产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
53BP1抗体
目录 :
NB100-304
规格 :
0.1 ml (also 0.025 ml)
价格 :
379美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
仓鼠, 人类, 小鼠, brown rat, ,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 189
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 图 2c
Wang H, Nakamura M, Abbott T, Zhao D, Luo K, Yu C, et al. CRISPR-mediated live imaging of genome editing and transcription. Science. 2019;: pubmed 出版商
  • 免疫细胞化学; 人类; 图 s10a
Zhang M, Wang B, Li T, Liu R, Xiao Y, Geng X, et al. Mammalian CST averts replication failure by preventing G-quadruplex accumulation. Nucleic Acids Res. 2019;47:5243-5259 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:5000; 图 s2d
López Erauskin J, Tadokoro T, Baughn M, Myers B, McAlonis Downes M, Chillon Marinas C, et al. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron. 2018;100:816-830.e7 pubmed 出版商
  • 免疫细胞化学; 人类; 1:250; 图 s5d
Schrank B, Aparicio T, Li Y, Chang W, Chait B, Gundersen G, et al. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018;559:61-66 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6
Cottineau J, Kottemann M, Lach F, Kang Y, Vély F, Deenick E, et al. Inherited GINS1 deficiency underlies growth retardation along with neutropenia and NK cell deficiency. J Clin Invest. 2017;127:1991-2006 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2b
Vancevska A, Douglass K, Pfeiffer V, Manley S, Lingner J. The telomeric DNA damage response occurs in the absence of chromatin decompaction. Genes Dev. 2017;31:567-577 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Liu Y, Cussiol J, Dibitetto D, Sims J, Twayana S, Weiss R, et al. TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol. 2017;216:623-639 pubmed 出版商
  • 免疫细胞化学; 人类
Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3d
Mytych J, Wos I, Solek P, Koziorowski M. Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes. Exp Cell Res. 2017;350:358-367 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 2a
Tumini E, Barroso S, Calero C, Aguilera A. Roles of human POLD1 and POLD3 in genome stability. Sci Rep. 2016;6:38873 pubmed 出版商
  • 免疫组化; 小鼠; 图 2c
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet Robinet E, Salles B, et al. Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms. Sci Rep. 2016;6:36022 pubmed 出版商
  • 免疫细胞化学; brown rat; 1:500; 图 4c
Piechota M, Sunderland P, Wysocka A, Nalberczak M, Sliwinska M, Radwanska K, et al. Is senescence-associated β-galactosidase a marker of neuronal senescence?. Oncotarget. 2016;7:81099-81109 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:600; 图 2
Lescale C, Lenden Hasse H, Blackford A, Balmus G, Bianchi J, Yu W, et al. Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination. Cell Rep. 2016;16:2967-2979 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s2d
Schmidt J, Zaug A, Cech T. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016;166:1188-1197.e9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000; 图 1
Mao P, Liu J, Zhang Z, Zhang H, Liu H, Gao S, et al. Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells. Nat Commun. 2016;7:12154 pubmed 出版商
  • 免疫细胞化学; 人类; 1:3000; 图 5
Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 2
Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
  • 免疫印迹; 人类; 图 4
Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3a
Medves S, Auchter M, Chambeau L, Gazzo S, Poncet D, Grangier B, et al. A high rate of telomeric sister chromatid exchange occurs in chronic lymphocytic leukaemia B-cells. Br J Haematol. 2016;174:57-70 pubmed 出版商
  • 免疫细胞化学; 人类; 图 1d
O Hagan Wong K, Nadeau S, Carrier Leclerc A, Apablaza F, Hamdy R, Shum Tim D, et al. Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells' homeostasis. Oncotarget. 2016;7:13285-96 pubmed 出版商
  • 免疫细胞化学; 人类; 1:1000; 图 2
  • 免疫印迹; 人类; 图 s3
Francia S, Cabrini M, Matti V, Oldani A, d Adda di Fagagna F. DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. J Cell Sci. 2016;129:1468-76 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen J, et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell. 2016;27:1346-57 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s7
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet. 2016;12:e1005791 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4
Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016;7:10201 pubmed 出版商
  • 免疫细胞化学; 仓鼠; 1:1000; 图 8
Chatalic K, Konijnenberg M, Nonnekens J, De Blois E, Hoeben S, de Ridder C, et al. In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies. Theranostics. 2016;6:104-17 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmüller L. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2016;35:3796-806 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000; 图 5a
Kubben N, Brimacombe K, Donegan M, Li Z, Misteli T. A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods. 2016;96:46-58 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 6c
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed 出版商
Parvin S, Ramírez Labrada A, Aumann S, Lu X, Weich N, Santiago G, et al. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Cancer Cell. 2019;36:237-249.e6 pubmed 出版商
Sundaravinayagam D, Rahjouei A, Andreani M, Tupiņa D, Balasubramanian S, Saha T, et al. 53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function. Cell Rep. 2019;28:1389-1399.e6 pubmed 出版商
Hill R, Crossan G. DNA cross-link repair safeguards genomic stability during premeiotic germ cell development. Nat Genet. 2019;51:1283-1294 pubmed 出版商
Jayavaradhan R, Pillis D, Goodman M, Zhang F, Zhang Y, Andreassen P, et al. CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Nat Commun. 2019;10:2866 pubmed 出版商
Brandsma I, Sato K, van Rossum Fikkert S, van Vliet N, Sleddens E, Reuter M, et al. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Cell Rep. 2019;27:3790-3798.e7 pubmed 出版商
Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed 出版商
Peng J, Tang L, Cai M, Chen H, Wong J, Zhang P. RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells. Cancer Med. 2019;8:4743-4752 pubmed 出版商
Grill S, Bisht K, Tesmer V, Shami A, Hammoud S, Nandakumar J. Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Cell Rep. 2019;27:3511-3521.e7 pubmed 出版商
Liu Y, Efimova E, Ramamurthy A, Kron S. Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. J Cell Sci. 2019;: pubmed 出版商
Pladevall Morera D, Munk S, Ingham A, Garribba L, Albers E, Liu Y, et al. Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability. Nucleic Acids Res. 2019;47:8004-8018 pubmed 出版商
Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed 出版商
Ge Y, Wu S, Zhang Z, Li X, Li F, Yan S, et al. Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers. Protein Cell. 2019;: pubmed 出版商
Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, et al. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Dev Cell. 2019;: pubmed 出版商
Campillo Marcos I, Lazo P. Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase. J Exp Clin Cancer Res. 2019;38:203 pubmed 出版商
Huang J, Zhang J, Bellani M, Pokharel D, Gichimu J, James R, et al. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Rep. 2019;27:1794-1808.e5 pubmed 出版商
Caron P, Pankotai T, Wiegant W, Tollenaere M, Furst A, Bonhomme C, et al. WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks. Genes Dev. 2019;33:684-704 pubmed 出版商
Lagunas A, FRANCIS M, Maniar N, Nikolova G, Wu J, Crowe D. Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP). Mol Cancer Res. 2019;: pubmed 出版商
Prieto I, Zambrano A, Laso J, Aranda A, Samper E, Monsalve M. Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts. Free Radic Biol Med. 2019;138:23-32 pubmed 出版商
Nadeau S, Cheng A, Colmegna I, Rodier F. Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures. Methods Mol Biol. 2019;: pubmed 出版商
Galindo Campos M, Bedora Faure M, Farrés J, Lescale C, Moreno Lama L, Martinez C, et al. Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function. Cell Death Differ. 2019;: pubmed 出版商
Gupta R, Li W, Yan X, Barrientos J, Kolitz J, Allen S, et al. Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins. J Immunol. 2019;202:2924-2944 pubmed 出版商
West K, Kelliher J, Xu Z, An L, Reed M, Eoff R, et al. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019;: pubmed 出版商
Michelini F, Rossiello F, d Adda di Fagagna F, Francia S. RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci. Nat Protoc. 2019;14:1489-1508 pubmed 出版商
Sekhar K, Wang J, Freeman M, Kirschner A. Radiosensitization by enzalutamide for human prostate cancer is mediated through the DNA damage repair pathway. PLoS ONE. 2019;14:e0214670 pubmed 出版商
Gourzones C, Bellanger C, Lamure S, Gadacha O, de Paco E, Vincent L, et al. Antioxidant Defenses Confer Resistance to High Dose Melphalan in Multiple Myeloma Cells. Cancers (Basel). 2019;11: pubmed 出版商
Li S, Su W, Zhang C. Linear double-stranded DNAs as innovative biological parts to implement genetic circuits in mammalian cells. FEBS J. 2019;286:2341-2354 pubmed 出版商
Belmans N, Gilles L, Virag P, Hedesiu M, Salmon B, Baatout S, et al. Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations. Dentomaxillofac Radiol. 2019;48:20180428 pubmed 出版商
Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, et al. Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response. Cell Stem Cell. 2019;24:551-565.e8 pubmed 出版商
Qin B, Yu J, Nowsheen S, Wang M, Tu X, Liu T, et al. UFL1 promotes histone H4 ufmylation and ATM activation. Nat Commun. 2019;10:1242 pubmed 出版商
Efimova E, Appelbe O, Ricco N, Lee S, Liu Y, Wolfgeher D, et al. O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors. Mol Cancer Res. 2019;17:1338-1350 pubmed 出版商
Selis D, Pande Y, Smoczer C, Wheater M, Alhabeil J, Paurazas S, et al. Cytotoxicity and Genotoxicity of a New Intracanal Medicament, 2-hydroxyisocaproic Acid-An In Vitro Study. J Endod. 2019;45:578-583 pubmed 出版商
Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224 pubmed 出版商
Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rodel F, et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel). 2019;11: pubmed 出版商
Ly P, Brunner S, Shoshani O, Kim D, Lan W, Pyntikova T, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019;51:705-715 pubmed 出版商
Wang Y, Yang J, Wild A, Wu W, Shah R, Danussi C, et al. G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma. Nat Commun. 2019;10:943 pubmed 出版商
Sen P, Lan Y, Li C, Sidoli S, Donahue G, Dou Z, et al. Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell. 2019;73:684-698.e8 pubmed 出版商
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Ogrodnik M, Zhu Y, Langhi L, Tchkonia T, Krüger P, Fielder E, et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metab. 2019;29:1061-1077.e8 pubmed 出版商
Coluzzi E, Leone S, Sgura A. Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest. Cells. 2019;8: pubmed 出版商
Tumini E, Herrera Moyano E, San Martín Alonso M, Barroso S, Galmarini C, Aguilera A. The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability. Mol Cancer Res. 2019;17:773-782 pubmed 出版商
Lafarga V, Sung H, Haneke K, Roessig L, Pauleau A, Bruer M, et al. TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress. EMBO Rep. 2019;20: pubmed 出版商
Bodo S, Campagne C, Thin T, Higginson D, Vargas H, Hua G, et al. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. J Clin Invest. 2019;129:786-801 pubmed 出版商
Fernandez Vidal A, Arnaud L, Maumus M, Chevalier M, Mirey G, Salles B, et al. Exposure to the Fungicide Captan Induces DNA Base Alterations and Replicative Stress in Mammalian Cells. Environ Mol Mutagen. 2019;60:286-297 pubmed 出版商
Wu J, Crowe D. Molecular and cellular basis of mammary gland fibrosis and cancer risk. Int J Cancer. 2019;144:2239-2253 pubmed 出版商
Muñoz Galvan S, Lucena Cacace A, Perez M, Otero Albiol D, Gomez Cambronero J, Carnero A. Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment. Oncogene. 2019;38:1309-1323 pubmed 出版商
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun. 2018;9:5435 pubmed 出版商
Guijarro T, Magro Lopez E, Manso J, Garcia Martinez R, Fernandez Aceñero M, Liste I, et al. Detrimental pro-senescence effects of vitamin D on lung fibrosis. Mol Med. 2018;24:64 pubmed 出版商
Becker J, Cuella Martin R, Barazas M, Liu R, Oliveira C, Oliver A, et al. The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity. Nat Commun. 2018;9:5406 pubmed 出版商
Majerská J, Feretzaki M, Glousker G, Lingner J. Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1. Life Sci Alliance. 2018;1:e201800121 pubmed 出版商
El Daher M, Cagnard N, Gil M, Da Cruz M, Leveau C, Sepulveda F, et al. Tetratricopeptide repeat domain 7A is a nuclear factor that modulates transcription and chromatin structure. Cell Discov. 2018;4:61 pubmed 出版商
Sung P, Yin T, Wallace C, Chen K, Shao P, Lee F, et al. Extracorporeal Shock Wave-Supported Adipose-Derived Fresh Stromal Vascular Fraction Preserved Left Ventricular (LV) Function and Inhibited LV Remodeling in Acute Myocardial Infarction in Rat. Oxid Med Cell Longev. 2018;2018:7518920 pubmed 出版商
Sargolzaeiaval F, Zhang J, Schleit J, Lessel D, Kubisch C, Precioso D, et al. CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures. Mol Genet Genomic Med. 2018;6:1148-1156 pubmed 出版商
Bhatia V, Valdés Sánchez L, Rodríguez Martínez D, Bhattacharya S. Formation of 53BP1 foci and ATM activation under oxidative stress is facilitated by RNA:DNA hybrids and loss of ATM-53BP1 expression promotes photoreceptor cell survival in mice. F1000Res. 2018;7:1233 pubmed 出版商
Piquet S, Le Parc F, Bai S, Chevallier O, Adam S, Polo S. The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage. Mol Cell. 2018;72:888-901.e7 pubmed 出版商
Chakraborty P, Huang J, Hiom K. DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing. Nat Commun. 2018;9:4346 pubmed 出版商
Tête A, Gallais I, Imran M, Chevanne M, Liamin M, Sparfel L, et al. Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide. Free Radic Biol Med. 2018;129:323-337 pubmed 出版商
Razdan N, Vasilopoulos T, Herbig U. Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts. Aging Cell. 2018;17:e12838 pubmed 出版商
Albers E, Sbroggiò M, Pladevall Morera D, Bizard A, Avram A, Gonzalez P, et al. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Cell Rep. 2018;24:3274-3284 pubmed 出版商
Johnson T, Costa A, Ferguson A, Frezza C. Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation. Cell Death Dis. 2018;9:913 pubmed 出版商
Chow T, Shi X, Wei J, Guan J, Stadler G, Huang B, et al. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun. 2018;9:3583 pubmed 出版商
Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed 出版商
Petroni M, Sardina F, Infante P, Bartolazzi A, Locatelli E, Fabretti F, et al. MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors. Cell Death Dis. 2018;9:895 pubmed 出版商
Hehlgans S, Booms P, Güllülü Ö, Sader R, Rodel C, Balermpas P, et al. Radiation Sensitization of Basal Cell and Head and Neck Squamous Cell Carcinoma by the Hedgehog Pathway Inhibitor Vismodegib. Int J Mol Sci. 2018;19: pubmed 出版商
Qi Y, Toyooka T, Kashiwagi H, Yanagiba Y, Koda S, Ohta H, et al. 2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1. Arch Toxicol. 2018;92:3093-3101 pubmed 出版商
Muoio D, Berardinelli F, Leone S, Coluzzi E, di Masi A, Doria F, et al. Naphthalene diimide-derivatives G-quadruplex ligands induce cell proliferation inhibition, mild telomeric dysfunction and cell cycle perturbation in U251MG glioma cells. FEBS J. 2018;285:3769-3785 pubmed 出版商
de Carcer G, Venkateswaran S, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, et al. Plk1 overexpression induces chromosomal instability and suppresses tumor development. Nat Commun. 2018;9:3012 pubmed 出版商
Evangelista F, Maglott Roth A, Stierlé M, Brino L, Soutoglou E, Tora L. Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair. J Cell Biol. 2018;217:3382-3397 pubmed 出版商
Timm S, Lorat Y, Jakob B, Taucher Scholz G, Rübe C. Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture. Radiother Oncol. 2018;129:600-610 pubmed 出版商
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Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. 2018;560:112-116 pubmed 出版商
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产品信息
SKU号 :
NB100-304
产品名称 :
53BP1抗体
单位尺寸 :
0.1 ml (also 0.025 ml)
描述 :
The 53BP1 Antibody from Novus is a rabbit polyclonal antibody to 53BP1. This antibody reacts with human, mouse, rat, bat, bovine, canine, fish, goat, primate. The 53BP1 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Flow (Intracellular), Immunocytochemistry, Knockout Validated, Knockdown Validated.
靶标 :
53BP1
类别 :
一抗
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
The epitope recognized by this antibody maps to a region between residues 350 and 400 of human 53BP1 [NP_005648.1].
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
Human, Mouse, Rat, Bat, Bovine, Canine, Fish, Goat, Primate
理论上的分子量 :
214 kDa
基因符号 :
TP53BP1
catalog number base :
NB100-304
应用 :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Flow (Intracellular), Immunocytochemistry, Knockout Validated, Knockdown Validated
2020 Proposedprice USD :
379美元
别名 :
53BP1, FLJ41424, MGC138366, p202, p53-binding protein 1, p53bp1, tumor protein 53-binding protein, 1, tumor protein p53 binding protein 1, tumor protein p53-binding protein, 1, tumor suppressor p53-binding protein 1
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。