产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
小鼠单克隆HIF-1甲抗体
目录 :
NB100-105
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
H1alpha67
反应物种 :
frogs and toads, 灵长类动物, 人类, 小鼠, 大鼠, , , , ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, proximity ligation assay, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 606
出版应用/物种/样品/稀释参考文献
  • 免疫组化; 小鼠; 1:500; 图 5e
Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2f
Kornberg M, Bhargava P, Kim P, Putluri V, Snowman A, Putluri N, et al. Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity. Science. 2018;360:449-453 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 1c
  • 免疫印迹; 人类; 1:600; 图 5f
Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, et al. HIF-2? regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma. J Cell Mol Med. 2017;21:2896-2908 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2a
An Y, Sun K, Joffin N, Zhang F, Deng Y, Donze O, et al. Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis. elife. 2017;6: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5c
Liao L, Song M, Li X, Tang L, Zhang T, Zhang L, et al. E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2017;77:2090-2101 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 s3a
Williams P, Harder J, Foxworth N, Cochran K, Philip V, Porciatti V, et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science. 2017;355:756-760 pubmed 出版商
  • 免疫细胞化学; 人类; 1:50; 图 s4a
  • 免疫印迹; 人类; 1:500; 图 s6
Yu Z, Mouillesseaux K, Kushner E, Bautch V. Tumor-Derived Factors and Reduced p53 Promote Endothelial Cell Centrosome Over-Duplication. PLoS ONE. 2016;11:e0168334 pubmed 出版商
  • 免疫沉淀; 大鼠; 图 4a
  • 免疫印迹; 大鼠; 图 2d
Li F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res. 2016;8:4791-4801 pubmed
  • 免疫组化; 小鼠; 1:500; 图 e4a
  • 免疫印迹; 小鼠; 1 mg/ml; 图 2b
Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:50; 图 1
Takasaki C, Kobayashi M, Ishibashi H, Akashi T, Okubo K. Expression of hypoxia-inducible factor-1? affects tumor proliferation and antiapoptosis in surgically resected lung cancer. Mol Clin Oncol. 2016;5:295-300 pubmed
  • 免疫细胞化学; 小鼠; 1:100; 图 1
  • 免疫印迹; 小鼠; 1:500; 图 5
Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed 出版商
  • 免疫组化; 人类; 图 1B
  • 免疫印迹; 人类; 1:500; 图 1B
Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1a
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 4
Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, et al. MiR675-5p Acts on HIF-1? to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma. Theranostics. 2016;6:1105-18 pubmed 出版商
  • 免疫组化; 小鼠; 图 1b
Guinot A, Lehmann H, Wild P, Frew I. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016;239:365-73 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Park S, Kim J, Kim N, Yang K, Shim J, Heo K. Estradiol, TGF-?1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration. Oncol Lett. 2016;11:1895-1902 pubmed
  • 免疫组化; 人类; 图 4
Ananthula S, Sinha A, El Gassim M, Batth S, Marshall G, Gardner L, et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget. 2016;7:20869-89 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 3
  • 免疫印迹; 人类; 图 3
Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3a
Maugeri G, D Amico A, Reitano R, Saccone S, Federico C, Cavallaro S, et al. Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro. Cell Tissue Res. 2016;364:465-74 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 2b
Sharpe M, Baskin D. Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3. Oncotarget. 2016;7:3379-93 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 s5
Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, et al. Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Sci. 2016;107:123-32 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
Hung Y, Chang S, Huang C, Yin J, Hwang C, Yang L, et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol Neurobiol. 2016;53:793-809 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Wang I, Sun K, Tsai T, Chen C, Chang S, Yu T, et al. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury. Life Sci. 2015;136:133-41 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 s4
Chan M, Atasoylu O, Hodson E, Tumber A, Leung I, Chowdhury R, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS ONE. 2015;10:e0132004 pubmed 出版商
  • 免疫印迹; 人类; 1:500
  • 免疫组化; 小鼠
Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed 出版商
  • 免疫印迹; 大鼠
Fan Y, Wang L, Liu C, Zhu H, Zhou L, Wang Y, et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Int J Clin Exp Pathol. 2015;8:2505-14 pubmed
  • 免疫印迹; 人类; 图 3a
Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, et al. A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway. Int J Biol Sci. 2015;11:664-71 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Joo H, Yun M, Jeong J, Park E, Shin H, Woo S, et al. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia. Biochem Biophys Res Commun. 2015;462:294-300 pubmed 出版商
  • 免疫印迹; 人类; 图 4c
Park H, Lee D, Yim M, Choi Y, Park S, Seo S, et al. 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions. Int J Mol Med. 2015;36:301-8 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Takata S, Masuda T, Nakamura S, Kuchimaru T, Tsuruma K, Shimazawa M, et al. The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe. Sci Rep. 2015;5:9898 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Liu X, Chen Z, Xu C, Leng X, Cao H, Ouyang G, et al. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res. 2015;43:5081-98 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell Dev Biol Anim. 2015;51:808-14 pubmed 出版商
  • 免疫印迹; 人类; 表 2
Chan N, He S, Spee C, Ishikawa K, Hinton D. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS ONE. 2015;10:e0120587 pubmed 出版商
  • 免疫印迹; 人类
Wang F, Zhang G, Xing T, Lu Z, Li J, Peng C, et al. Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α. J Cell Mol Med. 2015;19:1400-9 pubmed 出版商
  • 免疫印迹; 人类
Fillmore N, Huqi A, Jaswal J, Mori J, Paulin R, Haromy A, et al. Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. PLoS ONE. 2015;10:e0120257 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Srivastava S, Thakkar B, Yeoh K, Ho K, Teh M, Soong R, et al. Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma. Virchows Arch. 2015;466:541-8 pubmed 出版商
  • 免疫印迹; 人类
Paeng S, Jung W, Park W, Lee D, Kim G, Choi Y, et al. Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions. Int J Mol Med. 2015;35:1419-26 pubmed 出版商
  • 免疫印迹; 小鼠
Hasan A, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, et al. Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes. Mol Cell Endocrinol. 2015;406:10-8 pubmed 出版商
  • 免疫印迹; 大鼠
Li R, Wang Y, Yang Z, He Y, Zhao T, Fan M, et al. Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia. Cell Stress Chaperones. 2015;20:507-16 pubmed 出版商
  • 免疫印迹; 人类
Jeong S, Park H, Hong S, Yum S, Kim W, Jung Y. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur J Pharmacol. 2015;747:114-22 pubmed 出版商
  • 免疫印迹; 小鼠
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed 出版商
  • 免疫印迹; 人类
Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014;111:E5429-38 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Gillespie D, Aguirre M, Ravichandran S, Leishman L, Berrondo C, Gamboa J, et al. RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J Neurosurg. 2015;122:331-41 pubmed 出版商
  • 免疫印迹; 小鼠
Wu X, He L, Chen F, He X, Cai Y, Zhang G, et al. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS ONE. 2014;9:e112891 pubmed 出版商
  • 免疫印迹; 小鼠
Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, et al. The vitamin D analogue ED71 but Not 1,25(OH)2D3 targets HIF1α protein in osteoclasts. PLoS ONE. 2014;9:e111845 pubmed 出版商
  • 免疫印迹; 大鼠
Rahman S, Lee M, Baek J, Ryoo H, Woo K. The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization. PLoS ONE. 2014;9:e112078 pubmed 出版商
  • 免疫印迹; 大鼠
El Assar M, Sánchez Puelles J, Royo I, López Hernández E, Sánchez Ferrer A, Aceña J, et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br J Pharmacol. 2015;172:1277-91 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
Funk K, Scheerer N, Verhaegh R, Pütter C, Fandrey J, de Groot H. Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area. PLoS ONE. 2014;9:e111151 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Marhold M, Tomasich E, El Gazzar A, Heller G, Spittler A, Horvat R, et al. HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. Mol Cancer Res. 2015;13:556-64 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
He Y, Li M, Wu L, Zhao T, Di Y, Huang X, et al. Enhanced hypoxia-inducible factor (HIF)-1? stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia. Mol Med. 2015;20:590-600 pubmed 出版商
  • 免疫印迹; 人类
Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H. Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice. Biochem Biophys Res Commun. 2014;453:600-5 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Kasper L, Qu C, Obenauer J, McGoldrick D, Brindle P. Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res. 2014;42:11363-82 pubmed 出版商
  • 免疫印迹; 人类
Bordji K, Grandval A, Cuhna Alves L, Lechapt Zalcman E, Bernaudin M. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014;281:5220-36 pubmed 出版商
  • 免疫细胞化学; 人类
Shinohara M, Kibi M, Riley I, Chiang N, Dalli J, Kraft B, et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. Am J Physiol Lung Cell Mol Physiol. 2014;307:L746-57 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 1:200; 图 s2
Lee H, Kim K, Lim H, Choi M, Kim H, Ahn H, et al. Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model. J Cell Biochem. 2015;116:310-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Huang T, Huang W, Zhang Z, Yu L, Xie C, Zhu D, et al. Hypoxia-inducible factor-1? upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction. Neuroreport. 2014;25:1122-8 pubmed 出版商
  • 免疫沉淀; 大鼠
  • 免疫印迹; 大鼠
Gu J, Fan Y, Liu X, Zhou L, Cheng J, Cai R, et al. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway. Cardiovasc Res. 2014;104:83-92 pubmed 出版商
  • 免疫印迹; 小鼠
Zhou W, Marinescu M, Veltkamp R. Only very early oxygen therapy attenuates posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage. Neurocrit Care. 2015;22:121-32 pubmed 出版商
  • 免疫印迹; 人类
Kalamida D, Karagounis I, Giatromanolaki A, Koukourakis M. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS ONE. 2014;9:e102408 pubmed 出版商
  • 免疫印迹; 人类
Privat M, Radosevic Robin N, Aubel C, Cayre A, Penault Llorca F, Marceau G, et al. BRCA1 induces major energetic metabolism reprogramming in breast cancer cells. PLoS ONE. 2014;9:e102438 pubmed 出版商
  • 免疫组化; 人类
Yang M, Chiao M, Lee H, Chen C, Yang Y, Shen C, et al. An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior. J Biomed Mater Res B Appl Biomater. 2015;103:618-28 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Wu J, Shao C, Li X, Shi C, Li Q, Hu P, et al. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1?/OATPs signaling axis. Biomaterials. 2014;35:8175-85 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
Vorrink S, Sarsour E, Olivier A, Robertson L, Goswami P, Domann F. PCB 126 perturbs hypoxia-induced HIF-1? activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol. 2014;66:377-82 pubmed 出版商
  • 免疫印迹; 小鼠
Arreola A, Cowey C, Coloff J, Rathmell J, Rathmell W. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE. 2014;9:e98705 pubmed 出版商
  • 免疫印迹; 大鼠
Xiong Y, Qu Z, Chen N, Gong H, Song M, Chen X, et al. The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue. Mol Cell Endocrinol. 2014;392:106-14 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Xu W, Kwon J, Moon Y, Kim Y, Yu Y, Lee N, et al. Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1? pathway in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol. 2014;140:1507-15 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Kim Y, Lee H, Lim J, Kim Y, Jung C, Yoo S, et al. ?-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1?. J Nutr Biochem. 2014;25:655-64 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Zheng J, Song F, Lu S, Wang X. Dynamic hypoxia in scar tissue during human hypertrophic scar progression. Dermatol Surg. 2014;40:511-8 pubmed 出版商
  • 免疫印迹; 人类
Chang M, Chiu C, Shang F, Taylor A. High glucose activates ChREBP-mediated HIF-1? and VEGF expression in human RPE cells under normoxia. Adv Exp Med Biol. 2014;801:609-21 pubmed 出版商
  • 免疫印迹; 人类
Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
  • 免疫印迹; 大鼠
Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir Res. 2014;15:33 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, et al. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS ONE. 2014;9:e89830 pubmed 出版商
  • 免疫印迹; 人类
Pan W, Wong J, Fang E, Chan Y, Ng T, Cheung R. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem Pharmacol. 2014;89:329-39 pubmed 出版商
  • 免疫印迹; 大鼠
Zhao L, Yang Y, Gao Y, Wang S, Wang L, Zuo H, et al. Upregulation of HIF-1? via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells. Mol Neurobiol. 2014;50:1024-34 pubmed 出版商
  • 免疫组化; 大鼠
Gauter Fleckenstein B, Reboucas J, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, et al. Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol. 2014;2:400-10 pubmed 出版商
  • 免疫印迹; 大鼠
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An X, Xu G, Yang L, Wang Y, Li Y, McHepange U, et al. Expression of hypoxia-inducible factor-1?, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features. J Dermatol. 2014;41:76-83 pubmed 出版商
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Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed 出版商
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Xie L, Collins J. Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem. 2013;288:23943-52 pubmed 出版商
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Wu C, Zhou Y, Chang J, Xiao Y. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater. 2013;9:9159-68 pubmed 出版商
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Zhang H, Tang L, Chen S, Yang Y, Chen M, Luo J. Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1? and vascular endothelial growth factor proteins in RF/6A cells. Exp Ther Med. 2013;5:1519-1522 pubmed
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Park G, Lee M, Roh J, Choi S, Nam S, Kim S, et al. Phospho-Rb (Ser780) as a biomarker in patients with cervical lymph node metastases from an unknown primary tumour: a retrospective cohort study. Clin Otolaryngol. 2013;38:313-21 pubmed 出版商
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Loukovaara S, Koivunen P, Inglés M, Escobar J, Vento M, Andersson S. Elevated protein carbonyl and HIF-1? levels in eyes with proliferative diabetic retinopathy. Acta Ophthalmol. 2014;92:323-7 pubmed 出版商
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Hutter R, Speidl W, Valdiviezo C, Sauter B, Corti R, Fuster V, et al. Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1? activation: a novel aspect of angiogenesis in atherosclerosis. J Cardiovasc Transl Res. 2013;6:558-69 pubmed 出版商
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Bohuslavova R, Skvorova L, Sedmera D, Semenza G, Pavlinkova G. Increased susceptibility of HIF-1? heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol. 2013;60:129-41 pubmed 出版商
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Shackelford D, Vasquez D, Corbeil J, Wu S, Leblanc M, Wu C, et al. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A. 2009;106:11137-42 pubmed 出版商
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Benita Y, Kikuchi H, Smith A, Zhang M, Chung D, Xavier R. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009;37:4587-602 pubmed 出版商
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Guma M, Rius J, Duong Polk K, Haddad G, Lindsey J, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009;106:8760-5 pubmed 出版商
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Rhoads R, Johnson R, Rathbone C, Liu X, Temm Grove C, Sheehan S, et al. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Am J Physiol Cell Physiol. 2009;296:C1321-8 pubmed 出版商
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Kim J, Bagchi I, Bagchi M. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology. 2009;150:3392-400 pubmed 出版商
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Kimbrel E, Kung A. The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. J Biol Chem. 2009;284:13033-44 pubmed 出版商
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Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss T, et al. GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol. 2009;174:1544-52 pubmed 出版商
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Hong S, Yoo J, Kang H, Kim S, Lee D. HIF-1alpha-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses. Mol Cells. 2009;27:243-50 pubmed 出版商
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Zhu K, Chan W, Heymach J, Wilkinson M, McConkey D. Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression. Cancer Res. 2009;69:1836-43 pubmed 出版商
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Klatte T, Seligson D, Larochelle J, Shuch B, Said J, Riggs S, et al. Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. Cancer Epidemiol Biomarkers Prev. 2009;18:894-900 pubmed 出版商
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Lomb D, Desouza L, Franklin J, Freeman R. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic. Mol Pharmacol. 2009;75:1198-209 pubmed 出版商
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Tyagi A, Singh R, Ramasamy K, Raina K, Redente E, Dwyer Nield L, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila). 2009;2:74-83 pubmed 出版商
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Miyazawa M, Yasuda M, Fujita M, Kajiwara H, Hirabayashi K, Takekoshi S, et al. Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. Pathol Int. 2009;59:19-27 pubmed 出版商
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Yeh S, Hung J, Gean P, Chang W. Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression. J Neurosci. 2008;28:14259-70 pubmed 出版商
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El Hasnaoui Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, et al. Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009;296:R801-11 pubmed 出版商
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Wong W, Goehring A, Kapiloff M, Langeberg L, Scott J. mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal. 2008;1:ra18 pubmed 出版商
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Keely S, Glover L, MacManus C, Campbell E, Scully M, Furuta G, et al. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 2009;23:1338-46 pubmed 出版商
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Gilbert J, Gilbert S, Arany M, Granger J. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Hypertension. 2009;53:399-403 pubmed 出版商
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Zhang H, Qian D, Tan Y, Lee K, Gao P, Ren Y, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A. 2008;105:19579-86 pubmed 出版商
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Thomas R, Kim M. A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells. Prostate. 2009;69:263-75 pubmed 出版商
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Ngan B, Forte V, Campisi P. Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy. Arch Otolaryngol Head Neck Surg. 2008;134:1170-6 pubmed 出版商
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Akoyev V, Das S, Jena S, Grauer L, Takemoto D. Hypoxia-regulated activity of PKCepsilon in the lens. Invest Ophthalmol Vis Sci. 2009;50:1271-82 pubmed 出版商
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Kim H, Jo Y, Lee J, Lee S, Yoon K. The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer. Oncol Rep. 2008;20:1181-7 pubmed
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Nørregaard R, Bødker T, Jensen B, Stødkilde L, Nielsen S, Frøkiaer J. Increased renal adrenomedullin expression in rats with ureteral obstruction. Am J Physiol Regul Integr Comp Physiol. 2009;296:R185-92 pubmed 出版商
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Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development. 2008;135:3587-97 pubmed 出版商
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Hughes D, Fu A, Puggioni A, Glockner J, Anwer B, McGuire A, et al. Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study. Nephrol Dial Transplant. 2009;24:85-96 pubmed 出版商
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Moser C, Lang S, Mori A, Hellerbrand C, Schlitt H, Geissler E, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008;8:206 pubmed 出版商
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Champion K, Guinea M, Dammai V, Hsu T. Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Cancer Res. 2008;68:4649-57 pubmed 出版商
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Tacchini L, Gammella E, De Ponti C, Recalcati S, Cairo G. Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J Biol Chem. 2008;283:20674-86 pubmed 出版商
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Lin S, Shun C, Kok S, Wang C, Hsiao T, Liu C. Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis. Arch Otolaryngol Head Neck Surg. 2008;134:522-7 pubmed 出版商
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Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood. 2008;112:1482-92 pubmed 出版商
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Han S, Wang G, Qi X, Lee H, Englander E, Greeley G. A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1832-9 pubmed 出版商
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Borger D, Gavrilescu L, Bucur M, Ivan M, DeCaprio J. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008;370:230-4 pubmed 出版商
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Li N, Chen L, Yi F, Xia M, Li P. Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla. Circ Res. 2008;102:1101-8 pubmed 出版商
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Murphy B, Kimura T, Sato B, Shi Y, Andrews G. Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Mol Cancer Res. 2008;6:483-90 pubmed 出版商
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Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. J Biol Chem. 2008;283:11841-9 pubmed 出版商
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Rimon E, Chen B, Shanks A, Nelson D, Sadovsky Y. Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology. 2008;149:2952-8 pubmed 出版商
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Villanueva S, Cespedes C, Gonzalez A, Roessler E, Vio C. Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure. Am J Physiol Regul Integr Comp Physiol. 2008;294:R819-28 pubmed 出版商
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Gauter Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med. 2008;44:982-9 pubmed
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Kaukinen A, Kuusniemi A, Lautenschlager I, Jalanko H. Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrol Dial Transplant. 2008;23:1224-32 pubmed
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Ryu J, Lee C, Hong K, Shin J, Lim S, Park C, et al. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Cardiovasc Res. 2008;78:333-40 pubmed
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Kimura Y, Sumiyoshi M. High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice. Nutr Cancer. 2007;59:207-16 pubmed
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Black S, Devol J, Wedgwood S. Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation. Am J Physiol Cell Physiol. 2008;294:C345-54 pubmed 出版商
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Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed
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Lam W, Leung C, Bussom S, Cheng Y. The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. Mol Pharmacol. 2007;72:536-44 pubmed
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Khan Z, Michalopoulos G, Stolz D. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006;169:1251-69 pubmed
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Khurana A, Nakayama K, Williams S, Davis R, Mustelin T, RONAI Z. Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J Biol Chem. 2006;281:35316-26 pubmed
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Chen H, Yan Y, Davidson T, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res. 2006;66:9009-16 pubmed
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Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed
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Behan A, Doyle S, Farrell M. Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell. Mitochondrion. 2005;5:173-93 pubmed
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Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed
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Pascual O, Roux J, Soulage C, Morin Surun M, Denavit Saubié M, Pequignot J. Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells. Methods Enzymol. 2004;381:422-49 pubmed
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Erler J, Cawthorne C, Williams K, Koritzinsky M, Wouters B, Wilson C, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol. 2004;24:2875-89 pubmed
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Palladino M, Powell J, Korah N, Hermo L. Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis. Biol Reprod. 2004;70:1121-30 pubmed
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Powell J, Elshtein R, Forest D, Palladino M. Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Biol Reprod. 2002;67:995-1002 pubmed
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Pascual O, Denavit Saubie M, Dumas S, Kietzmann T, Ghilini G, Mallet J, et al. Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem. Eur J Neurosci. 2001;14:1981-91 pubmed
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Gothié E, Richard D, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J Biol Chem. 2000;275:6922-7 pubmed
  • 免疫组化-石蜡切片; 小鼠
  • 免疫组化-石蜡切片; 人类
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产品信息
SKU号 :
NB100-105
产品名称 :
小鼠单克隆HIF-1甲抗体
规格 :
0.1 ml (also 0.025 ml)
描述 :
The HIF-1 alpha Antibody (H1alpha67) from Novus Biologicals is a mouse monoclonal antibody to HIF-1 alpha. This antibody reacts with human, mouse, rat, porcine, bovine, canine, ferret, monkey, primate, rabbit, sheep, xenopus. The HIF-1 alpha Antibody (H1alpha67) has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Gel Super Shift Assays, Proximity Ligation Assay, Tissue Culture Substratum, Ligand Activation, Knockout Validated.
靶标 :
HIF-1甲
类别 :
一抗
缓冲液 :
Mouse Monoclonal HIF-1 alpha Antibody supplied in PBS with 1% BSA
克隆性 :
单克隆
克隆 :
H1alpha67
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
A fusion protein containing amino acids 432 - 528 of human HIF-1 alpha [UniProt# Q16665].
抗体亚型 :
IgG2b
纯度 :
蛋白质G纯化
物种活性 :
Human, Mouse, Rat, Porcine, Bovine, Canine, Ferret, Monkey, Primate, Rabbit, Sheep, Xenopus
Theoretical Molecular Weight :
93 kDa
基因符号 :
缺氧诱导因子1A
应用 :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Gel Super Shift Assays, Proximity Ligation Assay, Tissue Culture Substratum, Ligand Activation, Knockout Validated
价格 :
349美元
又名 :
anti-HIF-1 alpha, anti-HIF1A, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, H1alpha67, HIF-1 alpha, HIF1A, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1HIF1-ALPHA, PAS domain-containing protein 8, PASD8alpha subunit (basic helix-loop-helix transcription factor)
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。