产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
EGLN1/PHD2抗体
目录 :
NB100-137
规格 :
0.025毫克
价格 :
149美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 24
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 人类; 1:5000; 图 2D
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed 出版商
Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal J, et al. Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. J Cell Mol Med. 2019;23:7785-7795 pubmed 出版商
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza G, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nat Commun. 2019;10:2130 pubmed 出版商
Kurelac I, Iommarini L, Vatrinet R, Amato L, De Luise M, Leone G, et al. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nat Commun. 2019;10:903 pubmed 出版商
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed 出版商
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed 出版商
Kim G, Das R, Rao X, Zhong J, Deiuliis J, Ramirez Bergeron D, et al. CITED2 Restrains Proinflammatory Macrophage Activation and Response. Mol Cell Biol. 2018;38: pubmed 出版商
Hu J, Wang W, Zhang F, Li P, Boini K, Yi F, et al. Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells. Sci Rep. 2017;7:15878 pubmed 出版商
Wottawa M, Naas S, Bottger J, van Belle G, Mobius W, Revelo N, et al. Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiol (Oxf). 2017;221:59-73 pubmed 出版商
Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed 出版商
Burr S, Costa A, Grice G, Timms R, Lobb I, Freisinger P, et al. Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1? Stability in Aerobic Conditions. Cell Metab. 2016;24:740-752 pubmed 出版商
Chen T, Zhou Q, Tang H, Bozkanat M, Yuan J, Raj J, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016;5: pubmed
Lam Y, Lecce L, Tan J, Bursill C, Handelsman D, Ng M. Androgen Receptor-Mediated Genomic Androgen Action Augments Ischemia-Induced Neovascularization. Endocrinology. 2016;157:4853-4864 pubmed
Tao Y, Lin F, Li R, Shen J, Wang Z. Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner. Int J Biochem Cell Biol. 2016;77:129-140 pubmed 出版商
Mysore V, Szablowski J, Dervan P, FROST P. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. 2016;14:253-66 pubmed 出版商
Sun W, Kosyna F, Jelkmann W, Depping R. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression. Cell Physiol Biochem. 2015;37:2257-64 pubmed 出版商
Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed 出版商
Ryou M, Choudhury G, Li W, Winters A, Yuan F, Liu R, et al. Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience. 2015;301:193-203 pubmed 出版商
Zhang Z, Pang X, Tang Z, Yin D, Wang Z. Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells. Mol Med Rep. 2015;12:3809-3814 pubmed 出版商
Kumar P, Gullberg U, Olsson I, Ajore R. Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1. PLoS ONE. 2015;10:e0123725 pubmed 出版商
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed 出版商
Li J, Yuan W, Jiang S, Ye W, Yang H, Shapiro I, et al. Prolyl-4-hydroxylase domain protein 2 controls NF-κB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. J Biol Chem. 2015;290:7195-207 pubmed 出版商
Vogler M, Zieseniss A, Hesse A, Levent E, Tiburcy M, Heinze E, et al. Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult. Pflugers Arch. 2015;467:2141-9 pubmed 出版商
Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner Pfannschmidt U, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012;40:1928-43 pubmed 出版商
产品信息
品牌 :
Novus
SKU号 :
NB100-137
产品名称 :
EGLN1/PHD2抗体
单位尺寸 :
0.025毫克
描述 :
The EGLN1/PHD2 Antibody from Novus is a rabbit polyclonal antibody to EGLN1/PHD2. This antibody reacts with human, mouse, rat, primate. The EGLN1/PHD2 Antibody has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockdown Validated.
靶标 :
EGLN1/PHD2
类别 :
一抗
缓冲液 :
三羟甲基氨基甲烷柠檬酸盐/磷酸盐(pH值7.0-8.0)
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
The epitope recognized by this antibody maps to a region between residues 1 and 50 of human PHD2/HIF Prolyl Hydroxylase 2 using the numbering given in entry NP_071334.1 (GeneID 54583).
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 灵长类动物
理论上的分子量 :
46 kDa
基因符号 :
EGLN1
catalog number base :
NB100-137
accessionNumbers :
Q9GZT9
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockdown Validated
美元 :
149美元
applications abr :
WB, Simple Western, Flow, IHC, ICC/IF, IP, IHC-P, KD
别名 :
C1orf12HPH2, EC 1.14.11, EC 1.14.11.-, ECYT3, egl nine homolog 1, egl nine homolog 1 (C. elegans), egl nine-like protein 1, HIF prolyl hydroxylase 2, HIF-PH2, HIFPH2 EGL nine (C.elegans) homolog 1, HIF-prolyl hydroxylase 2, HPH-2, Hypoxia-inducible factor prolyl hydroxylase 2, PHD2SM20, Prolyl hydroxylase domain-containing protein 2, SM-20, zinc finger MYND domain-containing protein 6, ZMYND6DKFZp761F179
储存 :
存放在4C。 不冻结
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。