| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 染色质免疫沉淀
; 人类; 图 1d, s2
- 免疫印迹; 人类; 1:1000; 图 1a
| Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, et al. Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization. Sci Adv. 2021;7: pubmed 出版商 |
| Geng G, Liu J, Xu C, Pei Y, Chen L, Mu C, et al. Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. elife. 2021;10: pubmed 出版商 |
- 免疫组化; 小鼠; 图 1d
- 免疫印迹; 小鼠; 图 1b
| Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed 出版商 |
- 免疫印迹; 人类; 1:1000; 图 2f, 2g
| Dufies M, Verbiest A, Cooley L, Ndiaye P, He X, Nottet N, et al. Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma. Commun Biol. 2021;4:166 pubmed 出版商 |
| Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed 出版商 |
| Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed 出版商 |
| Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed 出版商 |
| Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed 出版商 |
| Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed 出版商 |
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| Kim Y, Lee M, Gu H, Kim J, Jeong S, Yeo S, et al. HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice. Dis Model Mech. 2018;11: pubmed 出版商 |
| Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed 出版商 |
| He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed 出版商 |
| Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed 出版商 |
- 免疫细胞化学; 小鼠; 1:200; 图 6c
- 免疫印迹; 小鼠; 图 6a
| Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed 出版商 |
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| Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed 出版商 |
- 免疫印迹; African green monkey; 图 3
- 免疫印迹; 人类; 图 1a
| Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed 出版商 |
- 免疫组化; 人类; 图 1B
- 免疫印迹; 人类; 1:500; 图 1B
| Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed 出版商 |
- 免疫组化-石蜡切片; 人类; 1:100; 图 1a
| Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed 出版商 |
- 染色质免疫沉淀
; 人类; 1:150; 图 3b
| Brooks D, Schwab L, Krutilina R, Parke D, Sethuraman A, Hoogewijs D, et al. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer. 2016;15:26 pubmed 出版商 |
| German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed 出版商 |
- 免疫印迹基因敲除验证; 小鼠; 图 3
- 免疫印迹; 人类; 图 3
| Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed 出版商 |
| Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed 出版商 |
| Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed 出版商 |
- 染色质免疫沉淀
; 人类; 图 10
- 免疫沉淀; 人类; 图 1
- 免疫印迹; 人类; 图 1
| Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed 出版商 |
- 染色质免疫沉淀
; 人类; 图 4d
- 免疫印迹; 人类; 图 2a
| Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed 出版商 |
| Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed 出版商 |
| Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed 出版商 |
- 免疫细胞化学; 人类; 1:100; 图 4
- 免疫印迹; 人类; 1:500; 图 3
| Aquino Gálvez A, González Ãvila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed 出版商 |
| Taïeb D, Barlier A, Yang C, Pertuit M, Tchoghandjian A, Rochette C, et al. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. J Neurooncol. 2016;126:473-81 pubmed 出版商 |
| Contenti J, Guo Y, Larcher M, Mirabal Ortega L, Rouleau M, Irondelle M, et al. HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma. bioRxiv. 2023;: pubmed 出版商 |
| Ting K, Yu P, Dow R, Floro E, Ibrahim H, Scipione C, et al. Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway. J Immunol. 2023;211:1561-1577 pubmed 出版商 |
| Alexander K, Yu R, Skuli N, Coffey N, Nguyen S, Faunce C, et al. Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer. bioRxiv. 2023;: pubmed 出版商 |
| Liao Q, Zhu C, Sun X, Wang Z, Chen X, Deng H, et al. Disruption of sirtuin 7 in zebrafish facilitates hypoxia tolerance. J Biol Chem. 2023;:105074 pubmed 出版商 |
| Kubaichuk K, Kietzmann T. USP10 Contributes to Colon Carcinogenesis via mTOR/S6K Mediated HIF-1α but Not HIF-2α Protein Synthesis. Cells. 2023;12: pubmed 出版商 |
| Yue Y, Tang Y, Huang H, Zheng D, Liu C, Zhang H, et al. VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α. J Biol Chem. 2023;299:104829 pubmed 出版商 |
| Aboouf M, Armbruster J, Guscetti F, Thiersch M, Boss A, G xf6 decke A, et al. Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT mice. Sci Rep. 2023;13:7530 pubmed 出版商 |
| Qu M, Long Y, Wang Y, Yin N, Zhang X, Zhang J. Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner. Int J Mol Sci. 2023;24: pubmed 出版商 |
| Leu T, Denda J, Wrobeln A, Fandrey J. Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog. Mol Cell Biol. 2023;43:174-183 pubmed 出版商 |
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| Sun H, Pratt R, Dzau V, Hodgkinson C. Neonatal and adult cardiac fibroblasts exhibit inherent differences in cardiac regenerative capacity. J Biol Chem. 2023;299:104694 pubmed 出版商 |
| Mayro B, Hoj J, Cerda Smith C, Hutchinson H, Caminear M, Thrash H, et al. ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1. Proc Natl Acad Sci U S A. 2023;120:e2210418120 pubmed 出版商 |
| Ye J, Chen J, Li Y, Sun L, Lu H. Hepatocyte-specific knockout of HIF-2α cannot alleviate carbon tetrachloride-induced liver fibrosis in mice. Peerj. 2023;11:e15191 pubmed 出版商 |
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| Sabharwal S, Dudley V, Landwerlin C, Schumacker P. H2O2 transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo. J Biol Chem. 2023;299:104624 pubmed 出版商 |
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| Kostyunina D, Rowan S, Pakhomov N, Dillon E, Rochfort K, Cummins P, et al. Shear Stress Markedly Alters the Proteomic Response to Hypoxia in Human Pulmonary Endothelial Cells. Am J Respir Cell Mol Biol. 2023;68:551-565 pubmed 出版商 |
| Quan Y, Dai J, Zhou S, Zhao L, Jin L, Long Y, et al. HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma. FEBS Open Bio. 2023;13:638-654 pubmed 出版商 |
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| D xe1 tilo M, Formigari G, de Faria J, de Faria J. AMP kinase activation by Omega-3 polyunsaturated fatty acid protects the retina against ischemic insult: An in vitro and in vivo study. Exp Eye Res. 2023;226:109345 pubmed 出版商 |
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| Li G, Liu J, Guo M, Gu Y, Guan Y, Shao Q, et al. Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation. Cell Death Discov. 2022;8:473 pubmed 出版商 |
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| Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gyorffy B, Jalaguier S, et al. RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53. Cell Mol Life Sci. 2022;79:270 pubmed 出版商 |
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| Xia Q, Wu F, Wu W, Dong H, Huang Z, Xu L, et al. Berberine reduces hepatic ceramide levels to improve insulin resistance in HFD-fed mice by inhibiting HIF-2α. Biomed Pharmacother. 2022;150:112955 pubmed 出版商 |
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| Wolf C, Smith S, van Wijk S. Zafirlukast Induces VHL- and HIF-2α-Dependent Oxidative Cell Death in 786-O Clear Cell Renal Carcinoma Cells. Int J Mol Sci. 2022;23: pubmed 出版商 |
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| Qin Y, Zhang J, Babapoor Farrokhran S, Applewhite B, Deshpande M, Megarity H, et al. PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients. Sci Adv. 2022;8:eabm1896 pubmed 出版商 |
| Zhao L, Han Q, Zhou L, Bai L, Wang Y, Wu Y, et al. Addition of glomerular lesion severity improves the value of anemia status for the prediction of renal outcomes in Chinese patients with type 2 diabetes. Ren Fail. 2022;44:346-357 pubmed 出版商 |
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| Medeiros P, Pascetta S, Kirsh S, Al Khazraji B, Uniacke J. Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. J Biol Chem. 2022;298:101645 pubmed 出版商 |
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| Sabui S, Ramamoorthy K, Romero J, Simões R, Fleckenstein J, Said H. Hypoxia inhibits colonic uptake of the microbiota-generated forms of vitamin B1 via HIF-1α-mediated transcriptional regulation of their transporters. J Biol Chem. 2022;298:101562 pubmed 出版商 |
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| Shih H, Pan S, Wu C, Chou Y, Chen C, Chang F, et al. Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells. J Biomed Sci. 2021;28:73 pubmed 出版商 |
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| Zhao S, Zhou L, Dicker D, Lev A, Zhang S, Ross E, et al. Anti-cancer efficacy including Rb-deficient tumors and VHL-independent HIF1α proteasomal destabilization by dual targeting of CDK1 or CDK4/6 and HSP90. Sci Rep. 2021;11:20871 pubmed 出版商 |
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| Sasagawa T, Nagamatsu T, Yanagisawa M, Fujii T, Shibuya M. Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts. Mol Hum Reprod. 2021;27: pubmed 出版商 |
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| Li X, Zhang X, Xia J, Zhang L, Chen B, Lian G, et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep. 2021;36:109607 pubmed 出版商 |
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