产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
HIF-2甲/EPAS1抗体(ep190b)
目录 :
NB100-132
规格 :
0.1 ml (also 0.025 ml)
价格 :
449美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ep190b
反应物种 :
仓鼠, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 188
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 s13g
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6a
  • 免疫细胞化学; 小鼠; 图 6h
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:1000; 图 5c
  • 免疫印迹; 人类; 1:3000; 图 2a
Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, et al. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2017;108:362-372 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s5
Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed 出版商
  • 免疫印迹; 人类; 图 s7
Kwak J, Lee N, Lee H, Hong I, Nam J. HIF2?/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy. Oncotarget. 2016;7:43518-43533 pubmed 出版商
  • 免疫组化; 小鼠; 1:150; 图 5
Espana Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson D, et al. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS ONE. 2016;11:e0148055 pubmed 出版商
  • 免疫组化; 人类; 1:200
Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:150
  • 免疫组化; 小鼠
Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
  • 免疫组化-石蜡切片; 小鼠
  • 免疫组化; 小鼠; 图 4b
  • 免疫印迹; 小鼠; 图 2a
Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
PÃ¥hlman S, Lund L, Jögi A. Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. PLoS ONE. 2015;10:e0125771 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed 出版商
  • 免疫印迹; 人类
Chen T, Zhou G, Zhou Q, Tang H, Ibe J, Cheng H, et al. Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015;191:678-92 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 1,000 ug/ml; 图 2
  • 免疫沉淀; 小鼠; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 2
  • 染色质免疫沉淀 ; 人类; 图 s1
  • 免疫沉淀; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Evans C, Wadoodi A, Humphries J, Lu X, Grover S, Saha P, et al. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thromb Res. 2014;134:757-60 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠
  • 免疫印迹; 大鼠
Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed 出版商
  • 免疫印迹; 人类
Carrera S, Senra J, Acosta M, Althubiti M, Hammond E, De Verdier P, et al. The role of the HIF-1? transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE. 2014;9:e97938 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, et al. Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male. Pediatrics. 2014;133:e1787-91 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Gregg J, Turner R, Chang G, Joshi D, Zhan Y, Chen L, et al. NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2?. Cancer Res. 2014;74:3501-3511 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014;184:1240-1250 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Hypoxia inducible factor-2? regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS ONE. 2014;9:e84736 pubmed 出版商
  • 免疫印迹; 小鼠
Anderson E, Taylor M, Xue X, Ramakrishnan S, Martin A, Xie L, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013;110:E4922-30 pubmed 出版商
  • 免疫印迹; 人类
Zhang T, Niu X, Liao L, Cho E, Yang H. The contributions of HIF-target genes to tumor growth in RCC. PLoS ONE. 2013;8:e80544 pubmed 出版商
  • 免疫印迹; 人类
Tsang W, Shu Y, Kwok P, Zhang F, Lee K, Tang M, et al. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS ONE. 2013;8:e76153 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Thompson A, Elks P, Marriott H, Eamsamarng S, Higgins K, Lewis A, et al. Hypoxia-inducible factor 2? regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123:366-76 pubmed 出版商
  • 免疫印迹; 人类
Klotzsche von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, et al. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-?. Mol Cancer Res. 2013;11:1337-48 pubmed 出版商
  • 免疫印迹; 人类
Yeh I, Ogba N, Bensigner H, Welford S, Montano M. HEXIM1 down-regulates hypoxia-inducible factor-1? protein stability. Biochem J. 2013;456:195-204 pubmed 出版商
  • 免疫印迹; 大鼠
Bruells C, Maes K, Rossaint R, Thomas D, Cielen N, Bleilevens C, et al. Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS ONE. 2013;8:e70524 pubmed 出版商
  • 免疫印迹; 小鼠
Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed 出版商
  • 免疫印迹; 人类
Gottfried E, Lang S, Renner K, Bosserhoff A, Gronwald W, Rehli M, et al. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS ONE. 2013;8:e66987 pubmed 出版商
  • 免疫印迹; 人类
Nakajima T, Nakajima E, Shearer T, Azuma M. Concerted inhibition of HIF-1? and -2? expression markedly suppresses angiogenesis in cultured RPE cells. Mol Cell Biochem. 2013;383:113-22 pubmed 出版商
  • 免疫印迹; 人类
Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed 出版商
  • 免疫印迹; 人类
Nakayama K. cAMP-response element-binding protein (CREB) and NF-?B transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem. 2013;288:22584-95 pubmed 出版商
  • 免疫印迹; 人类
Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka Kondoh S, Hiraoka M, et al. Development of a novel interferon-?2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro. Int J Clin Oncol. 2014;19:497-504 pubmed 出版商
  • 免疫印迹; 人类
Lee W, Lee J, Lim C, Kim S, Kim S. Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90. Chem Biol Interact. 2013;204:49-57 pubmed 出版商
  • 免疫印迹; 人类
Kucharzewska P, Christianson H, Welch J, Svensson K, Fredlund E, Ringner M, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013;110:7312-7 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Scheuermann T, Li Q, Ma H, Key J, Zhang L, Chen R, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9:271-6 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Huang C, Hales B. Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. PLoS ONE. 2012;7:e51937 pubmed 出版商
  • 免疫细胞化学; 人类
Sun H, Xu Y, Yang X, Wang W, Bai H, Shi R, et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology. 2013;57:1088-97 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? stability and MGMT expression. Cell Death Dis. 2012;3:e412 pubmed 出版商
  • 免疫印迹; 人类
Demachi Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. Autophagy creates a CTL epitope that mimics tumor-associated antigens. PLoS ONE. 2012;7:e47126 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Xue X, Shah Y. Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 2013;34:163-9 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Vaapil M, Helczynska K, Villadsen R, Petersen O, Johansson E, Beckman S, et al. Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS ONE. 2012;7:e46543 pubmed 出版商
  • 免疫印迹; 人类
Thomas S, Harding M, Smith S, Overdevest J, Nitz M, Frierson H, et al. CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 2012;72:5600-12 pubmed 出版商
  • 免疫印迹; 人类
Muratsu Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. PLoS ONE. 2012;7:e41462 pubmed 出版商
  • 免疫印迹; 大鼠
Mihaylova S, Killian A, Mayer K, Pullamsetti S, Schermuly R, Rosengarten B. Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. J Neuroinflammation. 2012;9:183 pubmed 出版商
  • 免疫沉淀; 人类
Chen R, Xu M, Hogg R, Li J, Little B, Gerard R, et al. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012;287:30800-11 pubmed 出版商
  • 免疫印迹; 小鼠
Kiss J, Mollenhauer M, Walmsley S, Kirchberg J, Radhakrishnan P, Niemietz T, et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol. 2012;189:1955-65 pubmed 出版商
  • 免疫印迹; 人类
Lim C, Kiriakidis S, Paleolog E, Davies A. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J Vasc Surg. 2012;56:1069-77 pubmed 出版商
  • 免疫印迹; 人类
El Naggar A, Clarkson P, Zhang F, Mathers J, Tognon C, Sorensen P. Expression and stability of hypoxia inducible factor 1? in osteosarcoma. Pediatr Blood Cancer. 2012;59:1215-22 pubmed 出版商
  • 免疫印迹; 人类
Jeong C, Yoon C, Jeong S, Hong S, Byun S, Kwak C, et al. The role of hypoxia-inducible factor-1? and -2? in androgen insensitive prostate cancer cells. Urol Oncol. 2013;31:1448-56 pubmed 出版商
  • 免疫印迹; 人类
Poey M, Albini M, Saona G, Laviña M. Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities. Microb Pathog. 2012;52:292-301 pubmed 出版商
  • 免疫印迹; 人类
Holland W, Tepper C, Pietri J, Chinn D, Gandara D, Mack P, et al. Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. Cancer Chemother Pharmacol. 2012;69:185-94 pubmed 出版商
  • 免疫印迹; 人类
Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011;9:757-65 pubmed 出版商
  • 免疫印迹; 仓鼠
Heikkilä M, Pasanen A, Kivirikko K, Myllyharju J. Roles of the human hypoxia-inducible factor (HIF)-3? variants in the hypoxia response. Cell Mol Life Sci. 2011;68:3885-901 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠
Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, et al. Hypoxia-inducible factor-2? mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140:2044-55 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Chen R, Dioum E, Hogg R, Gerard R, Garcia J. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem. 2011;286:13869-78 pubmed 出版商
  • 免疫印迹; 人类
Place T, Fitzgerald M, Venkataraman S, Vorrink S, Case A, Teoh M, et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE. 2011;6:e14617 pubmed 出版商
  • 免疫印迹; 小鼠
Li Q, Michaud M, Canosa S, Kuo A, Madri J. GSK-3?: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis. 2011;14:173-85 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
  • 免疫印迹; 人类
Bougatef F, Menashi S, Khayati F, Naimi B, Porcher R, Podgorniak M, et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS ONE. 2010;5:e12265 pubmed 出版商
  • 免疫印迹; 人类
Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, et al. Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Clin Cancer Res. 2010;16:4809-21 pubmed 出版商
  • 免疫印迹; 人类
Zimmer M, Lamb J, Ebert B, Lynch M, Neil C, Schmidt E, et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010;70:3071-9 pubmed 出版商
  • 免疫组化; 人类
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer. 2010;17:303-16 pubmed 出版商
  • 免疫印迹; 人类
Volke M, Gale D, Maegdefrau U, Schley G, Klanke B, Bosserhoff A, et al. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS ONE. 2009;4:e7875 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Figlin R, De Souza P, McDermott D, Dutcher J, Berkenblit A, Thiele A, et al. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer. 2009;115:3651-60 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Rasheed S, Harris A, Tekkis P, Turley H, Silver A, McDonald P, et al. Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. Br J Cancer. 2009;100:1666-73 pubmed 出版商
  • 免疫印迹; 人类
Zimmer M, Ebert B, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32:838-48 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Imamura T, Kikuchi H, Herraiz M, Park D, Mizukami Y, Mino Kenduson M, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009;124:763-71 pubmed 出版商
  • 免疫细胞化学; 人类
Westfall S, Sachdev S, Das P, Hearne L, Hannink M, Roberts R, et al. Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev. 2008;17:869-81 pubmed 出版商
  • 免疫组化; 人类
Evens A, Schumacker P, Helenowski I, Singh A, Dokic D, Keswani A, et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol. 2008;141:676-80 pubmed 出版商
  • 免疫印迹; 人类
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup K, et al. The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res. 2008;314:2016-27 pubmed 出版商
  • 免疫印迹; 人类
Borger D, Gavrilescu L, Bucur M, Ivan M, DeCaprio J. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008;370:230-4 pubmed 出版商
  • 免疫细胞化学; 人类
Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed
  • EMSA; 小鼠
Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed
  • 免疫印迹; 人类
Lau K, Tian Y, Raval R, Ratcliffe P, Pugh C. Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer. 2007;96:1284-92 pubmed
  • 免疫细胞化学; 人类
Harvey A, Kind K, Thompson J. Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Biol Reprod. 2007;77:93-101 pubmed
  • 免疫组化-石蜡切片; 大鼠
  • 免疫组化; 大鼠
Bernhardt W, Wiesener M, Weidemann A, Schmitt R, Weichert W, Lechler P, et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170:830-42 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫组化; 人类
Carroll P, Kenerson H, Yeung R, Lagunoff M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol. 2006;80:10802-12 pubmed
  • 酶联免疫吸附测定; 人类
Isaacs J, Jung Y, Mole D, Lee S, Torres Cabala C, Chung Y, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005;8:143-53 pubmed
  • 免疫组化-石蜡切片; 人类
Beasley N, Leek R, Alam M, Turley H, Cox G, Gatter K, et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002;62:2493-7 pubmed
  • 免疫组化-石蜡切片; 人类
Giatromanolaki A, Koukourakis M, Sivridis E, Pastorek J, Wykoff C, Gatter K, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001;61:7992-8 pubmed
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产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB100-132
SKU号 :
NB100-132
产品名称 :
HIF-2甲/EPAS1抗体(ep190b)
描述 :
The HIF-2 alpha/EPAS1 Antibody (ep190b) from Novus is a mouse monoclonal antibody to HIF-2 alpha/EPAS1. This antibody reacts with human, mouse, rat, bovine, hamster. The HIF-2 alpha/EPAS1 Antibody (ep190b) has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Gel Super Shift Assays, In vivo assay, Gel Supershift Assay, Chromatin Immunoprecipitation (ChIP), Knockdown Validated.
靶标 :
HIF-2甲/EPAS1
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS, 1% BSA
克隆性 :
单克隆
克隆 :
ep190b
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
The immunogen recognized by this HIF-2 alpha/EPAS1 Antibody (ep190b) maps to a region between amino acids 535-631. [UniProt# Q99814]
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠, 牛, 仓鼠
特异性 :
This HIF-2 alpha/EPAS1 Antibody (ep190b) is specific for HIF-2 alpha/EPAS1, and does not cross-react with HIF-1 alpha
理论上的分子量 :
96.5 kDa
基因符号 :
EPAS1
accessionNumbers :
Q99814
应用 :
Western Blot, Simple Western, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Gel Super Shift Assays, In vivo assay, Gel Supershift Assay, Chromatin Immunoprecipitation (ChIP), Knockdown Validated
美元 :
449美元
别名 :
Basic-helix-loop-helix-PAS protein MOP2, BHLHE73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain-containing protein 1, ep190b, EPAS1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2 alpha, HIF2A, hif2a angiogenesis, HIF-2-alpha, HIF2-alpha, HLF, hypoxia-inducible factor 2 alpha, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, MOP2, PAS domain-containing protein 2, PASD2
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。