产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
雄激素R/NR3C4[p Ser213, p Ser210]抗体(156C135.2)
目录 :
NB100-56603
规格 :
0.1 mg (also 0.025 mg)
价格 :
379美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
156C135.2
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类
Chen S, Gulla S, Cai C, Balk S. Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation. J Biol Chem. 2012;287:8571-83 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Cai H, Smith D, Memarzadeh S, Lowell C, Cooper J, Witte O. Differential transformation capacity of Src family kinases during the initiation of prostate cancer. Proc Natl Acad Sci U S A. 2011;108:6579-84 pubmed 出版商
  • 免疫印迹; 人类
Paliouras M, Diamandis E. An AKT activity threshold regulates androgen-dependent and androgen-independent PSA expression in prostate cancer cell lines. Biol Chem. 2008;389:773-80 pubmed 出版商
Grypari I, Logotheti S, Zolota V, Troncoso P, Efstathiou E, Bravou V, et al. The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression. Medicine (Baltimore). 2021;100:e27094 pubmed 出版商
McAllister M, McCall P, Dickson A, Underwood M, Andersen D, Holmes E, et al. Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer. Prostate Cancer Prostatic Dis. 2020;: pubmed 出版商
Hellwinkel J, Redzic J, Harland T, Gunaydin D, Anchordoquy T, Graner M. Glioma-derived extracellular vesicles selectively suppress immune responses. Neuro Oncol. 2016;18:497-506 pubmed 出版商
Zellweger T, Stürm S, Rey S, Zlobec I, Gsponer J, Rentsch C, et al. Estrogen receptor ? expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naive prostate cancer and are elevated in castration-resistant disease. Endocr Relat Cancer. 2013;20:403-13 pubmed 出版商
Kasina S, Macoska J. The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor. Mol Cell Endocrinol. 2012;351:249-63 pubmed 出版商
Varisli L, Gonen Korkmaz C, Syed H, Bogurcu N, Debelec Butuner B, Erbaykent Tepedelen B, et al. Androgen regulated HN1 leads proteosomal degradation of androgen receptor (AR) and negatively influences AR mediated transactivation in prostate cells. Mol Cell Endocrinol. 2012;350:107-17 pubmed 出版商
Palazzolo I, Burnett B, Young J, Brenne P, La Spada A, Fischbeck K, et al. Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity. Hum Mol Genet. 2007;16:1593-603 pubmed
Lin S, Chang D, Ying S. Hyaluronan stimulates transformation of androgen-independent prostate cancer. Carcinogenesis. 2007;28:310-20 pubmed
Kirkegaard T, Edwards J, Tovey S, McGlynn L, Krishna S, Mukherjee R, et al. Observer variation in immunohistochemical analysis of protein expression, time for a change?. Histopathology. 2006;48:787-94 pubmed
Agapova O, Malone P, Hernandez M. A neuroactive steroid 5alpha-androstane-3alpha,17beta-diol regulates androgen receptor level in astrocytes. J Neurochem. 2006;98:355-63 pubmed
Lin H, Hu Y, Yang L, Altuwaijri S, Chen Y, Kang H, et al. Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem. 2003;278:50902-7 pubmed
图像
图像 1 :
Novus Biologicals NB100-56603 图像 1
Western Blot: Androgen R/NR3C4 [p Ser213, p Ser210] Antibody (156C135.2) [NB100-56603] - Analysis using Azide Free version of NB100-56603. LNCaP cells (passage number 38) were serum-starved for 2 days. After serum starvation, cells were (A) left untreated, (B) treated with 100 ng/ml IGF-1 for 4h, or (C) incubated with 20 um LY294002 for 30 mi
产品信息
品牌 :
Novus
master code :
NB100-56603
SKU号 :
NB100-56603
产品名称 :
雄激素R/NR3C4[p Ser213, p Ser210]抗体(156C135.2)
描述 :
The Androgen R/NR3C4 [p Ser213, p Ser210] Antibody (156C135.2) from Novus Biologicals is a mouse monoclonal antibody to Androgen R/NR3C4. This antibody reacts with human, mouse, rat, canine, primate. The Androgen R/NR3C4 [p Ser213, p Ser210] Antibody (156C135.2) has been validated for the following applications: Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin.
靶标 :
雄激素R/NR3C4
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
156C135.2
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
This antibody was developed against a synthetic peptide corresponding to amino acids 207-221 (GRAREAS*GAPTSSKD) of human androgen receptor, containing the serine 213 phosphorylation site: GenBank Accession No. A39248. Note: S* refers to phosphorylated serine in the peptide sequence.
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠, 狗, 灵长类动物
特异性 :
In IGF-1 stimulated LNCaP cells (passage number 38), a ~110 kDa band was observed. Please see Lin et al. 2003 for additional details. The serine phosphorylation site recognized by this antibody has been alternatively referred to Ser213 (Lee and Chang, 2003) and Ser210 (Lin et al, 2003). Variations in denotation can arise from how the sequence is counted in various GenBank accession numbers. The site is denoted as Ser213 in GenBank Accession No. A39248, which was used to design the immunogen.
基因符号 :
AR
catalog number base :
NB100-56603
accessionNumbers :
P10275
应用 :
免疫印迹, 免疫组化, 免疫组化石蜡
美元2021 :
349
美元2022 :
379美元
atl names :
AIS, androgen receptor, DHTRTFM, Dihydrotestosterone receptorHYSP1, HUMARA, NR3C4KD, Nuclear receptor subfamily 3 group C member 4, SMAX1SBMA, spinal and bulbar muscular atrophy
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。