产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
小鼠单克隆HIF-1甲抗体
目录 :
NB100-123
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
H1alpha67
反应物种 :
, 人类, 小鼠, 大鼠, , , ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 133
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 小鼠; 图 2f
Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 1
  • 免疫印迹; 小鼠; 1:500; 图 5
Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Ohmoto T, Yoshitani N, Nishitsuji K, Takayama T, Yanagisawa Y, Takeya M, et al. CD44-expressing undifferentiated carcinoma with rhabdoid features of the pancreas: molecular analysis of aggressive invasion and metastasis. Pathol Int. 2015;65:264-70 pubmed 出版商
  • 免疫印迹; 小鼠
Hénique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, et al. Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. FASEB J. 2015;29:2473-83 pubmed 出版商
  • 免疫沉淀; 人类
Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Motzer R, Hutson T, Hudes G, Figlin R, Martini J, English P, et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother Pharmacol. 2014;74:739-50 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:200
Ramamoorthy P, Shi H. Ischemia induces different levels of hypoxia inducible factor-1? protein expression in interneurons and pyramidal neurons. Acta Neuropathol Commun. 2014;2:51 pubmed 出版商
  • 免疫印迹; 人类
Sun W, Depping R, Jelkmann W. Interleukin-1? promotes hypoxia-induced apoptosis of glioblastoma cells by inhibiting hypoxia-inducible factor-1 mediated adrenomedullin production. Cell Death Dis. 2014;5:e1020 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Chaux A, Albadine R, Schultz L, Hicks J, Carducci M, Argani P, et al. Dysregulation of the mammalian target of rapamycin pathway in chromophobe renal cell carcinomas. Hum Pathol. 2013;44:2323-30 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Sceneay J, Liu M, Chen A, Wong C, Bowtell D, Möller A. The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo. PLoS ONE. 2013;8:e66388 pubmed 出版商
  • 免疫细胞化学; 人类
Li C, Hashimi S, Cao S, Mellick A, Duan W, Good D, et al. The mechanisms of chansu in inducing efficient apoptosis in colon cancer cells. Evid Based Complement Alternat Med. 2013;2013:849054 pubmed 出版商
  • 免疫印迹; 小鼠
Li J, Levick S, Dipette D, Janicki J, Supowit S. Alpha-calcitonin gene-related peptide is protective against pressure overload-induced heart failure. Regul Pept. 2013;185:20-8 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Tanaka T, Yamaguchi J, Higashijima Y, Nangaku M. Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia. FASEB J. 2013;27:4059-75 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Toba H, Kondo K, Sadohara Y, Otsuka H, Morimoto M, Kajiura K, et al. 18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1?, glucose transporter-1 and vascular endothelial growth factor in thymic e. Eur J Cardiothorac Surg. 2013;44:e105-12 pubmed 出版商
  • 免疫印迹; 大鼠
Kar A, Macgibeny M, Gervasi N, Gioio A, Kaplan B. Intra-axonal synthesis of eukaryotic translation initiation factors regulates local protein synthesis and axon growth in rat sympathetic neurons. J Neurosci. 2013;33:7165-74 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Lundgrin E, Park M, Sharp J, Tang W, Thomas J, Asosingh K, et al. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013;10:1-9 pubmed 出版商
  • 免疫组化; 人类
Aziz S, Sznol J, Adeniran A, Parisi F, Kluger Y, Camp R, et al. Expression of drug targets in primary and matched metastatic renal cell carcinoma tumors. BMC Clin Pathol. 2013;13:3 pubmed 出版商
  • 免疫印迹; 大鼠
Reddy V, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N. Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. Mol Cell Biochem. 2013;375:39-47 pubmed 出版商
  • 免疫组化; 鸟
Brenner R, Slayden O. Molecular and functional aspects of menstruation in the macaque. Rev Endocr Metab Disord. 2012;13:309-18 pubmed 出版商
  • 免疫组化; 人类
Ioannou M, Pyrpasopoulou A, Simos G, Paraskeva E, Nikolaidou C, Venizelos I, et al. Upregulation of VEGF expression is associated with accumulation of HIF-1? in the skin of naïve scleroderma patients. Mod Rheumatol. 2013;23:1245-8 pubmed 出版商
  • 免疫组化; 人类
Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, et al. MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. Int J Urol. 2013;20:468-77 pubmed 出版商
  • 免疫印迹; 人类
Salem A, Howell A, Sartini M, Sotgia F, Lisanti M. Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1?, autophagy and ketone body production. Cell Cycle. 2012;11:4167-73 pubmed 出版商
  • 免疫印迹; 小鼠
Clarke D, Al Ahmad A, Lee B, Parham C, Auckland L, Fertala A, et al. Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin ?5?1 and ERK-dependent signaling pathways. PLoS ONE. 2012;7:e45257 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫组化; 大鼠
Ding A, Kalaignanasundaram P, Ricardo S, Abdelkader A, Witting P, Broughton B, et al. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clin Exp Pharmacol Physiol. 2012;39:917-29 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Gu H, Zheng X, Abu Seman N, Gu T, Botusan I, Sunkari V, et al. Impact of the hypoxia-inducible factor-1 ? (HIF1A) Pro582Ser polymorphism on diabetes nephropathy. Diabetes Care. 2013;36:415-21 pubmed 出版商
  • 免疫印迹; 人类
Zhao Y, Xiong X, Jia L, Sun Y. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death Dis. 2012;3:e386 pubmed 出版商
  • 免疫组化; 人类
Mhawech Fauceglia P, Wang D, Samrao D, Menesses T, Godoy H, Ough F, et al. The role of hypoxic-inducible factor (HIF1?) and aldolaseC protein in endometrial carcinogenesis: a retrospective study of 279 patients. BMJ Open. 2012;2: pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Chiavarina B, Martinez Outschoorn U, Whitaker Menezes D, Howell A, Tanowitz H, Pestell R, et al. Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1? and HIF2? in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle. 2012;11:3280-9 pubmed 出版商
  • 免疫组化; 人类
Mayer A, Schneider F, Vaupel P, Sommer C, Schmidberger H. Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. Int J Oncol. 2012;41:1260-70 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Kishimoto K, Yoshida S, Ibaragi S, Yoshioka N, Okui T, Hu G, et al. Hypoxia-induced up-regulation of angiogenin, besides VEGF, is related to progression of oral cancer. Oral Oncol. 2012;48:1120-7 pubmed 出版商
  • 免疫印迹; 大鼠
Jiang W, Zhu Z, McGinley J, El Bayoumy K, Manni A, Thompson H. Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Cancer Res. 2012;72:3795-806 pubmed 出版商
  • 流式细胞仪; 人类
  • 免疫细胞化学; 人类
Galzio R, Cristiano L, Fidoamore A, Cifone M, Benedetti E, Cinque B, et al. Hypoxia modulation of peroxisome proliferator-activated receptors (PPARs) in human glioblastoma stem cells. Implications for therapy. J Cell Biochem. 2012;113:3342-52 pubmed 出版商
  • 免疫组化; 人类
Weber D, Tille J, Combescure C, Egger J, Laouiti M, Hammad K, et al. The prognostic value of expression of HIF1?, EGFR and VEGF-A, in localized prostate cancer for intermediate- and high-risk patients treated with radiation therapy with or without androgen deprivation therapy. Radiat Oncol. 2012;7:66 pubmed 出版商
  • 免疫组化; 人类
Chaux A, Schultz L, Albadine R, Hicks J, Kim J, Allaf M, et al. Immunoexpression status and prognostic value of mammalian target of rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas. Hum Pathol. 2012;43:2129-37 pubmed 出版商
  • 免疫印迹; 人类
Jeong C, Yoon C, Jeong S, Hong S, Byun S, Kwak C, et al. The role of hypoxia-inducible factor-1? and -2? in androgen insensitive prostate cancer cells. Urol Oncol. 2013;31:1448-56 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Kaira K, Serizawa M, Koh Y, Takahashi T, Hanaoka H, Oriuchi N, et al. Relationship between 18F-FDG uptake on positron emission tomography and molecular biology in malignant pleural mesothelioma. Eur J Cancer. 2012;48:1244-54 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Hölscher M, Schafer K, Krull S, Farhat K, Hesse A, Silter M, et al. Unfavourable consequences of chronic cardiac HIF-1α stabilization. Cardiovasc Res. 2012;94:77-86 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, et al. L-type amino acid transporter 1 (LAT1) expression in malignant pleural mesothelioma. Anticancer Res. 2011;31:4075-82 pubmed
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
Chu W, Wan L, Zhao D, Qu X, Cai F, Huo R, et al. Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1?-mediated TRPC signalling. J Cell Mol Med. 2012;16:2022-34 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, et al. 18F-FDG uptake on PET in primary mediastinal non-thymic neoplasm: a clinicopathological study. Eur J Radiol. 2012;81:2423-9 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Okumura T, Nakagawa K, Ohde Y, Takahashi T, Murakami H, et al. MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer. Pathol Oncol Res. 2012;18:439-47 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Ohde Y, Nakagawa K, Okumura T, Murakami H, Takahashi T, et al. Thymidylate synthase expression is closely associated with outcome in patients with pulmonary adenocarcinoma. Med Oncol. 2012;29:1663-72 pubmed 出版商
  • 免疫印迹; 人类
Sreekumar P, Hinton D, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011;2:184-92 pubmed 出版商
  • 免疫组化; 人类
Peurala E, Koivunen P, Bloigu R, Haapasaari K, Jukkola Vuorinen A. Expressions of individual PHDs associate with good prognostic factors and increased proliferation in breast cancer patients. Breast Cancer Res Treat. 2012;133:179-88 pubmed 出版商
  • 免疫印迹; 小鼠
Schneider C, Krischke G, Rascher W, Gassmann M, Trollmann R. Systemic hypoxia differentially affects neurogenesis during early mouse brain maturation. Brain Dev. 2012;34:261-73 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Ohde Y, Endo M, Nakagawa K, Okumura T, Takahashi T, et al. Expression of 4F2hc (CD98) in pulmonary neuroendocrine tumors. Oncol Rep. 2011;26:931-7 pubmed 出版商
  • 免疫组化; 人类
Monzon F, Alvarez K, Peterson L, Truong L, Amato R, Hernandez McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol. 2011;24:1470-9 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 免疫细胞化学; 小鼠
Evenou F, Hamon M, Fujii T, Takeuchi S, Sakai Y. Gas-permeable membranes and co-culture with fibroblasts enable high-density hepatocyte culture as multilayered liver tissues. Biotechnol Prog. 2011;27:1146-53 pubmed 出版商
  • 免疫印迹; 小鼠
Namas R, Metukuri M, Dhupar R, Velosa C, Jefferson B, Myer E, et al. Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1? in mouse hepatocytes. Shock. 2011;36:196-202 pubmed 出版商
  • 免疫印迹; 人类
Park H, Baek K, Lee H, Kwon A, Hwang H, Qadir A, et al. Hypoxia inducible factor-1? directly induces the expression of receptor activator of nuclear factor-?B ligand in periodontal ligament fibroblasts. Mol Cells. 2011;31:573-8 pubmed 出版商
  • 免疫组化; 人类
Weroha S, Oberg A, Ziegler K, Dakhilm S, Rowland K, Hartmann L, et al. Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol Oncol. 2011;122:116-20 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫组化; 人类
Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Oriuchi N, et al. Correlation between 18F-FDG uptake on PET and molecular biology in metastatic pulmonary tumors. J Nucl Med. 2011;52:705-11 pubmed 出版商
  • 免疫印迹; 大鼠
Huang L, Chuang I, Dong H, Yang R. Hypoxia-inducible factor 1? regulates the expression of the mitochondrial ATPase inhibitor protein (IF1) in rat liver. Shock. 2011;36:90-6 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Hölscher M, Silter M, Krull S, von Ahlen M, Hesse A, Schwartz P, et al. Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-94 pubmed 出版商
  • 免疫印迹; 大鼠
Gibbings S, Elkins N, Fitzgerald H, Tiao J, Weyman M, Shibao G, et al. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-{gamma} sumoylation, and HIF-1{alpha}. J Biol Chem. 2011;286:961-75 pubmed 出版商
  • 免疫组化; 人类
Monsef N, Soller M, Panagopoulos I, Abrahamsson P. HIF1alpha isoforms in benign and malignant prostate tissue and their correlation to neuroendocrine differentiation. BMC Cancer. 2010;10:385 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, et al. Biologic correlates of ¹?F-FDG uptake on PET in pulmonary pleomorphic carcinoma. Lung Cancer. 2011;71:144-50 pubmed 出版商
  • 免疫组化; 人类
Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, et al. Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. J Clin Oncol. 2010;28:3746-53 pubmed 出版商
  • 免疫印迹; 人类
Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, et al. Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay. Oncol Rep. 2010;24:161-9 pubmed
  • 免疫组化; 人类
Choudhury K, Yagle K, Swanson P, Krohn K, Rajendran J. A robust automated measure of average antibody staining in immunohistochemistry images. J Histochem Cytochem. 2010;58:95-107 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
  • 免疫细胞化学; 小鼠
  • 免疫印迹; 小鼠
Lee D, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal M, et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem. 2009;284:29065-76 pubmed 出版商
  • 免疫组化; 人类
Evenou F, Fujii T, Sakai Y. Spontaneous formation of highly functional three-dimensional multilayer from human hepatoma Hep G2 cells cultured on an oxygen-permeable polydimethylsiloxane membrane. Tissue Eng Part C Methods. 2010;16:311-8 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed 出版商
  • 免疫细胞化学; 大鼠
  • 免疫印迹; 大鼠
Rhoads R, Johnson R, Rathbone C, Liu X, Temm Grove C, Sheehan S, et al. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Am J Physiol Cell Physiol. 2009;296:C1321-8 pubmed 出版商
  • 免疫组化; 猪
Gossl M, Versari D, Lerman L, Chade A, Beighley P, Erbel R, et al. Low vasa vasorum densities correlate with inflammation and subintimal thickening: potential role in location--determination of atherogenesis. Atherosclerosis. 2009;206:362-8 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Hatipoglu O, Hirohata S, Cilek M, Ogawa H, Miyoshi T, Obika M, et al. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. J Biol Chem. 2009;284:16325-33 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Stagg J, Sharkey J, Pommey S, Young R, Takeda K, Yagita H, et al. Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response. Proc Natl Acad Sci U S A. 2008;105:16254-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Flynn J, Wang L, Gillespie D, Stoddard G, Reid J, Owens J, et al. Hypoxia-regulated protein expression, patient characteristics, and preoperative imaging as predictors of survival in adults with glioblastoma multiforme. Cancer. 2008;113:1032-42 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
Rosenberger C, Rosen S, Shina A, Frei U, Eckardt K, Flippin L, et al. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant. 2008;23:3472-8 pubmed 出版商
  • 免疫印迹; 大鼠
  • 免疫印迹; 小鼠
Radek K, Kovacs E, Gallo R, DiPietro L. Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol. 2008;295:H174-84 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Klatte T, Seligson D, Riggs S, Leppert J, Berkman M, Kleid M, et al. Hypoxia-inducible factor 1 alpha in clear cell renal cell carcinoma. Clin Cancer Res. 2007;13:7388-93 pubmed
  • 免疫组化-石蜡切片; 人类
Yamamoto Y, Ibusuki M, Okumura Y, Kawasoe T, Kai K, Iyama K, et al. Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res Treat. 2008;110:465-75 pubmed
  • 染色质免疫沉淀 ; 小鼠
Tracy K, Dibling B, Spike B, Knabb J, Schumacker P, Macleod K. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol. 2007;27:6229-42 pubmed
  • 免疫细胞化学; 人类
Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
Anderson K, Tsui P, Guinan P, Rubenstein M. The proliferative response of hela cells to 2-deoxy-D-glucose under hypoxic or anoxic conditions: an analogue for studying some properties of in vivo solid cancers. Anticancer Res. 2006;26:4155-62 pubmed
  • 免疫印迹; 小鼠
Gagnon P, Simmons D, Bao J, Lei D, Ortmann A, Ohlemiller K. Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice. Hear Res. 2007;226:79-91 pubmed
  • 酶联免疫吸附测定; 人类
  • 酶联免疫吸附测定; 小鼠
Ramanathan M, Pinhal Enfield G, Hao I, Leibovich S. Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell. 2007;18:14-23 pubmed
  • 免疫组化-石蜡切片; 大鼠
  • 免疫细胞化学; 大鼠
  • 免疫组化; 大鼠
Khan Z, Michalopoulos G, Stolz D. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006;169:1251-69 pubmed
  • 免疫印迹; 人类
  • 免疫印迹; 小鼠
An H, Maeng O, Kang K, Lee J, Kim Y, Paik S, et al. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death. J Biol Chem. 2006;281:33939-48 pubmed
  • 免疫印迹; 小鼠
Laderoute K, Amin K, Calaoagan J, Knapp M, Le T, Orduna J, et al. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol. 2006;26:5336-47 pubmed
  • 免疫沉淀; 兔
  • 免疫印迹; 兔
Zheng X, Ruas J, Cao R, Salomons F, Cao Y, Poellinger L, et al. Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol Cell Biol. 2006;26:4628-41 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung A, et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res. 2006;66:3639-48 pubmed
  • 免疫组化; 人类
Michelsen J, Thiesson H, Walter S, Ottosen P, Skøtt O, Jensen B. Tissue expression and plasma levels of adrenomedullin in renal cancer patients. Clin Sci (Lond). 2006;111:61-70 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Lu H, Dalgard C, Mohyeldin A, McFate T, Tait A, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem. 2005;280:41928-39 pubmed
  • 免疫印迹; 小鼠
Murphy B, Sato B, Dalton T, Laderoute K. The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress. Biochem Biophys Res Commun. 2005;337:860-7 pubmed
  • 酶联免疫吸附测定; 人类
Isaacs J, Jung Y, Mole D, Lee S, Torres Cabala C, Chung Y, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005;8:143-53 pubmed
  • 免疫印迹; 大鼠
Brown N, Streeter E, Jones A, Harris A, Bicknell R. Cooperative stimulation of vascular endothelial growth factor expression by hypoxia and reactive oxygen species: the effect of targeting vascular endothelial growth factor and oxidative stress in an orthotopic xenograft model of bladder carcinoma. Br J Cancer. 2005;92:1696-701 pubmed
  • 免疫组化; 大鼠
Luyendyk J, Maddox J, Green C, Ganey P, Roth R. Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats. Hepatology. 2004;40:1342-51 pubmed
  • 免疫组化-石蜡切片; 人类
TEZEL G, Wax M. Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol. 2004;122:1348-56 pubmed
  • 免疫组化; 人类
Cangul H. Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet. 2004;5:27 pubmed
  • 免疫细胞化学; 人类
Uchida T, Rossignol F, Matthay M, Mounier R, Couette S, Clottes E, et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J Biol Chem. 2004;279:14871-8 pubmed
  • 免疫组化-石蜡切片; 小鼠
de Candia P, Solit D, Giri D, Brogi E, Siegel P, Olshen A, et al. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci U S A. 2003;100:12337-42 pubmed
  • 免疫组化; 人类
Burke B, Giannoudis A, Corke K, Gill D, Wells M, Ziegler Heitbrock L, et al. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol. 2003;163:1233-43 pubmed
  • 免疫组化-石蜡切片; 人类
Mandriota S, Turner K, Davies D, Murray P, Morgan N, Sowter H, et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell. 2002;1:459-68 pubmed
  • 免疫细胞化学; 人类
Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, et al. Effect of hypoxia on human seminoma cells. Int J Oncol. 2002;20:955-62 pubmed
  • 免疫印迹; 人类
Tang T, Arbiser J, Brandt S. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. J Biol Chem. 2002;277:18365-72 pubmed
  • 免疫印迹; 人类
Duyndam M, Hulscher T, Fontijn D, Pinedo H, Boven E. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem. 2001;276:48066-76 pubmed
  • 免疫印迹; 人类
Tacchini L, Dansi P, Matteucci E, Desiderio M. Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells. Carcinogenesis. 2001;22:1363-71 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
  • 免疫组化-石蜡切片; 小鼠
  • 免疫印迹; 小鼠
Zhong H, De Marzo A, Laughner E, Lim M, Hilton D, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830-5 pubmed
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed 出版商
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell W, Tan A, et al. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017;6:e287 pubmed 出版商
Takasaki C, Kobayashi M, Ishibashi H, Akashi T, Okubo K. Expression of hypoxia-inducible factor-1? affects tumor proliferation and antiapoptosis in surgically resected lung cancer. Mol Clin Oncol. 2016;5:295-300 pubmed
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed 出版商
Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, et al. Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS ONE. 2016;11:e0148666 pubmed 出版商
Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed 出版商
Bruns D, Brown R, Stenmark K, Buttrick P, Walker L. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015;308:L158-67 pubmed 出版商
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, et al. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. Eur J Clin Invest. 2014;44:989-99 pubmed 出版商
Xiao W, Shinohara M, Komori K, Sakai Y, Matsui H, Osada T. The importance of physiological oxygen concentrations in the sandwich cultures of rat hepatocytes on gas-permeable membranes. Biotechnol Prog. 2014;30:1401-10 pubmed 出版商
Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H. Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther. 2014;8:701-17 pubmed 出版商
Obama T, Takayanagi T, Kobayashi T, Bourne A, Elliott K, Charbonneau M, et al. Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1?. Am J Hypertens. 2015;28:10-4 pubmed 出版商
Kaira K, Murakami H, Endo M, Ohde Y, Naito T, Kondo H, et al. Biological correlation of ¹?F-FDG uptake on PET in pulmonary neuroendocrine tumors. Anticancer Res. 2013;33:4219-28 pubmed
Kaira K, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, et al. Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer. Int J Surg Pathol. 2012;20:223-32 pubmed 出版商
Kaira K, Oriuchi N, Takahashi T, Nakagawa K, Ohde Y, Okumura T, et al. LAT1 expression is closely associated with hypoxic markers and mTOR in resected non-small cell lung cancer. Am J Transl Res. 2011;3:468-78 pubmed
Schultz L, Chaux A, Albadine R, Hicks J, Kim J, De Marzo A, et al. Immunoexpression status and prognostic value of mTOR and hypoxia-induced pathway members in primary and metastatic clear cell renal cell carcinomas. Am J Surg Pathol. 2011;35:1549-56 pubmed 出版商
Tandon R, SenGupta D, Ndhlovu L, Vieira R, Jones R, York V, et al. Identification of human endogenous retrovirus-specific T cell responses in vertically HIV-1-infected subjects. J Virol. 2011;85:11526-31 pubmed 出版商
. RETRACTED ARTICLE: Relationship between (18)F-FDG uptake on PET and various biologic molecular markers in benign pulmonary lesion: comparison with primary lung cancer. Ann Nucl Med. 2012;26:288 pubmed 出版商
Chiavarina B, Whitaker Menezes D, Migneco G, Martinez Outschoorn U, Pavlides S, Howell A, et al. HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle. 2010;9:3534-51 pubmed
Martinez Outschoorn U, Trimmer C, Lin Z, Whitaker Menezes D, Chiavarina B, Zhou J, et al. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NF?B activation in the tumor stromal microenvironment. Cell Cycle. 2010;9:3515-33 pubmed
Hsu K, Chi N, Gucek M, Van Eyk J, Cole R, Lin M, et al. Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. Blood. 2009;114:1919-28 pubmed 出版商
Virmani S, Rhee T, Ryu R, Sato K, Lewandowski R, Mulcahy M, et al. Comparison of hypoxia-inducible factor-1alpha expression before and after transcatheter arterial embolization in rabbit VX2 liver tumors. J Vasc Interv Radiol. 2008;19:1483-9 pubmed 出版商
Diensthuber M, Potinius M, Rodt T, Stan A, Welkoborsky H, Samii M, et al. Expression of bcl-2 is associated with microvessel density in olfactory neuroblastoma. J Neurooncol. 2008;89:131-9 pubmed 出版商
López Avilés S, Lambea E, Moldón A, Grande M, Fajardo A, Rodríguez Gabriel M, et al. Activation of Srk1 by the mitogen-activated protein kinase Sty1/Spc1 precedes its dissociation from the kinase and signals its degradation. Mol Biol Cell. 2008;19:1670-9 pubmed 出版商
Cabuk D, Basaran G, Celikel C, Dane F, Yumuk P, Iyikesici M, et al. Vascular endothelial growth factor, hypoxia-inducible factor 1 alpha and CD34 expressions in early-stage gastric tumors: relationship with pathological factors and prognostic impact on survival. Oncology. 2007;72:111-7 pubmed
Isaacs J, Pili R, Qian D, Dalrymple S, Garrison J, Kyprianou N, et al. Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer. Prostate. 2006;66:1768-78 pubmed
Kim C, Vocke C, Torres Cabala C, Yang Y, Schmidt L, Walther M, et al. Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors. J Urol. 2006;175:1908-14 pubmed
Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U. Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures. Int J Oncol. 2005;27:807-14 pubmed
Li Y, Zhou B, Deng J, Pan Y, Hay N, Hung M. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res. 2005;65:3257-63 pubmed
Caron A, Desrosiers R, Beliveau R. Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules. Arch Biochem Biophys. 2004;431:31-46 pubmed
Nordal R, Nagy A, Pintilie M, Wong C. Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor. Clin Cancer Res. 2004;10:3342-53 pubmed
Reichner J, Albina J. Determination of the role of hypoxia-inducible factor 1 in wound healing. Methods Enzymol. 2004;381:527-38 pubmed
Bernaudin M, Sharp F. Methods to detect hypoxia-induced ischemic tolerance in the brain. Methods Enzymol. 2004;381:399-416 pubmed
Seagroves T, Hadsell D, McManaman J, Palmer C, Liao D, McNulty W, et al. HIF1alpha is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland. Development. 2003;130:1713-24 pubmed
Albina J, Mastrofrancesco B, Vessella J, Louis C, Henry W, Reichner J. HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol. 2001;281:C1971-7 pubmed
产品信息
SKU号 :
NB100-123
产品名称 :
小鼠单克隆HIF-1甲抗体
规格 :
0.1 ml (also 0.025 ml)
描述 :
The HIF-1 alpha Antibody (H1alpha67) from Novus Biologicals is a mouse monoclonal antibody to HIF-1 alpha. This antibody reacts with human, mouse, rat, porcine, avian, bovine, canine, ferret, primate, rabbit, sheep. The HIF-1 alpha Antibody (H1alpha67) has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Gel Super Shift Assays, Knockout Validated.
靶标 :
HIF-1甲
类别 :
一抗
缓冲液 :
PBS with 1% BSA
克隆性 :
单克隆
克隆 :
H1alpha67
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
A fusion protein containing amino acids 432 - 528 of human HIF-1 alpha [UniProt# Q16665].
抗体亚型 :
IgG2b
纯度 :
蛋白质A纯化
物种活性 :
Human, Mouse, Rat, Porcine, Avian, Bovine, Canine, Ferret, Primate, Rabbit, Sheep
理论上的分子量 :
93 kDa
基因符号 :
缺氧诱导因子1A
应用 :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Gel Super Shift Assays, Knockout Validated
价格 :
349美元
又名 :
ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, HIF-1 alpha, HIF1A, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1HIF1-ALPHA, PAS domain-containing protein 8, PASD8alpha subunit (basic helix-loop-helix transcription factor)
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。