产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
HIF-2甲/EPAS1抗体
目录 :
NB100-122
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
African green monkey, 仓鼠, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 602
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:100; 图 1j
Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 2g
Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3b
Kim Y, Lee M, Gu H, Kim J, Jeong S, Yeo S, et al. HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice. Dis Model Mech. 2018;11: pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 1d
Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5c
He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 表 s1
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 6c
  • 免疫印迹; 小鼠; 图 6a
Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed 出版商
  • 免疫印迹; 人类; 图 1e
Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4f
Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Lee M, Huang H, Chang T, Huang H, Hsieh S, Chen Y, et al. Genome-wide analysis of HIF-2? chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep. 2016;6:29311 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3a
Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed 出版商
  • 免疫印迹; African green monkey; 图 3
  • 免疫印迹; 人类; 图 1a
Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed 出版商
  • 免疫组化; 人类; 图 1B
  • 免疫印迹; 人类; 1:500; 图 1B
Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1a
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:150; 图 3b
Brooks D, Schwab L, Krutilina R, Parke D, Sethuraman A, Hoogewijs D, et al. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer. 2016;15:26 pubmed 出版商
  • 免疫印迹; 人类; 图 3
German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 3
  • 免疫印迹; 人类; 图 3
Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4f
Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 10
  • 免疫沉淀; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 4d
  • 免疫印迹; 人类; 图 2a
Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2
Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 7
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2a
Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015;10:229 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 4
  • 免疫印迹; 人类; 1:500; 图 3
Aquino Gálvez A, González Ávila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed 出版商
  • 免疫沉淀; 人类; 1:2000; 图 2a
Taïeb D, Barlier A, Yang C, Pertuit M, Tchoghandjian A, Rochette C, et al. Somatic gain-of-function HIF2A mutations in sporadic central nervous system hemangioblastomas. J Neurooncol. 2016;126:473-81 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:150; 图 s2
Saini Y, Proper S, Dornbos P, Greenwood K, Kopec A, Lynn S, et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE. 2015;10:e0139270 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 9e
Badal S, Her Y, Maher L. Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells. J Biol Chem. 2015;290:22287-97 pubmed 出版商
  • 免疫印迹; 小鼠
Matsuyama T, Tanaka T, Tatsumi K, Daijo H, Kai S, Harada H, et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur J Pharmacol. 2015;761:189-98 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s2
  • 免疫印迹; 人类
Lin A, Beasley F, Olson J, Keller N, Shalwitz R, Hannan T, et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015;11:e1004818 pubmed 出版商
  • 免疫印迹; 小鼠
Forristal C, Brown A, Helwani F, Winkler I, Nowlan B, Barbier V, et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia. 2015;29:2075-85 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 s10
  • 免疫细胞化学; 人类
Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol Cancer. 2015;14:77 pubmed 出版商
  • 免疫印迹; 小鼠
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell Dev Biol Anim. 2015;51:808-14 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew D, et al. Pharmacological inhibition of FTO. PLoS ONE. 2015;10:e0121829 pubmed 出版商
  • 免疫印迹; 人类
Qiu B, Ackerman D, Sanchez D, Li B, Ochocki J, Grazioli A, et al. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov. 2015;5:652-67 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Zeng H, Vaka V, He X, Booz G, Chen J. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J Cell Mol Med. 2015;19:1847-56 pubmed 出版商
  • 免疫印迹; 大鼠
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116:1680-90 pubmed 出版商
  • 免疫印迹; 人类
Doonachar A, Gallo M, Doukas D, Pasricha R, Lantsberg I, Schoenfeld A. Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines. Cancer Cell Int. 2015;15:23 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
Jimenez K, Khare V, Evstatiev R, Kulnigg Dabsch S, Jambrich M, Strobl H, et al. Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J Thromb Haemost. 2015;13:1113-27 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Matak P, Heinis M, Mathieu J, Corriden R, Cuvellier S, Delga S, et al. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015;194:3259-66 pubmed 出版商
  • 免疫印迹; 人类
Nozawa Suzuki N, Nagasawa H, Ohnishi K, Morishige K. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer. Biochem Biophys Res Commun. 2015;457:706-11 pubmed 出版商
  • 免疫印迹; 人类
Neelam S, Brooks M, Cammarata P. Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization. Mol Vis. 2014;20:1758-75 pubmed
  • 染色质免疫沉淀 ; 人类
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Xiang L, Gilkes D, Hu H, Takano N, Luo W, Lu H, et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014;5:12509-27 pubmed
  • 免疫印迹; 人类
Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015;11:e1004898 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠
Tsuboi I, Yamashita T, Nagano M, Kimura K, To a Salazar G, Ohneda O. Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia. J Cell Physiol. 2015;230:1534-48 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, et al. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget. 2015;6:2206-21 pubmed
  • 免疫印迹; 人类
Singleton D, Rouhi P, Zois C, Haider S, Li J, Kessler B, et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. 2015;34:4713-22 pubmed 出版商
  • 免疫印迹; 人类
Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014;111:E5429-38 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 6A
  • 免疫沉淀; 人类; 图 S3C
  • 免疫细胞化学; 人类; 图 5A
  • 免疫印迹; 人类; 图 S2
Koh M, Nguyen V, Lemos R, Darnay B, Kiriakova G, Abdelmelek M, et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015;75:316-29 pubmed 出版商
  • 免疫印迹; 人类
Hou P, Kuo C, Cheng C, Liou J, Ann D, Chen Q. Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2. PLoS ONE. 2014;9:e113865 pubmed 出版商
  • 免疫印迹; 小鼠
Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong G, et al. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2015;22:875-84 pubmed 出版商
  • 免疫印迹; 人类
Chen S, Hoffman N, Shanmughapriya S, Bao L, Keefer K, Conrad K, et al. A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α. J Biol Chem. 2014;289:36284-302 pubmed 出版商
  • 免疫印迹; 大鼠
El Assar M, Sánchez Puelles J, Royo I, López Hernández E, Sánchez Ferrer A, Aceña J, et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br J Pharmacol. 2015;172:1277-91 pubmed 出版商
  • 免疫印迹; 人类
Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Wu R, Chang H, Khechaduri A, Chawla K, Tran M, Chai X, et al. Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy. J Clin Invest. 2014;124:4795-806 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Hu H, Takano N, Xiang L, Gilkes D, Luo W, Semenza G. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014;5:8853-68 pubmed
  • 免疫组化; 人类
Zhou Y, Yuge A, Rajah A, Unek G, Rinaudo P, Maltepe E. LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia. Am J Pathol. 2014;184:3321-31 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫细胞化学; 人类
Petruzzelli R, Christensen D, Parry K, Sanchez Elsner T, Houghton F. HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element. PLoS ONE. 2014;9:e108309 pubmed 出版商
  • 免疫印迹; 人类
Bordji K, Grandval A, Cuhna Alves L, Lechapt Zalcman E, Bernaudin M. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014;281:5220-36 pubmed 出版商
  • 免疫印迹; 小鼠
Muz B, de la Puente P, Azab F, Ghobrial I, Azab A. Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia. Mol Cancer Res. 2015;13:263-72 pubmed 出版商
  • 免疫印迹; 人类
Asnaghi L, Lin M, Lim K, Lim K, Tripathy A, Wendeborn M, et al. Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation. PLoS ONE. 2014;9:e105372 pubmed 出版商
  • 免疫印迹; 人类
Hubbi M, Gilkes D, Hu H, Kshitiz -, Ahmed I, Semenza G. Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1? to promote cell-cycle progression. Proc Natl Acad Sci U S A. 2014;111:E3325-34 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Li B, Qiu B, Lee D, Walton Z, Ochocki J, Mathew L, et al. Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature. 2014;513:251-5 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Mésange P, Poindessous V, Sabbah M, Escargueil A, de Gramont A, Larsen A. Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Oncotarget. 2014;5:4709-21 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类; 图 1a
Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 仓鼠
Slominski A, Kim T, Brozyna A, Janjetovic Z, Brooks D, Schwab L, et al. The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1? expression and HIF-dependent attendant pathways. Arch Biochem Biophys. 2014;563:79-93 pubmed 出版商
  • 免疫印迹; 仓鼠
  • 免疫印迹; 人类
Kono K, Tamashiro D, Alarcon V. Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst. Dev Biol. 2014;394:142-55 pubmed 出版商
  • 免疫印迹; 人类
Takano N, Sarfraz Y, Gilkes D, Chaturvedi P, Xiang L, Suematsu M, et al. Decreased expression of cystathionine ?-synthase promotes glioma tumorigenesis. Mol Cancer Res. 2014;12:1398-406 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard O Riley R, Wilson T, et al. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014;393:124-36 pubmed 出版商
  • 免疫印迹; 人类
Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira A, Burke S, et al. Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1? pathway. FASEB J. 2014;28:4324-34 pubmed 出版商
  • 免疫印迹; 人类
Furcht C, Buonato J, Skuli N, Mathew L, Muñoz Rojas A, Simon M, et al. Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells. J Cell Sci. 2014;127:3555-67 pubmed 出版商
  • 免疫细胞化学; 小鼠
Arreola A, Cowey C, Coloff J, Rathmell J, Rathmell W. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE. 2014;9:e98705 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Chaturvedi P, Gilkes D, Takano N, Semenza G. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. 2014;111:E2120-9 pubmed 出版商
  • 免疫印迹; 人类
Ding Z, German P, Bai S, Reddy A, Liu X, Sun M, et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014;74:3127-36 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
  • 免疫组化-石蜡切片; 小鼠
  • 免疫印迹; 小鼠
Qin N, de Cubas A, Garcia Martin R, Richter S, Peitzsch M, Menschikowski M, et al. Opposing effects of HIF1? and HIF2? on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X. Int J Cancer. 2014;135:2054-64 pubmed 出版商
  • 流式细胞仪; 人类
Heyboer M, Milovanova T, Wojcik S, Grant W, Chin M, Hardy K, et al. CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage. Stem Cell Res. 2014;12:638-45 pubmed 出版商
  • 免疫印迹; 人类
Zhang J, Ma W. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet Mol Res. 2014;13:9324-35 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Huang Y, Lin M, Wang P, Wu Y, Chiang H, Wang Y, et al. Hypoxia inducible factor 2?/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol Hum Reprod. 2014;20:526-37 pubmed 出版商
  • 免疫印迹; 人类
Lian G, Wei C, Wang D, Cui M, Wang Z, Liu X, et al. Protein profiling of Helicobacter pylori-associated gastric cancer. Am J Pathol. 2014;184:1343-54 pubmed 出版商
  • 免疫印迹; 人类
Yoshizawa S, Brown A, Barchowsky A, Sfeir C. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation. Acta Biomater. 2014;10:2834-42 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014;184:1240-1250 pubmed 出版商
  • 免疫印迹; 小鼠
Wojciak Stothard B, Abdul Salam V, Lao K, Tsang H, Irwin D, Lisk C, et al. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation. 2014;129:1770-80 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 染色质免疫沉淀 ; 人类
Weisel F, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation. 2014;129:1510-23 pubmed 出版商
  • 免疫印迹; 人类
Chen Z, Liu X, Mei Z, Wang Z, Xiao W. EAF2 suppresses hypoxia-induced factor 1? transcriptional activity by disrupting its interaction with coactivator CBP/p300. Mol Cell Biol. 2014;34:1085-99 pubmed 出版商
  • 免疫印迹; 小鼠
Kumar V, Everingham S, Hall C, Greer P, Craig A. Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model. Eur J Immunol. 2014;44:831-41 pubmed 出版商
  • 免疫印迹; 人类
Place T, Nauseef J, Peterson M, Henry M, Mezhir J, Domann F. Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition. PLoS ONE. 2013;8:e83021 pubmed 出版商
  • 免疫印迹; 小鼠
Gomes A, Price N, Ling A, Moslehi J, Montgomery M, Rajman L, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155:1624-38 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Pasupuleti V, Du W, Gupta Y, Yeh I, MONTANO M, Magi Galuzzi C, et al. Dysregulated D-dopachrome tautomerase, a hypoxia-inducible factor-dependent gene, cooperates with macrophage migration inhibitory factor in renal tumorigenesis. J Biol Chem. 2014;289:3713-23 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠
Zhu J, Jiang X, Chehab F. FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2? at the CYP51 promoter. J Lipid Res. 2014;55:431-42 pubmed 出版商
  • 免疫印迹; 人类
Razorenova O, Castellini L, Colavitti R, Edgington L, Nicolau M, Huang X, et al. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol. 2014;34:739-51 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
  • 免疫印迹; 大鼠
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Takano N, Peng Y, Kumar G, Luo W, Hu H, Shimoda L, et al. Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression. Biochem J. 2014;458:203-11 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Bocca C, Ievolella M, Autelli R, Motta M, Mosso L, Torchio B, et al. Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness. Expert Opin Ther Targets. 2014;18:121-35 pubmed 出版商
  • 免疫组化; 人类
Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE. 2013;8:e80337 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Gilkes D, Xiang L, Lee S, Chaturvedi P, Hubbi M, Wirtz D, et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A. 2014;111:E384-93 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Glover L, Bowers B, Saeedi B, Ehrentraut S, Campbell E, Bayless A, et al. Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis. Proc Natl Acad Sci U S A. 2013;110:19820-5 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Proper S, Saini Y, Greenwood K, Bramble L, Downing N, Harkema J, et al. Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury. Toxicol Sci. 2014;137:447-57 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
  • 免疫组化-石蜡切片; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Xu Z, Zhao L, Zhu L, He M, Zheng L, Wu Y. MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2?. PLoS ONE. 2013;8:e77890 pubmed 出版商
  • 免疫印迹; 人类
Poitz D, Augstein A, Hesse K, Christoph M, Ibrahim K, Braun Dullaeus R, et al. Regulation of the HIF-system in human macrophages--differential regulation of HIF-? subunits under sustained hypoxia. Mol Immunol. 2014;57:226-35 pubmed 出版商
  • 免疫印迹; 人类
Scholz C, Cavadas M, Tambuwala M, Hams E, Rodriguez J, von Kriegsheim A, et al. Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways. Proc Natl Acad Sci U S A. 2013;110:18490-5 pubmed 出版商
  • 免疫印迹; 人类
Selvarajah J, Nathawat K, Moumen A, Ashcroft M, Carroll V. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell Death Dis. 2013;4:e865 pubmed 出版商
  • 免疫印迹; 大鼠
Nanduri J, Vaddi D, Khan S, Wang N, Makerenko V, Prabhakar N. Xanthine oxidase mediates hypoxia-inducible factor-2? degradation by intermittent hypoxia. PLoS ONE. 2013;8:e75838 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 免疫印迹; 小鼠
Cowburn A, Takeda N, Boutin A, Kim J, Sterling J, Nakasaki M, et al. HIF isoforms in the skin differentially regulate systemic arterial pressure. Proc Natl Acad Sci U S A. 2013;110:17570-5 pubmed 出版商
  • 免疫印迹; 人类
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers C, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11:e1001665 pubmed 出版商
  • 免疫印迹; 小鼠
Doedens A, Phan A, Stradner M, Fujimoto J, Nguyen J, Yang E, et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol. 2013;14:1173-82 pubmed 出版商
  • 免疫印迹; 人类
Cowburn A, Alexander L, Southwood M, Nizet V, Chilvers E, Johnson R. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Dermatol. 2014;134:801-808 pubmed 出版商
  • 免疫印迹; 小鼠
Wei K, Piecewicz S, McGinnis L, Taniguchi C, Wiegand S, Anderson K, et al. A liver Hif-2?-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013;19:1331-1337 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Pawlus M, Wang L, Murakami A, Dai G, Hu C. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE. 2013;8:e72358 pubmed 出版商
  • 免疫印迹; 人类
Luo X, Hill M, Johnson A, Latunde Dada G. Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2? in cultured cells. Biochim Biophys Acta. 2014;1840:106-12 pubmed 出版商
  • 免疫印迹; 人类
Befani C, Mylonis I, Gkotinakou I, Georgoulias P, Hu C, Simos G, et al. Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. Int J Biochem Cell Biol. 2013;45:2359-68 pubmed 出版商
  • 免疫印迹; 人类
Hanna C, Hubchak S, Liang X, Rozen Zvi B, Schumacker P, Hayashida T, et al. Hypoxia-inducible factor-2? and TGF-? signaling interact to promote normoxic glomerular fibrogenesis. Am J Physiol Renal Physiol. 2013;305:F1323-31 pubmed 出版商
  • 免疫印迹; 人类
Regan Anderson T, Peacock D, Daniel A, Hubbard G, Lofgren K, Girard B, et al. Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res. 2013;73:5810-20 pubmed 出版商
  • 免疫印迹; 小鼠
Brackmann F, Link A, Jung S, Richter M, Zoglauer D, Walkinshaw G, et al. Activin A regulation under global hypoxia in developing mouse brain. Brain Res. 2013;1531:65-74 pubmed 出版商
  • 免疫印迹; 人类
Poitz D, Augstein A, Gradehand C, Ende G, Schmeisser A, Strasser R. Regulation of the Hif-system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation. Mol Immunol. 2013;56:442-51 pubmed 出版商
  • 免疫印迹; 小鼠
You Q, Holt M, Yin H, Li G, Hu C, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013;86:836-43 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Kim M, Park H, Seol J, Jang J, Cho Y, Kim K, et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013;5:1415-30 pubmed 出版商
  • 免疫印迹; 人类
Wong W, Qiu B, Nakazawa M, Qing G, Simon M. MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death. Mol Cell Biol. 2013;33:3494-504 pubmed 出版商
  • ChIP-Seq; 大鼠
  • 染色质免疫沉淀 ; 大鼠
  • 免疫印迹; 大鼠
Xie L, Collins J. Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem. 2013;288:23943-52 pubmed 出版商
  • 免疫组化; 人类
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013;45:860-7 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
  • 免疫细胞化学; 人类
Goetze O, Schmitt J, Spliethoff K, Theurl I, Weiss G, Swinkels D, et al. Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers. Hepatology. 2013;58:2153-62 pubmed 出版商
  • 免疫印迹; 人类
Ikeda J, Ichiki T, Matsuura H, Inoue E, Kishimoto J, Watanabe A, et al. Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling. J Am Heart Assoc. 2013;2:e000178 pubmed 出版商
  • 免疫印迹; 小鼠
Wilkinson N, Pantopoulos K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2? mRNA translation. Blood. 2013;122:1658-68 pubmed 出版商
  • 免疫印迹; 小鼠
Kerkela R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, et al. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Mol Cell Biol. 2013;33:3321-9 pubmed 出版商
  • 免疫印迹; 人类
Hubbi M, Hu H, Kshitiz -, Gilkes D, Semenza G. Sirtuin-7 inhibits the activity of hypoxia-inducible factors. J Biol Chem. 2013;288:20768-75 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Forristal C, Christensen D, Chinnery F, Petruzzelli R, Parry K, Sanchez Elsner T, et al. Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells. PLoS ONE. 2013;8:e62507 pubmed 出版商
  • 免疫印迹; 人类
Thapa R, Chen P, Cheung M, Nogusa S, Pei J, Peri S, et al. NF-?B inhibition by bortezomib permits IFN-?-activated RIP1 kinase-dependent necrosis in renal cell carcinoma. Mol Cancer Ther. 2013;12:1568-78 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Mao X, Xue X, Wang L, Zhang X, Yan M, Tu Y, et al. CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia. Neuro Oncol. 2013;15:865-79 pubmed 出版商
  • 免疫印迹; 人类
Pawlus M, Wang L, Hu C. STAT3 and HIF1? cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014;33:1670-9 pubmed 出版商
  • 免疫印迹; 大鼠
Luo B, Jiang M, Yang X, Zhang Z, Xiong J, Schluesener H, et al. Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis. Biochim Biophys Acta. 2013;1832:1260-70 pubmed 出版商
  • 免疫印迹; 小鼠
Matak P, Zumerle S, Mastrogiannaki M, El Balkhi S, Delga S, Mathieu J, et al. Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2? and altered expression of iron absorption genes in mice. PLoS ONE. 2013;8:e59538 pubmed 出版商
  • 免疫印迹; 人类
Gilkes D, Chaturvedi P, Bajpai S, Wong C, Wei H, Pitcairn S, et al. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Res. 2013;73:3285-96 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Mohlin S, Hamidian A, Påhlman S. HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts. Neoplasia. 2013;15:328-34 pubmed
  • 免疫印迹; 人类
Parks S, Mazure N, Counillon L, Pouyssegur J. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels. J Cell Physiol. 2013;228:1854-62 pubmed 出版商
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
González Flores A, Aguilar Quesada R, Siles E, Pozo S, Rodríguez Lara M, Lopez Jimenez L, et al. Interaction between PARP-1 and HIF-2? in the hypoxic response. Oncogene. 2014;33:891-8 pubmed 出版商
  • 免疫组化; 小鼠
Fu L, Wang G, Shevchuk M, Nanus D, Gudas L. Activation of HIF2? in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer Res. 2013;73:2916-25 pubmed 出版商
  • 免疫印迹; 小鼠
Maruyama T, Miyamoto Y, Yamamoto G, Yamada A, Yoshimura K, Suzawa T, et al. Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes. PLoS ONE. 2013;8:e56984 pubmed 出版商
  • 免疫印迹; 小鼠
Choi H, Sanders T, Tormos K, Ameri K, Tsai J, Park A, et al. ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement. PLoS ONE. 2013;8:e56949 pubmed 出版商
  • 免疫印迹; 人类
Finger E, Cheng C, Williams T, Rankin E, Bedogni B, Tachiki L, et al. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 2014;33:1093-100 pubmed 出版商
  • 免疫印迹; 人类
Gilkes D, Bajpai S, Chaturvedi P, Wirtz D, Semenza G. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. J Biol Chem. 2013;288:10819-29 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Emerling B, Benes C, Poulogiannis G, Bell E, Courtney K, Liu H, et al. Identification of CDCP1 as a hypoxia-inducible factor 2? (HIF-2?) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013;110:3483-8 pubmed 出版商
  • 免疫印迹; 人类
Gilkes D, Bajpai S, Wong C, Chaturvedi P, Hubbi M, Wirtz D, et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res. 2013;11:456-66 pubmed 出版商
  • 免疫印迹; 人类
Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, et al. Hypoxia-inducible factor (HIF)-1? suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia. 2013;27:1697-706 pubmed 出版商
  • 免疫印迹; 人类
Neelam S, Brooks M, Cammarata P. Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1? and -2? and vascular endothelial growth factor in lens epithelial cell survival in hypoxia. Mol Vis. 2013;19:1-15 pubmed
  • 免疫印迹; 人类
Pang Y, Xu Y, Li H, Li Y, Zhao Y, Jiang R, et al. The inhibition of HIF-2? on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation. Toxicol Lett. 2013;218:105-17 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Zhang Y, Wang H, Zhang J, Lv J, Huang Y. Positive feedback loop and synergistic effects between hypoxia-inducible factor-2? and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Sci. 2013;104:416-22 pubmed 出版商
  • 免疫印迹; 人类
Shimanishi M, Ogi K, Sogabe Y, Kaneko T, Dehari H, Miyazaki A, et al. Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia. J Oral Pathol Med. 2013;42:382-8 pubmed 出版商
  • 免疫印迹; 小鼠
Vanharanta S, Shu W, Brenet F, Hakimi A, Heguy A, Viale A, et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat Med. 2013;19:50-6 pubmed 出版商
  • 免疫印迹; 人类
Xu Y, Li Y, Li H, Pang Y, Zhao Y, Jiang R, et al. The accumulations of HIF-1? and HIF-2? by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells. Toxicol Appl Pharmacol. 2013;266:187-97 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
Salnikov A, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E, et al. Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS ONE. 2012;7:e46391 pubmed 出版商
  • 免疫印迹; 人类
Croci D, Salatino M, Rubinstein N, Cerliani J, Cavallin L, Leung H, et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med. 2012;209:1985-2000 pubmed 出版商
  • 免疫印迹; 人类
Casagrande S, Ruf M, Rechsteiner M, Morra L, Brun Schmid S, von Teichman A, et al. The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma. J Pathol. 2013;229:525-34 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Pawlus M, Wang L, Ware K, Hu C. Upstream stimulatory factor 2 and hypoxia-inducible factor 2? (HIF2?) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012;32:4595-610 pubmed 出版商
  • 免疫印迹; 小鼠
Park S, Lee K, Lee S, Kim S, Park S, Jeon M, et al. L-2-Oxothiazolidine-4-carboxylic acid or ?-lipoic acid attenuates airway remodeling: involvement of nuclear factor-?B (NF-?B), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF). Int J Mol Sci. 2012;13:7915-37 pubmed 出版商
  • 免疫印迹; 人类
Krishnamachary B, Penet M, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, et al. Hypoxia regulates CD44 and its variant isoforms through HIF-1? in triple negative breast cancer. PLoS ONE. 2012;7:e44078 pubmed 出版商
  • 免疫印迹; 人类
Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012;103:2027-37 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 大鼠
Sciorra V, Sanchez M, Kunibe A, Wurmser A. Suppression of glioma progression by Egln3. PLoS ONE. 2012;7:e40053 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Chiavarina B, Martinez Outschoorn U, Whitaker Menezes D, Howell A, Tanowitz H, Pestell R, et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1? and HIF2? in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle. 2012;11:3280-9 pubmed 出版商
  • 免疫印迹; 小鼠
Anderson E, Taylor M, Xue X, Martin A, Moons D, Omary M, et al. The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression. Mol Cell Biol. 2012;32:4068-77 pubmed 出版商
  • 免疫印迹; 人类
Nayak B, Feliers D, Sudarshan S, Friedrichs W, Day R, New D, et al. Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation. Oncogene. 2013;32:3147-55 pubmed 出版商
  • 免疫印迹; 人类
Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, et al. Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release. J Biol Chem. 2012;287:31962-72 pubmed 出版商
  • 免疫印迹; 小鼠
Lee S, Jeong H, Lee J, Yang J, Lee E, Kim S, et al. Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med. 2012;4:924-38 pubmed 出版商
  • 免疫印迹; 人类
Chen R, Xu M, Hogg R, Li J, Little B, Gerard R, et al. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012;287:30800-11 pubmed 出版商
  • 免疫印迹; 人类
Boysen G, Bausch Fluck D, Thoma C, Nowicka A, Stiehl D, Cima I, et al. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia. 2012;14:535-46 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
Chintala S, Najrana T, Toth K, Cao S, Durrani F, Pili R, et al. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer. 2012;12:293 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Qi Y, Tian X, Liu J, Han Y, Graham A, Simon M, et al. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 2012;198:103-14 pubmed 出版商
  • 免疫印迹; 人类
Lee J, Jung E, Hyun J, Park D. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1? via activation of PGE(2)-cAMP signaling. J Cell Biochem. 2012;113:3681-91 pubmed 出版商
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
Ho J, Metcalf J, Yan M, Turgeon P, Wang J, Chalsev M, et al. Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem. 2012;287:29003-20 pubmed 出版商
  • 免疫印迹; 小鼠
Park S, Lee K, Kim S, Chae H, Yoo W, Kim D, et al. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflamm Res. 2012;61:1069-83 pubmed 出版商
  • 免疫印迹; 人类
Pourvali K, Matak P, Latunde Dada G, Solomou S, Mastrogiannaki M, Peyssonnaux C, et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2?. FEBS Lett. 2012;586:2423-7 pubmed 出版商
  • 免疫印迹; 人类
Uniacke J, Holterman C, Lachance G, Franovic A, Jacob M, Fabian M, et al. An oxygen-regulated switch in the protein synthesis machinery. Nature. 2012;486:126-9 pubmed 出版商
  • 免疫印迹; 人类
Zhou Q, Chen T, Ibe J, Raj J, Zhou G. Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization. FEBS Lett. 2012;586:1510-5 pubmed 出版商
  • 免疫印迹; 人类
Xu Y, Li Y, Pang Y, Ling M, Shen L, Yang X, et al. EMT and stem cell-like properties associated with HIF-2? are involved in arsenite-induced transformation of human bronchial epithelial cells. PLoS ONE. 2012;7:e37765 pubmed 出版商
  • 免疫印迹; 人类
Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O Flaherty L, et al. Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism. Mol Cell Biol. 2012;32:3081-94 pubmed 出版商
  • 免疫组化; 小鼠
Rankin E, Wu C, Khatri R, Wilson T, Andersen R, Araldi E, et al. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012;149:63-74 pubmed 出版商
  • 免疫印迹; 人类
Xu Y, Li Y, Pang Y, Ling M, Shen L, Jiang R, et al. Blockade of p53 by HIF-2?, but not HIF-1?, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells. Arch Toxicol. 2012;86:947-59 pubmed 出版商
  • 免疫印迹; 人类
Che Y, Ye F, Xu R, Qing H, Wang X, Yin F, et al. Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma. Am J Pathol. 2012;180:1798-807 pubmed 出版商
  • 免疫印迹; 人类
Yu B, Li M, Wang W, Wang Y, Jiang Y, Yang S, et al. Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model. J Mol Med (Berl). 2012;90:971-81 pubmed 出版商
  • 免疫印迹; 大鼠
Salman S, Brown S, Nurse C. Chronic nicotine induces hypoxia inducible factor-2? in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Am J Physiol Cell Physiol. 2012;302:C1531-8 pubmed 出版商
  • 免疫印迹; 人类
Ding Z, German P, Bai S, Feng Z, Gao M, Si W, et al. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. J Biomol Screen. 2012;17:572-80 pubmed 出版商
  • 免疫印迹; 人类
Koivunen P, Lee S, Duncan C, Lopez G, Lu G, Ramkissoon S, et al. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012;483:484-8 pubmed 出版商
  • 免疫印迹; 小鼠
Wiese M, Gerlach R, Popp I, Matuszak J, Mahapatro M, Castiglione K, et al. Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages. Infect Immun. 2012;80:1455-66 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Hubbi M, Gilkes D, Baek J, Semenza G. Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1. J Biol Chem. 2012;287:6139-49 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Ma Y, Liang D, Liu J, Axcrona K, Kvalheim G, Stokke T, et al. Prostate cancer cell lines under hypoxia exhibit greater stem-like properties. PLoS ONE. 2011;6:e29170 pubmed 出版商
  • 免疫印迹; 人类
Zhou W, Dosey T, Biechele T, Moon R, Horwitz M, Ruohola Baker H. Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. PLoS ONE. 2011;6:e27460 pubmed 出版商
  • 免疫印迹; 人类
Metallo C, Gameiro P, Bell E, Mattaini K, Yang J, Hiller K, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011;481:380-4 pubmed 出版商
  • 免疫组化-冰冻切片; 人类
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
Schrobback K, Malda J, Crawford R, Upton Z, Leavesley D, Klein T. Effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Eng Part A. 2012;18:920-33 pubmed 出版商
  • 免疫印迹; 小鼠
Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G. Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int J Cancer. 2012;131:E603-13 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Veeranna R, Haque M, Davis D, Yang M, Yarchoan R. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors. J Virol. 2012;86:1097-108 pubmed 出版商
  • 免疫印迹; 小鼠
Sakoda Y, Anand S, Zhao Y, Park J, Liu Y, Kuramasu A, et al. Herpesvirus entry mediator regulates hypoxia-inducible factor-1? and erythropoiesis in mice. J Clin Invest. 2011;121:4810-9 pubmed 出版商
  • 免疫印迹; 人类
Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, et al. JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma. Oncogene. 2012;31:3098-110 pubmed 出版商
  • 免疫印迹; 大鼠
Farrow E, Yu X, Summers L, Davis S, Fleet J, Allen M, et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci U S A. 2011;108:E1146-55 pubmed 出版商
  • 免疫印迹; 小鼠
Tsui A, Marsden P, Mazer C, Adamson S, Henkelman R, Ho J, et al. Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia. Proc Natl Acad Sci U S A. 2011;108:17544-9 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Shen G, Zhao Y, Chen M, Zhang F, Liu X, Wang Y, et al. Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia. Biochem J. 2012;441:675-83 pubmed 出版商
  • 免疫印迹; 人类
Wong C, Gilkes D, Zhang H, Chen J, Wei H, Chaturvedi P, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A. 2011;108:16369-74 pubmed 出版商
  • 免疫印迹; 人类
Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, et al. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2? through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms. Biochem Biophys Res Commun. 2011;413:201-5 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Ryu J, Shin Y, Huh Y, Yang S, Chun C, Chun J. Hypoxia-inducible factor-2? regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction. Cell Death Differ. 2012;19:440-50 pubmed 出版商
  • 免疫印迹; 人类
Zhang H, Wong C, Wei H, Gilkes D, Korangath P, Chaturvedi P, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene. 2012;31:1757-70 pubmed 出版商
  • 免疫印迹; 人类
Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, et al. Epigenetic regulation of HIF-1? in renal cancer cells involves HIF-1?/2? binding to a reverse hypoxia-response element. Oncogene. 2012;31:1065-72 pubmed 出版商
  • 免疫印迹; 人类
Heddleston J, Wu Q, Rivera M, Minhas S, Lathia J, Sloan A, et al. Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 2012;19:428-39 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Bruning U, Cerone L, Neufeld Z, Fitzpatrick S, Cheong A, Scholz C, et al. MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia. Mol Cell Biol. 2011;31:4087-96 pubmed 出版商
  • 免疫组化; 人类
Monzon F, Alvarez K, Peterson L, Truong L, Amato R, Hernandez McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011;24:1470-9 pubmed 出版商
  • 免疫印迹; 人类
Hubbi M, Luo W, Baek J, Semenza G. MCM proteins are negative regulators of hypoxia-inducible factor 1. Mol Cell. 2011;42:700-12 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Luo W, Hu H, Chang R, Zhong J, Knabel M, O Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732-44 pubmed 出版商
  • 免疫印迹; 人类
Wang H, Gillis A, Zhao C, Lee E, Wu J, Zhang F, et al. Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells. Mutat Res. 2011;723:171-6 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
  • 免疫组化; 人类
  • 免疫印迹; 人类
Jham B, Ma T, Hu J, Chaisuparat R, Friedman E, Pandolfi P, et al. Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma. PLoS ONE. 2011;6:e19103 pubmed 出版商
  • 免疫印迹; 人类
Poitz D, Augstein A, Weinert S, Braun Dullaeus R, Strasser R, Schmeisser A. OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res Cardiol. 2011;106:761-72 pubmed 出版商
  • 免疫印迹; 小鼠
Matak P, Deschemin J, Peyssonnaux C, Vaulont S. Lack of iron-related phenotype in Sp6 intestinal knockout mice. Blood Cells Mol Dis. 2011;47:46-9 pubmed 出版商
  • 免疫印迹; 小鼠
Koh M, Lemos R, Liu X, Powis G. The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 2011;71:4015-27 pubmed 出版商
  • 免疫印迹; 小鼠
Lange C, Heynen S, Tanimoto N, Thiersch M, Le Y, Meneau I, et al. Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration. Invest Ophthalmol Vis Sci. 2011;52:5872-80 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice. Am J Pathol. 2011;178:1881-90 pubmed 出版商
  • 染色质免疫沉淀 ; 大鼠
Xie L, Collins J. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;300:C1298-305 pubmed 出版商
  • 免疫印迹; 人类
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch Biochem Biophys. 2011;509:1-8 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Chen C, Ma Q, Ma X, Liu Z, Liu X. Association of elevated HIF-2? levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma. Ann Surg Oncol. 2011;18:2364-72 pubmed 出版商
  • 免疫印迹; 人类
Place T, Fitzgerald M, Venkataraman S, Vorrink S, Case A, Teoh M, et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE. 2011;6:e14617 pubmed 出版商
  • 免疫印迹; 人类
Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, et al. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke. 2011;42:754-63 pubmed 出版商
  • 免疫印迹; 小鼠
Peng Y, Nanduri J, Khan S, Yuan G, Wang N, Kinsman B, et al. Hypoxia-inducible factor 2? (HIF-2?) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011;108:3065-70 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Cassinat B, Zassadowski F, Ferry C, Llopis L, Bruck N, Lainey E, et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor ? recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation. Mol Cell Biol. 2011;31:1409-18 pubmed 出版商
  • 免疫印迹; 人类
Razorenova O, Finger E, Colavitti R, Chernikova S, Boiko A, Chan C, et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011;108:1931-6 pubmed 出版商
  • 免疫印迹; 小鼠
Ren H, Liu N, Song X, Ma Y, Zhai X. A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1? and HIF-2?. Invest Ophthalmol Vis Sci. 2011;52:3112-8 pubmed 出版商
  • 免疫印迹; 小鼠
Barshishat Kupper M, Mungunsukh O, Tipton A, McCart E, Panganiban R, Davis T, et al. Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation. Exp Hematol. 2011;39:293-304 pubmed 出版商
  • 免疫印迹; 小鼠
Rasbach K, Gupta R, Ruas J, Wu J, Naseri E, Estall J, et al. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A. 2010;107:21866-71 pubmed 出版商
  • 免疫印迹; 大鼠
Palladino M, Pirlamarla P, McNamara J, Sottas C, Korah N, Hardy M, et al. Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro. J Androl. 2011;32:307-23 pubmed 出版商
  • 免疫印迹; 人类
Neal C, Michael M, Rawlings L, Van der Hoek M, Gleadle J. The VHL-dependent regulation of microRNAs in renal cancer. BMC Med. 2010;8:64 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Qing G, Skuli N, Mayes P, Pawel B, Martinez D, Maris J, et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res. 2010;70:10351-61 pubmed 出版商
  • 免疫印迹; 小鼠
Pareek T, Lam E, Zheng X, Askew D, Kulkarni A, Chance M, et al. Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med. 2010;207:2507-19 pubmed 出版商
  • 免疫印迹; 小鼠
Copple B, Bai S, Burgoon L, Moon J. Hypoxia-inducible factor-1? regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int. 2011;31:230-44 pubmed 出版商
  • 免疫印迹; 小鼠
Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, et al. Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision. Neurobiol Dis. 2011;41:119-30 pubmed 出版商
  • 免疫印迹; 小鼠
Moslehi J, Minamishima Y, Shi J, Neuberg D, Charytan D, Padera R, et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation. 2010;122:1004-16 pubmed 出版商
  • 免疫印迹; 人类
Hu Z, Gulec S, Collins J. Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells. Am J Physiol Cell Physiol. 2010;299:C930-8 pubmed 出版商
  • 免疫印迹; 小鼠
Minamishima Y, Kaelin W. Reactivation of hepatic EPO synthesis in mice after PHD loss. Science. 2010;329:407 pubmed 出版商
  • 免疫印迹; 人类
Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup K, et al. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. FASEB J. 2010;24:4443-58 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Wu D, Paulson R. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE. 2010;5:e11303 pubmed 出版商
  • 免疫印迹; 人类
van De Sluis B, Mao X, Zhai Y, Groot A, Vermeulen J, van der Wall E, et al. COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion. J Clin Invest. 2010;120:2119-30 pubmed 出版商
  • 免疫印迹; 人类
Zimmer M, Lamb J, Ebert B, Lynch M, Neil C, Schmidt E, et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010;70:3071-9 pubmed 出版商
  • 免疫印迹; 小鼠
Copple B. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int. 2010;30:669-82 pubmed 出版商
  • 免疫印迹; 人类
Henze A, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, et al. Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res. 2010;70:357-66 pubmed 出版商
  • 免疫印迹; 人类
Martin S, Diamond P, WILLIAMS S, To L, Peet D, Fujii N, et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica. 2010;95:776-84 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza G. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem. 2010;285:3651-63 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Krieg A, Rankin E, Chan D, Razorenova O, Fernandez S, Giaccia A. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010;30:344-53 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Finley D, Narula N, Valera V, Merino M, Fruehauf J, Wu M, et al. Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report. Urol Oncol. 2011;29:85-9 pubmed 出版商
Schwartz A, Converso Baran K, Michele D, Shah Y. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. J Biol Chem. 2019;294:14991-15002 pubmed 出版商
Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis. 2019;10:544 pubmed 出版商
Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed 出版商
Aquino Galvez A, Gonzalez Avila G, Jiménez Sánchez L, Maldonado Martínez H, Cisneros J, Toscano Marquez F, et al. Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis. Respir Res. 2019;20:130 pubmed 出版商
Maugeri G, D Amico A, Federico C, Saccone S, Giunta S, Cavallaro S, et al. Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway. J Mol Neurosci. 2019;: pubmed 出版商
Yamamoto A, Hester J, Macklin P, Kawai K, Uchiyama M, Biggs D, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019;130:3640-3656 pubmed 出版商
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza G, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nat Commun. 2019;10:2130 pubmed 出版商
Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth P, et al. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Nat Commun. 2019;10:2126 pubmed 出版商
Fujimoto T, Colbert L, Huang Y, Molkentine J, Deorukhkar A, Baseler L, et al. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res. 2019;79:2327-2338 pubmed 出版商
Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, et al. Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells. Cancers (Basel). 2019;11: pubmed 出版商
Chaurasia S, Kushwaha G, Kulkarni P, Mallick R, Latheef N, Mishra J, et al. Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release. Haematologica. 2019;: pubmed 出版商
Sumi C, Matsuo Y, Kusunoki M, Shoji T, Uba T, Iwai T, et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PLoS ONE. 2019;14:e0215072 pubmed 出版商
Gkotinakou I, Befani C, Simos G, Liakos P. ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling. J Cell Sci. 2019;132: pubmed 出版商
Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed 出版商
Chachami G, Stankovic Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, et al. Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen. Mol Cell Proteomics. 2019;18:1197-1209 pubmed 出版商
Arthur S, Blaydes J, Houghton F. Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs. Stem Cell Reports. 2019;12:728-742 pubmed 出版商
Natarajan S, Foreman K, Soriano M, Rossen N, Shehade H, Fregoso D, et al. Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis. Cancer Res. 2019;79:2271-2284 pubmed 出版商
Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al. A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Nat Commun. 2019;10:1152 pubmed 出版商
Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed 出版商
Ndiaye P, Dufies M, Giuliano S, Douguet L, Grepin R, Durivault J, et al. VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. Theranostics. 2019;9:661-675 pubmed 出版商
Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, et al. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. Redox Biol. 2019;22:101145 pubmed 出版商
Xiong Y, Liu L, Xia Y, Qi Y, Chen Y, Chen L, et al. Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma. Cancer Immunol Immunother. 2019;68:731-741 pubmed 出版商
Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, et al. TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. Int J Biol Sci. 2019;15:587-597 pubmed 出版商
Lee B, Jun H, Kim J, Kim J. Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina. FASEB J. 2019;33:6045-6054 pubmed 出版商
Tian Z, Yao L, Shen Y, Guo X, Duan X. Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia. Int J Biochem Cell Biol. 2019;109:33-39 pubmed 出版商
Jarman E, Ward C, Turnbull A, Martinez Perez C, Meehan J, Xintaropoulou C, et al. HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer. Breast Cancer Res. 2019;21:10 pubmed 出版商
Ma X, Das N, Castillo C, Gourani A, Perekatt A, Verzi M, et al. SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes. J Biol Chem. 2019;294:3974-3986 pubmed 出版商
Guo H, Ci X, Ahmed M, Hua J, Soares F, Lin D, et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019;10:278 pubmed 出版商
Karagiota A, Kourti M, Simos G, Mylonis I. HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia. Cell Mol Life Sci. 2019;76:809-825 pubmed 出版商
Xu M, Tan X, Li N, Wu H, Wang Y, Xie J, et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons. J Cell Physiol. 2019;234:4232-4242 pubmed 出版商
Olcina M, Balanis N, Kim R, Aksoy B, Kodysh J, Thompson M, et al. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018;25:3721-3732.e6 pubmed 出版商
Choi S, Kim Y, Park Y, Yang H, Jeong P, Cha J, et al. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2018;: pubmed 出版商
Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, et al. Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Sci Rep. 2018;8:16475 pubmed 出版商
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed 出版商
Liao L, Liu Z, Langbein L, Cai W, Cho E, Na J, et al. Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. elife. 2018;7: pubmed 出版商
Carolina E, Kato T, Khanh V, Moriguchi K, Yamashita T, Takeuchi K, et al. Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway. Front Med (Lausanne). 2018;5:276 pubmed 出版商
Fortenbery G, Sarathy B, Carraway K, Mansfield K. Hypoxic stabilization of mRNA is HIF-independent but requires mtROS. Cell Mol Biol Lett. 2018;23:48 pubmed 出版商
Sethuraman A, Brown M, Krutilina R, Wu Z, Seagroves T, Pfeffer L, et al. BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion. Breast Cancer Res. 2018;20:117 pubmed 出版商
Ow C, Ngo J, Ullah M, Barsha G, Meex R, Watt M, et al. Absence of renal hypoxia in the subacute phase of severe renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2018;315:F1358-F1369 pubmed 出版商
Zaini M, Patel S, Syafruddin S, Rodrigues P, Vanharanta S. Endogenous HIF2A reporter systems for high-throughput functional screening. Sci Rep. 2018;8:12063 pubmed 出版商
Anea C, Merloiu A, Fulton D, Patel V, Rudic R. Immunohistochemistry of the circadian clock in mouse and human vascular tissues. Vessel Plus. 2018;2: pubmed 出版商
Regan Anderson T, Ma S, Perez Kerkvliet C, Peng Y, Helle T, Krutilina R, et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res. 2018;16:1761-1772 pubmed 出版商
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al. NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis. Cancer Discov. 2018;8:850-865 pubmed 出版商
Miess H, Dankworth B, Gouw A, Rosenfeldt M, Schmitz W, Jiang M, et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. 2018;37:5435-5450 pubmed 出版商
Kumar V, Biswas S, Sharma N, Stone S, Fam C, Cox G, et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Phys. 2018;115:65-76 pubmed 出版商
Landau D, London L, Bandach I, Segev Y. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE. 2018;13:e0196684 pubmed 出版商
Thompson J, Alvarez A, Singha M, Pavesic M, Nguyen Q, Nelson L, et al. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther. 2018;17:1781-1792 pubmed 出版商
Maugeri G, D Amico A, Rasà D, Saccone S, Federico C, Cavallaro S, et al. PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia. Neuropeptides. 2018;69:84-91 pubmed 出版商
Schofield H, Tandon M, Park M, Halbrook C, Ramakrishnan S, Kim E, et al. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol. 2018;5:169-185.e2 pubmed 出版商
Yang Q, Guo X, Yang L. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). Med Sci Monit. 2018;24:2225-2234 pubmed
Ferecatu I, Canal F, Fabbri L, Mazure N, Bouton C, Golinelli Cohen M. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1? activation. PLoS ONE. 2018;13:e0194782 pubmed 出版商
Xie L, Yin A, Nichenko A, Beedle A, Call J, Yin H. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J Clin Invest. 2018;128:2339-2355 pubmed 出版商
Kim H, Lin Q, Glazer P, Yun Z. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018;20:16 pubmed 出版商
Abdul Aziz A, Shafat M, Sun Y, Marlein C, Piddock R, Robinson S, et al. HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene. 2018;37:2676-2686 pubmed 出版商
Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE. 2018;13:e0193477 pubmed 出版商
Robinson C, Lefebvre F, Poon B, Bousard A, Fan X, Lathrop M, et al. Consequences of VHL Loss on Global DNA Methylome. Sci Rep. 2018;8:3313 pubmed 出版商
Senavirathna L, Huang C, Yang X, Munteanu M, Sathiaseelan R, Xu D, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018;8:2709 pubmed 出版商
Mira E, Carmona Rodríguez L, Pérez Villamil B, Casas J, Fernández Aceñero M, Martínez Rey D, et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nat Commun. 2018;9:575 pubmed 出版商
Frump A, Selej M, Wood J, Albrecht M, Yakubov B, Petrache I, et al. Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner. Am J Respir Cell Mol Biol. 2018;59:114-126 pubmed 出版商
Samanta D, Park Y, Ni X, Li H, Zahnow C, Gabrielson E, et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proc Natl Acad Sci U S A. 2018;115:E1239-E1248 pubmed 出版商
Maybin J, Murray A, Saunders P, Hirani N, Carmeliet P, Critchley H. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun. 2018;9:295 pubmed 出版商
Dopeso H, Jiao H, Cuesta A, Henze A, Jurida L, Kracht M, et al. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018;78:1805-1819 pubmed 出版商
Bogurcu N, Seidel S, Garvalov B, Acker T. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol Biol. 2018;1742:283-300 pubmed 出版商
Brooks D, Seagroves T. Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models. Methods Mol Biol. 2018;1742:67-79 pubmed 出版商
Ho J, Balukoff N, Cervantes G, Malcolm P, Krieger J, Lee S. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep. 2018;22:17-26 pubmed 出版商
Casillas A, Toth R, Sainz A, Singh N, Desai A, Kraft A, et al. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin Cancer Res. 2018;24:169-180 pubmed 出版商
Kelly N, Varga J, Specker E, Romeo C, Coomber B, Uniacke J. Hypoxia activates cadherin-22 synthesis via eIF4E2 to drive cancer cell migration, invasion and adhesion. Oncogene. 2018;37:651-662 pubmed 出版商
Liu S, Tetzlaff M, Wang T, Chen X, Yang R, Kumar S, et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget. 2017;8:115140-115152 pubmed 出版商
Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T. Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury. FASEB J. 2017;: pubmed 出版商
Gastelum G, Poteshkina A, Veena M, Artiga E, Weckstein G, Frost P. Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2? expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PLoS ONE. 2017;12:e0188438 pubmed 出版商
Shi M, Flores B, Li P, Gillings N, McMillan K, Ye J, et al. Effects of Erythropoietin Receptor Activity on Angiogenesis, Tubular Injury and Fibrosis in Acute Kidney Injury: A "U-Shaped" Relationship. Am J Physiol Renal Physiol. 2017;:ajprenal.00306.2017 pubmed 出版商
Du W, Zhang L, Brett Morris A, Aguila B, Kerner J, Hoppel C, et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. Nat Commun. 2017;8:1769 pubmed 出版商
Ho J, Abdullah L, Pang Q, Jha S, Chow E, Yang H, et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE. 2017;12:e0188051 pubmed 出版商
Bino L, Prochazkova J, Radaszkiewicz K, Kucera J, Kudová J, Pachernik J, et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner. Oncotarget. 2017;8:83684-83697 pubmed 出版商
Palazon A, Tyrakis P, Macías D, Veliça P, Rundqvist H, Fitzpatrick S, et al. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017;32:669-683.e5 pubmed 出版商
Suh J, Lai L, Nam D, Kim J, Jo J, Taffet G, et al. Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. J Biol Chem. 2017;292:21643-21652 pubmed 出版商
Fanelli G, Gonzalez Cordero A, Gardner P, Peng Q, Fernando M, Kloc M, et al. Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress. Sci Rep. 2017;7:14625 pubmed 出版商
Hascoet P, Chesnel F, Jouan F, Le Goff C, Couturier A, Darrigrand E, et al. The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13. Oncotarget. 2017;8:75989-76002 pubmed 出版商
Tang H, Babicheva A, McDermott K, Gu Y, Ayon R, Song S, et al. Endothelial HIF-2? Contributes to Severe Pulmonary Hypertension by Inducing Endothelial-to-Mesenchymal Transition. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00096.2017 pubmed 出版商
Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017;23:1298-1308 pubmed 出版商
Strowitzki M, Ritter A, Radhakrishnan P, Harnoss J, Opitz V, Biller M, et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep. 2017;7:13151 pubmed 出版商
Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017;8:584 pubmed 出版商
Ariazi J, Duffy K, Adams D, Fitch D, Luo L, Pappalardi M, et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther. 2017;363:336-347 pubmed 出版商
Kong K, Oh H, Lim B, Kim M, Han K, Choi Y, et al. Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Sci Rep. 2017;7:11351 pubmed 出版商
Dobrynin G, McAllister T, Leszczynska K, Ramachandran S, Krieg A, Kawamura A, et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep. 2017;7:11094 pubmed 出版商
Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed 出版商
Ma X, Zhang H, Xue X, Shah Y. Hypoxia-inducible factor 2? (HIF-2?) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem. 2017;292:17046-17056 pubmed 出版商
Shved N, Warsow G, Eichinger F, Hoogewijs D, Brandt S, Wild P, et al. Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts. Sci Rep. 2017;7:8576 pubmed 出版商
McGinn O, Gupta V, Dauer P, Arora N, Sharma N, Nomura A, et al. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer. Sci Rep. 2017;7:7872 pubmed 出版商
Tsang K, Hyun J, Cheng K, Vargas M, Mehta D, Ushio Fukai M, et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?. Stem Cell Reports. 2017;9:796-806 pubmed 出版商
Sun W, Kato H, Kitajima S, Lee K, Gradin K, Okamoto T, et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep. 2017;7:7190 pubmed 出版商
Bhan A, Deb P, Shihabeddin N, Ansari K, Brotto M, Mandal S. Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. Gene. 2017;629:16-28 pubmed 出版商
Jain C, Jessmon P, Barrak C, Bolnick A, Kilburn B, Hertz M, et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ. 2017;24:1772-1783 pubmed 出版商
Westerlund I, Shi Y, Toskas K, Fell S, Li S, Surova O, et al. Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression. Proc Natl Acad Sci U S A. 2017;114:E6137-E6146 pubmed 出版商
Lim E, Kuo C, Tu H, Yang C. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. J Chin Med Assoc. 2017;80:651-656 pubmed 出版商
Okamoto A, Sumi C, Tanaka H, Kusunoki M, Iwai T, Nishi K, et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep. 2017;7:3816 pubmed 出版商
Wu D, Huang R, Hamanaka R, Krause M, Oh M, Kuo C, et al. HIF-1? is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. elife. 2017;6: pubmed 出版商
Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget. 2017;8:49451-49469 pubmed 出版商
Harashima N, Takenaga K, Akimoto M, Harada M. HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression. Oncotarget. 2017;8:42887-42900 pubmed 出版商
Sun L, Kong Y, Cao M, Zhou H, Li H, Cui Y, et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. Cancer Sci. 2017;108:1338-1346 pubmed 出版商
Lee H, Liu S, Lin C, Lee S, Hsu C, Sytwu H, et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics. 2017;7:855-875 pubmed 出版商
Wang S, Zeng H, Chen S, Zhou L, Xie X, He X, et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J Cell Mol Med. 2017;21:1967-1978 pubmed 出版商
Lu H, Chen I, Shimoda L, Park Y, Zhang C, Tran L, et al. Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep. 2017;18:1946-1957 pubmed 出版商
Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017;36:3609-3617 pubmed 出版商
Hoppe Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci U S A. 2017;114:E990-E998 pubmed 出版商
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun. 2017;8:13946 pubmed 出版商
Shneor D, Folberg R, Pe er J, Honigman A, Frenkel S. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther. 2017;24:64-74 pubmed 出版商
Ke S, Chen S, Dong Z, Hong C, Zhang Q, Tang L, et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017;65:134-151 pubmed 出版商
Nunomiya A, Shin J, Kitajima Y, Dan T, Miyata T, Nagatomi R. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf). 2017;220:99-112 pubmed 出版商
Nakayama T, Otsuka S, Kobayashi T, Okajima H, Matsumoto K, Hagiya Y, et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep. 2016;6:36478 pubmed 出版商
Zhang L, Du J, Justus S, Hsu C, Bonet Ponce L, Wu W, et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest. 2016;126:4659-4673 pubmed 出版商
Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res. 2016;6:2263-2276 pubmed
Ha J, Doguer C, Collins J. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016;8:963-972 pubmed
D Alessio A, Proietti G, Lama G, Biamonte F, Lauriola L, Moscato U, et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget. 2016;7:78541-78556 pubmed 出版商
Pangou E, Befani C, Mylonis I, Samiotaki M, Panayotou G, Simos G, et al. HIF-2? phosphorylation by CK1? promotes erythropoietin secretion in liver cancer cells under hypoxia. J Cell Sci. 2016;129:4213-4226 pubmed
Dehn S, DeBerge M, Yeap X, Yvan Charvet L, Fang D, Eltzschig H, et al. HIF-2? in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. J Immunol. 2016;197:3639-3649 pubmed
Wang S, Zeng H, Xie X, Tao Y, He X, Roman R, et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget. 2016;7:58848-58861 pubmed 出版商
Görtz G, Horstmann M, Aniol B, Reyes B, Fandrey J, Eckstein A, et al. Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking. J Clin Endocrinol Metab. 2016;101:4834-4842 pubmed
Zhang C, Zhi W, Lu H, Samanta D, Chen I, Gabrielson E, et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016;7:64527-64542 pubmed 出版商
Prakash H, Nadella V, Singh S, Schmitz Winnenthal H. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep. 2016;6:31490 pubmed 出版商
Gstalder C, Ader I, Cuvillier O. FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Mol Cancer Ther. 2016;15:2465-2474 pubmed
Nauta T, Duyndam M, Weijers E, van Hinsbergh V, Koolwijk P. HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE. 2016;11:e0160700 pubmed 出版商
Depner C, Zum Buttel H, Bogurcu N, Cuesta A, Aburto M, Seidel S, et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun. 2016;7:12329 pubmed 出版商
Leinonen H, Rossi M, Salo A, Tiainen P, Hyvärinen J, Pitkänen M, et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet. 2016;25:3810-3823 pubmed 出版商
Cui J, Duan B, Zhao X, Chen Y, Sun S, Deng W, et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016;37:13455-13467 pubmed
Pramono A, Zahabi A, Morishima T, Lan D, Welte K, Skokowa J. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop. Ann N Y Acad Sci. 2016;1375:38-51 pubmed 出版商
Chen H, Hong F, Chen Y, Li J, Yao Y, Zhang Y, et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion. Eur J Pharmacol. 2016;789:354-361 pubmed 出版商
Luo B, Wang J, Liu Z, Shen Z, Shi R, Liu Y, et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun. 2016;7:12177 pubmed 出版商
Diaz Trelles R, Scimia M, Bushway P, Tran D, Monosov A, Monosov E, et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016;7:12088 pubmed 出版商
Kowitzke B, Cohrs G, Leuschner I, Koch A, Synowitz M, Mehdorn H, et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J Neuropathol Exp Neurol. 2016;75:827-42 pubmed 出版商
Mao X, Wang C, Liu D, Zhang X, Wang L, Yan M, et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Oncotarget. 2016;7:47808-47820 pubmed 出版商
Zhang X, Prasadam I, Fang W, Crawford R, Xiao Y. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2? activity. Osteoarthritis Cartilage. 2016;24:1970-1980 pubmed 出版商
Mahara S, Lee P, Feng M, Tergaonkar V, Chng W, Yu Q. HIFI-? activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc Natl Acad Sci U S A. 2016;113:E3735-44 pubmed 出版商
Hoang N, Kadonosono T, Kuchimaru T, Kizaka Kondoh S. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016;107:1151-8 pubmed 出版商
Mammadzada P, Gudmundsson J, Kvanta A, André H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol. 2016;94:805-814 pubmed 出版商
Rodriguez S, Rudloff S, Koenig K, Karthik S, Hoogewijs D, Huynh Do U. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016;468:1433-48 pubmed 出版商
Warfel N, Sainz A, Song J, Kraft A. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016;15:1637-47 pubmed 出版商
Christinat Y, Pawłowski R, Krek W. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics. 2016;32:2111-9 pubmed 出版商
Dai Z, Li M, Wharton J, Zhu M, Zhao Y. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2?. Circulation. 2016;133:2447-58 pubmed 出版商
Fitzpatrick S, Fabian Z, Schaible B, Lenihan C, Schwarzl T, Rodriguez J, et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-?B-dependent manner. Biochem Biophys Res Commun. 2016;474:579-586 pubmed 出版商
Selfridge A, Cavadas M, Scholz C, Campbell E, Welch L, Lecuona E, et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016;291:11800-8 pubmed 出版商
Timpano S, Uniacke J. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J Biol Chem. 2016;291:10772-82 pubmed 出版商
Zhang C, Samanta D, Lu H, Bullen J, Zhang H, Chen I, et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m?A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016;113:E2047-56 pubmed 出版商
Nam H, Jones D, Cooksey R, Gao Y, Sink S, Cox J, et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes. 2016;65:1521-33 pubmed 出版商
You A, Cao M, Guo Z, Zuo B, Gao J, Zhou H, et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol. 2016;9:20 pubmed 出版商
Zeng H, He X, Tuo Q, Liao D, Zhang G, Chen J. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep. 2016;6:20931 pubmed 出版商
Kadam P, Chuan H. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016;27:505 pubmed 出版商
Qian F, He M, Duan W, Mao L, Li Q, Yu Z, et al. Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res. 2015;7:2364-78 pubmed
Mysore V, Szablowski J, Dervan P, FROST P. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. 2016;14:253-66 pubmed 出版商
Binó L, Kučera J, Å tefková K, Å vihálková Å indlerová L, Lánová M, Kudová J, et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem Biol Interact. 2016;244:204-14 pubmed 出版商
Messai Y, Gad S, Noman M, Le Teuff G, Couve S, Janji B, et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur Urol. 2016;70:623-632 pubmed 出版商
Laukka T, Mariani C, Ihantola T, Cao J, Hokkanen J, Kaelin W, et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016;291:4256-65 pubmed 出版商
Cavadas M, Mesnieres M, Crifò B, Manresa M, Selfridge A, Scholz C, et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep. 2015;5:17851 pubmed 出版商
Vukovic M, Guitart A, Sepúlveda C, Villacreces A, O Duibhir E, Panagopoulou T, et al. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. J Exp Med. 2015;212:2223-34 pubmed 出版商
Bhanu N, Sidoli S, Garcia B. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics. 2016;16:448-58 pubmed 出版商
Sun W, Kosyna F, Jelkmann W, Depping R. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression. Cell Physiol Biochem. 2015;37:2257-64 pubmed 出版商
Cheng S, Xing W, Pourteymoor S, Schulte J, Mohan S. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. 2016;157:127-40 pubmed 出版商
Highet A, Khoda S, Buckberry S, Leemaqz S, Bianco Miotto T, Harrington E, et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur J Cell Biol. 2015;94:589-602 pubmed 出版商
Huh Y, Lee G, Lee K, Koh J, Chun J, Ryu J. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res Ther. 2015;17:302 pubmed 出版商
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015;34:2953-70 pubmed 出版商
Frey J, Stonko D, Faugere M, Riddle R. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res. 2014;2:14005 pubmed 出版商
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112:E4600-9 pubmed 出版商
Ramakrishnan S, Anderson E, Martin A, Centofanti B, Shah Y. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proc Natl Acad Sci U S A. 2015;112:E3738-47 pubmed 出版商
Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin L, et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res. 2014;2:14015 pubmed 出版商
Otto T, Gellhaus A, Lüschen N, Scheidler J, Bendix I, Dunk C, et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia?. J Cell Biochem. 2015;116:2924-37 pubmed 出版商
Rad E, Dodd K, Thomas L, Upadhyaya M, Tee A. STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol Cancer Res. 2015;13:1149-60 pubmed 出版商
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther. 2015;15:313-25 pubmed
Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed 出版商
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed 出版商
Gong H, Rehman J, Tang H, Wary K, Mittal M, Chaturvedi P, et al. HIF2α signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest. 2015;125:652-64 pubmed 出版商
Henze A, Garvalov B, Seidel S, Cuesta A, Ritter M, Filatova A, et al. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Nat Commun. 2014;5:5582 pubmed 出版商
Nagaya Y, Aoyama M, Tamura T, Kakita H, Kato S, Hida H, et al. Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α. Eur J Neurosci. 2014;40:3620-6 pubmed 出版商
Bürgi S, Seuwen A, Keist R, Vom Berg J, Grandjean J, Rudin M. In vivo imaging of hypoxia-inducible factor regulation in a subcutaneous and orthotopic GL261 glioma tumor model using a reporter gene assay. Mol Imaging. 2014;13: pubmed 出版商
Lalevée S, Lapaire O, Bühler M. miR455 is linked to hypoxia signaling and is deregulated in preeclampsia. Cell Death Dis. 2014;5:e1408 pubmed 出版商
Fujikuni N, Yamamoto H, Tanabe K, Naito Y, Sakamoto N, Tanaka Y, et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci. 2014;105:1411-20 pubmed 出版商
Yoshizawa S, Brown A, Barchowsky A, Sfeir C. Role of magnesium ions on osteogenic response in bone marrow stromal cells. Connect Tissue Res. 2014;55 Suppl 1:155-9 pubmed 出版商
Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed 出版商
Salman S, Holloway A, Nurse C. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2? and protein kinase A. Am J Physiol Cell Physiol. 2014;307:C266-77 pubmed 出版商
Rawłuszko Wieczorek A, Horbacka K, Krokowicz P, Misztal M, Jagodziński P. Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer. Mol Cancer Res. 2014;12:1112-27 pubmed 出版商
Gerovac B, Valencia M, Baumlin N, Salathe M, Conner G, Fregien N. Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am J Respir Cell Mol Biol. 2014;51:516-25 pubmed 出版商
Glasmacher S. [Recommendation for vaccination against polio]. Gesundheitswesen. 2014;76:71 pubmed
Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, et al. Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation. PLoS ONE. 2014;9:e93856 pubmed 出版商
Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, et al. Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1. Biochim Biophys Acta. 2014;1839:259-64 pubmed 出版商
Chiatar S, Eze O, Schoenfeld A. Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation. Cell Dev Biol. 2013;2: pubmed 出版商
Xiang L, Gilkes D, Chaturvedi P, Luo W, Hu H, Takano N, et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2014;92:151-64 pubmed 出版商
Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol Dis. 2013;50:25-30 pubmed 出版商
Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1?-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012;26:2620-30 pubmed 出版商
Conley S, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath A, et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A. 2012;109:2784-9 pubmed 出版商
Gabai V, Meng L, Kim G, Mills T, Benjamin I, Sherman M. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Mol Cell Biol. 2012;32:929-40 pubmed 出版商
Bohonowych J, Peng S, Gopal U, Hance M, Wing S, Argraves K, et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer. 2011;11:520 pubmed 出版商
Mohanty S. Multidimensional poverty and child survival in India. PLoS ONE. 2011;6:e26857 pubmed 出版商
Bussolati B, Moggio A, Collino F, Aghemo G, D Armento G, Grange C, et al. Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance. Am J Physiol Renal Physiol. 2012;302:F116-28 pubmed 出版商
Brown S, Reyes E, Nurse C. Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2?: role in modulating secretion. Biochem Biophys Res Commun. 2011;412:466-72 pubmed 出版商
Zhang H, Zhang G, Gonzalez F, Park S, Cai D. Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation. PLoS Biol. 2011;9:e1001112 pubmed 出版商
Russell R, Sufan R, Zhou B, Heir P, Bunda S, Sybingco S, et al. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat Med. 2011;17:845-53 pubmed 出版商
Lee S, Kim H, Jin Y, Choi A, Ryter S. Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis. Autophagy. 2011;7:829-39 pubmed
Nagao K, Oka K. HIF-2 directly activates CD82 gene expression in endothelial cells. Biochem Biophys Res Commun. 2011;407:260-5 pubmed 出版商
van Uden P, Kenneth N, Webster R, Müller H, Mudie S, Rocha S. Evolutionary conserved regulation of HIF-1β by NF-κB. PLoS Genet. 2011;7:e1001285 pubmed 出版商
Husted R, Lu H, Sigmund R, Stokes J. Oxygen regulation of the epithelial Na channel in the collecting duct. Am J Physiol Renal Physiol. 2011;300:F412-24 pubmed 出版商
Manisterski M, Golan M, Amir S, Weisman Y, Mabjeesh N. Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2?. Cell Cycle. 2010;9:3723-9 pubmed
Terzuoli E, Puppo M, Rapisarda A, Uranchimeg B, Cao L, Burger A, et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010;70:6837-48 pubmed 出版商
Cho D, Cohen M, Panka D, Collins M, Ghebremichael M, Atkins M, et al. The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma. Clin Cancer Res. 2010;16:3628-38 pubmed 出版商
Costa B, Dettori D, Lorenzato A, Bardella C, Coltella N, Martino C, et al. Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis. FASEB J. 2010;24:2680-8 pubmed 出版商
van Hagen M, Overmeer R, Abolvardi S, Vertegaal A. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha. Nucleic Acids Res. 2010;38:1922-31 pubmed 出版商
Franovic A, Holterman C, Payette J, Lee S. Human cancers converge at the HIF-2alpha oncogenic axis. Proc Natl Acad Sci U S A. 2009;106:21306-11 pubmed 出版商
Luo T, Zhang X, Nicholson W, Zhu B, McBride J. Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis. Clin Vaccine Immunol. 2010;17:87-97 pubmed 出版商
Rey S, Lee K, Wang C, Gupta K, Chen S, McMillan A, et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A. 2009;106:20399-404 pubmed 出版商
Lee K, Zhang H, Qian D, Rey S, Liu J, Semenza G. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A. 2009;106:17910-5 pubmed 出版商
Przybytkowski E, Behrendt M, Dubois D, Maysinger D. Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability. FEBS J. 2009;276:6204-17 pubmed 出版商
Chua R, MacKelfresh J, Cohen C, Varma V, Fried L, Arbiser J. Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2. J Am Acad Dermatol. 2009;61:730-2 pubmed 出版商
Minamishima Y, Moslehi J, Padera R, Bronson R, Liao R, Kaelin W. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol. 2009;29:5729-41 pubmed 出版商
Tanaka T, Wiesener M, Bernhardt W, Eckardt K, Warnecke C. The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem J. 2009;424:143-51 pubmed 出版商
Hansen S, Trakooljul N, Liu H, Moeser A, Spears J. Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs. J Nutr. 2009;139:1474-9 pubmed 出版商
Tuller E, Beavers C, Lou J, Ihnat M, Benbrook D, Ding W. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009;76:588-95 pubmed 出版商
Petrella B, Brinckerhoff C. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma. Cancer Biol Ther. 2009;8:1389-401 pubmed
Fang H, Hughes R, Murdoch C, Coffelt S, Biswas S, Harris A, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009;114:844-59 pubmed 出版商
Bohensky J, Terkhorn S, Freeman T, Adams C, Garcia J, Shapiro I, et al. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009;60:1406-15 pubmed 出版商
Luu V, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild P, et al. Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin Cancer Res. 2009;15:3297-304 pubmed 出版商
Mastrogiannaki M, Matak P, Keith B, Simon M, Vaulont S, Peyssonnaux C. HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest. 2009;119:1159-66 pubmed 出版商
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, et al. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Am J Pathol. 2009;174:1663-74 pubmed 出版商
Woo J, Choi D, Tran H, Gilbert B, Hong W, Lee H. Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis. Cancer Prev Res (Phila). 2009;2:361-9 pubmed 出版商
Kim J, Bagchi I, Bagchi M. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology. 2009;150:3392-400 pubmed 出版商
Copple B, Bustamante J, Welch T, Kim N, Moon J. Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes. Liver Int. 2009;29:1010-21 pubmed 出版商
Lee C, Hickey M, Sanford C, McGuire C, Cowey C, Simon M, et al. VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo. Oncogene. 2009;28:1694-705 pubmed 出版商
Lomb D, Desouza L, Franklin J, Freeman R. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic. Mol Pharmacol. 2009;75:1198-209 pubmed 出版商
Walter A, Etienne Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte P, et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J Pharmacol Exp Ther. 2009;329:699-707 pubmed 出版商
Lee K, Qian D, Rey S, Wei H, Liu J, Semenza G. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci U S A. 2009;106:2353-8 pubmed 出版商
Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol. 2009;29:1707-18 pubmed 出版商
Choi Y, Cowan D, Nathan M, Poutias D, Stamm C, del Nido P, et al. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS ONE. 2008;3:e4042 pubmed 出版商
Zimmer M, Ebert B, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32:838-48 pubmed 出版商
Sears J, Hoppe G, Ebrahem Q, Anand Apte B. Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy. Proc Natl Acad Sci U S A. 2008;105:19898-903 pubmed 出版商
Zhang H, Qian D, Tan Y, Lee K, Gao P, Ren Y, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A. 2008;105:19579-86 pubmed 出版商
Regazzetti C, Peraldi P, Gremeaux T, Najem Lendom R, Ben Sahra I, Cormont M, et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes. 2009;58:95-103 pubmed 出版商
Koh M, Darnay B, Powis G. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol Cell Biol. 2008;28:7081-95 pubmed 出版商
Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola O, et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1973-81 pubmed 出版商
Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, et al. A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells. Mol Cancer Res. 2008;6:1397-409 pubmed 出版商
Lu C, Lin S, Chen K, Lai Y, Tsai S. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem. 2008;283:28106-14 pubmed 出版商
Ben Shoshan J, Schwartz S, Luboshits G, Maysel Auslender S, Barzelay A, Polak Charcon S, et al. Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties. Stem Cells. 2008;26:2634-43 pubmed 出版商
Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol Cancer Ther. 2008;7:1974-84 pubmed 出版商
Dutta D, Ray S, Vivian J, Paul S. Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis. J Biol Chem. 2008;283:25404-13 pubmed 出版商
Mahajan S, Dammai V, Hsu T, Kraft A. Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis. 2008;29:1734-41 pubmed 出版商
Lee K, Lynd J, O Reilly S, Kiupel M, McCormick J, LaPres J. The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res. 2008;6:829-42 pubmed 出版商
Wu S, Nishiyama N, Kano M, Morishita Y, Miyazono K, Itaka K, et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. Mol Ther. 2008;16:1227-34 pubmed 出版商
Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood. 2008;112:1482-92 pubmed 出版商
Korgaonkar S, Feng X, Ross M, Lu T, D AGATI V, Iyengar R, et al. HIV-1 upregulates VEGF in podocytes. J Am Soc Nephrol. 2008;19:877-83 pubmed 出版商
Evens A, Schumacker P, Helenowski I, Singh A, Dokic D, Keswani A, et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol. 2008;141:676-80 pubmed 出版商
van Uden P, Kenneth N, Rocha S. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J. 2008;412:477-84 pubmed 出版商
Brown S, Nurse C. Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am J Physiol Cell Physiol. 2008;294:C1305-12 pubmed 出版商
Ginouves A, Ilc K, Macías N, Pouyssegur J, Berra E. PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. Proc Natl Acad Sci U S A. 2008;105:4745-50 pubmed 出版商
Arab A, Kuemmerer K, Wang J, Bode C, Hehrlein C. Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity. J Pharmacol Exp Ther. 2008;325:417-24 pubmed 出版商
Rajakumar A, Michael H, Daftary A, Jeyabalan A, Gilmour C, Conrad K. Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta. 2008;29:290-9 pubmed 出版商
Minamishima Y, Moslehi J, Bardeesy N, Cullen D, Bronson R, Kaelin W. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood. 2008;111:3236-44 pubmed
Zhou G, Dada L, Chandel N, Iwai K, Lecuona E, Ciechanover A, et al. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. FASEB J. 2008;22:1335-42 pubmed
Takeda K, Aguila H, Parikh N, Li X, Lamothe K, Duan L, et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. Blood. 2008;111:3229-35 pubmed
Hickey M, Lam J, Bezman N, Rathmell W, Simon M. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J Clin Invest. 2007;117:3879-89 pubmed
Cheng G, Shao Z, Chaudhari B, Agrawal D. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1339-47 pubmed
Hu C, Sataur A, Wang L, Chen H, Simon M. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007;18:4528-42 pubmed
Lomb D, Straub J, Freeman R. Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. J Neurochem. 2007;103:1897-906 pubmed
Takeda K, Cowan A, Fong G. Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007;116:774-81 pubmed
Milkiewicz M, Doyle J, Fudalewski T, Ispanovic E, Aghasi M, Haas T. HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol. 2007;583:753-66 pubmed
Hughes M, Kapllani E, Alexander A, Burk R, Schoenfeld A. HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation. Cancer Cell Int. 2007;7:13 pubmed 出版商
Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed
Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert S, et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest. 2007;117:1616-26 pubmed
Li L, Zhang L, Zhang X, Yan Q, Minamishima Y, Olumi A, et al. Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations. Mol Cell Biol. 2007;27:5381-92 pubmed
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller K, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007;11:407-20 pubmed
Sanchez M, Galy B, Muckenthaler M, Hentze M. Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol. 2007;14:420-6 pubmed
Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed
Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, et al. Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. Blood. 2007;110:151-60 pubmed
Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol. 2007;18:1218-26 pubmed
MacKenzie E, Selak M, Tennant D, Payne L, Crosby S, Frederiksen C, et al. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol. 2007;27:3282-9 pubmed
Grover T, Asikainen T, Kinsella J, Abman S, White C. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1345-51 pubmed 出版商
Gruber M, Hu C, Johnson R, Brown E, Keith B, Simon M. Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci U S A. 2007;104:2301-6 pubmed
Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark R, et al. NAD(P)H oxidases regulate HIF-2alpha protein expression. J Biol Chem. 2007;282:8019-26 pubmed
Groenman F, Rutter M, Caniggia I, Tibboel D, Post M. Hypoxia-inducible factors in the first trimester human lung. J Histochem Cytochem. 2007;55:355-63 pubmed
Evans A, Russell R, Roche O, Burry T, Fish J, Chow V, et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol. 2007;27:157-69 pubmed
Irwin R, LaPres J, Kinser S, McCabe L. Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype. J Cell Biochem. 2007;100:762-72 pubmed
Koizume S, Jin M, Miyagi E, Hirahara F, Nakamura Y, Piao J, et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006;66:9453-60 pubmed
Kim W, Safran M, Buckley M, Ebert B, Glickman J, Bosenberg M, et al. Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo. EMBO J. 2006;25:4650-62 pubmed
Chavez J, Baranova O, Lin J, Pichiule P. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci. 2006;26:9471-81 pubmed
Takeda K, Ho V, Takeda H, Duan L, Nagy A, Fong G. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol. 2006;26:8336-46 pubmed
Carroll P, Kenerson H, Yeung R, Lagunoff M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol. 2006;80:10802-12 pubmed
Liu Y, Yu J, Song X, Wang X, Xing L, Gao B. Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines. Cancer Biol Ther. 2006;5:1320-6 pubmed
Lin Q, Lee Y, Yun Z. Differentiation arrest by hypoxia. J Biol Chem. 2006;281:30678-83 pubmed
Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis. 2007;28:529-36 pubmed
Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, et al. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Res. 2006;66:8083-90 pubmed
Lutz M, Burk R. Primary cilium formation requires von hippel-lindau gene function in renal-derived cells. Cancer Res. 2006;66:6903-7 pubmed
Hergovich A, Lisztwan J, Thoma C, Wirbelauer C, Barry R, Krek W. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol Cell Biol. 2006;26:5784-96 pubmed
Bracken C, Fedele A, Linke S, Balrak W, Lisy K, Whitelaw M, et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem. 2006;281:22575-85 pubmed
Nakamura K, Martin K, Jackson J, Beppu K, Woo C, Thiele C. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006;66:4249-55 pubmed
Hu C, Iyer S, Sataur A, Covello K, Chodosh L, Simon M. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26:3514-26 pubmed
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, et al. Dynamic HIF1A regulation during human placental development. Biol Reprod. 2006;75:112-21 pubmed
Okuyama H, Krishnamachary B, Zhou Y, Nagasawa H, Bosch Marce M, Semenza G. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem. 2006;281:15554-63 pubmed
Mizukami Y, Fujiki K, Duerr E, Gala M, Jo W, Zhang X, et al. Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc. J Biol Chem. 2006;281:13957-63 pubmed
Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek J, et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006;66:2725-31 pubmed
Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed
Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006;66:1313-9 pubmed
Schultz K, Fanburg B, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;290:H2528-34 pubmed
Calvani M, Rapisarda A, Uranchimeg B, Shoemaker R, Melillo G. Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood. 2006;107:2705-12 pubmed
Lee S, Nakamura E, Yang H, Wei W, Linggi M, Sajan M, et al. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 2005;8:155-67 pubmed
Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali M, et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005;65:6178-88 pubmed
Asikainen T, Schneider B, Waleh N, Clyman R, Ho W, Flippin L, et al. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005;102:10212-7 pubmed
Maltepe E, Krampitz G, Okazaki K, Red Horse K, Mak W, Simon M, et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005;132:3393-403 pubmed
Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005;65:5221-30 pubmed
Temes E, Martin Puig S, Acosta Iborra B, Castellanos M, Feijóo Cuaresma M, Olmos G, et al. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J Biol Chem. 2005;280:24238-44 pubmed
Miller F, Kentsis A, Osman R, Pan Z. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex. J Biol Chem. 2005;280:7985-96 pubmed
Petrella B, Lohi J, Brinckerhoff C. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene. 2005;24:1043-52 pubmed
Rathmell W, Hickey M, Bezman N, Chmielecki C, Carraway N, Simon M. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004;64:8595-603 pubmed
Tang N, Wang L, Esko J, Giordano F, Huang Y, Gerber H, et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004;6:485-95 pubmed
Freeburg P, Abrahamson D. Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney. J Am Soc Nephrol. 2004;15:2569-78 pubmed
Biju M, Neumann A, Bensinger S, Johnson R, Turka L, Haase V. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol. 2004;24:9038-47 pubmed
Rajakumar A, Brandon H, Daftary A, Ness R, Conrad K. Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta. 2004;25:763-9 pubmed
Takeda N, Maemura K, Imai Y, Harada T, Kawanami D, Nojiri T, et al. Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1. Circ Res. 2004;95:146-53 pubmed
Grabmaier K, A de Weijert M, Verhaegh G, Schalken J, Oosterwijk E. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene. 2004;23:5624-31 pubmed
Mekhail K, Gunaratnam L, Bonicalzi M, Lee S. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat Cell Biol. 2004;6:642-7 pubmed
Pan Y, Oprysko P, Asham A, Koch C, Simon M. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene. 2004;23:4975-83 pubmed
Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, et al. The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells. Am J Respir Cell Mol Biol. 2004;31:209-15 pubmed
Welsh S, Williams R, Kirkpatrick L, Paine Murrieta G, Powis G. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther. 2004;3:233-44 pubmed
Mizukami Y, Li J, Zhang X, Zimmer M, Iliopoulos O, Chung D. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004;64:1765-72 pubmed
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res. 2004;2:89-95 pubmed
Uchida T, Rossignol F, Matthay M, Mounier R, Couette S, Clottes E, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004;279:14871-8 pubmed
Martin Puig S, Temes E, Olmos G, Jones D, Aragones J, Landazuri M. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J Biol Chem. 2004;279:9504-11 pubmed
Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74 pubmed
Yuan H, Li X, Pitera J, Long D, Woolf A. Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha. Am J Pathol. 2003;163:2289-301 pubmed
Cuevas Y, Hernandez Alcoceba R, Aragones J, Naranjo Suarez S, Castellanos M, Esteban M, et al. Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas. Cancer Res. 2003;63:6877-84 pubmed
Corn P, McDonald E, Herman J, El Deiry W. Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein. Nat Genet. 2003;35:229-37 pubmed
del Peso L, Castellanos M, Temes E, Martin Puig S, Cuevas Y, Olmos G, et al. The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen. J Biol Chem. 2003;278:48690-5 pubmed
Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley E, Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature. 2003;425:307-11 pubmed
Mohan S, Burk R. von Hippel-Lindau protein complex is regulated by cell density. Oncogene. 2003;22:5270-80 pubmed
Palayoor S, Tofilon P, Coleman C. Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003;9:3150-7 pubmed
Mabjeesh N, Willard M, Frederickson C, Zhong H, Simons J. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res. 2003;9:2416-25 pubmed
Park S, Dadak A, Haase V, Fontana L, Giaccia A, Johnson R. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol. 2003;23:4959-71 pubmed
Naranjo Suarez S, Castellanos M, Alvarez Tejado M, Vara A, Landazuri M, del Peso L. Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation. J Biol Chem. 2003;278:31895-901 pubmed
Liu M, Poellinger L, Walker C. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003;63:2675-80 pubmed
Baba M, Hirai S, Yamada Okabe H, Hamada K, Tabuchi H, Kobayashi K, et al. Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene. 2003;22:2728-38 pubmed
Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
Khatua S, Peterson K, Brown K, Lawlor C, Santi M, Lafleur B, et al. Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. 2003;63:1865-70 pubmed
Graven K, Bellur D, Klahn B, Lowrey S, Amberger E. HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells. Biochim Biophys Acta. 2003;1626:10-8 pubmed
del Toro R, Levitsky K, Lopez Barneo J, Chiara M. Induction of T-type calcium channel gene expression by chronic hypoxia. J Biol Chem. 2003;278:22316-24 pubmed
Yuan Y, Hilliard G, Ferguson T, Millhorn D. Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha. J Biol Chem. 2003;278:15911-6 pubmed
Mack F, Rathmell W, Arsham A, Gnarra J, Keith B, Simon M. Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell. 2003;3:75-88 pubmed
Chan D, Sutphin P, Denko N, Giaccia A. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem. 2002;277:40112-7 pubmed
Bernaudin M, Tang Y, Reilly M, Petit E, Sharp F. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 2002;277:39728-38 pubmed
Maranchie J, Vasselli J, Riss J, Bonifacino J, Linehan W, Klausner R. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell. 2002;1:247-55 pubmed
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin W. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 2002;1:237-46 pubmed
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology. 2002;59:774-8 pubmed
Liang Y, Li X, Rebar E, Li P, Zhou Y, Chen B, et al. Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility. J Biol Chem. 2002;277:20087-94 pubmed
Alvarez Tejado M, Alfranca A, Aragones J, Vara A, Landazuri M, del Peso L. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem. 2002;277:13508-17 pubmed
Burke B, Tang N, Corke K, Tazzyman D, Ameri K, Wells M, et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol. 2002;196:204-12 pubmed
Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem. 2002;277:6183-7 pubmed
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature. 2001;414:550-4 pubmed
Ad N, Snir E, Vidne B, Golomb E. Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation. Ann Thorac Surg. 2001;72:688-93 pubmed
Luo J, Shibuya M. A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha). Oncogene. 2001;20:1435-44 pubmed
Alvarez Tejado M, Naranjo Suarez S, Jimenez C, Carrera A, Landázuri M, del Peso L. Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem. 2001;276:22368-74 pubmed
Haase V, Glickman J, Socolovsky M, Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A. 2001;98:1583-8 pubmed
de Paulsen N, Brychzy A, Fournier M, Klausner R, Gnarra J, Pause A, et al. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci U S A. 2001;98:1387-92 pubmed
Bonicalzi M, Groulx I, de Paulsen N -, Lee S. Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 2001;276:1407-16 pubmed
Rajakumar A, Conrad K. Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta. Biol Reprod. 2000;63:559-69 pubmed
Ohh M, Park C, Ivan M, Hoffman M, Kim T, Huang L, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423-7 pubmed
Conrad P, Freeman T, Beitner Johnson D, Millhorn D. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J Biol Chem. 1999;274:33709-13 pubmed
产品信息
SKU号 :
NB100-122
产品名称 :
HIF-2甲/EPAS1抗体
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The HIF-2 alpha/EPAS1 Antibody from Novus is a rabbit polyclonal antibody to HIF-2 alpha/EPAS1. This antibody reacts with human, mouse, rat, fish, hamster, primate, rabbit, sheep. The HIF-2 alpha/EPAS1 Antibody has been validated for the following applications: Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Gel Super Shift Assays, SDS-Page, Knockout Validated.
靶标 :
HIF-2甲/EPAS1
类别 :
一抗
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
This HIF-2 alpha / EPAS1 Antibody was developed against a peptide derived from the C-terminus of mouse / human HIF-2 alpha protein.
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 鱼类, 仓鼠, 灵长类动物, 兔, 羊
特异性 :
This HIF-2 alpha / EPAS1 Antibody is specific for HIF-2 alpha / EPAS, and does not cross-react with HIF-1 alpha
理论上的分子量 :
96.5 kDa
基因符号 :
EPAS1
catalog number base :
NB100-122
应用 :
Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Gel Super Shift Assays, SDS-Page, Knockout Validated
2020 Proposedprice USD :
349美元
别名 :
anti hif 2 alpha, anti-HIF-2 alpha, Basic-helix-loop-helix-PAS protein MOP2, BHLHE73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain-containing protein 1, EPAS1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2 alpha, HIF2A, hif2a angiogenesis, HIF-2-alpha, HIF2-alpha, HLF, hypoxia-inducible factor 2 alpha, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, MOP2, PAS domain-containing protein 2, PASD2
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。