产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
MTH1 Antibody - BSA Free
目录 :
NB100-109
规格 :
0.2 ml (also 0.05 ml)
价格 :
449美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
L5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 79
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 s1b
  • 免疫印迹; 人类; 1:1000; 图 s1b
Zou X, Owusu M, Harris R, Jackson S, Loizou J, Nik Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018;9:1744 pubmed 出版商
Ding Y, Gui X, Chu X, Sun Y, Zhang S, Tong H, et al. MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis. Nat Commun. 2023;14:4829 pubmed 出版商
Henriksson S, Calder xf3 n Monta xf1 o J, Solvie D, Warpman Berglund U, Helleday T. Overexpressed c-Myc Sensitizes Cells to TH1579, a Mitotic Arrest and Oxidative DNA Damage Inducer. Biomolecules. 2022;12: pubmed 出版商
Bialkowski K, Szpila A. Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer. Free Radic Biol Med. 2021;176:257-264 pubmed 出版商
Karsten S, Fiskesund R, Zhang X, Marttila P, Sanjiv K, Pham T, et al. MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells. Cell Death Differ. 2021;: pubmed 出版商
Zhang L, Misiara L, Samaranayake G, Sharma N, Nguyen D, Tahara Y, et al. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biol. 2021;40:101848 pubmed 出版商
Arczewska K, Krasuska W, Stachurska A, Karpińska K, Sikorska J, Kiedrowski M, et al. hMTH1 and GPX1 expression in human thyroid tissue is interrelated to prevent oxidative DNA damage. DNA Repair (Amst). 2020;95:102954 pubmed 出版商
Okubo T, Patella P, D Alessandro I, Wilson R. A Neural Network for Wind-Guided Compass Navigation. Neuron. 2020;107:924-940.e18 pubmed 出版商
Godoy P, Pour Khavari A, Rizzo M, Sakamoto Hojo E, Haghdoost S. Targeting NRF2, Regulator of Antioxidant System, to Sensitize Glioblastoma Neurosphere Cells to Radiation-Induced Oxidative Stress. Oxid Med Cell Longev. 2020;2020:2534643 pubmed 出版商
McKellar C, Siwanowicz I, Dickson B, Simpson J. Controlling motor neurons of every muscle for fly proboscis reaching. elife. 2020;9: pubmed 出版商
Städele C, Keles M, Mongeau J, Frye M. Non-canonical Receptive Field Properties and Neuromodulation of Feature-Detecting Neurons in Flies. Curr Biol. 2020;30:2508-2519.e6 pubmed 出版商
Rudd S, Gad H, Sanjiv K, Amaral N, Hagenkort A, Groth P, et al. MTH1 inhibitor TH588 disturbs mitotic progression and induces mitosis-dependent accumulation of genomic 8-oxodG. Cancer Res. 2020;: pubmed 出版商
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, et al. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020;139:1001-1024 pubmed 出版商
Moukengue B, Brown H, Charrier C, Battaglia S, Baud huin M, Quillard T, et al. TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model. EBioMedicine. 2020;53:102704 pubmed 出版商
Shiozaki H, Ohta K, Kazama H. A Multi-regional Network Encoding Heading and Steering Maneuvers in Drosophila. Neuron. 2020;106:126-141.e5 pubmed 出版商
Tan G, Pryce B, Stabio A, Brigande J, Wang C, Xia Z, et al. Tgfβ signaling is critical for maintenance of the tendon cell fate. elife. 2020;9: pubmed 出版商
Heath S, Christenson M, Oriol E, Saavedra Weisenhaus M, Kohn J, Behnia R. Circuit Mechanisms Underlying Chromatic Encoding in Drosophila Photoreceptors. Curr Biol. 2020;30:264-275.e8 pubmed 出版商
Hernandez E, MacNamee S, Kaplan L, Lance K, Garcia Verdugo H, Farhadi D, et al. The astrocyte network in the ventral nerve cord neuropil of the Drosophila third-instar larva. J Comp Neurol. 2020;528:1683-1703 pubmed 出版商
Bialkowski K, Kasprzak K. A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis. Free Radic Biol Med. 2020;148:1-21 pubmed 出版商
Fisher Y, Lu J, D Alessandro I, Wilson R. Sensorimotor experience remaps visual input to a heading-direction network. Nature. 2019;576:121-125 pubmed 出版商
Yadav S, Bhagat S, Gupta A, Samaiya A, Srivastava A, Shukla S. Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer. BMC Cancer. 2019;19:1031 pubmed 出版商
Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, et al. Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene. 2020;39:617-636 pubmed 出版商
Wang J, Nagy N, Masucci M. The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization. Oncogene. 2020;39:603-616 pubmed 出版商
McPherson L, Troccoli C, Ji D, Bowles A, Gardiner M, Mohsen M, et al. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. DNA Repair (Amst). 2019;83:102644 pubmed 出版商
Zhou W, Ma L, Yang J, Qiao H, Li L, Guo Q, et al. Potent and specific MTH1 inhibitors targeting gastric cancer. Cell Death Dis. 2019;10:434 pubmed 出版商
Dolan M, Frechter S, Bates A, Dan C, Huoviala P, Roberts R, et al. Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body. elife. 2019;8: pubmed 出版商
Losier T, Akuma M, McKee Muir O, LeBlond N, Suk Y, Alsaadi R, et al. AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. Cell Rep. 2019;26:2150-2165.e5 pubmed 出版商
Andrade I, Riebli N, Nguyen B, Omoto J, Cardona A, Hartenstein V. Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex. Curr Biol. 2019;29:412-425.e3 pubmed 出版商
McKellar C, Lillvis J, Bath D, Fitzgerald J, Cannon J, Simpson J, et al. Threshold-Based Ordering of Sequential Actions during Drosophila Courtship. Curr Biol. 2019;29:426-434.e6 pubmed 出版商
Pompsch M, Vogel J, Classen F, Kranz P, Iliakis G, Riffkin H, et al. The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia. BMC Cancer. 2018;18:1190 pubmed 出版商
Cosmanescu F, Katsamba P, Sergeeva A, Ahlsen G, Patel S, Brewer J, et al. Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins. Neuron. 2018;100:1385-1400.e6 pubmed 出版商
Barnhart E, Wang I, Wei H, Desplan C, Clandinin T. Sequential Nonlinear Filtering of Local Motion Cues by Global Motion Circuits. Neuron. 2018;100:229-243.e3 pubmed 出版商
Chang Y, Tsao C, Sun Y. Temporal and spatial order of photoreceptor and glia projections into optic lobe in Drosophila. Sci Rep. 2018;8:12669 pubmed 出版商
Wolff T, Rubin G. Neuroarchitecture of the Drosophila central complex: A catalog of nodulus and asymmetrical body neurons and a revision of the protocerebral bridge catalog. J Comp Neurol. 2018;526:2585-2611 pubmed 出版商
Gupta A, Ajith A, Singh S, Panday R, Samaiya A, Shukla S. PAK2-c-Myc-PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect. Cell Death Dis. 2018;9:825 pubmed 出版商
Ribeiro I, Drews M, Bahl A, Machacek C, Borst A, Dickson B. Visual Projection Neurons Mediating Directed Courtship in Drosophila. Cell. 2018;174:607-621.e18 pubmed 出版商
Konstantinides N, Kapuralin K, Fadil C, Barboza L, Satija R, Desplan C. Phenotypic Convergence: Distinct Transcription Factors Regulate Common Terminal Features. Cell. 2018;174:622-635.e13 pubmed 出版商
Imaimatsu K, Fujii W, Hiramatsu R, Miura K, Kurohmaru M, Kanai Y. CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene. J Reprod Dev. 2018;64:283-287 pubmed 出版商
Xie T, Ho M, Liu Q, Horiuchi W, Lin C, Task D, et al. A Genetic Toolkit for Dissecting Dopamine Circuit Function in Drosophila. Cell Rep. 2018;23:652-665 pubmed 出版商
Fan J, Zhao R, Parro C, Zhao W, Chou H, Robert J, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. J Lipid Res. 2018;59:830-842 pubmed 出版商
Saumweber T, Rohwedder A, Schleyer M, Eichler K, Chen Y, Aso Y, et al. Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila. Nat Commun. 2018;9:1104 pubmed 出版商
Hashiguchi K, Hayashi M, Sekiguchi M, Umezu K. The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress. Mutat Res. 2018;808:10-19 pubmed 出版商
Page B, Valerie N, Wright R, Wallner O, Isaksson R, Carter M, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat Commun. 2018;9:250 pubmed 出版商
Tocker A, Durocher E, Jacob K, Trieschman K, Talento S, Rechnitzer A, et al. The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. J Immunol. 2017;199:2896-2909 pubmed 出版商
Yamamoto H, Umeda D, Matsumoto S, Kikuchi A. LDL switches the LRP6 internalization route from flotillin dependent to clathrin dependent in hepatic cells. J Cell Sci. 2017;130:3542-3556 pubmed 出版商
Coleman S, Choi K, McGregor A. Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig. Virology. 2017;509:205-221 pubmed 出版商
Hattori D, Aso Y, Swartz K, Rubin G, Abbott L, Axel R. Representations of Novelty and Familiarity in a Mushroom Body Compartment. Cell. 2017;169:956-969.e17 pubmed 出版商
Wreden C, Meng J, Feng W, Chi W, Marshall Z, Heckscher E. Temporal Cohorts of Lineage-Related Neurons Perform Analogous Functions in Distinct Sensorimotor Circuits. Curr Biol. 2017;27:1521-1528.e4 pubmed 出版商
Eshtad S, Mavajian Z, Rudd S, Visnes T, Bostrom J, Altun M, et al. hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia. Oncogenesis. 2016;5:e275 pubmed 出版商
Earley L, Powers J, Adachi K, Baumgart J, Meyer N, Xie Q, et al. Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol. 2017;91: pubmed 出版商
Zhou H, Jian Y, Leng Y, Liu N, Tian Y, Wang G, et al. Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma. Int J Hematol. 2017;105:318-325 pubmed 出版商
Shirangi T, Wong A, Truman J, Stern D. Doublesex Regulates the Connectivity of a Neural Circuit Controlling Drosophila Male Courtship Song. Dev Cell. 2016;37:533-44 pubmed 出版商
Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M. Identification of PSD-95 Depalmitoylating Enzymes. J Neurosci. 2016;36:6431-44 pubmed 出版商
Zhou B, Ritt D, Morrison D, Der C, Cox A. Protein Kinase CK2? Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2? Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. J Biol Chem. 2016;291:17804-15 pubmed 出版商
Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, et al. Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet. 2016;98:1082-1091 pubmed 出版商
Lacin H, Truman J. Lineage mapping identifies molecular and architectural similarities between the larval and adult Drosophila central nervous system. elife. 2016;5:e13399 pubmed 出版商
Ichinose T, Aso Y, Yamagata N, Abe A, Rubin G, Tanimoto H. Reward signal in a recurrent circuit drives appetitive long-term memory formation. elife. 2015;4:e10719 pubmed 出版商
Huber K, Olek K, Müller A, Tan C, Bennett K, Colinge J, et al. Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling. Nat Methods. 2015;12:1055-7 pubmed 出版商
Hampel S, Franconville R, Simpson J, Seeds A. A neural command circuit for grooming movement control. elife. 2015;4:e08758 pubmed 出版商
Carter M, Jemth A, Hagenkort A, Page B, Gustafsson R, Griese J, et al. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2. Nat Commun. 2015;6:7871 pubmed 出版商
Ohyama T, Schneider Mizell C, Fetter R, Aleman J, Franconville R, Rivera Alba M, et al. A multilevel multimodal circuit enhances action selection in Drosophila. Nature. 2015;520:633-9 pubmed 出版商
Giribaldi M, Muñoz A, Halvorsen K, Patel A, Rai P. MTH1 expression is required for effective transformation by oncogenic HRAS. Oncotarget. 2015;6:11519-29 pubmed
Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed 出版商
Earley L, Kawano Y, Adachi K, Sun X, Dai M, Nakai H. Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein. J Virol. 2015;89:3038-48 pubmed 出版商
Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 2014;9:1841-55 pubmed 出版商
Wolff T, Iyer N, Rubin G. Neuroarchitecture and neuroanatomy of the Drosophila central complex: A GAL4-based dissection of protocerebral bridge neurons and circuits. J Comp Neurol. 2015;523:997-1037 pubmed 出版商
Oliverio S, Corazzari M, Sestito C, Piredda L, Ippolito G, Piacentini M. The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A. Amino Acids. 2014;46:2767-76 pubmed 出版商
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产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB100-109
SKU号 :
NB100-109
产品名称 :
MTH1 Antibody - BSA Free
描述 :
The MTH1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to MTH1. This antibody reacts with human, mouse, rat. The MTH1 Antibody - BSA Free has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Knockout Validated, Single Cell Western, Knockdown Validated.
靶标 :
MTH1
类别 :
一抗
单位尺寸 :
0.2 ml (also 0.05 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
A C-terminal peptide derived from human MTH1, conjugated to KLH. [UniProt# P36639]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠
理论上的分子量 :
18 kDa
基因符号 :
NUDT1
accessionNumbers :
P36639
应用 :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Knockout Validated, Single Cell Western, Knockdown Validated
美元 :
449美元
别名 :
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, EC 3.6.1.-, MTH1Nucleoside diphosphate-linked moiety X motif 1, mutT human homolog 1,8-oxo-dGTPase, nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase, nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase, Nudix motif 1
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。