产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
p73 Antibody (5B1288) - BSA Free
目录 :
NB100-56674
规格 :
0.1 mg (also 0.025 mg)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5B1288
反应物种 :
人类, 小鼠, brewer's yeast
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 61
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; brewer's yeast; 图 5d
Billant O, Léon A, Le Guellec S, Friocourt G, Blondel M, Voisset C. The dominant-negative interplay between p53, p63 and p73: A family affair. Oncotarget. 2016;7:69549-69564 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 e1
  • 染色质免疫沉淀 ; 小鼠; 图 e5
Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015;517:626-30 pubmed 出版商
  • 免疫印迹; 人类
Lu H, Yan C, Quan X, Yang X, Zhang J, Bian Y, et al. CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia. 2014;16:789-800 pubmed 出版商
  • 免疫沉淀; 小鼠
King K, Reddi D, Ponnamperuma R, Gerdes M, Weinberg W. Dysregulated ?Np63? negatively regulates the maspin promoter in keratinocytes via blocking endogenous p73 binding. Mol Carcinog. 2014;53:698-710 pubmed 出版商
  • 免疫组化; 小鼠
Lin Y, Sengupta S, Gurdziel K, Bell G, Jacks T, Flores E. p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet. 2009;5:e1000680 pubmed 出版商
  • 免疫印迹; 人类
Thottassery J, Westbrook L, Someya H, Parker W. c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. Mol Cancer Ther. 2006;5:400-10 pubmed
  • 免疫印迹; 人类
Sayan A, Paradisi A, Vojtesek B, Knight R, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005;330:186-93 pubmed
Gao M, Liu H, Xiao Y, Guo Y, Wan X, Li X, et al. xCT regulates redox homeostasis and promotes photoreceptor survival after retinal detachment. Free Radic Biol Med. 2020;158:32-43 pubmed 出版商
Long Y, Tao H, Karachi A, Grippin A, Jin L, Chang Y, et al. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res. 2020;80:499-509 pubmed 出版商
Wu W, Sun H, Chen J, OuYang H, Yu X, Chen H, et al. Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer. Cancer Immunol Res. 2019;7:1605-1618 pubmed 出版商
Pitman K, Alluri S, Kristian A, Aarnes E, Lyng H, Riss P, et al. Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. Eur J Nucl Med Mol Imaging. 2019;46:2190-2198 pubmed 出版商
Isobe S, Kataoka M, Endo J, Moriyama H, Okazaki S, Tsuchihashi K, et al. Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019;: pubmed 出版商
Ungard R, Linher Melville K, Nashed M, Sharma M, Wen J, Singh G. xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain. Mol Pain. 2019;15:1744806918822185 pubmed 出版商
Li C, Chen H, Lan Z, He S, Chen R, Wang F, et al. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019;: pubmed 出版商
Greenwood H, McCormick P, Gendron T, Glaser M, Pereira R, Maddocks O, et al. Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography. Clin Cancer Res. 2019;25:2471-2482 pubmed 出版商
Mi D, Dixit S, Warner T, Kennard J, Scharf D, Kessler E, et al. Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging. 2018;71:241-254 pubmed 出版商
Miladinovic T, Ungard R, Linher Melville K, Popovic S, Singh G. Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain. Mol Pain. 2018;14:1744806918776467 pubmed 出版商
Hoehne A, James M, Alam I, Ronald J, Schneider B, D Souza A, et al. [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. J Neuroinflammation. 2018;15:55 pubmed 出版商
Bechard A, Hamor P, Schwendt M, Knackstedt L. The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens. Psychopharmacology (Berl). 2018;235:837-848 pubmed 出版商
Nasca C, Bigio B, Zelli D, De Angelis P, Lau T, Okamoto M, et al. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. 2017;96:402-413.e5 pubmed 出版商
Sayin V, LeBoeuf S, Singh S, Davidson S, Biancur D, Guzelhan B, et al. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. elife. 2017;6: pubmed 出版商
Ng K, Chan L, Chai S, Tong M, Guan X, Lee N, et al. TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma. Cancer Res. 2017;77:4602-4612 pubmed 出版商
Bertaux Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, et al. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol. 2017;242:463-475 pubmed 出版商
Lacrosse A, O Donovan S, Sepulveda Orengo M, McCullumsmith R, Reissner K, Schwendt M, et al. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. J Neurosci. 2017;37:5809-5821 pubmed 出版商
Suárez Pozos E, Martínez Lozada Z, Méndez Flores O, Guillem A, Hernández Kelly L, Castelán F, et al. Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells. Neurochem Int. 2017;108:52-59 pubmed 出版商
Martin C, Patel M, Melendez Ferro M, Sims B. Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc. Exp Cell Res. 2017;352:202-206 pubmed 出版商
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed 出版商
Kavanaugh G, Williams J, Morris A, Nickels M, Walker R, Koglin N, et al. Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population. Mol Imaging Biol. 2016;18:924-934 pubmed
Polewski M, Reveron Thornton R, Cherryholmes G, Marinov G, Cassady K, Aboody K. Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Mol Cancer Res. 2016;14:1229-1242 pubmed
Linher Melville K, Nashed M, Ungard R, Haftchenary S, Rosa D, Gunning P, et al. Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity. PLoS ONE. 2016;11:e0161202 pubmed 出版商
Slosky L, Bassirirad N, Symons A, Thompson M, Doyle T, Forte B, et al. The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. Pain. 2016;157:2605-2616 pubmed
Soria F, Zabala A, Pampliega O, Palomino A, Miguelez C, Ugedo L, et al. Cystine/glutamate antiporter blockage induces myelin degeneration. Glia. 2016;64:1381-95 pubmed 出版商
Pati D, Kelly K, Stennett B, Frazier C, Knackstedt L. Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release. Eur J Neurosci. 2016;44:1896-905 pubmed 出版商
Von Grabowiecki Y, Abreu P, Blanchard O, Palamiuc L, Benosman S, Mériaux S, et al. Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63. elife. 2016;5: pubmed 出版商
Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin Arbelet V, Holmseth S, et al. Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed. J Comp Neurol. 2016;524:1015-32 pubmed 出版商
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112:E4600-9 pubmed 出版商
Merckx E, Demuyser T, Bentea E, Van Liefferinge J, Albertini G, Deneyer L, et al. Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻. Neurosci Lett. 2015;593:124-8 pubmed 出版商
Rao P, Saternos H, Goodwani S, Sari Y. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Psychopharmacology (Berl). 2015;232:2333-42 pubmed 出版商
Aal Aaboda M, Alhaddad H, Osowik F, Nauli S, Sari Y. Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats. J Neurosci Res. 2015;93:930-7 pubmed 出版商
Martin L, Gardner L. Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11. Oncogene. 2015;34:4211-8 pubmed 出版商
Guerrieri F, Piconese S, Lacoste C, Schinzari V, Testoni B, Valogne Y, et al. The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells. Cell Death Dis. 2013;4:e807 pubmed 出版商
Du W, Jiang P, Mancuso A, Stonestrom A, Brewer M, Minn A, et al. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol. 2013;15:991-1000 pubmed 出版商
Niemantsverdriet M, Nagle P, Chiu R, Langendijk J, Kampinga H, Coppes R. ?Np73 enhances promoter activity of TGF-? induced genes. PLoS ONE. 2012;7:e50815 pubmed 出版商
Leonard M, Kommagani R, Payal V, Mayo L, Shamma H, Kadakia M. ?Np63? regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ. 2011;18:1924-33 pubmed 出版商
Rosenbluth J, Johnson K, Tang L, Triplett T, Pietenpol J. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009;8:3702-6 pubmed
Kommagani R, Whitlatch A, Leonard M, Kadakia M. p73 is essential for vitamin D-mediated osteoblastic differentiation. Cell Death Differ. 2010;17:398-407 pubmed 出版商
Rosenbluth J, Mays D, Pino M, Tang L, Pietenpol J. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008;28:5951-64 pubmed 出版商
Jones E, Dickman M, Whitmarsh A. Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Biochem J. 2007;405:617-23 pubmed
Limesand K, Schwertfeger K, Anderson S. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006;26:8840-56 pubmed
Belloni L, Moretti F, Merlo P, Damalas A, Costanzo A, Blandino G, et al. DNp73alpha protects myogenic cells from apoptosis. Oncogene. 2006;25:3606-12 pubmed
Lunghi P, Costanzo A, Salvatore L, Noguera N, Mazzera L, Tabilio A, et al. MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis. Blood. 2006;107:4549-53 pubmed
Accardi R, Dong W, Smet A, Cui R, Hautefeuille A, Gabet A, et al. Skin human papillomavirus type 38 alters p53 functions by accumulation of deltaNp73. EMBO Rep. 2006;7:334-40 pubmed
Kulesz Martin M, Lagowski J, Fei S, Pelz C, Sears R, Powell M, et al. Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc. 2005;10:142-52 pubmed
Tomasini R, Seux M, Nowak J, Bontemps C, Carrier A, Dagorn J, et al. TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene. 2005;24:8093-104 pubmed
Merlo P, Fulco M, Costanzo A, Mangiacasale R, Strano S, Blandino G, et al. A role of p73 in mitotic exit. J Biol Chem. 2005;280:30354-60 pubmed
Papoutsaki M, Lanza M, Marinari B, Nistico S, Moretti F, Levrero M, et al. The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene. J Invest Dermatol. 2004;123:1162-8 pubmed
Lunghi P, Costanzo A, Levrero M, Bonati A. Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells. Blood. 2004;104:519-25 pubmed
Tullo A, Mastropasqua G, Bourdon J, Centonze P, Gostissa M, Costanzo A, et al. Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target. Oncogene. 2003;22:8738-48 pubmed
Fulco M, Costanzo A, Merlo P, Mangiacasale R, Strano S, Blandino G, et al. p73 is regulated by phosphorylation at the G2/M transition. J Biol Chem. 2003;278:49196-202 pubmed
Vella V, Zhu J, Frasca F, Li C, Vigneri P, Vigneri R, et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003;278:25151-7 pubmed
Costanzo A, Merlo P, Pediconi N, Fulco M, Sartorelli V, Cole P, et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol Cell. 2002;9:175-86 pubmed
产品信息
品牌 :
Novus
MasterCode :
NB100-56674
SKU号 :
NB100-56674
产品名称 :
p73 Antibody (5B1288) - BSA Free
描述 :
The p73 Antibody (5B1288) - BSA Free from NB100-56674 is a nb100-56674 antibody to . This antibody reacts with apoptosis, cancer, tumor suppressors. The p73 Antibody (5B1288) - BSA Free has been validated for the following applications: O15350.
靶标 :
p73
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
5B1288
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
This antibody was raised against full-length human p73. The epitope is thought to lie around the center of the molecule (NP_005418).
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠
特异性 :
It reacts with alpha, beta, gamma and delta isoforms of mouse and human p73 as well as the dominant negative p73 (Costanzo, et al, 2002)
理论上的分子量 :
73 kDa
基因符号 :
TP73
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Immunohistochemistry-Paraffin-NB100-56674-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Immunohistochemistry-Paraffin-NB100-56674-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Immunohistochemistry-Paraffin-NB100-56674-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Immunohistochemistry-Paraffin-NB100-56674-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p73-Antibody-(5B1288)-Western-Blot-NB100-56674-img0006.jpg
accessionNumbers :
O15350
应用 :
免疫印迹, 染色质免疫沉淀 , 免疫组化, 免疫细胞化学/免疫荧光, 免疫沉淀, 免疫组化石蜡, 染色质免疫沉淀 (ChIP)
美元 :
399美元
别名 :
p53-related protein, P73p53-like transcription factor, TA p73, TAp73, tumor protein p73
储存 :
存放在-20C。 避免冻融循环
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。