产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
MDM2/HDM2 Antibody (SMP14) - BSA Free
目录 :
NB100-2736
规格 :
0.1 ml (also 0.025 ml)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
SMP14
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 34
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠
  • 免疫印迹; 小鼠
Joshi Y, Sória M, Quadrato G, Inak G, Zhou L, Hervera A, et al. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015;138:1843-62 pubmed 出版商
  • 免疫印迹; 人类
Inaba H, Kuboniwa M, Sugita H, Lamont R, Amano A. Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts. Infect Immun. 2012;80:2847-57 pubmed 出版商
  • 免疫组化; 人类
de Freitas M, Ramalho L, Xavier F, Moreira A, Reis S. p53 and MDM2 protein expression in actinic cheilitis. J Appl Oral Sci. 2008;16:414-9 pubmed
  • 免疫印迹; 人类
Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn E, et al. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007;26:5029-37 pubmed
  • 免疫沉淀; 人类
Stevenson L, Sparks A, Allende Vega N, Xirodimas D, Lane D, Saville M. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J. 2007;26:976-86 pubmed
  • 免疫组化; 大鼠
Pääjärvi G, Roudier E, Crisby M, Hogberg J, Stenius U. HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005;19:476-8 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Minsky N, Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell. 2004;16:631-9 pubmed
  • 免疫印迹; 人类
Menendez S, Higgins M, Berkson R, Edling C, Lane D, Lain S. Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein. Br J Cancer. 2003;88:636-43 pubmed
  • 免疫印迹; 人类
Goldberg Z, Vogt Sionov R, Berger M, Zwang Y, Perets R, Van Etten R, et al. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. EMBO J. 2002;21:3715-27 pubmed
  • 免疫组化-石蜡切片; 人类
Kersemaekers A, Mayer F, Molier M, Van Weeren P, Oosterhuis J, Bokemeyer C, et al. Role of P53 and MDM2 in treatment response of human germ cell tumors. J Clin Oncol. 2002;20:1551-61 pubmed
  • 免疫印迹; 人类
Hjerrild M, Milne D, Dumaz N, Hay T, Issinger O, Meek D. Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells. Biochem J. 2001;355:347-56 pubmed
  • 免疫印迹; 人类
Rodriguez Lopez A, Xenaki D, Eden T, Hickman J, Chresta C. MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells. Mol Pharmacol. 2001;59:135-43 pubmed
  • 免疫印迹; 人类
Berger M, Vogt Sionov R, Levine A, Haupt Y. A role for the polyproline domain of p53 in its regulation by Mdm2. J Biol Chem. 2001;276:3785-90 pubmed
  • 免疫印迹; 人类
Sionov R, Moallem E, Berger M, Kazaz A, Gerlitz O, Ben Neriah Y, et al. c-Abl neutralizes the inhibitory effect of Mdm2 on p53. J Biol Chem. 1999;274:8371-4 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Shieh S, Ikeda M, Taya Y, Prives C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell. 1997;91:325-34 pubmed
Lee S, Jeong H, Hwang B, Yu B, Cho Y, Nam K, et al. Helicobacter pylori promotes epithelial-to-mesenchymal transition by downregulating CK2β in gastric cancer cells. Biochim Biophys Acta Mol Basis Dis. 2022;1869:166588 pubmed 出版商
K x131 yga E, Ad x131 g xfc zel Z, xd6 nay U xe7 ar E. Temozolomide increases heat shock proteins in extracellular vesicles released from glioblastoma cells. Mol Biol Rep. 2022;49:8701-8713 pubmed 出版商
Kaczorowski A, Tolstov Y, Falkenstein M, Vasioukhin V, Prigge E, Geisler C, et al. Rearranged ERG confers robustness to prostate cancer cells by subverting the function of p53. Urol Oncol. 2020;38:736.e1-736.e10 pubmed 出版商
Xu Y, Gao Q, Zhang J, Lu Y, Xing D, Qin Y, et al. Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1. Cell Death Differ. 2020;27:2131-2142 pubmed 出版商
Xu Y, Gao Q, Xue Y, Li X, Xu L, Li C, et al. Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner. J Biol Chem. 2019;294:9949-9958 pubmed 出版商
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen E, et al. Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53. J Virol. 2019;93: pubmed 出版商
Egners A, Rezaei M, Kuzmanov A, Poitz D, Streichert D, MULLER REICHERT T, et al. PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling. Cancers (Basel). 2018;10: pubmed 出版商
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, et al. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 2018;25:561-570.e6 pubmed 出版商
Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, et al. PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes. Sci Rep. 2018;8:14290 pubmed 出版商
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macías D, et al. The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia. Cell Metab. 2018;27:898-913.e7 pubmed 出版商
Ramos G, Cruz A, Silva W, Rozanski A, Baptista I, Silvestre J, et al. Thyroid hormone upregulates MDM2 in rat type i fiber: implications for skeletal muscle mass regulation. Acta Physiol (Oxf). 2017;: pubmed 出版商
Bialešová L, Xu L, Gustafsson J, Haldosén L, Zhao C, Dahlman Wright K. Estrogen receptor ?2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1?. Oncotarget. 2017;8:76622-76633 pubmed 出版商
Gibier J, Hemon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, et al. Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1336-1349 pubmed 出版商
Tan J, Prosser H, Dunn L, Vanags L, Ridiandries A, Tsatralis T, et al. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes. 2016;65:3091-103 pubmed 出版商
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed 出版商
Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed 出版商
Zieseniss A, Hesse A, Jatho A, Krull S, Hölscher M, Vogel S, et al. Cardiomyocyte-Specific Transgenic Expression of Prolyl-4-Hydroxylase Domain 3 Impairs the Myocardial Response to Ischemia. Cell Physiol Biochem. 2015;36:843-51 pubmed 出版商
Pastor Soler N, Sutton T, Mang H, Kinlough C, Gendler S, Madsen C, et al. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015;308:F1452-62 pubmed 出版商
Martin K, Trouche D, Hagemeier C, Sørensen T, La Thangue N, Kouzarides T. Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein. Nature. 1995;375:691-4 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-2736
SKU号 :
NB100-2736
产品名称 :
MDM2/HDM2 Antibody (SMP14) - BSA Free
描述 :
The MDM2/HDM2 Antibody (SMP14) - BSA Free from NB100-2736 is a nb100-2736 antibody to . This antibody reacts with p53 pathway. The MDM2/HDM2 Antibody (SMP14) - BSA Free has been validated for the following applications: Q00987.
靶标 :
鼠双微基因2/HDM2
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
SMP14
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Synthetic peptide C-SRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2/HDM2. [UniProt# Q00987]
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠
特异性 :
The SMP14 monoclonal antibody also recognises a peptide epitope around Thr-216 of murine MDM2 (when Thr-216 is unphosphorylated) see Zhang & Prives, 2001 (PMID: 11359766) for further details
基因符号 :
鼠双微基因2
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Western-Blot-NB100-2736-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Western-Blot-NB100-2736-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Immunohistochemistry-Paraffin-NB100-2736-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Immunohistochemistry-Paraffin-NB100-2736-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Immunohistochemistry-Paraffin-NB100-2736-img0002.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/MDM2-HDM2-Antibody-(SMP14)-Immunohistochemistry-Paraffin-NB100-2736-img0002.jpg
accessionNumbers :
Q00987
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 免疫组化石蜡, 免疫组化冷冻
美元 :
399美元
别名 :
ACTFS, HDM2, HDMX, 鼠双微基因2癌基因, E3泛素蛋白连接酶
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。