产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
毛细血管扩张性共济失调症突变蛋白抗体(5C2)
目录 :
NB100-220
规格 :
0.1毫升
价格 :
459美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5C2
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 38
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 2c
Barnard R, Regan D, Hansen R, Maycotte P, Thorburn A, Gustafson D. Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease. J Pharmacol Exp Ther. 2016;358:282-93 pubmed 出版商
Najnin R, Al Mahmud M, Rahman M, Takeda S, Sasanuma H, Tanaka H, et al. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen. Cell Rep. 2023;42:111909 pubmed 出版商
Han Y, Lee Y, Jang Y, Kim H, Seo H, Jung T, et al. Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. Biomed Res Int. 2020;2020:7806860 pubmed 出版商
Iizuka Y, Chiba K, Kim H, Hirako S, Wada M, Matsumoto A. Impact of discontinuation of fish oil after pioglitazone-fish oil combination therapy in diabetic KK mice. J Nutr Biochem. 2020;76:108265 pubmed 出版商
Gang X, Xuan L, Zhao X, Lv Y, Li F, Wang Y, et al. Speckle-type POZ protein suppresses lipid accumulation and prostate cancer growth by stabilizing fatty acid synthase. Prostate. 2019;79:864-871 pubmed 出版商
Meister Broekema M, Freilich R, Jagadeesan C, Rauch J, Bengoechea R, Motley W, et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nat Commun. 2018;9:5342 pubmed 出版商
Li M, Vera N, Yang Y, Zhang B, Ni W, Ziso Qejvanaj E, et al. Adipocyte OGT governs diet-induced hyperphagia and obesity. Nat Commun. 2018;9:5103 pubmed 出版商
Walz J, Saha J, Arora A, Khammanivong A, O Sullivan M, Dickerson E. Fatty acid synthase as a potential therapeutic target in feline oral squamous cell carcinoma. Vet Comp Oncol. 2018;16:E99-E108 pubmed 出版商
Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed 出版商
Chen C, Chuang W, Lin A, Tsai C, Huang C, Chen Y, et al. Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBP? expression and activation. Toxicol Appl Pharmacol. 2016;307:115-122 pubmed 出版商
Karlas A, Berrè S, Couderc T, Varjak M, Braun P, Meyer M, et al. A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nat Commun. 2016;7:11320 pubmed 出版商
Gang X, Yang Y, Zhong J, Jiang K, Pan Y, Karnes R, et al. P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth. Oncotarget. 2016;7:15135-49 pubmed 出版商
Aumailley L, Garand C, Dubois M, Johnson F, Marette A, Lebel M. Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice. PLoS ONE. 2015;10:e0140292 pubmed 出版商
Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11:1161-78 pubmed 出版商
Kim K, Cho Y, Park B, Lee J, Ro J, Go H, et al. Histological and immunohistochemical markers for progression prediction in transurethrally resected high-grade non-muscle invasive bladder cancer. Int J Clin Exp Pathol. 2015;8:743-50 pubmed
Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, et al. Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation. IUBMB Life. 2012;64:853-61 pubmed 出版商
Daniel J, Pellegrini M, Lee B, Guo Z, Filsuf D, Belkina N, et al. Loss of ATM kinase activity leads to embryonic lethality in mice. J Cell Biol. 2012;198:295-304 pubmed 出版商
Hou Y, Toh M, Wang X. NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity. Cell Biochem Funct. 2012;30:233-42 pubmed 出版商
Vogel R, Seyffert M, Strasser R, de Oliveira A, Dresch C, Glauser D, et al. Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol. 2012;86:143-55 pubmed 出版商
Rankin A, Sarkar S, Faller D. Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. J Cell Physiol. 2012;227:2586-94 pubmed 出版商
Gapud E, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald G, et al. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108:2022-7 pubmed 出版商
Cam H, Easton J, High A, Houghton P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010;40:509-20 pubmed 出版商
Craig A, Holcakova J, Finlan L, Nekulova M, Hrstka R, Gueven N, et al. DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Mol Cancer. 2010;9:195 pubmed 出版商
Alimonti A, Nardella C, Chen Z, Clohessy J, Carracedo A, Trotman L, et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010;120:681-93 pubmed 出版商
Gonzalez Suarez I, Redwood A, Perkins S, Vermolen B, Lichtensztejin D, Grotsky D, et al. Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J. 2009;28:2414-27 pubmed 出版商
Efeyan A, Murga M, Martinez Pastor B, Ortega Molina A, Soria R, Collado M, et al. Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. PLoS ONE. 2009;4:e5475 pubmed 出版商
Siehler S, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmuller L. Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst). 2009;8:242-52 pubmed 出版商
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed 出版商
Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
Chen J, Ozanne S. Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress. FEBS Lett. 2006;580:6669-73 pubmed
Sun Y, Jiang X, Chen S, Price B. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006;580:4353-6 pubmed
Roy K, Wang L, Makrigiorgos G, Price B. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun. 2006;344:821-6 pubmed
Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
Fernandes N, Sun Y, Chen S, Paul P, Shaw R, Cantley L, et al. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005;280:15158-64 pubmed
Lai C, Chun H, Nahas S, Mitui M, Gamo K, Du L, et al. Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004;101:15676-81 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-220
SKU号 :
NB100-220
产品名称 :
毛细血管扩张性共济失调症突变蛋白抗体(5C2)
描述 :
The ATM Antibody (5C2) from NB100-220 is a nb100-220 antibody to . This antibody reacts with apoptosis, breast cancer, cancer, cell cycle and replication, checkpoint signaling, chromatin research, dna double strand break repair, dna repair, genes sensitive to dna damaging agents, hypoxia, modulation of dna pools, p53 pathway, protein kinase, tumor suppressors.
靶标 :
毛细血管扩张性共济失调症突变蛋白
类别 :
一抗
单位尺寸 :
0.1毫升
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
5C2
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
ATM Antibody (5C2) was made to a recombinant protein expressed in E. coli corresponding to amino acids 980-1512.
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Rat, Monkey
理论上的分子量 :
351 kDa
基因符号 :
毛细血管扩张性共济失调症突变蛋白
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Immunocytochemistry-Immunofluorescence-NB100-220-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATM-Antibody-(5C2)-Western-Blot-NB100-220-img0002.jpg
应用 :
免疫印迹, 免疫组化, 免疫细胞化学/免疫荧光, 免疫沉淀
美元 :
459美元
别名 :
AT mutated, A-T mutated, AT1, ATA, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATC, ATD, ATDC, ATE, ATM serine/threonine kinase, DKFZp781A0353, EC 2.7.11.1, MGC74674, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。