产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
IkB-alpha Antibody (6A920) - BSA Free
目录 :
NB100-56507
规格 :
0.1 mg (also 0.025 mg)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
DyLight488
克隆名称 :
6A920
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 40
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 4
Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, et al. IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB. Int J Mol Med. 2016;37:347-58 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed 出版商
  • 免疫印迹; 人类
Ikeno H, Apel M, Zouboulis C, Luger T, Böhm M. L-Ascorbyl-2-phosphate attenuates NF-κB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion. Arch Dermatol Res. 2015;307:595-605 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠
Yang X, Zhao N, Liu Y, Hu B, Sun K, Chang X, et al. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury. Evid Based Complement Alternat Med. 2013;2013:728020 pubmed 出版商
  • 免疫细胞化学; 人类
Tabit C, Shenouda S, Holbrook M, Fetterman J, Kiani S, Frame A, et al. Protein kinase C-? contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 2013;127:86-95 pubmed 出版商
  • 免疫印迹; 人类
Endo T, Nishio M, Enzler T, Cottam H, Fukuda T, James D, et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 2007;109:703-10 pubmed
  • 免疫印迹; 小鼠
Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, et al. Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Toxicol Appl Pharmacol. 2006;217:35-42 pubmed
  • 免疫印迹; 人类
Strozyk E, Poppelmann B, Schwarz T, Kulms D. Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene. 2006;25:6239-51 pubmed
  • 免疫印迹; 小鼠
Perez Moreno M, Davis M, Wong E, Pasolli H, Reynolds A, Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell. 2006;124:631-44 pubmed
  • 免疫印迹; 人类
Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol. 2005;6:769-76 pubmed
  • 免疫印迹; 人类
Bernasconi D, Amici C, La Frazia S, Ianaro A, Santoro M. The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells. J Biol Chem. 2005;280:24127-34 pubmed
  • 免疫印迹; 人类
Saccani S, Pantano S, Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 2002;3:69-75 pubmed
  • 免疫印迹; 小鼠
Saccani S, Pantano S, Natoli G. Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med. 2001;193:1351-9 pubmed
Zeng L, Herdman D, Lee S, Tao A, Das M, Bertin S, et al. Loss of cAMP Signaling in CD11c Immune Cells Protects Against Diet-Induced Obesity. Diabetes. 2023;72:1235-1250 pubmed 出版商
Ohta S, Asanoma M, Irie N, Tachibana N, Kohno M. Soy Phospholipids Exert a Renoprotective Effect by Inhibiting the Nuclear Factor Kappa B Pathway in Macrophages. Metabolites. 2022;12: pubmed 出版商
Stanfield B, Purves T, Palmer S, Sullenger B, Welty Wolf K, Haines K, et al. IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages. PLoS ONE. 2021;16:e0245169 pubmed 出版商
Korgaonkar A, Nguyen S, Li Y, Sekhar D, Subramanian D, Guevarra J, et al. Distinct cellular mediators drive the Janus faces of toll-like receptor 4 regulation of network excitability which impacts working memory performance after brain injury. Brain Behav Immun. 2020;88:381-395 pubmed 出版商
Kamohara A, Hirata H, Xu X, Shiraki M, Yamada S, Zhang J, et al. IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2. Int Immunol. 2020;32:89-104 pubmed 出版商
Chen Z, Yao L, Liu Y, Pan Z, Peng S, Wan G, et al. Astragaloside IV regulates NF-κB-mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF-BB-induced activation. Exp Ther Med. 2019;18:3741-3750 pubmed 出版商
Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018;15:909-912 pubmed 出版商
Zhu F, Willette Brown J, Song N, Lomada D, Song Y, Xue L, et al. Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis. Cell Host Microbe. 2017;21:478-493.e7 pubmed 出版商
Tomasi M, Ramani K, Ryoo M. Ubiquitin-Conjugating Enzyme 9 Phosphorylation as a Novel Mechanism for Potentiation of the Inflammatory Response. Am J Pathol. 2016;186:2326-36 pubmed 出版商
Pejanovic N, Hochrainer K, Liu T, Aerne B, Soares M, Anrather J. Regulation of nuclear factor ?B (NF-?B) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). PLoS ONE. 2012;7:e42020 pubmed 出版商
Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed 出版商
Harikumar K, Sung B, Pandey M, Guha S, Krishnan S, Aggarwal B. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-27 pubmed 出版商
Yu M, Su L, Zou L, Liu Y, Wu N, Kong L, et al. An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells. Nat Immunol. 2008;9:898-907 pubmed 出版商
Nishioka C, Ikezoe T, Jing Y, Umezawa K, Yokoyama A. DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic ce. Immunology. 2008;124:198-205 pubmed 出版商
Shakibaei M, John T, Schulze Tanzil G, Lehmann I, Mobasheri A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007;73:1434-45 pubmed
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, et al. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007;13:70-7 pubmed
Santhi W, Sebastian P, Varghese B, Prakash O, Pillai M. NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins. Exp Mol Pathol. 2006;81:123-30 pubmed
Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, et al. A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J Exp Med. 2006;203:1481-92 pubmed
Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-13 pubmed
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Saccani S, Marazzi I, Beg A, Natoli G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med. 2004;200:107-13 pubmed
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产品信息
品牌 :
Novus
MasterCode :
NB100-56507
SKU号 :
NB100-56507
产品名称 :
IkB-alpha Antibody (6A920) - BSA Free
描述 :
The IkB-alpha Antibody (6A920) - BSA Free from NB100-56507 is a nb100-56507 antibody to . This antibody reacts with apoptosis, chaperone mediated autophagy (cma), diabetes research. The IkB-alpha Antibody (6A920) - BSA Free has been validated for the following applications: P25963.
靶标 :
IkB-alpha
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
6A920
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Partial recombinant protein corresponding to amino acid residues 32-291 of human IkB-alpha.
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠
基因符号 :
NFKBIA
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Knockout-Validated-NB100-56507-img0032.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Knockout-Validated-NB100-56507-img0032.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0031.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0031.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Immunocytochemistry-Immunofluorescence-NB100-56507-img0035.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Immunocytochemistry-Immunofluorescence-NB100-56507-img0035.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Immunohistochemistry-Paraffin-NB100-56507-img0036.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Immunohistochemistry-Paraffin-NB100-56507-img0036.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0034.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0034.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0028.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Western-Blot-NB100-56507-img0028.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0025.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0025.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0033.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Flow-Cytometry-NB100-56507-img0033.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Simple-Western-NB100-56507-img0024.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IkB-alpha-Antibody-(6A920)-Simple-Western-NB100-56507-img0024.jpg
accessionNumbers :
P25963
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, CyTOF-ready, Knockout Validated
美元 :
399美元
别名 :
alpha, I-kappa-B-alpha, IkappaBalphaNF-kappa-B inhibitor alpha, IKBAikB-alpha, IkB-alpha, MAD3, MAD-3, Major histocompatibility complex enhancer-binding protein MAD3, NFKBI, nuclear factor of kappa light chain gene enhancer in B-cells, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。