产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
IKK beta Antibody (10AG2) - BSA Free
目录 :
NB100-56509
规格 :
0.1 mg (also 0.025 mg)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10AG2
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 55
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| Beraza N, Ludde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology. 2007;132:2504-17 pubmed
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| Herrmann O, Baumann B, De Lorenzi R, Muhammad S, Zhang W, Kleesiek J, et al. IKK mediates ischemia-induced neuronal death. Nat Med. 2005;11:1322-9 pubmed
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| Shishodia S, Aggarwal B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148-58 pubmed
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| Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed
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| Leis H, Page A, Ramirez A, Bravo A, Segrelles C, Paramio J, et al. Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway. Mol Endocrinol. 2004;18:303-11 pubmed
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| Santos M, Perez P, Segrelles C, Ruiz S, Jorcano J, Paramio J. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J Biol Chem. 2003;278:13422-30 pubmed
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Kirkley K, Walton K, Duncan C, Tjalkens R. Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2. Comp Med. 2017;67:407-415 pubmed
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Lamothe B, Webster W, Gopinathan A, Besse A, Campos A, Darnay B. TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun. 2007;359:1044-9 pubmed
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Vunta H, Davis F, Palempalli U, Bhat D, Arner R, Thompson J, et al. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. J Biol Chem. 2007;282:17964-73 pubmed
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Leis H, Sanchis A, Perez P. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway. Exp Cell Res. 2007;313:742-52 pubmed
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Jackson Bernitsas D, Ichikawa H, Takada Y, Myers J, Lin X, Darnay B, et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007;26:1385-97 pubmed
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Sethi G, Ahn K, Sandur S, Lin X, Chaturvedi M, Aggarwal B. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425-35 pubmed
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Sandur S, Ichikawa H, Sethi G, Ahn K, Aggarwal B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemoth. J Biol Chem. 2006;281:17023-33 pubmed
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Ichikawa H, Aggarwal B. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006;12:662-8 pubmed
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Nenci A, Huth M, Funteh A, Schmidt Supprian M, Bloch W, Metzger D, et al. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet. 2006;15:531-42 pubmed
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Takada Y, Gillenwater A, Ichikawa H, Aggarwal B. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J Biol Chem. 2006;281:5612-22 pubmed
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Shishodia S, Gutierrez A, Lotan R, Aggarwal B. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer Res. 2005;65:9555-65 pubmed
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Shishodia S, Amin H, Lai R, Aggarwal B. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005;70:700-13 pubmed
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Ichikawa H, Takada Y, Murakami A, Aggarwal B. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005;174:7383-92 pubmed
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Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt Supprian M, et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005;115:849-59 pubmed
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Shishodia S, Koul D, Aggarwal B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004;173:2011-22 pubmed
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Takada Y, Fang X, Jamaluddin M, Boyd D, Aggarwal B. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004;279:39541-54 pubmed
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Takada Y, Khuri F, Aggarwal B. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:26287-99 pubmed
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Takada Y, Aggarwal B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem. 2004;279:4750-9 pubmed
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Majumdar S, Aggarwal B. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene. 2003;22:1206-18 pubmed
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Ashikawa K, Majumdar S, Banerjee S, Bharti A, Shishodia S, Aggarwal B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002;169:6490-7 pubmed
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Anto R, Mukhopadhyay A, Shishodia S, Gairola C, Aggarwal B. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002;23:1511-8 pubmed
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Majumdar S, Lamothe B, Aggarwal B. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol. 2002;168:2644-51 pubmed
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Majumdar S, Aggarwal B. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001;167:2911-20 pubmed
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Miller B, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001;276:36320-6 pubmed
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Manna S, Mukhopadhyay A, Aggarwal B. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-9 pubmed
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产品信息
品牌 :
Novus
MasterCode :
NB100-56509
SKU号 :
NB100-56509
产品名称 :
IKK beta Antibody (10AG2) - BSA Free
描述 :
The IKK beta Antibody (10AG2) - BSA Free from NB100-56509 is a nb100-56509 antibody to . This antibody reacts with cancer, immunology, innate immunity, mtor pathway, protein kinase. The IKK beta Antibody (10AG2) - BSA Free has been validated for the following applications: O14920.
靶标 :
IKK乙
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
10AG2
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
全长重组人类IKK乙蛋白(NP_001547)
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠
理论上的分子量 :
87 kDa
基因符号 :
IKBKB
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunohistochemistry-Paraffin-NB100-56509-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunohistochemistry-Paraffin-NB100-56509-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Simple-Western-NB100-56509-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Simple-Western-NB100-56509-img0008.jpg
accessionNumbers :
O14920
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunoblotting, CyTOF-ready
美元 :
399美元
别名 :
EC 2.7.11, EC 2.7.11.10, I-kappa-B kinase 2, I-kappa-B-kinase beta, IkBKB, IKK2FLJ38368, IKK-B, IKK-betaFLJ36218, IKKBFLJ40509, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa-B kinase subunit beta, MGC131801, NFKBIKBFLJ33771, Nuclear factor NF-kappa-B inhibitor kinase beta
储存 :
存放在-20C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。