产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
毛细血管扩张性共济失调症突变蛋白[p Ser1981]抗体(10H11.E12)
目录 :
NB100-306
规格 :
0.1 ml (also 0.025 ml)
价格 :
409美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10H11.E12
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 70
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类
Liedtke S, Biebernick S, Radke T, Stapelkamp D, Coenen C, Zaehres H, et al. DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells. Stem Cells Transl Med. 2015;4:576-89 pubmed 出版商
  • 免疫印迹; 小鼠
Park Y, Jeon Y, Kim I. Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B. Biochim Biophys Acta. 2012;1823:2217-26 pubmed 出版商
  • 免疫细胞化学; 人类
Someya M, Sakata K, Matsumoto Y, Tauchi H, Kai M, Hareyama M, et al. Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation. J Radiat Res. 2012;53:250-6 pubmed
  • 免疫印迹; 小鼠
  • 免疫印迹; 大鼠
Guerra L, Albihn A, Tronnersjö S, Yan Q, Guidi R, Stenerlow B, et al. Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. PLoS ONE. 2010;5:e8924 pubmed 出版商
Moon D, Padanilam B, Jang H, Kim J. 2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation. Pharmacol Rep. 2022;74:1041-1053 pubmed 出版商
Yang Y, Lu H, Chen C, Lyu Y, Cole R, Semenza G. HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. Nat Commun. 2022;13:316 pubmed 出版商
Wang X, Lupton C, Lauth A, Wan T, Foster P, Patterson M, et al. Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes. J Mol Cell Cardiol. 2021;155:88-98 pubmed 出版商
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020;11:4766 pubmed 出版商
Wimbish R, Deluca K, Mick J, Himes J, Jiménez Sánchez I, Jeyaprakash A, et al. The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore-microtubule attachment formation and Ska complex recruitment. Mol Biol Cell. 2020;31:1453-1473 pubmed 出版商
Gautam D, Stanley G, Owen M, Bridge E. Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation. Virology. 2019;527:47-56 pubmed 出版商
He D, Wang L, Zhang Z, Guo K, Li J, He X, et al. Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes. Zool Res. 2018;39:387-395 pubmed 出版商
Raab M, Sanhaji M, Matthess Y, Hörlin A, Lorenz I, Dötsch C, et al. PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells. Nat Commun. 2018;9:1106 pubmed 出版商
Deluca K, Meppelink A, Broad A, Mick J, Peersen O, Pektas S, et al. Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics. J Cell Biol. 2018;217:163-177 pubmed 出版商
Dumitru A, Rusin S, Clark A, Kettenbach A, Compton D. Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability. elife. 2017;6: pubmed 出版商
Li Z, Liu J, Li J, Kong Y, Sandusky G, Rao X, et al. Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice. J Biol Chem. 2017;292:17461-17472 pubmed 出版商
Niikura Y, Kitagawa R, Ogi H, Kitagawa K. SGT1-HSP90 complex is required for CENP-A deposition at centromeres. Cell Cycle. 2017;16:1683-1694 pubmed 出版商
Wu P, Wang J, Chen C, Chao K, Chang M, Chen W, et al. Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. Stem Cells Transl Med. 2017;6:1504-1514 pubmed 出版商
Liu X, Liu F, Gao S, Reske J, Li A, Wu C, et al. A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation. Cancer Lett. 2017;391:152-161 pubmed 出版商
Banerjee K, Banerjee S, Mandal M. Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions. J Colloid Interface Sci. 2017;491:98-110 pubmed 出版商
Takai H, Jenkinson E, Kabir S, Babul Hirji R, Najm Tehrani N, Chitayat D, et al. A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus. Genes Dev. 2016;30:812-26 pubmed 出版商
Yang Z, Shen Y, Oishi H, Matteson E, Tian L, Goronzy J, et al. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med. 2016;8:331ra38 pubmed 出版商
Tauchman E, Boehm F, DeLuca J. Stable kinetochore-microtubule attachment is sufficient to silence the spindle assembly checkpoint in human cells. Nat Commun. 2015;6:10036 pubmed 出版商
Caserta E, Egriboz O, Wang H, MARTIN C, Koivisto C, Pecót T, et al. Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes Dev. 2015;29:1707-20 pubmed 出版商
Nakamura K, Fike F, Haghayegh S, Saunders Pullman R, Dawson A, Dork T, et al. A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity. Mol Genet Genomic Med. 2014;2:332-40 pubmed 出版商
Kleyman M, Kabeche L, Compton D. STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments. J Cell Sci. 2014;127:4225-33 pubmed 出版商
Sayin V, Ibrahim M, Larsson E, Nilsson J, Lindahl P, Bergo M. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014;6:221ra15 pubmed 出版商
Sivakumar S, Daum J, Tipton A, Rankin S, Gorbsky G. The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell. 2014;25:594-605 pubmed 出版商
Yao R, Kondoh Y, Natsume Y, Yamanaka H, Inoue M, Toki H, et al. A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. Oncogene. 2014;33:4242-52 pubmed 出版商
Kabeche L, Compton D. Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation. Nature. 2013;502:110-3 pubmed 出版商
Maier B, Kirsch M, Anderhub S, Zentgraf H, Krämer A. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle. 2013;12:1457-71 pubmed 出版商
De Antoni A, Maffini S, Knapp S, Musacchio A, Santaguida S. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012;199:269-84 pubmed 出版商
Hwang M, Peddibhotla S, McHenry P, Chang P, Yochum Z, Park K, et al. P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells. Cancers (Basel). 2012;4:475-89 pubmed 出版商
Matson D, Demirel P, Stukenberg P, Burke D. A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint. Genes Dev. 2012;26:542-7 pubmed 出版商
Chan Y, Jeyaprakash A, Nigg E, Santamaria A. Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction. J Cell Biol. 2012;196:563-71 pubmed 出版商
Krenn V, Wehenkel A, Li X, Santaguida S, Musacchio A. Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J Cell Biol. 2012;196:451-67 pubmed 出版商
Thompson S, Compton D. Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors. Proc Natl Acad Sci U S A. 2011;108:17974-8 pubmed 出版商
Serio G, Margaria V, Jensen S, Oldani A, Bartek J, Bussolino F, et al. Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores. Proc Natl Acad Sci U S A. 2011;108:17337-42 pubmed 出版商
Ma N, Titus J, Gable A, Ross J, Wadsworth P. TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle. J Cell Biol. 2011;195:87-98 pubmed 出版商
Barnhart M, Kuich P, Stellfox M, Ward J, Bassett E, Black B, et al. HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore. J Cell Biol. 2011;194:229-43 pubmed 出版商
Santaguida S, Vernieri C, Villa F, Ciliberto A, Musacchio A. Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J. 2011;30:1508-19 pubmed 出版商
Screpanti E, De Antoni A, Alushin G, Petrovic A, Melis T, Nogales E, et al. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol. 2011;21:391-8 pubmed 出版商
Tooley J, Miller S, Stukenberg P. The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement. Mol Biol Cell. 2011;22:1217-26 pubmed 出版商
Sundin L, Guimaraes G, DeLuca J. The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis. Mol Biol Cell. 2011;22:759-68 pubmed 出版商
Zanet J, Freije A, Ruiz M, Coulon V, Sanz J, Chiesa J, et al. A mitosis block links active cell cycle with human epidermal differentiation and results in endoreplication. PLoS ONE. 2010;5:e15701 pubmed 出版商
Zeng K, Bastos R, Barr F, Gruneberg U. Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J Cell Biol. 2010;191:1315-32 pubmed 出版商
Petrovic A, Pasqualato S, Dube P, Krenn V, Santaguida S, Cittaro D, et al. The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol. 2010;190:835-52 pubmed 出版商
Screpanti E, Santaguida S, Nguyen T, Silvestri R, Gussio R, Musacchio A, et al. A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds. PLoS ONE. 2010;5:e11603 pubmed 出版商
Santaguida S, Tighe A, D Alise A, Taylor S, Musacchio A. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J Cell Biol. 2010;190:73-87 pubmed 出版商
Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo C, et al. A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010;12:351-61 pubmed 出版商
Wu G, Wei R, Cheng E, Ngo B, Lee W. Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1. Mol Biol Cell. 2009;20:4686-95 pubmed 出版商
Yang Z, Kenny A, Brito D, Rieder C. Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments. J Cell Biol. 2009;186:675-84 pubmed 出版商
Caslini C, Connelly J, Serna A, Broccoli D, Hess J. MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol Cell Biol. 2009;29:4519-26 pubmed 出版商
Chan Y, Fava L, Uldschmid A, Schmitz M, Gerlich D, Nigg E, et al. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J Cell Biol. 2009;185:859-74 pubmed 出版商
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy J, Weyand C. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med. 2009;206:1435-49 pubmed 出版商
Cai S, Weaver L, Ems McClung S, Walczak C. Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell. 2009;20:1348-59 pubmed 出版商
Spardy N, Duensing A, Hoskins E, Wells S, Duensing S. HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies. Cancer Res. 2008;68:9954-63 pubmed 出版商
Zhu H, Coppinger J, Jang C, Yates J, Fang G. FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle. J Cell Biol. 2008;183:835-48 pubmed 出版商
Miller S, Johnson M, Stukenberg P. Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). Curr Biol. 2008;18:1785-91 pubmed 出版商
Wu G, Qiu X, Zhou L, Zhu J, Chamberlin R, Lau J, et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008;68:8393-9 pubmed 出版商
Barr A, Gergely F. MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics. Mol Cell Biol. 2008;28:7199-211 pubmed 出版商
Yalcin S, Zhang X, Luciano J, Mungamuri S, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692-705 pubmed 出版商
Jang C, Wong J, Coppinger J, Seki A, Yates J, Fang G. DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008;181:255-67 pubmed 出版商
Wong J, Lerrigo R, Jang C, Fang G. Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol Biol Cell. 2008;19:2083-91 pubmed 出版商
Montembault E, Dutertre S, Prigent C, Giet R. PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. J Cell Biol. 2007;179:601-9 pubmed
Luo M, Rosenke K, Czornak K, Fortunato E. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol. 2007;81:1934-50 pubmed
Wong J, Fang G. HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J Cell Biol. 2006;173:879-91 pubmed
Klein U, Nigg E, Gruneberg U. Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006;17:2547-58 pubmed
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Ganem N, Compton D. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol. 2004;166:473-8 pubmed
Bakkenist C, Drissi R, Wu J, Kastan M, Dome J. Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. Cancer Res. 2004;64:3748-52 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-306
SKU号 :
NB100-306
产品名称 :
毛细血管扩张性共济失调症突变蛋白[p Ser1981]抗体(10H11.E12)
描述 :
The ATM [p Ser1981] Antibody (10H11.E12) from NB100-306 is a nb100-306 antibody to . This antibody reacts with apoptosis, breast cancer, cancer, cell cycle and replication, checkpoint signaling, chromatin research, dna double strand break repair, dna repair, genes sensitive to dna damaging agents, hypoxia, modulation of dna pools, p53 pathway, protein kinase, tumor suppressors. The ATM [p Ser1981] Antibody (10H11.E12) has been validated for the following applications: Q13315.
靶标 :
毛细血管扩张性共济失调症突变蛋白
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
10H11.E12
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
ATM [p Ser1981] Antibody (10H11.E12) was made to a synthetic peptide made to a region surrounding the phosphorylated Serine 1981 of human ATM. [UniProt# Q13315]
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Rat, Canine (Negative)
理论上的分子量 :
351 kDa
基因符号 :
毛细血管扩张性共济失调症突变蛋白
accessionNumbers :
Q13315
应用 :
免疫印迹, 免疫组化, 免疫细胞化学/免疫荧光, 免疫沉淀, 免疫组化石蜡
美元 :
409美元
别名 :
AT mutated, A-T mutated, AT1, ATA, ataxia telangiectasia mutated, ataxia telangiectasia mutated (includes complementation groups A, C and D), ATC, ATD, ATDC, ATE, ATM serine/threonine kinase, DKFZp781A0353, EC 2.7.11.1, MGC74674, serine-protein kinase ATM, TEL1, TEL1, telomere maintenance 1, homolog, TELO1
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。