产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
EGLN1/PHD2 Antibody - BSA Free
目录 :
NB100-2219
规格 :
0.1 ml (also 0.025 ml)
价格 :
449美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
DyLight系列染料550
克隆名称 :
6H12
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 18
参考文献
Sun L, Wu C, Ming J, Guo E, Zhang W, Li L, et al. EGLN1 induces tumorigenesis and radioresistance in nasopharyngeal carcinoma by promoting ubiquitination of p53 in a hydroxylase-dependent manner. J Cancer. 2022;13:2061-2073 pubmed 出版商
Elamaa H, Kaakinen M, N xe4 tynki M, Szabo Z, Ronkainen V, xc4 ij xe4 l xe4 V, et al. PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis. Angiogenesis. 2022;25:259-274 pubmed 出版商
Röning T, Magga J, Laitakari A, Halmetoja R, Tapio J, Dimova E, et al. Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy. J Mol Cell Cardiol. 2022;164:148-155 pubmed 出版商
Ju S, Lim L, Wi K, Park C, Ki Y, Choi D, et al. LRP5 Regulates HIF-1α Stability via Interaction with PHD2 in Ischemic Myocardium. Int J Mol Sci. 2021;22: pubmed 出版商
van Kuijk K, Demandt J, Perales Paton J, Theelen T, Kuppe C, Marsch E, et al. DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic effects of myeloid PHD knockdown. Cardiovasc Res. 2021;: pubmed 出版商
Laitakari A, Huttunen R, Kuvaja P, Hannuksela P, Szabo Z, Heikkilä M, et al. Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span. FASEB J. 2020;34:5590-5609 pubmed 出版商
Kim S, Jo C, Kim G. Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats. Hypertens Res. 2019;42:1905-1915 pubmed 出版商
Chowdhury D, Alrefai H, Landero Figueroa J, Candor K, Porollo A, Fecher R, et al. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Rep. 2019;27:3873-3886.e7 pubmed 出版商
Yamamoto A, Hester J, Macklin P, Kawai K, Uchiyama M, Biggs D, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019;130:3640-3656 pubmed 出版商
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macías D, et al. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018;27:898-913.e7 pubmed 出版商
Akat F, Ficicilar H, Durak A, Tuncay E, Dursun A, Topal Celikkan F, et al. Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat. Anatol J Cardiol. 2018;19:259-266 pubmed 出版商
Flisinski M, Wisniewska Chudy E, Brymora A, Stefanska A, Strozecki P, Manitius J. Chronic kidney disease leads to hypoxia inducible factor-1alpha to hypoxia inducible factor-2alpha switch in the gastrocnemius muscle. J Physiol Pharmacol. 2017;68:419-425 pubmed
Wang S, Zeng H, Chen S, Zhou L, Xie X, He X, et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J Cell Mol Med. 2017;21:1967-1978 pubmed 出版商
Choi J, Kim J, Song N, Suh J, Kim D, Kim S, et al. 15-Deoxy-?12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1? through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2. Free Radic Res. 2016;50:1140-1152 pubmed
Zeng H, He X, Tuo Q, Liao D, Zhang G, Chen J. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep. 2016;6:20931 pubmed 出版商
Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko K, Myllyharju J, et al. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med (Berl). 2016;94:301-10 pubmed 出版商
Xie L, Pi X, Townley Tilson W, Li N, Wehrens X, Entman M, et al. PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. J Clin Invest. 2015;125:2759-71 pubmed 出版商
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther. 2015;15:313-25 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-2219
SKU号 :
NB100-2219
产品名称 :
EGLN1/PHD2 Antibody - BSA Free
描述 :
The EGLN1/PHD2 Antibody - BSA Free from NB100-2219 is a nb100-2219 antibody to . This antibody reacts with angiogenesis, cancer, chromatin research, hypoxia, immunology, lipid and metabolism.
靶标 :
EGLN1/PHD2
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
This EGLN1/PHD2 antibody was developed against a synthetic peptide made to an internal portion of mouse PHD2/HIF Prolyl Hydroxylase 2 (between residues 300-400). [Uniprot: Q91YE3]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠
理论上的分子量 :
43 kDa
基因符号 :
EGLN1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockdown-Validated-NB100-2219-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Knockdown-Validated-NB100-2219-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-Paraffin-NB100-2219-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-Paraffin-NB100-2219-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-2219-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Western-Blot-NB100-2219-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunocytochemistry-Immunofluorescence-NB100-2219-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/EGLN1-PHD2-Antibody-Immunohistochemistry-NB100-2219-img0010.jpg
应用 :
免疫印迹, 免疫组化, 免疫细胞化学/免疫荧光, 免疫沉淀, 免疫组化石蜡, 基因敲除验证, 基因敲减验证
美元 :
449美元
别名 :
C1orf12, EC 1.14.11.29, EC:1.14.11.291, ECYT3, egl nine homolog 1, egl nine-like protein 1, EGLN1, HALAH, HIF prolyl hydroxylase 2, HIFPH2, HIF-PH2, HIF-prolyl hydroxylase 2, HPH2, HPH-2, Hypoxia-inducible factor prolyl hydroxylase 2, PHD2, PNAS-118, PNAS-137, Prolyl hydroxylase domain-containing protein 2, SM20, SM-20, zinc finger MYND domain-containing protein 6, ZMYND6
储存 :
存放在4C。 不冻结
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。