产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
EGLN1/PHD2抗体
目录 :
NB100-137
规格 :
0.1毫克
价格 :
449美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 20
参考文献
Sallais J, Park C, Alahari S, Porter T, Liu R, Kurt M, et al. HIF1 inhibitor acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2. JCI Insight. 2022;7: pubmed 出版商
Schlegel C, Liu K, Spring B, Dietz S, Poets C, Hudalla H, et al. Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia. Pediatr Res. 2022;: pubmed 出版商
Jian C, Yu X, Gao H, Chen H, Jheng R, Chen C, et al. Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α. Nanomaterials (Basel). 2022;12: pubmed 出版商
Li J, Lu X, Wei L, Ye D, Lin J, Tang X, et al. PHD2 attenuates high-glucose-induced blood retinal barrier breakdown in human retinal microvascular endothelial cells by regulating the Hif-1α/VEGF pathway. Inflamm Res. 2022;71:69-79 pubmed 出版商
Kumar P, Verma V, Mohania D, Gupta S, Babbar A, Rathi B, et al. Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells. J Cell Biochem. 2021;: pubmed 出版商
Shi M, Dai W, Jia R, Zhang Q, Wei J, Wang Y, et al. APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett. 2021;496:144-155 pubmed 出版商
Mei H, Wu N, Huang X, Cui Z, Xu J, Yang X, et al. Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats. J Ethnopharmacol. 2021;266:113448 pubmed 出版商
Bhute V, Harte J, Houghton J, Maxwell P. Mannose Binding Lectin Is Hydroxylated by Collagen Prolyl-4-hydroxylase and Inhibited by Some PHD Inhibitors. Kidney360. 2020;1:447-457 pubmed 出版商
Wang F, Yu H, Huang S, Zheng L, Zheng P, Zhang S, et al. Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling. Evid Based Complement Alternat Med. 2020;2020:8894257 pubmed 出版商
Sundaramurthi H, Roche S, Grice G, Moran A, Dillion E, Campiani G, et al. Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Front Cell Dev Biol. 2020;8:689 pubmed 出版商
Settelmeier S, Schreiber T, M ki J, Byts N, Koivunen P, Myllyharju J, et al. Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice. PLoS ONE. 2020;15:e0233261 pubmed 出版商
Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal J, et al. Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. J Cell Mol Med. 2019;23:7785-7795 pubmed 出版商
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza G, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nat Commun. 2019;10:2130 pubmed 出版商
Kurelac I, Iommarini L, Vatrinet R, Amato L, De Luise M, Leone G, et al. Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Nat Commun. 2019;10:903 pubmed 出版商
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, et al. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018;9:5426 pubmed 出版商
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed 出版商
Kim G, Das R, Rao X, Zhong J, Deiuliis J, Ramirez Bergeron D, et al. CITED2 Restrains Proinflammatory Macrophage Activation and Response. Mol Cell Biol. 2018;38: pubmed 出版商
Hu J, Wang W, Zhang F, Li P, Boini K, Yi F, et al. Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells. Sci Rep. 2017;7:15878 pubmed 出版商
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed 出版商
Wottawa M, Naas S, Bottger J, van Belle G, Mobius W, Revelo N, et al. Hypoxia-stimulated membrane trafficking requires T-plastin. Acta Physiol (Oxf). 2017;221:59-73 pubmed 出版商
图像
图像 1 :
Novus Biologicals NB100-137 图像 1
Knockout Validated: EGLN1/PHD2 Antibody [NB100-137] - Immunoblot validation of HIF2A and PHD2 KO clones using HIF2A (#NB100-122; dilution: 1/300), PHD2 (#NB100-137; dilution: 1/500). To blot HIFs factor cells were first pre-treated for 5 h with CoCl2 300 uM before protein extraction, a condition that promotes HIF factor accumulation. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/s41467-018-06988-3) licensed under a CC-BY licence.
产品信息
品牌 :
Novus
MasterCode :
NB100-137
SKU号 :
NB100-137
产品名称 :
EGLN1/PHD2抗体
描述 :
The EGLN1/PHD2 Antibody from NB100-137 is a nb100-137 antibody to . This antibody reacts with angiogenesis, cancer, chromatin research, hypoxia, immunology, lipid and metabolism. The EGLN1/PHD2 Antibody has been validated for the following applications: Q9GZT9.
靶标 :
EGLN1/PHD2
类别 :
一抗
单位尺寸 :
0.1毫克
缓冲液 :
Tris-Citrate/Phosphate (pH 7 to 8)
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
The epitope recognized by this EGLN1/PHD2 antibody maps to a region between residues 1 and 50 of human PHD2/HIF Prolyl Hydroxylase 2 using the numbering given in entry NP_071334.1 (GeneID 54583).
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 灵长类动物
理论上的分子量 :
46 kDa
基因符号 :
EGLN1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockout-Validated-NB100-137-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockout-Validated-NB100-137-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Simple-Western-NB100-137-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Simple-Western-NB100-137-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-137-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-137-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-137-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-137-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Flow-Cytometry-NB100-137-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Flow-Cytometry-NB100-137-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-137-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-137-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-137-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-137-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-137-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Flow-Cytometry-NB100-137-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Flow-Cytometry-NB100-137-img0007.jpg
accessionNumbers :
Q9GZT9
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockout Validated, Knockdown Validated
美元 :
449美元
别名 :
C1orf12, EC 1.14.11.29, EC:1.14.11.291, ECYT3, egl nine homolog 1, egl nine-like protein 1, EGLN1, HALAH, HIF prolyl hydroxylase 2, HIFPH2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH2, HPH-2, Hypoxia-inducible factor prolyl hydroxylase 2, PHD2, PNAS-118, PNAS-137, Prolyl hydroxylase domain-containing protein 2, SM20, SM-20, zinc finger MYND domain-containing protein 6, ZMYND6
储存 :
存放在4C。 不冻结
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。