产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
EGLN3/PHD3 Antibody - BSA Free
目录 :
NB100-139
规格 :
0.1 ml (also 0.025 ml)
价格 :
399美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 16
参考文献
Saggese P, Pandey A, Fung E, Hall A, Yanagawa J, Rodriguez E, et al. Glucose deprivation promotes pseudo-hypoxia and de-differentiation in lung adenocarcinoma. bioRxiv. 2023;: pubmed 出版商
Seike K, Kiledal A, Fujiwara H, Henig I, Burgos da Silva M, van den Brink M, et al. Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation. Immunity. 2023;56:353-368.e6 pubmed 出版商
Ciminera A, Shuck S, Termini J. Elevated glucose increases genomic instability by inhibiting nucleotide excision repair. Life Sci Alliance. 2021;4: pubmed 出版商
Nasteska D, Cuozzo F, Viloria K, Johnson E, Thakker A, Bany Bakar R, et al. Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice. JCI Insight. 2021;6: pubmed 出版商
Ju S, Lim L, Wi K, Park C, Ki Y, Choi D, et al. LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium. Int J Mol Sci. 2021;22: pubmed 出版商
Shi M, Dai W, Jia R, Zhang Q, Wei J, Wang Y, et al. APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma. Cancer Lett. 2021;496:144-155 pubmed 出版商
Yoon H, Spinelli J, Zaganjor E, Wong S, German N, Randall E, et al. PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020;32:215-228.e7 pubmed 出版商
Kozlova N, Mennerich D, Samoylenko A, Dimova E, Koivunen P, Biterova E, et al. The pro-oncogenic adaptor CIN85 acts as an inhibitory binding partner of hypoxia-inducible factor prolyl hydroxylase 2. Cancer Res. 2019;: pubmed 出版商
Miikkulainen P, Högel H, Seyednasrollah F, Rantanen K, Elo L, Jaakkola P. Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma. J Biol Chem. 2019;294:3760-3771 pubmed 出版商
Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, et al. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep. 2018;8:14290 pubmed 出版商
Pan H, Strickland A, Madhu V, Johnson Z, Chand S, Brody J, et al. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biol. 2019;77:23-40 pubmed 出版商
Akat F, Ficicilar H, Durak A, Tuncay E, Dursun A, Topal Celikkan F, et al. Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat. Anatol J Cardiol. 2018;19:259-266 pubmed 出版商
Bryant J, Brown M, Dobrikov M, Dobrikova E, Gemberling S, Zhang Q, et al. Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2. Mol Cell Biol. 2018;38: pubmed 出版商
Miikkulainen P, Högel H, Rantanen K, Suomi T, Kouvonen P, Elo L, et al. HIF prolyl hydroxylase PHD3 regulates translational machinery and glucose metabolism in clear cell renal cell carcinoma. Cancer Metab. 2017;5:5 pubmed 出版商
Bruno T, Valerio M, Casadei L, De Nicola F, Goeman F, Pallocca M, et al. Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization. J Exp Clin Cancer Res. 2017;36:32 pubmed 出版商
Barnes E, Chen C, Sedan O, Cornfield D. Loss of smooth muscle cell hypoxia inducible factor-1? underlies increased vascular contractility in pulmonary hypertension. FASEB J. 2017;31:650-662 pubmed 出版商
图像
图像 1 :
Novus Biologicals NB100-139 图像 1
Knockdown Validated: EGLN3/PHD3 Antibody [NB100-139] - PHD3 is required for SCC cell survival in prolonged hypoxia. PHD3 is induced in hypoxia. Knock-down of PHD3 expression with siRNA (siPHD3) is specific and does not affect PHD2 or HIF-1 alpha expression. siScr = scrambled control siRNA. Image collected and cropped by CiteAb from the following publication (//doi.org/10.1371/journal.pone.0014617), licensed under a CC-BY licence.
产品信息
品牌 :
Novus
MasterCode :
NB100-139
SKU号 :
NB100-139
产品名称 :
EGLN3/PHD3 Antibody - BSA Free
描述 :
The EGLN3/PHD3 Antibody - BSA Free from NB100-139 is a nb100-139 antibody to . This antibody reacts with cancer, hypoxia. The EGLN3/PHD3 Antibody - BSA Free has been validated for the following applications: Q9H6Z9.
靶标 :
EGLN3/PHD3
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
Synthetic peptide corresponding to residues between 50-100 of human PHD3/HIF Prolyl Hydroxylase 3 using the numbering given in entry NP_071356.1 (GeneID 112399).
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠
理论上的分子量 :
28 kDa
基因符号 :
EGLN3
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Immunohistochemistry-Paraffin-NB100-139-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Immunohistochemistry-Paraffin-NB100-139-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Immunocytochemistry-Immunofluorescence-NB100-139-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Immunocytochemistry-Immunofluorescence-NB100-139-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Knockdown-Validated-NB100-139-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Western-Blot-NB100-139-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Western-Blot-NB100-139-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Western-Blot-NB100-139-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN3-PHD3-Antibody-Western-Blot-NB100-139-img0013.jpg
accessionNumbers :
Q9H6Z9
应用 :
Western Blot, Chromatin Immunoprecipitation, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Electron Microscopy, Mass Spectrometry, Knockdown Validated
美元 :
399美元
别名 :
EC 1.14.11, EC 1.14.11.-, EGL nine (C.elegans) homolog 3, egl nine homolog 3, egl nine homolog 3 (C. elegans), egl nine-like protein 3 isoform, FLJ21620, HIF prolyl hydroxylase 3, HIF-PH3, HIFPH3 MGC125998, HIF-prolyl hydroxylase 3, HPH-1, HPH-3, Hypoxia-inducible factor prolyl hydroxylase 3, MGC125999, pdh3, PHD3, Prolyl hydroxylase domain-containing protein 3
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。