产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
IKK beta Antibody (10AG2) - BSA Free
目录 :
NB100-56509
规格 :
0.1 mg (also 0.025 mg)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10AG2
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 55
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:75; 图 s2a
Reid M, Lowman X, Pan M, Tran T, Warmoes M, Ishak Gabra M, et al. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016;30:1837-51 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Buhrmann C, Büsch F, Shayan P, Shakibaei M. Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J Biol Chem. 2014;289:22048-62 pubmed 出版商
  • 免疫印迹; 小鼠
Das U, Manna K, Sinha M, Datta S, Das D, Chakraborty A, et al. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS ONE. 2014;9:e97599 pubmed 出版商
  • 免疫细胞化学; 小鼠
Paul S, Traver M, Kashyap A, Washington M, Latoche J, Schaefer B. T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome. Sci Signal. 2014;7:ra45 pubmed 出版商
  • 免疫印迹; 人类
Breuer R, Becker M, Brechmann M, Mock T, Arnold R, Krammer P. The protein phosphatase 2A regulatory subunit B56? mediates suppression of T cell receptor (TCR)-induced nuclear factor-?B (NF-?B) activity. J Biol Chem. 2014;289:14996-5004 pubmed 出版商
  • 免疫印迹; 小鼠
Gray C, Remouchamps C, McCorkell K, Solt L, Dejardin E, Orange J, et al. Noncanonical NF-?B signaling is limited by classical NF-?B activity. Sci Signal. 2014;7:ra13 pubmed 出版商
  • 免疫印迹; 人类
Ren T, Takahashi Y, Liu X, Loughran T, Sun S, Wang H, et al. HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains. Oncogene. 2015;34:334-45 pubmed 出版商
  • 免疫印迹; 人类
Bimonte S, Barbieri A, Palma G, Luciano A, Rea D, Arra C. Curcumin inhibits tumor growth and angiogenesis in an orthotopic mouse model of human pancreatic cancer. Biomed Res Int. 2013;2013:810423 pubmed 出版商
  • 免疫印迹; 小鼠
Page A, Cascallana J, Casanova M, Navarro M, Alameda J, Perez P, et al. IKK? overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia. Mol Cancer Res. 2011;9:1329-38 pubmed 出版商
  • 免疫细胞化学; 小鼠
Koch K, Maeda S, He G, Karin M, Leffert H. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochem Biophys Res Commun. 2009;380:349-54 pubmed 出版商
  • 免疫印迹; 人类
Huang J, Ren T, Guan H, Jiang Y, Cheng H. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J Biol Chem. 2009;284:6208-17 pubmed 出版商
  • 免疫印迹; 人类
Pandey M, Sung B, Kunnumakkara A, Sethi G, Chaturvedi M, Aggarwal B. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res. 2008;68:5370-9 pubmed 出版商
  • 免疫印迹; 人类
Kasinski A, Du Y, Thomas S, Zhao J, Sun S, Khuri F, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008;74:654-61 pubmed 出版商
  • 免疫沉淀; 小鼠
Beraza N, Ludde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology. 2007;132:2504-17 pubmed
  • 免疫印迹; 小鼠
Herrmann O, Baumann B, De Lorenzi R, Muhammad S, Zhang W, Kleesiek J, et al. IKK mediates ischemia-induced neuronal death. Nat Med. 2005;11:1322-9 pubmed
  • 免疫印迹; 人类
Shishodia S, Aggarwal B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148-58 pubmed
  • 免疫印迹; 人类
Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed
  • 免疫印迹; 小鼠
Leis H, Page A, Ramirez A, Bravo A, Segrelles C, Paramio J, et al. Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway. Mol Endocrinol. 2004;18:303-11 pubmed
  • 免疫印迹; 小鼠
Santos M, Perez P, Segrelles C, Ruiz S, Jorcano J, Paramio J. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J Biol Chem. 2003;278:13422-30 pubmed
Karim K, Giribabu N, Salleh N. Marantodes pumilum Var Alata (Kacip Fatimah) ameliorates derangement in RANK/RANKL/OPG pathway and reduces inflammation and oxidative stress in the bone of estrogen-deficient female rats with type-2 diabetes. Phytomedicine. 2021;91:153677 pubmed 出版商
Best K, Nichols A, Knapp E, Hammert W, Ketonis C, Jonason J, et al. NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival. Sci Signal. 2020;13: pubmed 出版商
Rahtes A, Li L. Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin. Front Immunol. 2020;11:1478 pubmed 出版商
Sun L, Lin P, Chen Y, Yu H, Ren S, Wang J, et al. miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism. Theranostics. 2020;10:5581-5599 pubmed 出版商
De S, Karim F, Kiessu E, Cushing L, Lin L, Ghandil P, et al. Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling. J Biol Chem. 2018;293:15208-15220 pubmed 出版商
Abdi K, Lai C, Paez Gonzalez P, Lay M, Pyun J, Kuo C. Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus. Nat Commun. 2018;9:1655 pubmed 出版商
Kirkley K, Walton K, Duncan C, Tjalkens R. Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2. Comp Med. 2017;67:407-415 pubmed
Cleary M, Mansoor A, Settelmeyer T, Ijiri Y, Ladner K, Svalina M, et al. NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017;10:1109-1115 pubmed 出版商
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, et al. Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell. 2016;167:1052-1066.e18 pubmed 出版商
Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed 出版商
Harikumar K, Sung B, Pandey M, Guha S, Krishnan S, Aggarwal B. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-27 pubmed 出版商
Jin H, Lee D, Kim D, Chung J, Lee S, Lee T. cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. Cancer Res. 2009;69:1782-91 pubmed 出版商
Lamothe B, Webster W, Gopinathan A, Besse A, Campos A, Darnay B. TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation. Biochem Biophys Res Commun. 2007;359:1044-9 pubmed
Vunta H, Davis F, Palempalli U, Bhat D, Arner R, Thompson J, et al. The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages. J Biol Chem. 2007;282:17964-73 pubmed
Leis H, Sanchis A, Perez P. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway. Exp Cell Res. 2007;313:742-52 pubmed
Jackson Bernitsas D, Ichikawa H, Takada Y, Myers J, Lin X, Darnay B, et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007;26:1385-97 pubmed
Sethi G, Ahn K, Sandur S, Lin X, Chaturvedi M, Aggarwal B. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425-35 pubmed
Sandur S, Ichikawa H, Sethi G, Ahn K, Aggarwal B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemoth. J Biol Chem. 2006;281:17023-33 pubmed
Ichikawa H, Aggarwal B. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006;12:662-8 pubmed
Nenci A, Huth M, Funteh A, Schmidt Supprian M, Bloch W, Metzger D, et al. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling. Hum Mol Genet. 2006;15:531-42 pubmed
Takada Y, Gillenwater A, Ichikawa H, Aggarwal B. Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J Biol Chem. 2006;281:5612-22 pubmed
Shishodia S, Gutierrez A, Lotan R, Aggarwal B. N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products. Cancer Res. 2005;65:9555-65 pubmed
Shishodia S, Amin H, Lai R, Aggarwal B. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005;70:700-13 pubmed
Ichikawa H, Takada Y, Murakami A, Aggarwal B. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005;174:7383-92 pubmed
Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt Supprian M, et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005;115:849-59 pubmed
Shishodia S, Koul D, Aggarwal B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004;173:2011-22 pubmed
Takada Y, Fang X, Jamaluddin M, Boyd D, Aggarwal B. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004;279:39541-54 pubmed
Takada Y, Khuri F, Aggarwal B. Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:26287-99 pubmed
Takada Y, Aggarwal B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem. 2004;279:4750-9 pubmed
Majumdar S, Aggarwal B. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene. 2003;22:1206-18 pubmed
Ashikawa K, Majumdar S, Banerjee S, Bharti A, Shishodia S, Aggarwal B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002;169:6490-7 pubmed
Anto R, Mukhopadhyay A, Shishodia S, Gairola C, Aggarwal B. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002;23:1511-8 pubmed
Majumdar S, Lamothe B, Aggarwal B. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol. 2002;168:2644-51 pubmed
Majumdar S, Aggarwal B. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001;167:2911-20 pubmed
Miller B, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001;276:36320-6 pubmed
Manna S, Mukhopadhyay A, Aggarwal B. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-9 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-56509
SKU号 :
NB100-56509
产品名称 :
IKK beta Antibody (10AG2) - BSA Free
描述 :
The IKK beta Antibody (10AG2) - BSA Free from NB100-56509 is a nb100-56509 antibody to . This antibody reacts with cancer, immunology, innate immunity, mtor pathway, protein kinase. The IKK beta Antibody (10AG2) - BSA Free has been validated for the following applications: O14920.
靶标 :
IKK乙
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
10AG2
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
全长重组人类IKK乙蛋白(NP_001547)
抗体亚型 :
IgG1
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠
理论上的分子量 :
87 kDa
基因符号 :
IKBKB
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0015.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunohistochemistry-Paraffin-NB100-56509-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunohistochemistry-Paraffin-NB100-56509-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Western-Blot-NB100-56509-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Immunocytochemistry-Immunofluorescence-NB100-56509-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Flow-Cytometry-NB100-56509-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Simple-Western-NB100-56509-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/IKK-beta-Antibody-(10AG2)-Simple-Western-NB100-56509-img0008.jpg
accessionNumbers :
O14920
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunoblotting, CyTOF-ready
美元 :
399美元
别名 :
EC 2.7.11, EC 2.7.11.10, I-kappa-B kinase 2, I-kappa-B-kinase beta, IkBKB, IKK2FLJ38368, IKK-B, IKK-betaFLJ36218, IKKBFLJ40509, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa-B kinase subunit beta, MGC131801, NFKBIKBFLJ33771, Nuclear factor NF-kappa-B inhibitor kinase beta
储存 :
存放在-20C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。