产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
HIF-2甲/EPAS1抗体(ep190b)
目录 :
NB100-132
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ep190b
反应物种 :
仓鼠, 人类, 小鼠, brown rat
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, EMSA, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 168
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 s13g
Moya I, Castaldo S, Van den Mooter L, Soheily S, Sansores Garcia L, Jacobs J, et al. Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice. Science. 2019;366:1029-1034 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6a
  • 免疫细胞化学; 小鼠; 图 6h
Liu N, Luo J, Kuang D, Xu S, Duan Y, Xia Y, et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression. J Clin Invest. 2019;129:631-646 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 1:1000; 图 5c
  • 免疫印迹; 人类; 1:3000; 图 2a
Shiraishi A, Tachi K, Essid N, Tsuboi I, Nagano M, Kato T, et al. Hypoxia promotes the phenotypic change of aldehyde dehydrogenase activity of breast cancer stem cells. Cancer Sci. 2017;108:362-372 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:100; 图 s5
Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed 出版商
  • 免疫印迹; 人类; 图 s7
Kwak J, Lee N, Lee H, Hong I, Nam J. HIF2?/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy. Oncotarget. 2016;7:43518-43533 pubmed 出版商
  • 免疫组化; 小鼠; 1:150; 图 5
Espana Agusti J, Zou X, Wong K, Fu B, Yang F, Tuveson D, et al. Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells. PLoS ONE. 2016;11:e0148055 pubmed 出版商
  • 免疫组化; 人类; 1:200
Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:150
  • 免疫组化; 小鼠
Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
  • 免疫组化-石蜡切片; 小鼠
  • 免疫组化; 小鼠; 图 4b
  • 免疫印迹; 小鼠; 图 2a
Her Y, Nelson Holte M, MAHER L. Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PLoS ONE. 2015;10:e0127471 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
PÃ¥hlman S, Lund L, Jögi A. Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution. PLoS ONE. 2015;10:e0125771 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed 出版商
  • 免疫印迹; 人类
Chen T, Zhou G, Zhou Q, Tang H, Ibe J, Cheng H, et al. Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015;191:678-92 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠; 1 mg/ml; 图 2
  • 免疫沉淀; 小鼠; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 2
  • 染色质免疫沉淀 ; 人类; 图 s1
  • 免疫沉淀; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Xu M, Nagati J, Xie J, Li J, Walters H, Moon Y, et al. An acetate switch regulates stress erythropoiesis. Nat Med. 2014;20:1018-26 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Evans C, Wadoodi A, Humphries J, Lu X, Grover S, Saha P, et al. Local accumulation of hypoxia-inducible factor 2 alpha during venous thrombus resolution. Thromb Res. 2014;134:757-60 pubmed 出版商
  • 免疫组化-冰冻切片; brown rat
  • 免疫印迹; brown rat
Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed 出版商
  • 免疫印迹; 人类
Carrera S, Senra J, Acosta M, Althubiti M, Hammond E, De Verdier P, et al. The role of the HIF-1? transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE. 2014;9:e97938 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Toyoda H, Hirayama J, Sugimoto Y, Uchida K, Ohishi K, Hirayama M, et al. Polycythemia and paraganglioma with a novel somatic HIF2A mutation in a male. Pediatrics. 2014;133:e1787-91 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Gregg J, Turner R, Chang G, Joshi D, Zhan Y, Chen L, et al. NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2?. Cancer Res. 2014;74:3501-3511 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014;184:1240-1250 pubmed 出版商
  • 免疫印迹; 小鼠
Duan L, Takeda K, Fong G. Hypoxia inducible factor-2? regulates the development of retinal astrocytic network by maintaining adequate supply of astrocyte progenitors. PLoS ONE. 2014;9:e84736 pubmed 出版商
  • 免疫印迹; 小鼠
Anderson E, Taylor M, Xue X, Ramakrishnan S, Martin A, Xie L, et al. Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci U S A. 2013;110:E4922-30 pubmed 出版商
  • 免疫印迹; 人类
Zhang T, Niu X, Liao L, Cho E, Yang H. The contributions of HIF-target genes to tumor growth in RCC. PLoS ONE. 2013;8:e80544 pubmed 出版商
  • 免疫印迹; 人类
Tsang W, Shu Y, Kwok P, Zhang F, Lee K, Tang M, et al. CD146+ human umbilical cord perivascular cells maintain stemness under hypoxia and as a cell source for skeletal regeneration. PLoS ONE. 2013;8:e76153 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Thompson A, Elks P, Marriott H, Eamsamarng S, Higgins K, Lewis A, et al. Hypoxia-inducible factor 2? regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123:366-76 pubmed 出版商
  • 免疫印迹; 人类
Klotzsche von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, et al. PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-?. Mol Cancer Res. 2013;11:1337-48 pubmed 出版商
  • 免疫印迹; 人类
Yeh I, Ogba N, Bensigner H, Welford S, Montano M. HEXIM1 down-regulates hypoxia-inducible factor-1? protein stability. Biochem J. 2013;456:195-204 pubmed 出版商
  • 免疫印迹; brown rat
Bruells C, Maes K, Rossaint R, Thomas D, Cielen N, Bleilevens C, et al. Prolonged mechanical ventilation alters the expression pattern of angio-neogenetic factors in a pre-clinical rat model. PLoS ONE. 2013;8:e70524 pubmed 出版商
  • 免疫印迹; 小鼠
Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed 出版商
  • 免疫印迹; 人类
Gottfried E, Lang S, Renner K, Bosserhoff A, Gronwald W, Rehli M, et al. New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells. PLoS ONE. 2013;8:e66987 pubmed 出版商
  • 免疫印迹; 人类
Nakajima T, Nakajima E, Shearer T, Azuma M. Concerted inhibition of HIF-1? and -2? expression markedly suppresses angiogenesis in cultured RPE cells. Mol Cell Biochem. 2013;383:113-22 pubmed 出版商
  • 免疫印迹; 人类
Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed 出版商
  • 免疫印迹; 人类
Nakayama K. cAMP-response element-binding protein (CREB) and NF-?B transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1. J Biol Chem. 2013;288:22584-95 pubmed 出版商
  • 免疫印迹; 人类
Fukui N, Kageyama Y, Higashi Y, Kihara K, Kizaka Kondoh S, Hiraoka M, et al. Development of a novel interferon-?2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro. Int J Clin Oncol. 2014;19:497-504 pubmed 出版商
  • 免疫印迹; 人类
Lee W, Lee J, Lim C, Kim S, Kim S. Structural requirements within protoporphyrin IX in the inhibition of heat shock protein 90. Chem Biol Interact. 2013;204:49-57 pubmed 出版商
  • 免疫印迹; 人类
Kucharzewska P, Christianson H, Welch J, Svensson K, Fredlund E, Ringner M, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A. 2013;110:7312-7 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Scheuermann T, Li Q, Ma H, Key J, Zhang L, Chen R, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9:271-6 pubmed 出版商
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Huang C, Hales B. Effects of exposure to a DNA damaging agent on the hypoxia inducible factors in organogenesis stage mouse limbs. PLoS ONE. 2012;7:e51937 pubmed 出版商
  • 免疫细胞化学; 人类
Sun H, Xu Y, Yang X, Wang W, Bai H, Shi R, et al. Hypoxia inducible factor 2 alpha inhibits hepatocellular carcinoma growth through the transcription factor dimerization partner 3/ E2F transcription factor 1-dependent apoptotic pathway. Hepatology. 2013;57:1088-97 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Persano L, Pistollato F, Rampazzo E, Della Puppa A, Abbadi S, Frasson C, et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1? stability and MGMT expression. Cell Death Dis. 2012;3:e412 pubmed 出版商
  • 免疫印迹; 人类
Demachi Okamura A, Torikai H, Akatsuka Y, Miyoshi H, Yoshimori T, Kuzushima K. Autophagy creates a CTL epitope that mimics tumor-associated antigens. PLoS ONE. 2012;7:e47126 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
Xue X, Shah Y. Hypoxia-inducible factor-2? is essential in activating the COX2/mPGES-1/PGE2 signaling axis in colon cancer. Carcinogenesis. 2013;34:163-9 pubmed 出版商
  • 免疫组化; 人类
  • 免疫印迹; 人类
Vaapil M, Helczynska K, Villadsen R, Petersen O, Johansson E, Beckman S, et al. Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells. PLoS ONE. 2012;7:e46543 pubmed 出版商
  • 免疫印迹; 人类
Thomas S, Harding M, Smith S, Overdevest J, Nitz M, Frierson H, et al. CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res. 2012;72:5600-12 pubmed 出版商
  • 免疫印迹; 人类
Muratsu Ikeda S, Nangaku M, Ikeda Y, Tanaka T, Wada T, Inagi R. Downregulation of miR-205 modulates cell susceptibility to oxidative and endoplasmic reticulum stresses in renal tubular cells. PLoS ONE. 2012;7:e41462 pubmed 出版商
  • 免疫印迹; brown rat
Mihaylova S, Killian A, Mayer K, Pullamsetti S, Schermuly R, Rosengarten B. Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats. J Neuroinflammation. 2012;9:183 pubmed 出版商
  • 免疫沉淀; 人类
Chen R, Xu M, Hogg R, Li J, Little B, Gerard R, et al. The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling. J Biol Chem. 2012;287:30800-11 pubmed 出版商
  • 免疫印迹; 小鼠
Kiss J, Mollenhauer M, Walmsley S, Kirchberg J, Radhakrishnan P, Niemietz T, et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol. 2012;189:1955-65 pubmed 出版商
  • 免疫印迹; 人类
Lim C, Kiriakidis S, Paleolog E, Davies A. The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent. J Vasc Surg. 2012;56:1069-77 pubmed 出版商
  • 免疫印迹; 人类
El Naggar A, Clarkson P, Zhang F, Mathers J, Tognon C, Sorensen P. Expression and stability of hypoxia inducible factor 1? in osteosarcoma. Pediatr Blood Cancer. 2012;59:1215-22 pubmed 出版商
  • 免疫印迹; 人类
Jeong C, Yoon C, Jeong S, Hong S, Byun S, Kwak C, et al. The role of hypoxia-inducible factor-1? and -2? in androgen insensitive prostate cancer cells. Urol Oncol. 2013;31:1448-56 pubmed 出版商
  • 免疫印迹; 人类
Poey M, Albini M, Saona G, Laviña M. Virulence profiles in uropathogenic Escherichia coli isolated from pregnant women and children with urinary tract abnormalities. Microb Pathog. 2012;52:292-301 pubmed 出版商
  • 免疫印迹; 人类
Holland W, Tepper C, Pietri J, Chinn D, Gandara D, Mack P, et al. Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. Cancer Chemother Pharmacol. 2012;69:185-94 pubmed 出版商
  • 免疫印迹; 人类
Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011;9:757-65 pubmed 出版商
  • 免疫印迹; 仓鼠
Heikkilä M, Pasanen A, Kivirikko K, Myllyharju J. Roles of the human hypoxia-inducible factor (HIF)-3? variants in the hypoxia response. Cell Mol Life Sci. 2011;68:3885-901 pubmed 出版商
  • 染色质免疫沉淀 ; 小鼠
  • 免疫印迹; 小鼠
Taylor M, Qu A, Anderson E, Matsubara T, Martin A, Gonzalez F, et al. Hypoxia-inducible factor-2? mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology. 2011;140:2044-55 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫印迹; 人类
Chen R, Dioum E, Hogg R, Gerard R, Garcia J. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J Biol Chem. 2011;286:13869-78 pubmed 出版商
  • 免疫印迹; 人类
Place T, Fitzgerald M, Venkataraman S, Vorrink S, Case A, Teoh M, et al. Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells. PLoS ONE. 2011;6:e14617 pubmed 出版商
  • 免疫印迹; 小鼠
Li Q, Michaud M, Canosa S, Kuo A, Madri J. GSK-3?: a signaling pathway node modulating neural stem cell and endothelial cell interactions. Angiogenesis. 2011;14:173-85 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫组化; 人类
  • 免疫印迹; 人类
Bougatef F, Menashi S, Khayati F, Naimi B, Porcher R, Podgorniak M, et al. EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. PLoS ONE. 2010;5:e12265 pubmed 出版商
  • 免疫印迹; 人类
Pastorino F, Loi M, Sapra P, Becherini P, Cilli M, Emionite L, et al. Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor. Clin Cancer Res. 2010;16:4809-21 pubmed 出版商
  • 免疫印迹; 人类
Zimmer M, Lamb J, Ebert B, Lynch M, Neil C, Schmidt E, et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010;70:3071-9 pubmed 出版商
  • 免疫组化; 人类
Arvidsson Y, Bergström A, Arvidsson L, Kristiansson E, Ahlman H, Nilsson O. Hypoxia stimulates CXCR4 signalling in ileal carcinoids. Endocr Relat Cancer. 2010;17:303-16 pubmed 出版商
  • 免疫印迹; 人类
Volke M, Gale D, Maegdefrau U, Schley G, Klanke B, Bosserhoff A, et al. Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. PLoS ONE. 2009;4:e7875 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Figlin R, De Souza P, McDermott D, Dutcher J, Berkenblit A, Thiele A, et al. Analysis of PTEN and HIF-1alpha and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-alpha. Cancer. 2009;115:3651-60 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Rasheed S, Harris A, Tekkis P, Turley H, Silver A, McDonald P, et al. Hypoxia-inducible factor-1alpha and -2alpha are expressed in most rectal cancers but only hypoxia-inducible factor-1alpha is associated with prognosis. Br J Cancer. 2009;100:1666-73 pubmed 出版商
  • 免疫印迹; 人类
Zimmer M, Ebert B, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32:838-48 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Imamura T, Kikuchi H, Herraiz M, Park D, Mizukami Y, Mino Kenduson M, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009;124:763-71 pubmed 出版商
  • 免疫细胞化学; 人类
Westfall S, Sachdev S, Das P, Hearne L, Hannink M, Roberts R, et al. Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. Stem Cells Dev. 2008;17:869-81 pubmed 出版商
  • 免疫组化; 人类
Evens A, Schumacker P, Helenowski I, Singh A, Dokic D, Keswani A, et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol. 2008;141:676-80 pubmed 出版商
  • 免疫印迹; 人类
Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup K, et al. The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp Cell Res. 2008;314:2016-27 pubmed 出版商
  • 免疫印迹; 人类
Borger D, Gavrilescu L, Bucur M, Ivan M, DeCaprio J. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008;370:230-4 pubmed 出版商
  • 免疫细胞化学; 人类
Monsef N, Helczynski L, Lundwall A, Påhlman S. Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands. Prostate. 2007;67:1219-29 pubmed
  • EMSA; 小鼠
Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed
  • 免疫印迹; 人类
Lau K, Tian Y, Raval R, Ratcliffe P, Pugh C. Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br J Cancer. 2007;96:1284-92 pubmed
  • 免疫细胞化学; 人类
Harvey A, Kind K, Thompson J. Regulation of gene expression in bovine blastocysts in response to oxygen and the iron chelator desferrioxamine. Biol Reprod. 2007;77:93-101 pubmed
  • 免疫组化-石蜡切片; brown rat
  • 免疫组化; brown rat
Bernhardt W, Wiesener M, Weidemann A, Schmitt R, Weichert W, Lechler P, et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170:830-42 pubmed
  • 免疫组化-石蜡切片; 人类
  • 免疫组化; 人类
Carroll P, Kenerson H, Yeung R, Lagunoff M. Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors. J Virol. 2006;80:10802-12 pubmed
  • 酶联免疫吸附测定; 人类
Isaacs J, Jung Y, Mole D, Lee S, Torres Cabala C, Chung Y, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 2005;8:143-53 pubmed
  • 免疫组化-石蜡切片; 人类
Beasley N, Leek R, Alam M, Turley H, Cox G, Gatter K, et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002;62:2493-7 pubmed
  • 免疫组化-石蜡切片; 人类
Giatromanolaki A, Koukourakis M, Sivridis E, Pastorek J, Wykoff C, Gatter K, et al. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001;61:7992-8 pubmed
  • 免疫组化-石蜡切片; 人类
Koukourakis M, Giatromanolaki A, Skarlatos J, Corti L, Blandamura S, Piazza M, et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res. 2001;61:1830-2 pubmed
Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, et al. H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer. Int J Mol Sci. 2019;20: pubmed 出版商
Tang K, Yu Y, Zhu L, Xu P, Chen J, Ma J, et al. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019;: pubmed 出版商
Das B, Pal B, Bhuyan R, Li H, Sarma A, Gayan S, et al. MYC regulates the HIF-2α stemness pathway via Nanog and Sox2 to maintain self-renewal in cancer stem cells versus non-stem cancer cells. Cancer Res. 2019;: pubmed 出版商
Knowles H. The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments. Cells. 2019;8: pubmed 出版商
Duan L, Fong G. Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism. Development. 2019;146: pubmed 出版商
Han J, Lee J, Kong J, Ji Y, Kim J, Choe S, et al. Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor. Mol Cell Biol. 2019;39: pubmed 出版商
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed 出版商
Delbrel E, Soumare A, Naguez A, Label R, Bernard O, Bruhat A, et al. HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci Rep. 2018;8:17939 pubmed 出版商
Sasagawa T, Nagamatsu T, Morita K, Mimura N, Iriyama T, Fujii T, et al. HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts. Sci Rep. 2018;8:17375 pubmed 出版商
Krueger K, Catanese L, Sciesielski L, Kirschner K, Scholz H. Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1862:71-83 pubmed 出版商
Moreno Roig E, Yaromina A, Houben R, Groot A, Dubois L, Vooijs M. Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis. Front Oncol. 2018;8:224 pubmed 出版商
Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, et al. Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther. 2018;9:47 pubmed 出版商
Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, et al. Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma. Chin J Cancer. 2018;37:2 pubmed 出版商
Chen R, Xu M, Nagati J, Garcia J. Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells. PLoS ONE. 2017;12:e0190241 pubmed 出版商
Carew J, Espitia C, Zhao W, Mita M, Mita A, Nawrocki S. Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas. Oncotarget. 2017;8:86769-86783 pubmed 出版商
Sadiku P, Willson J, Dickinson R, Murphy F, Harris A, Lewis A, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. J Clin Invest. 2017;127:3407-3420 pubmed 出版商
Padró M, Louie R, Lananna B, Krieg A, Timmerman L, Chan D. Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. BMC Cancer. 2017;17:203 pubmed 出版商
Liu W, Chen H, Wong N, Haynes W, Baker C, Wang X. Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma. Cancer Lett. 2017;394:65-75 pubmed 出版商
Endo H, Okami J, Okuyama H, Nishizawa Y, Imamura F, Inoue M. The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations. Oncogene. 2017;36:2824-2834 pubmed 出版商
Leszczynska K, Dobrynin G, Leslie R, Ient J, Boumelha A, Senra J, et al. Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer. Radiother Oncol. 2016;121:232-238 pubmed 出版商
Szendroi A, Szász A, Kardos M, Tokes A, Idan R, Szucs M, et al. Opposite prognostic roles of HIF1? and HIF2? expressions in bone metastatic clear cell renal cell cancer. Oncotarget. 2016;7:42086-42098 pubmed 出版商
Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dotsch J, et al. Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency. Endocrinology. 2016;157:1813-25 pubmed 出版商
Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed 出版商
Su J, Li Z, Cui S, Ji L, Geng H, Chai K, et al. The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness. High Alt Med Biol. 2015;16:318-30 pubmed 出版商
Seidl C, Martinez Sanchez A, Murphy C. Derepression of MicroRNA-138 Contributes to Loss of the Human Articular Chondrocyte Phenotype. Arthritis Rheumatol. 2016;68:398-409 pubmed 出版商
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, et al. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. Eur J Clin Invest. 2014;44:989-99 pubmed 出版商
Motzer R, Hutson T, Hudes G, Figlin R, Martini J, English P, et al. Investigation of novel circulating proteins, germ line single-nucleotide polymorphisms, and molecular tumor markers as potential efficacy biomarkers of first-line sunitinib therapy for advanced renal cell carcinoma. Cancer Chemother Pharmacol. 2014;74:739-50 pubmed 出版商
Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed 出版商
Ellinghaus P, Heisler I, Unterschemmann K, Haerter M, Beck H, Greschat S, et al. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013;2:611-24 pubmed 出版商
David J, Owens T, Barwe S, Rajasekaran A. Gramicidin A induces metabolic dysfunction and energy depletion leading to cell death in renal cell carcinoma cells. Mol Cancer Ther. 2013;12:2296-307 pubmed 出版商
Jamil S, Cedervall J, Hultman I, Ali R, Margaryan N, Rasmuson A, et al. Neuroblastoma cells injected into experimental mature teratoma reveal a tropism for embryonic loose mesenchyme. Int J Oncol. 2013;43:831-8 pubmed 出版商
Onnis B, Fer N, Rapisarda A, Perez V, Melillo G. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest. 2013;123:1615-29 pubmed 出版商
Macaulay I, Thon J, Tijssen M, Steele B, MacDonald B, Meade G, et al. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013;121:188-96 pubmed 出版商
Havasi A, Haegele J, Gall J, Blackmon S, Ichimura T, Bonegio R, et al. Histone acetyl transferase (HAT) HBO1 and JADE1 in epithelial cell regeneration. Am J Pathol. 2013;182:152-62 pubmed 出版商
Conley S, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath A, et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci U S A. 2012;109:2784-9 pubmed 出版商
Carew J, Esquivel J, Espitia C, Schultes C, Mulbaier M, Lewis J, et al. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. PLoS ONE. 2012;7:e31120 pubmed 出版商
Munksgaard Persson M, Johansson M, Monsef N, Planck M, Beckman S, Seckl M, et al. HIF-2? expression is suppressed in SCLC cells, which survive in moderate and severe hypoxia when HIF-1? is repressed. Am J Pathol. 2012;180:494-504 pubmed 出版商
Niu X, Zhang T, Liao L, Zhou L, Lindner D, Zhou M, et al. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene. 2012;31:776-86 pubmed 出版商
Xie L, Collins J. Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells. Am J Physiol Cell Physiol. 2011;300:C1298-305 pubmed 出版商
Nakamura K, Tan F, Li Z, Thiele C. NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α. Mol Cell Neurosci. 2011;46:498-506 pubmed 出版商
Husted R, Lu H, Sigmund R, Stokes J. Oxygen regulation of the epithelial Na channel in the collecting duct. Am J Physiol Renal Physiol. 2011;300:F412-24 pubmed 出版商
Werth N, Beerlage C, Rosenberger C, Yazdi A, Edelmann M, Amr A, et al. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens. PLoS ONE. 2010;5:e11576 pubmed 出版商
Martin S, Diamond P, WILLIAMS S, To L, Peet D, Fujii N, et al. Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells. Haematologica. 2010;95:776-84 pubmed 出版商
Kim Y, Lin Q, Zelterman D, Yun Z. Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res. 2009;69:9271-80 pubmed 出版商
Noguera R, Fredlund E, Piqueras M, Pietras A, Beckman S, Navarro S, et al. HIF-1alpha and HIF-2alpha are differentially regulated in vivo in neuroblastoma: high HIF-1alpha correlates negatively to advanced clinical stage and tumor vascularization. Clin Cancer Res. 2009;15:7130-6 pubmed 出版商
Abbruzzetti S, Faggiano S, Bruno S, Spyrakis F, Mozzarelli A, Dewilde S, et al. Ligand migration through the internal hydrophobic cavities in human neuroglobin. Proc Natl Acad Sci U S A. 2009;106:18984-9 pubmed 出版商
Lee D, Rajagopalan S, Siddiq A, Gwiazda R, Yang L, Beal M, et al. Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease. J Biol Chem. 2009;284:29065-76 pubmed 出版商
Bangiyeva V, Rosenbloom A, Alexander A, Isanova B, Popko T, Schoenfeld A. Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes. BMC Cancer. 2009;9:229 pubmed 出版商
Tuller E, Beavers C, Lou J, Ihnat M, Benbrook D, Ding W. Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling. Mol Pharmacol. 2009;76:588-95 pubmed 出版商
Burkitt K, Chun S, Dang D, Dang L. Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment. Mol Cancer Ther. 2009;8:1148-56 pubmed 出版商
Ndubuizu O, Chavez J, Lamanna J. Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain. Am J Physiol Regul Integr Comp Physiol. 2009;297:R158-65 pubmed 出版商
Li Y, Qiu X, Zhang S, Zhang Q, Wang E. Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung cancer cells. Cancer Biol Ther. 2009;8:322-30 pubmed
Walter A, Etienne Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte P, et al. Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb. J Pharmacol Exp Ther. 2009;329:699-707 pubmed 出版商
Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, et al. Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol. 2009;29:1707-18 pubmed 出版商
Kubo T, Sugita T, Shimose S, Matsuo T, Arihiro K, Ochi M. Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. J Bone Joint Surg Br. 2008;90:364-70 pubmed 出版商
Chintalapudi M, Markiewicz M, Kose N, Dammai V, Champion K, Hoda R, et al. Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis. 2008;29:696-703 pubmed 出版商
Chan D, Krieg A, Turcotte S, Giaccia A. HIF gene expression in cancer therapy. Methods Enzymol. 2007;435:323-45 pubmed
Scheuermann T, Yang J, Zhang L, Gardner K, Bruick R. Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function. Methods Enzymol. 2007;435:3-24 pubmed
Sutphin P, Chan D, Li J, Turcotte S, Krieg A, Giaccia A. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Res. 2007;67:5896-905 pubmed
Kyriacou H, Steen K, Raza A, Arman M, Warimwe G, Bull P, et al. In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate. Antimicrob Agents Chemother. 2007;51:1321-6 pubmed
Yan Q, Bartz S, Mao M, Li L, Kaelin W. The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo. Mol Cell Biol. 2007;27:2092-102 pubmed
Koizume S, Jin M, Miyagi E, Hirahara F, Nakamura Y, Piao J, et al. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII. Cancer Res. 2006;66:9453-60 pubmed
Khan Z, Michalopoulos G, Stolz D. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006;169:1251-69 pubmed
Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M. Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha. Carcinogenesis. 2007;28:529-36 pubmed
Zheng X, Ruas J, Cao R, Salomons F, Cao Y, Poellinger L, et al. Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization. Mol Cell Biol. 2006;26:4628-41 pubmed
Kim C, Vocke C, Torres Cabala C, Yang Y, Schmidt L, Walther M, et al. Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors. J Urol. 2006;175:1908-14 pubmed
Nakamura E, Abreu E Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, et al. Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein. Am J Pathol. 2006;168:574-84 pubmed
Eul B, Rose F, Krick S, Savai R, Goyal P, Klepetko W, et al. Impact of HIF-1alpha and HIF-2alpha on proliferation and migration of human pulmonary artery fibroblasts in hypoxia. FASEB J. 2006;20:163-5 pubmed
Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik S, et al. Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res. 2005;65:7249-58 pubmed
Bilton R, Mazure N, Trottier E, Hattab M, Déry M, Richard D, et al. Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF. J Biol Chem. 2005;280:31132-40 pubmed
Yoshimura H, Dhar D, Kohno H, Kubota H, Fujii T, Ueda S, et al. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res. 2004;10:8554-60 pubmed
Rathmell W, Hickey M, Bezman N, Chmielecki C, Carraway N, Simon M. In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations. Cancer Res. 2004;64:8595-603 pubmed
Grabmaier K, A de Weijert M, Verhaegh G, Schalken J, Oosterwijk E. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene. 2004;23:5624-31 pubmed
Mekhail K, Gunaratnam L, Bonicalzi M, Lee S. HIF activation by pH-dependent nucleolar sequestration of VHL. Nat Cell Biol. 2004;6:642-7 pubmed
Harvey A, Kind K, Pantaleon M, Armstrong D, Thompson J. Oxygen-regulated gene expression in bovine blastocysts. Biol Reprod. 2004;71:1108-19 pubmed
Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, et al. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A. 2004;101:8132-7 pubmed
Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed
Pan Y, Oprysko P, Asham A, Koch C, Simon M. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene. 2004;23:4975-83 pubmed
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res. 2004;2:89-95 pubmed
Kondo K, Kim W, Lechpammer M, Kaelin W. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 2003;1:E83 pubmed
Martin Puig S, Temes E, Olmos G, Jones D, Aragones J, Landazuri M. Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms. J Biol Chem. 2004;279:9504-11 pubmed
Mohan S, Burk R. von Hippel-Lindau protein complex is regulated by cell density. Oncogene. 2003;22:5270-80 pubmed
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K. Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer. Urology. 2002;59:774-8 pubmed
Blancher C, Moore J, Talks K, Houlbrook S, Harris A. Relationship of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression to vascular endothelial growth factor induction and hypoxia survival in human breast cancer cell lines. Cancer Res. 2000;60:7106-13 pubmed
Talks K, Turley H, Gatter K, Maxwell P, Pugh C, Ratcliffe P, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000;157:411-21 pubmed
Wiesener M, Turley H, Allen W, Willam C, Eckardt K, Talks K, et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood. 1998;92:2260-8 pubmed
产品信息
SKU号 :
NB100-132
产品名称 :
HIF-2甲/EPAS1抗体(ep190b)
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The HIF-2 alpha/EPAS1 Antibody (ep190b) from Novus is a mouse monoclonal antibody to HIF-2 alpha/EPAS1. This antibody reacts with human, mouse, rat, hamster. The HIF-2 alpha/EPAS1 Antibody (ep190b) has been validated for the following applications: Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, In vivo assay, Immunofluorescence, Gel Supershift Assay.
靶标 :
HIF-2甲/EPAS1
类别 :
一抗
缓冲液 :
PBS with 1% BSA
克隆性 :
单克隆
克隆 :
ep190b
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
The immunogen recognized by this HIF-2 alpha / EPAS1 Antibody (ep190b) maps to a region between amino acids 535-631. [UniProt# Q99814]
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠, 仓鼠
特异性 :
This HIF-2 alpha / EPAS1 Antibody (ep190b) is specific for HIF-2 alpha / EPAS1, and does not cross-react with HIF-1 alpha
理论上的分子量 :
96.5 kDa
基因符号 :
EPAS1
catalog number base :
NB100-132
accessionNumbers :
Q99814
应用 :
Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, In vivo assay, Immunofluorescence, Gel Supershift Assay
2020 Proposedprice USD :
349美元
别名 :
Basic-helix-loop-helix-PAS protein MOP2, BHLHE73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain-containing protein 1, ep190b, EPAS1, EPAS-1, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF-2 alpha, HIF2A, hif2a angiogenesis, HIF-2-alpha, HIF2-alpha, HLF, hypoxia-inducible factor 2 alpha, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, MOP2, PAS domain-containing protein 2, PASD2
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。