产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
HIF-1甲抗体
目录 :
NB100-449
规格 :
0.1毫升
价格 :
399美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
生物素
克隆名称 :
OTI2B3
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 105
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; 小鼠; 图 3a
Kim Y, Lee M, Gu H, Kim J, Jeong S, Yeo S, et al. HIF-1α activation in myeloid cells accelerates dextran sodium sulfate-induced colitis progression in mice. Dis Model Mech. 2018;11: pubmed 出版商
  • 免疫印迹; 小鼠; 图 5b
Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, et al. HIF-1?-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7a
Kobayashi H, Liu Q, Binns T, Urrutia A, Davidoff O, Kapitsinou P, et al. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest. 2016;126:1926-38 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3
Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed 出版商
Kim K, Kim Y, Choi K, Lee M, Lee S, Im W, et al. Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients. Transl Neurodegener. 2020;9:23 pubmed 出版商
Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, et al. Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation. Cancer Res. 2020;80:3542-3555 pubmed 出版商
Hu L, Chen X, Qiu S, Yang J, Liu H, Zhang J, et al. Intra-Pancreatic Insulin Nourishes Cancer Cells: Do Insulin-Receptor Antagonists such as PGG and EGCG Play a Role?. Am J Chin Med. 2020;48:1005-1019 pubmed 出版商
Sil S, Hu G, Liao K, Niu F, Callen S, Periyasamy P, et al. HIV-1 Tat-mediated astrocytic amyloidosis involves the HIF-1α/lncRNA BACE1-AS axis. PLoS Biol. 2020;18:e3000660 pubmed 出版商
Doigneaux C, Pedley A, Mistry I, Papayova M, Benkovic S, Tavassoli A. Hypoxia drives the assembly of the multienzyme purinosome complex. J Biol Chem. 2020;295:9551-9566 pubmed 出版商
Alexander R, Liou Y, Knudsen N, Starost K, Xu C, Hyde A, et al. Bmal1 integrates mitochondrial metabolism and macrophage activation. elife. 2020;9: pubmed 出版商
Yamazaki H, Tanaka T, Mie K, Nishida H, Miura N, Akiyoshi H. Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs. J Vet Intern Med. 2020;34:1272-1281 pubmed 出版商
das Gupta K, Shakespear M, Curson J, Murthy A, Iyer A, Hodson M, et al. Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2. Cell Rep. 2020;30:2712-2728.e8 pubmed 出版商
Sugahara M, Tanaka S, Tanaka T, Saito H, Ishimoto Y, Wakashima T, et al. Prolyl Hydroxylase Domain Inhibitor Protects against Metabolic Disorders and Associated Kidney Disease in Obese Type 2 Diabetic Mice. J Am Soc Nephrol. 2020;31:560-577 pubmed 出版商
Sola Penna M, Paixão L, Branco J, Ochioni A, Albanese J, Mundim D, et al. Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively. Br J Cancer. 2020;122:194-208 pubmed 出版商
Di Gioia M, Spreafico R, Springstead J, Mendelson M, Joehanes R, Levy D, et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020;21:42-53 pubmed 出版商
Yambire K, Rostosky C, Watanabe T, Pacheu Grau D, Torres Odio S, Sánchez Guerrero A, et al. Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo. elife. 2019;8: pubmed 出版商
Gupta S, Sharp R, Hofferek C, Kuai L, Dorn G, Wang J, et al. NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells. Cell Rep. 2019;29:1862-1877.e7 pubmed 出版商
Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, et al. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Sci Signal. 2019;12: pubmed 出版商
Lin H, Chou P, Chen Y, Lai L, Chung T, Walzem R, et al. Dietary Supplementation of 25-Hydroxycholecalciferol Improves Livability in Broiler Breeder Hens-Amelioration of Cardiac Pathogenesis and Hepatopathology. Animals (Basel). 2019;9: pubmed 出版商
Nasyrov E, Nolan K, Wenger R, Marti H, Kunze R. The neuronal oxygen-sensing pathway controls postnatal vascularization of the murine brain. FASEB J. 2019;33:12812-12824 pubmed 出版商
Bailey J, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, et al. Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation. Cell Rep. 2019;28:218-230.e7 pubmed 出版商
Bahrami B, Shen W, Zhu L, Zhang T, Chang A, Gillies M. Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia. Clin Exp Ophthalmol. 2019;: pubmed 出版商
Baik S, Kang S, Lee W, Choi H, Chung S, Kim J, et al. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell Metab. 2019;30:493-507.e6 pubmed 出版商
Chowdhury D, Alrefai H, Landero Figueroa J, Candor K, Porollo A, Fecher R, et al. Metallothionein 3 Controls the Phenotype and Metabolic Programming of Alternatively Activated Macrophages. Cell Rep. 2019;27:3873-3886.e7 pubmed 出版商
Chen Y, Zhao B, Zhu Y, Zhao H, Ma C. HIF-1-VEGF-Notch mediates angiogenesis in temporomandibular joint osteoarthritis. Am J Transl Res. 2019;11:2969-2982 pubmed
Elder M, Webster S, Fitzmaurice T, Shaunak A, Steinmetz M, Chee R, et al. Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling. Front Immunol. 2019;10:921 pubmed 出版商
Igari K, Kelly M, Yamanouchi D. Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages. J Vasc Res. 2019;:1-10 pubmed 出版商
Duan L, Fong G. Developmental vascular pruning in neonatal mouse retinas is programmed by the astrocytic oxygen-sensing mechanism. Development. 2019;146: pubmed 出版商
Grigelioniene G, Suzuki H, Taylan F, Mirzamohammadi F, Borochowitz Z, Ayturk U, et al. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med. 2019;25:583-590 pubmed 出版商
Li H, Zhou Y, Li L, Li S, Long D, Chen X, et al. HIF-1α protects against oxidative stress by directly targeting mitochondria. Redox Biol. 2019;:101109 pubmed 出版商
Valencia Cervantes J, Huerta Yepez S, Aquino Jarquin G, Rodriguez Enriquez S, Martinez Fong D, Arias Montaño J, et al. Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation. Oncol Rep. 2019;41:178-190 pubmed 出版商
Krueger K, Catanese L, Sciesielski L, Kirschner K, Scholz H. Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochim Biophys Acta Gene Regul Mech. 2018;1862:71-83 pubmed 出版商
Bae Y, Joo H, Bae J, Hyeon S, Her S, Ko E, et al. Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage. Cell Death Dis. 2018;9:1125 pubmed 出版商
Fauzia E, Barbhuyan T, Shrivastava A, Kumar M, Garg P, Khan M, et al. Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism. Front Pharmacol. 2018;9:1034 pubmed 出版商
Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, et al. PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin. Cell Death Dis. 2018;9:931 pubmed 出版商
Koenis D, Medzikovic L, van Loenen P, van Weeghel M, Huveneers S, Vos M, et al. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Cell Rep. 2018;24:2127-2140.e7 pubmed 出版商
Koenis D, Medzikovic L, Vos M, Beldman T, van Loenen P, Van Tiel C, et al. Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans. J Biol Chem. 2018;293:15070-15083 pubmed 出版商
Li B, Zhu Y, Sun Q, Yu C, Chen L, Tian Y, et al. Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling. Int J Mol Med. 2018;42:1391-1400 pubmed 出版商
Mekki M, Mougel A, Vinchent A, Paquet C, Copin M, Leroy C, et al. Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors. Oncotarget. 2018;9:27039-27058 pubmed 出版商
Hamann I, Krys D, Glubrecht D, Bouvet V, Marshall A, Vos L, et al. Expression and function of hexose transporters GLUT1, GLUT2, and GLUT5 in breast cancer-effects of hypoxia. FASEB J. 2018;32:5104-5118 pubmed 出版商
Niland S, Komljenovic D, Macas J, Bracht T, Bauerle T, Liebner S, et al. Rhodocetin-αβ selectively breaks the endothelial barrier of the tumor vasculature in HT1080 fibrosarcoma and A431 epidermoid carcinoma tumor models. Oncotarget. 2018;9:22406-22422 pubmed 出版商
Fukushima A, Zhang L, Huqi A, Lam V, Rawat S, Altamimi T, et al. Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism. JCI Insight. 2018;3: pubmed 出版商
Ferecatu I, Canal F, Fabbri L, Mazure N, Bouton C, Golinelli Cohen M. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1? activation. PLoS ONE. 2018;13:e0194782 pubmed 出版商
Cho J, Kim G, Mansfield B, Chou J. Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia. Biochem Biophys Res Commun. 2018;498:925-931 pubmed 出版商
Almiron Bonnin D, Havrda M, Lee M, Liu H, Zhang Z, Nguyen L, et al. Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia. Oncogene. 2018;37:1107-1118 pubmed 出版商
Goodwin J, Choi H, Hsieh M, Neugent M, Ahn J, Hayenga H, et al. Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018;58:216-231 pubmed 出版商
MacLauchlan S, Calabro N, Huang Y, Krishna M, Bancroft T, Sharma T, et al. HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2. Matrix Biol. 2018;65:45-58 pubmed 出版商
Lee S, Kim J, Lee J, Lee J, Han J. Non-invasive monitoring of the therapeutic response in sorafenib-treated hepatocellular carcinoma based on photoacoustic imaging. Eur Radiol. 2018;28:372-381 pubmed 出版商
Bok S, Kim Y, Woo Y, Kim S, Kang S, Lee Y, et al. Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice. Oncotarget. 2017;8:111508-111521 pubmed 出版商
Geoghegan F, Buckland R, Rogers E, Khalifa K, O Connor E, Rooney M, et al. Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells. Oncotarget. 2017;8:94711-94725 pubmed 出版商
Palazon A, Tyrakis P, Macías D, Veliça P, Rundqvist H, Fitzpatrick S, et al. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017;32:669-683.e5 pubmed 出版商
Palsson McDermott E, Dyck L, Zasłona Z, Menon D, McGettrick A, Mills K, et al. Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors. Front Immunol. 2017;8:1300 pubmed 出版商
Lee S, Kim J, Lee J, Zen Y, Han J. Imaging Monitoring of Kupffer Cell Function and Hepatic Oxygen Saturation in Preneoplastic Changes During Cholangiocarcinogenesis. Sci Rep. 2017;7:14203 pubmed 出版商
Domingo Gonzalez R, Das S, Griffiths K, Ahmed M, Bambousková M, Gopal R, et al. Interleukin-17 limits hypoxia-inducible factor 1? and development of hypoxic granulomas during tuberculosis. JCI Insight. 2017;2: pubmed 出版商
Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, et al. HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica. 2017;102:1956-1968 pubmed 出版商
Elder M, Webster S, Chee R, Williams D, Hill Gaston J, Goodall J. β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production. Front Immunol. 2017;8:791 pubmed 出版商
Tavernier S, Vanlangenakker N, Vetters J, Carmeliet P, Janssens S, Lambrecht B. Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages. J Leukoc Biol. 2017;102:1115-1126 pubmed 出版商
Zhang J, Wang Y, Chen J, Zhang X, Dong J, Tsang L, et al. Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis. Sci Rep. 2017;7:5233 pubmed 出版商
Papathanassiu A, Ko J, Imprialou M, Bagnati M, Srivastava P, Vu H, et al. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Nat Commun. 2017;8:16040 pubmed 出版商
Carlessi R, Chen Y, Rowlands J, Cruzat V, Keane K, Egan L, et al. GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation. Sci Rep. 2017;7:2661 pubmed 出版商
Goodwin J, Neugent M, Lee S, Choe J, Choi H, Jenkins D, et al. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017;8:15503 pubmed 出版商
Feigenson M, Eliseev R, Jonason J, Mills B, O Keefe R. PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism. J Cell Biochem. 2017;118:4383-4393 pubmed 出版商
Kowalski G, Kraakman M, Mason S, Murphy A, Bruce C. Resolution of glucose intolerance in long-term high-fat, high-sucrose-fed mice. J Endocrinol. 2017;233:269-279 pubmed 出版商
Evans C, Palazon A, Sim J, Tyrakis P, Prodger A, Lu X, et al. Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis. Biol Open. 2017;6:688-697 pubmed 出版商
Shen W, Yau B, Lee S, Zhu L, Yam M, Gillies M. Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions. Int J Mol Sci. 2017;18: pubmed 出版商
Mistry I, Tavassoli A. Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor. ACS Synth Biol. 2017;6:518-527 pubmed 出版商
McGettrick A, Corcoran S, Barry P, McFarland J, Crès C, Curtis A, et al. Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion. Proc Natl Acad Sci U S A. 2016;113:E7778-E7787 pubmed
Wang Y, Wang H, Li J, Entenberg D, Xue A, Wang W, et al. Direct visualization of the phenotype of hypoxic tumor cells at single cell resolution in vivo using a new hypoxia probe. Intravital. 2016;5: pubmed
Mills E, Kelly B, Logan A, Costa A, Varma M, Bryant C, et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167:457-470.e13 pubmed 出版商
Alonso J, Galán M, Martí Pàmies I, Romero J, Camacho M, Rodriguez C, et al. NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress. Sci Rep. 2016;6:34056 pubmed 出版商
Turlejski T, Humoud I, Desai R, Smith K, Marina N. Immunohistochemical evidence of tissue hypoxia and astrogliosis in the rostral ventrolateral medulla of spontaneously hypertensive rats. Brain Res. 2016;1650:178-183 pubmed 出版商
Prakash H, Nadella V, Singh S, Schmitz Winnenthal H. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep. 2016;6:31490 pubmed 出版商
Lampropoulou V, Sergushichev A, Bambousková M, Nair S, Vincent E, Loginicheva E, et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016;24:158-66 pubmed 出版商
Mirzamohammadi F, Papaioannou G, Inloes J, Rankin E, Xie H, Schipani E, et al. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047 pubmed 出版商
Pei L, Solis G, Nguyen M, Kamat N, Magenheimer L, Zhuo M, et al. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016;126:2509-18 pubmed 出版商
Tu D, Chang W, Lin S, Kuo C, Tsao Y, Lee C. Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor. Oncotarget. 2016;7:37513-37523 pubmed 出版商
Nüsken E, Wohlfarth M, Lippach G, Rauh M, Schneider H, Dotsch J, et al. Reduced Perinatal Leptin Availability May Contribute to Adverse Metabolic Programming in a Rat Model of Uteroplacental Insufficiency. Endocrinology. 2016;157:1813-25 pubmed 出版商
Kurihara T, Westenskow P, Gantner M, Usui Y, Schultz A, Bravo S, et al. Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. elife. 2016;5: pubmed 出版商
Farsijani N, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, et al. Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest. 2016;126:1425-37 pubmed 出版商
Chapple S, Keeley T, Mastronicola D, Arno M, Vizcay Barrena G, Fleck R, et al. Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels. Free Radic Biol Med. 2016;92:152-162 pubmed 出版商
Shum L, White N, Mills B, Bentley K, Eliseev R. Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation. Stem Cells Dev. 2016;25:114-22 pubmed 出版商
Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, et al. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015;23:1059-75 pubmed 出版商
Lojk J, Mis K, Pirkmajer S, Pavlin M. siRNA delivery into cultured primary human myoblasts--optimization of electroporation parameters and theoretical analysis. Bioelectromagnetics. 2015;36:551-63 pubmed 出版商
Niebler S, Angele P, Kujat R, Bosserhoff A. Hypoxia-Inducible Factor 1 Is an Inductor of Transcription Factor Activating Protein 2 Epsilon Expression during Chondrogenic Differentiation. Biomed Res Int. 2015;2015:380590 pubmed 出版商
Miao H, Chen L, Hao L, Zhang X, Chen Y, Ruan Z, et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. Sci Rep. 2015;5:13092 pubmed 出版商
Le Moan N, Baeten K, Rafalski V, Ryu J, Rios Coronado P, Bédard C, et al. Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease,. Eneuro. 2015;2: pubmed
Garhyan J, Bhuyan S, Pulu I, Kalita D, Das B, Bhatnagar R. Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy. Am J Pathol. 2015;185:1924-34 pubmed 出版商
Fan D, Coughlin L, Neubauer M, Kim J, Kim M, Zhan X, et al. Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization. Nat Med. 2015;21:808-14 pubmed 出版商
Kambayashi S, Igase M, Kobayashi K, Kimura A, Shimokawa Miyama T, Baba K, et al. Hypoxia inducible factor 1α expression and effects of its inhibitors in canine lymphoma. J Vet Med Sci. 2015;77:1405-12 pubmed 出版商
Qiao S, Dennis M, Song X, Vadysirisack D, Salunke D, Nash Z, et al. A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity. Nat Commun. 2015;6:7014 pubmed 出版商
Hribar K, Finlay D, Ma X, Qu X, Ondeck M, Chung P, et al. Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture. Lab Chip. 2015;15:2412-8 pubmed 出版商
Forsberg E, Botusan I, Wang J, Peters V, Ansurudeen I, Brismar K, et al. Carnosine decreases IGFBP1 production in db/db mice through suppression of HIF-1. J Endocrinol. 2015;225:159-67 pubmed 出版商
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther. 2015;15:313-25 pubmed
Hénique C, Mansouri A, Vavrova E, Lenoir V, Ferry A, Esnous C, et al. Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. FASEB J. 2015;29:2473-83 pubmed 出版商
Matak P, Heinis M, Mathieu J, Corriden R, Cuvellier S, Delga S, et al. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015;194:3259-66 pubmed 出版商
Teranishi Y, Matsubara T, Krausz K, Le T, Gonzalez F, Yoshizato K, et al. Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism. Lab Invest. 2015;95:515-24 pubmed 出版商
Nüsken E, Herrmann Y, Wohlfarth M, Goecke T, Appel S, Schneider H, et al. Strong hypoxia reduces leptin synthesis in purified primary human trophoblasts. Placenta. 2015;36:427-32 pubmed 出版商
Robin E, Marcillac F, Raddatz E. A hypoxic episode during cardiogenesis downregulates the adenosinergic system and alters the myocardial anoxic tolerance. Am J Physiol Regul Integr Comp Physiol. 2015;308:R614-26 pubmed 出版商
Chang E, Paterno J, Duscher D, Maan Z, Chen J, Januszyk M, et al. Exercise induces stromal cell-derived factor-1α-mediated release of endothelial progenitor cells with increased vasculogenic function. Plast Reconstr Surg. 2015;135:340e-50e pubmed 出版商
Palsson McDermott E, Curtis A, Goel G, Lauterbach M, Sheedy F, Gleeson L, et al. Pyruvate kinase M2 regulates Hif-1? activity and IL-1? induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21:65-80 pubmed 出版商
Tsuboi I, Yamashita T, Nagano M, Kimura K, To a Salazar G, Ohneda O. Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia. J Cell Physiol. 2015;230:1534-48 pubmed 出版商
Mai J, Wang F, Qiu Q, Tang B, Lin Y, Luo N, et al. Tachycardia pacing induces myocardial neovascularization and mobilizes circulating endothelial progenitor cells partly via SDF-1 pathway in canines. Heart Vessels. 2016;31:230-40 pubmed 出版商
Appel S, Turnwald E, Ankerne J, Wohlfarth M, Appel J, Rother E, et al. Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice. Reprod Sci. 2015;22:735-42 pubmed 出版商
Colegio O, Chu N, Szabo A, Chu T, Rhebergen A, Jairam V, et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014;513:559-63 pubmed 出版商
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图像 1 :
Novus Biologicals NB100-449 图像 1
Knockdown Validated: HIF-1 alpha Antibody [NB100-449] - Morphological alterations induced by DMOG are HIF-1alpha dependent. glEND.2 cells were stably transfected with shGFP, shHIF-1alpha or shHIF-2alpha. The clones were cultured under normoxic (N) or hypoxic (H, 1% O2) conditions, or treated with DMOG for 6 h. 30 ug protein of cellular protein were loaded for the detection of HIF-1alpha, and nuclear extracts (20 ug protein) were used for the detection of HIF-2alpha. Image collected and cropped by CiteAb from the following publication (http://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-80) licensed under a CC-BY licence.
产品信息
品牌 :
Novus
master code :
NB100-449
SKU号 :
NB100-449
产品名称 :
HIF-1甲抗体
描述 :
The HIF-1 alpha Antibody from Novus Biologicals is a rabbit polyclonal antibody to HIF-1 alpha. This antibody reacts with human, mouse, rat, canine, chicken, goat, primate, monkey. The HIF-1 alpha Antibody has been validated for the following applications: Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated, Knockdown Validated.
靶标 :
HIF-1甲
类别 :
一抗
单位尺寸 :
0.1毫升
缓冲液 :
TBS, 0.1% BSA
克隆性 :
多克隆
浓度 :
0.2毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
The immunogen recognized by this HIF-1 alpha Antibody maps to a region between residues 775 and the C-terminus (residue 826) of human hypoxia-inducible factor 1 [Uniprot# Q16665].
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
Human, Mouse, Rat, Canine, Chicken, Goat, Primate, Monkey
理论上的分子量 :
93 kDa
基因符号 :
缺氧诱导因子1A
catalog number base :
NB100-449
accessionNumbers :
Q16665
应用 :
Western Blot, Simple Western, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated, Knockdown Validated
2020美元 :
399
2021美元 :
399美元
别名 :
AINT, anti-HIF-1 alpha, anti-HIF1A, ARNT interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, HIF1, HIF-1 alpha, HIF1A, HIF-1A, HIF-1alpha, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1, PAS domain-containing protein 8, PASD8
储存 :
存放在4C。 不冻结
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。