Nbs1抗体 | Novus Biologicals NB100-143 产品信息

产品简要

公司名称 :

Novus Biologicals

其他品牌 :

IMGENEX

产品类型 :

抗体

产品名称 :

Nbs1抗体

NB100-143

规格 :

0.05 ml (also 0.025 ml)

价格 :

449美元

克隆性 :

多克隆

宿主 :

domestic rabbit

共轭标签 :

未共轭

反应物种 :

人类, 小鼠

应用 :

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片

更多信息或购买 :

Novus Biologicals 产品网页

文章摘录数: 37

参考文献
Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, et al. The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response. Cell Rep. 2022;41:111819 pubmed 出版商
Mann A, Ramirez Otero M, De Antoni A, Hanthi Y, Sannino V, Baldi G, et al. POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps. Mol Cell. 2022;82:4218-4231.e8 pubmed 出版商
Ferrari S, Jacob A, Cesana D, Laugel M, Beretta S, Varesi A, et al. Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells. Cell Stem Cell. 2022;29:1428-1444.e9 pubmed 出版商
Berthault N, Bergam P, Pereira F, Girard P, Dutreix M. Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA. Cells. 2022;11: pubmed 出版商
Fitieh A, Locke A, Mashayekhi F, Khaliqdina F, Sharma A, Ismail I. BMI-1 regulates DNA end resection and homologous recombination repair. Cell Rep. 2022;38:110536 pubmed 出版商
Park D, Gharghabi M, Schrock M, Plow R, Druck T, Yungvirt C, et al. Interaction of Wwox with Brca1 and associated complex proteins prevents premature resection at double-strand breaks and aberrant homologous recombination. DNA Repair (Amst). 2022;110:103264 pubmed 出版商
Bakr A, Hey J, Sigismondo G, Liu C, Sadik A, Goyal A, et al. ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. Nucleic Acids Res. 2021;49:11666-11689 pubmed 出版商
Isobe S, Hiraga S, Nagao K, Sasanuma H, Donaldson A, Obuse C. Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action. Cell Rep. 2021;36:109383 pubmed 出版商
Na J, Newman J, Then C, Syed J, Vendrell I, Torrecilla I, et al. SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells. Cell Death Dis. 2021;12:165 pubmed 出版商
Sharma S, Anand R, Zhang X, Francia S, Michelini F, Galbiati A, et al. MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends. Cell Rep. 2021;34:108565 pubmed 出版商
Chansel Da Cruz M, Hohl M, Ceppi I, Kermasson L, Maggiorella L, Modesti M, et al. A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans. Cell Rep. 2020;33:108559 pubmed 出版商
Herrmann C, Dybas J, Liddle J, Price A, Hayer K, Lauman R, et al. Adenovirus-mediated ubiquitination alters protein-RNA binding and aids viral RNA processing. Nat Microbiol. 2020;5:1217-1231 pubmed 出版商
Howard S, Ceppi I, Anand R, Geiger R, Cejka P. The internal region of CtIP negatively regulates DNA end resection. Nucleic Acids Res. 2020;48:5485-5498 pubmed 出版商
Ragamin A, Yigit G, Bousset K, Beleggia F, Verheijen F, de Wit M, et al. Human RAD50 deficiency: Confirmation of a distinctive phenotype. Am J Med Genet A. 2020;182:1378-1386 pubmed 出版商
Qi F, Meng Q, Hayashi I, Kobayashi J. FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses. J Radiat Res. 2020;61:368-375 pubmed 出版商
Mooser C, Symeonidou I, Leimbacher P, Ribeiro A, Shorrocks A, Jungmichel S, et al. Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation. Nat Commun. 2020;11:123 pubmed 出版商
Völkening L, Vatselia A, Asgedom G, Bastians H, Lavin M, Schindler D, et al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020;34:2812-2820 pubmed 出版商
Yoshimura Y. Increased error-free DNA repair gene expression through reprogramming in human iPS cells. Regen Ther. 2019;11:101-105 pubmed 出版商
Korsholm L, Gál Z, Lin L, Quevedo O, Ahmad D, Dulina E, et al. Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair. Nucleic Acids Res. 2019;47:8019-8035 pubmed 出版商
Leimbacher P, Jones S, Shorrocks A, De Marco Zompit M, Day M, Blaauwendraad J, et al. MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis. Mol Cell. 2019;74:571-583.e8 pubmed 出版商
Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, et al. UFL1 promotes histone H4 ufmylation and ATM activation. Nat Commun. 2019;10:1242 pubmed 出版商
Erickson K, Garcea R. Viral replication centers and the DNA damage response in JC virus-infected cells. Virology. 2019;528:198-206 pubmed 出版商
Anand R, Jasrotia A, Bundschuh D, Howard S, Ranjha L, Stucki M, et al. NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation. EMBO J. 2019;38: pubmed 出版商
Suh K, Ryu H, Lee K, Kim H, Min A, Kim T, et al. Prognostic effects of abnormal DNA damage response protein expression in breast cancer. Breast Cancer Res Treat. 2019;175:117-127 pubmed 出版商
Lamarche B, Orazio N, Goben B, Meisenhelder J, You Z, Weitzman M, et al. Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays. DNA Repair (Amst). 2019;74:80-90 pubmed 出版商
Gao Y, Kardos J, Yang Y, Tamir T, Mutter Rottmayer E, Weissman B, et al. The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells. Sci Rep. 2018;8:15304 pubmed 出版商
Gustafsson N, Färnegårdh K, Bonagas N, Ninou A, Groth P, Wiita E, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018;9:3872 pubmed 出版商
Qian M, Liu Z, Peng L, Tang X, Meng F, Ao Y, et al. Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria. elife. 2018;7: pubmed 出版商
Pancholi N, Weitzman M. Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex. Virology. 2018;518:221-231 pubmed 出版商
Lee K, Im J, Shibata E, Dutta A. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks. Mol Cell. 2017;68:61-75.e5 pubmed 出版商
Moyal L, Goldfeiz N, Gorovitz B, Rephaeli A, Tal E, Tarasenko N, et al. AN-7, a butyric acid prodrug, sensitizes cutaneous T-cell lymphoma cell lines to doxorubicin via inhibition of DNA double strand breaks repair. Invest New Drugs. 2018;36:1-9 pubmed 出版商
Ward T, McHugh P, Durant S. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS ONE. 2017;12:e0179278 pubmed 出版商
Burke R, Marcus J, Orth J. Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells. Oncotarget. 2017;8:39460-39475 pubmed 出版商
Mariggiò G, Koch S, Zhang G, Weidner Glunde M, Rückert J, Kati S, et al. Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. PLoS Pathog. 2017;13:e1006335 pubmed 出版商
Zhou H, Kawamura K, Yanagihara H, Kobayashi J, Zhang Akiyama Q. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein. J Radiat Res. 2017;58:487-494 pubmed 出版商
Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017;7:44662 pubmed 出版商
Campos León K, Wijendra K, Siddiqa A, Pentland I, Feeney K, Knapman A, et al. Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication. J Virol. 2017;91: pubmed 出版商

图像

图像 1 :

Knockout Validated: Nbs1 Antibody [NB100-143] - Lysates of HeLa human cervical epithelial carcinoma parental cell line and Nbs1 knockout (KO) HeLa cell line. PVDF membrane was probed with 1:1000 of Rabbit Anti-Human Polyclonal [NB100-143] followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (HAF008). Specific band was detected for Nbs1 at approximately 95 kDa (as indicated) in the parental HeLa cell line, but is not detectable in the knockout HeLa cell line. This experiment was conducted under reducing conditions.

产品信息

品牌 :

Novus

MasterCode :

NB100-143

SKU号 :

NB100-143

产品名称 :

Nbs1抗体

描述 :

The Nbs1 Antibody from NB100-143 is a nb100-143 antibody to . This antibody reacts with breast cancer, cancer, cell cycle and replication, checkpoint signaling, chromatin research, dna double strand break repair, dna repair, homologous recombination, non homologous end joining, tumor suppressors. The Nbs1 Antibody has been validated for the following applications: O60934.

靶标 :

Nbs1

类别 :

一抗

单位尺寸 :

0.05 ml (also 0.025 ml)

缓冲液 :

Whole antisera

克隆性 :

多克隆

共轭标签 :

未共轭

宿主 :

兔

免疫原 :

Nbs1 Antibody was made to a partial length human NBS1 protein [Swiss-Prot: O60934].

抗体亚型 :

IgG

纯度 :

Unpurified

物种 :

人类, 小鼠, 仓鼠, 哺乳动物, 灵长类动物

理论上的分子量 :

85 kDa

基因符号 :

NBN

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Knockout-Validated-NB100-143-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Knockout-Validated-NB100-143-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-143-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-143-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunohistochemistry-Paraffin-NB100-143-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunohistochemistry-Paraffin-NB100-143-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Western-Blot-NB100-143-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-143-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1-Antibody-Immunocytochemistry-Immunofluorescence-NB100-143-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1 Antibody-Knockdown Validated-NB100-143-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Nbs1 Antibody-Knockdown Validated-NB100-143-img0017.jpg

accessionNumbers :

O60934

应用 :

Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunoblotting, In-situ Hybridization, SDS-Page, Chromatin Immunoprecipitation (ChIP), Knockout Validated, Knockdown Validated

美元 :

449美元

别名 :

ATV, AT-V1, AT-V2, Cell cycle regulatory protein p95, FLJ10155, MGC87362, NBS, NBS1P95, nibrin, Nijmegen breakage syndrome 1 (nibrin), Nijmegen breakage syndrome protein 1, p95, p95 protein of the MRE11/RAD50 complex

储存 :

存放在4C。不冻结

更多信息或购买 :

Novus Biologicals 产品网页

公司信息

Novus Biologicals

10771 E Easter Ave
Centennial, CO 80112

technical@novusbio.com

https://www.novusbio.com

1-888-506-6887 303-730-1950

公司总部: 美国

Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。