitochondrial Complex I Activity Is Required for Maximal Autophagy. Cell Rep. 2018;24:2404-2417.e8 pubmed 出版商
Xu G, Li T, Chen J, Li C, Zhao H, Yao C, et al. Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing. Autophagy. 2018;14:1818-1830 pubmed 出版商
Lizama B, Palubinsky A, Raveendran V, Moore A, Federspiel J, Codreanu S, et al. Neuronal Preconditioning Requires the Mitophagic Activity of C-terminus of HSC70-Interacting Protein. J Neurosci. 2018;38:6825-6840 pubmed 出版商
Marcassa E, Kallinos A, Jardine J, Rusilowicz Jones E, Martinez A, Kuehl S, et al. Dual role of USP30 in controlling basal pexophagy and mitophagy. EMBO Rep. 2018;19: pubmed 出版商
Sun Y, Yao X, Zhang Q, Zhu M, Liu Z, Ci B, et al. Beclin-1-Dependent Autophagy Protects the Heart During Sepsis. Circulation. 2018;: pubmed 出版商
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y. Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway. Toxicol Lett. 2018;291:92-100 pubmed 出版商
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产品信息
SKU号 :
BC100-494
产品名称 :
PINK1抗体
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The PINK1 Antibody from Novus is a rabbit polyclonal antibody to PINK1. This antibody reacts with human, mouse, rat, drosophila, rabbit. The PINK1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunoblotting, Peptide ELISA, SDS-Page, Knockout Validated.
靶标 :
PINK1
类别 :
一抗
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
PINK1 antibody was developed using a synthetic peptide made to the human PINK1 protein sequence (between residues 175-250). [Swiss-Prot Q9BXM7]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 果蝇, 兔
特异性 :
Human PINK1 Antibody will be reactive to isoform 2
理论上的分子量 :
62.7 kDa
基因符号 :
PINK1
catalog number base :
BC100-494
accessionNumbers :
Q9BXM7
应用 :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunoblotting, Peptide ELISA, SDS-Page, Knockout Validated
2020 Proposedprice USD :
349美元
别名 :
Anti-PINK1, BRPK, EC 2.7.11.1, FLJ27236, Mitochondrial, PARK6, Parkinson disease (autosomal recessive) 6, PINK1, PINK1 mouse, PINK1 polyclonal, protein kinase BRPK, PTEN Induced Kinase 1, PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, serine/threonine-protein kinase PINK1, mitochondrial
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。