产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
ATR抗体(2B5)
目录 :
NB100-308
规格 :
0.1毫升
价格 :
469美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
2B5
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 27
参考文献
Uchida C, Niida H, Sakai S, Iijima K, Kitagawa K, Ohhata T, et al. p130RB2 positively contributes to ATR activation in response to replication stress via the RPA32-ETAA1 axis. Biochim Biophys Acta Mol Cell Res. 2023;1870:119484 pubmed 出版商
Chakraborty P, Hiom K. DHX9-dependent recruitment of BRCA1 to RNA promotes DNA end resection in homologous recombination. Nat Commun. 2021;12:4126 pubmed 出版商
Harasim Symbor E, Polak Iwaniuk A, Konstantynowicz Nowicka K, Bielawiec P, Malinowska B, Kasacka I, et al. Experimental Activation of Endocannabinoid System Reveals Antilipotoxic Effects on Cardiac Myocytes. Molecules. 2020;25: pubmed 出版商
Kim W, Zhao F, Wu R, Qin S, Nowsheen S, Huang J, et al. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nat Commun. 2019;10:5304 pubmed 出版商
Larsen S, Vigelsø A, Dandanell S, Prats C, Dela F, Helge J. Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study. J Diabetes Res. 2018;2018:9257874 pubmed 出版商
Van Pelt D, Guth L, Wang A, Horowitz J. Factors regulating subcutaneous adipose tissue storage, fibrosis, and inflammation may underlie low fatty acid mobilization in insulin-sensitive obese adults. Am J Physiol Endocrinol Metab. 2017;313:E429-E439 pubmed 出版商
Cubizolle A, Guillou L, Mollereau B, Hamel C, Brabet P. Fatty acid transport protein 1 regulates retinoid metabolism and photoreceptor development in mouse retina. PLoS ONE. 2017;12:e0180148 pubmed 出版商
Newsom S, Everett A, Park S, Van Pelt D, Hinko A, Horowitz J. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signaling in cultured muscle cells. PLoS ONE. 2015;10:e0120871 pubmed 出版商
Choi Y, Lee C, Lee K, Jung S, Lee B. Increased hepatic Fatty Acid uptake and esterification contribute to tetracycline-induced steatosis in mice. Toxicol Sci. 2015;145:273-82 pubmed 出版商
Larsen S, Danielsen J, Søndergård S, Søgaard D, Vigelsoe A, Dybboe R, et al. The effect of high-intensity training on mitochondrial fat oxidation in skeletal muscle and subcutaneous adipose tissue. Scand J Med Sci Sports. 2015;25:e59-69 pubmed 出版商
Haro K, Sheth A, Scheinberg D. Dysregulation of IRP1-mediated iron metabolism causes gamma ray-specific radioresistance in leukemia cells. PLoS ONE. 2012;7:e48841 pubmed 出版商
Oku T, Nakano M, Kaneko Y, Ando Y, Kenmotsu H, Itoh S, et al. Constitutive turnover of phosphorylation at Thr-412 of human p57/coronin-1 regulates the interaction with actin. J Biol Chem. 2012;287:42910-20 pubmed 出版商
Ha K, Fiskus W, Rao R, Balusu R, Venkannagari S, Nalabothula N, et al. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Mol Cancer Ther. 2011;10:1194-206 pubmed 出版商
Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
Zuco V, Benedetti V, Zunino F. ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Cancer Lett. 2010;292:186-96 pubmed 出版商
Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed 出版商
Katsuki Y, Nakada S, Yokoyama T, Imoto I, Inazawa J, Nagasawa M, et al. Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Cancer Sci. 2008;99:1539-45 pubmed 出版商
Kulkarni A, Das K. Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Am J Physiol Lung Cell Mol Physiol. 2008;294:L998-L1006 pubmed 出版商
Liu X, Matsuda A, Plunkett W. Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Mol Cancer Ther. 2008;7:133-42 pubmed 出版商
Manthey K, Opiyo S, Glanzer J, Dimitrova D, Elliott J, Oakley G. NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J Cell Sci. 2007;120:4221-9 pubmed
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119:4644-9 pubmed
Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
Tyagi A, Singh R, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis. 2006;27:2269-80 pubmed
Wu X, Shell S, Yang Z, Zou Y. Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res. 2006;66:2997-3005 pubmed
Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
Horton J, Stefanick D, Naron J, Kedar P, Wilson S. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. J Biol Chem. 2005;280:15773-85 pubmed
Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-308
SKU号 :
NB100-308
产品名称 :
ATR抗体(2B5)
描述 :
The ATR Antibody (2B5) from NB100-308 is a nb100-308 antibody to . This antibody reacts with cancer, checkpoint signaling, dna double strand break repair, dna repair, immunology, p53 pathway, virology bacteria and parasites. The ATR Antibody (2B5) has been validated for the following applications: Q13535.
靶标 :
ATR
类别 :
一抗
单位尺寸 :
0.1毫升
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
2B5
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Recombinant fragment, corresponding to amino acids 710-1100 of Human ATR.
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠
理论上的分子量 :
317 kDa
基因符号 :
ATR
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATR-Antibody-(2B5)-Western-Blot-NB100-308-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATR-Antibody-(2B5)-Immunocytochemistry-Immunofluorescence-NB100-308-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATR-Antibody-(2B5)-Western-Blot-NB100-308-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ATR-Antibody-(2B5)-Western-Blot-NB100-308-img0005.jpg
accessionNumbers :
Q13535
应用 :
Western Blot, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Functional, In vitro assay, Knockout Validated
美元 :
469美元
别名 :
ataxia telangiectasia and Rad3 related, Ataxia telangiectasia and Rad3-related protein, EC 2.7.11.1, FRAP-related protein 1, FRP1FRAP-related protein-1, MEC1, protein kinase ATR, Rad3 related protein, SCKL1, SCKLMEC1, mitosis entry checkpoint 1, homolog, serine/threonine-protein kinase ATR
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。