产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Caspase-3 Antibody (31A1067) - (Pro and Active)
目录 :
NB100-56708
规格 :
0.1 mg (also 0.025 mg)
价格 :
379美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
31A1067
反应物种 :
仓鼠, 人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 157
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4
Chen N, Chyau C, Lee Y, Tseng H, Chou F. Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells. Sci Rep. 2016;6:20417 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
  • 免疫印迹; 人类
Jaworski S, Sawosz E, Kutwin M, Wierzbicki M, Hinzmann M, Grodzik M, et al. In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma. Int J Nanomedicine. 2015;10:1585-96 pubmed 出版商
  • 免疫印迹; 仓鼠
Roobol A, Roobol J, Bastide A, Knight J, Willis A, Smales C. p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015;465:213-25 pubmed 出版商
  • 免疫印迹; 人类
Liu T, Lo H, Wei L, Hsiao H, Yang P. S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells. Anticancer Drugs. 2015;26:139-47 pubmed 出版商
  • 免疫印迹; 人类
Xia M, Meng G, Jiang A, Chen A, Dahlhaus M, Gonzalez P, et al. Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Oncotarget. 2014;5:3907-18 pubmed
  • 免疫印迹; 人类; 图 1c
Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, et al. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014;5:e1316 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1
Kaneko Y, Ota A, Nakashima A, Nagasaki H, Kodani Y, Mori K, et al. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G? phase and protects them from UV light-induced apoptosis. J Neural Transm (Vienna). 2015;122:187-99 pubmed 出版商
  • 免疫印迹; 人类
Yi L, Zongyuan Y, Cheng G, Lingyun Z, Guilian Y, Wei G. Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pa. Cancer Sci. 2014;105:520-7 pubmed 出版商
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Lin W, Tsai H, Liao H, Tang C, Wu Y, Hsu P, et al. Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP. Cell Death Dis. 2014;5:e1109 pubmed 出版商
  • 免疫印迹; 人类
Chen C, Chen M, Wang J, Tsai A, Chen C, Liou J, et al. Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. Clin Cancer Res. 2014;20:1274-1287 pubmed 出版商
  • 免疫印迹; 小鼠
Mukherjee S, Chowdhury D, Kotcherlakota R, Patra S, B V, Bhadra M, et al. Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system). Theranostics. 2014;4:316-35 pubmed 出版商
  • 免疫组化; 小鼠
Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana M. RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience. 2014;265:253-62 pubmed 出版商
  • 免疫印迹; 人类
Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014;33:3 pubmed 出版商
  • 免疫印迹; 人类
Paul S, Kundu R. Antiproliferative activity of methanolic extracts from two green algae, Enteromorpha intestinalis and Rizoclonium riparium on HeLa cells. Daru. 2013;21:72 pubmed 出版商
  • 免疫印迹; 人类
Tsai A, Pai H, Wang C, Liou J, Teng C, Wang J, et al. In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells. Br J Pharmacol. 2014;171:122-33 pubmed 出版商
  • 免疫印迹; 人类
Weissinger D, Tagscherer K, Macher Göppinger S, Haferkamp A, Wagener N, Roth W. The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol Cancer. 2013;12:120 pubmed 出版商
  • 免疫印迹; 人类
Kant S, Kumar A, Singh S. Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype. Biochim Biophys Acta. 2014;1840:294-302 pubmed 出版商
  • 免疫细胞化学; 小鼠
  • 免疫组化; 小鼠; 图 8
Palavicini J, Lloyd B, Hayes C, Bianchi E, Kang D, Dawson Scully K, et al. RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PLoS ONE. 2013;8:e66908 pubmed 出版商
  • 免疫印迹; 人类
Hossain A, Radwan F, Doonan B, God J, Zhang L, Bell P, et al. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012;17:1066-78 pubmed 出版商
  • 免疫印迹; 小鼠
Fernandez K, Serinagaoglu Y, Hammond S, Martin L, Martin P. Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Am J Pathol. 2010;176:416-34 pubmed 出版商
  • 免疫印迹; 人类
Tsai A, Pan S, Sun H, Wang C, Peng C, Wang S, et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 2010;285:5497-506 pubmed 出版商
  • 免疫印迹; 人类
Joy B, Sivadasan R, Abraham T E, John M, Sobhan P, Seervi M, et al. Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis. Mol Carcinog. 2010;49:324-36 pubmed 出版商
  • 免疫印迹; 人类
Louneva N, Cohen J, Han L, Talbot K, Wilson R, Bennett D, et al. Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am J Pathol. 2008;173:1488-95 pubmed 出版商
  • 免疫印迹; 人类
Zou W, Yue P, Khuri F, Sun S. Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation. Cancer Res. 2008;68:7484-92 pubmed 出版商
  • 免疫印迹; 人类
Ray P, De A, Patel M, Gambhir S. Monitoring caspase-3 activation with a multimodality imaging sensor in living subjects. Clin Cancer Res. 2008;14:5801-9 pubmed 出版商
  • 免疫印迹; 人类
Hsiao C, Ho Y, Hsu J, Chang W, Chen Y, Shen Y, et al. Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:599-608 pubmed 出版商
  • 免疫印迹; 人类
Chen T, Pan S, Guh J, Chen C, Huang Y, Pai H, et al. Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:447-57 pubmed 出版商
  • 免疫印迹; 人类
Chen T, Pan S, Guh J, Liao C, Huang D, Chen C, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008;14:4250-8 pubmed 出版商
  • 免疫印迹; 人类
Yui S, Kanamoto R, Saeki T. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutr Cancer. 2008;60:91-6 pubmed 出版商
  • 免疫印迹; 人类
Wang S, Pan S, Huang Y, Guh J, Chiang P, Huang D, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008;7:350-60 pubmed 出版商
  • 免疫印迹; 人类
Gdynia G, Lehmann Koch J, Sieber S, Tagscherer K, Fassl A, Zentgraf H, et al. BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis. Apoptosis. 2008;13:437-47 pubmed 出版商
  • 免疫印迹; 大鼠
Lee A, Su M. Comparison of the cardiac effects between quinazoline-based alpha1-adrenoceptor antagonists on occlusion-reperfusion injury. J Biomed Sci. 2008;15:239-49 pubmed
  • 免疫印迹; 人类
Li J, Yang J. Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. J Cell Physiol. 2007;212:481-8 pubmed
  • 免疫印迹; 人类
Schultze K, Böck B, Eckert A, Oevermann L, Ramacher D, Wiestler O, et al. Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006;11:1503-12 pubmed
  • 免疫印迹; 人类
Chiang P, Kung F, Huang D, Li T, Fan J, Pan S, et al. Induction of Fas clustering and apoptosis by coral prostanoid in human hormone-resistant prostate cancer cells. Eur J Pharmacol. 2006;542:22-30 pubmed
  • 免疫印迹; 大鼠
Jarskog L, Gilmore J, Glantz L, Gable K, German T, Tong R, et al. Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics. Neuropsychopharmacology. 2007;32:95-102 pubmed
  • 免疫印迹; 人类
Huang Y, Pan S, Guh J, Chang Y, Lee F, Kuo S, et al. YC-1 suppresses constitutive nuclear factor-kappaB activation and induces apoptosis in human prostate cancer cells. Mol Cancer Ther. 2005;4:1628-35 pubmed
  • 免疫组化-冰冻切片; 大鼠
Zhang W, Sato K, Iwai M, Nagano I, Manabe Y, Abe K. Therapeutic time window of adenovirus-mediated GDNF gene transfer after transient middle cerebral artery occlusion in rat. Brain Res. 2002;947:140-5 pubmed
  • 免疫印迹; 人类
Sun S, Yue P, Chen X, Hong W, Lotan R. The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells. Cancer Res. 2002;62:2430-6 pubmed
Xu Y, Sun Q, Yuan F, Dong H, Zhang H, Geng R, et al. RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway. J Exp Clin Cancer Res. 2020;39:174 pubmed 出版商
Shrestha S, Adhikary G, Xu W, Kandasamy S, Eckert R. ACTL6A suppresses p21Cip1 expression to enhance the epidermal squamous cell carcinoma phenotype. Oncogene. 2020;39:5855-5866 pubmed 出版商
Renema P, Kozhukhar N, Pastukh V, Spadafora D, Subedi Paudel S, Tambe D, et al. Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: Modulation of transmissible cytotoxicity. Am J Physiol Lung Cell Mol Physiol. 2020;: pubmed 出版商
Lee J, Han S, Park M, Song I, Choi M, Yu E, et al. N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Nat Commun. 2020;11:2358 pubmed 出版商
Nepali K, Chang T, Lai M, Hsu K, Yen Y, Lin T, et al. Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors. Eur J Med Chem. 2020;196:112291 pubmed 出版商
Wang Y, Guo S, Li D, Tang Y, Li L, Su L, et al. YIPF2 promotes chemotherapeutic agent-mediated apoptosis via enhancing TNFRSF10B recycling to plasma membrane in non-small cell lung cancer cells. Cell Death Dis. 2020;11:242 pubmed 出版商
Xiao X, Sticht C, Yin L, Liu L, Karakhanova S, Yin Y, et al. Novel plant microRNAs from broccoletti sprouts do not show cross-kingdom regulation of pancreatic cancer. Oncotarget. 2020;11:1203-1217 pubmed 出版商
de Jesus Silva S, de Moraes Silva M, Carbonel A, Grillo Filho G, Grigório T, Simões M, et al. Heparin Attenuates Visceral Apoptosis in a Swine Model of Hemorrhagic Shock and Reperfusion Injury. Ann Vasc Surg. 2020;: pubmed 出版商
Wang Y, Su G, Huang Z, Wang Z, Zhou P, Fan J, et al. Cepharanthine hydrochloride induces mitophagy targeting GPR30 in hepatocellular carcinoma (HCC). Expert Opin Ther Targets. 2020;24:389-402 pubmed 出版商
Yalcınkaya M, Kerksiek A, Gebert K, Annema W, Sibler R, Radosavljevic S, et al. HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened. J Lipid Res. 2020;61:492-504 pubmed 出版商
Lai C, Chen R, Hsieh H, Tsai S, Chang K, Yen C, et al. A selective Aurora-A 5'-UTR siRNA inhibits tumor growth and metastasis. Cancer Lett. 2020;472:97-107 pubmed 出版商
Ye S, Apple J, Ren X, Tang F, Yao L, Wang Y, et al. Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex. J Neuroinflammation. 2019;16:235 pubmed 出版商
Huang H, Liu Y, Sung T, Huang T, Cheng Y, Liou J, et al. TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis. Theranostics. 2019;9:6676-6689 pubmed 出版商
Chen J, Hsieh Y, Lo H, Li A, Chou C, Yang P. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells. Biomolecules. 2019;9: pubmed 出版商
Kuthati Y, Goutham Davuluri V, Yang C, Chang H, Chang C, Wong C. Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. J Pain Res. 2019;12:2473-2485 pubmed 出版商
Chang W, Wu C, Lin Y, Wu M, Su K, Yuan S, et al. C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death. Int J Mol Sci. 2019;20: pubmed 出版商
Sun C, Enkhjargal B, Reis C, Zhou K, Xie Z, Wu L, et al. Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther. 2019;25:1162-1172 pubmed 出版商
Caron J, Pène V, Tolosa L, Villaret M, Luce E, Fourrier A, et al. Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection. Stem Cell Res Ther. 2019;10:221 pubmed 出版商
Nyunt T, Britton M, Wanichthanarak K, Budamagunta M, Voss J, Wilson D, et al. Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury. Free Radic Biol Med. 2019;143:25-46 pubmed 出版商
Mu N, Lei Y, Wang Y, Wang Y, Duan Q, Ma G, et al. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Apoptosis. 2019;24:798-811 pubmed 出版商
Wang Y, Su G, Huang Z, Fan J, Wang Y. Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells. Eur J Pharmacol. 2019;861:172534 pubmed 出版商
Burgener S, Leborgne N, Snipas S, Salvesen G, Bird P, Benarafa C. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Rep. 2019;27:3646-3656.e5 pubmed 出版商
Wu M, Chien C, Chang J, Chen Y. Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress. J Cell Mol Med. 2019;23:5692-5704 pubmed 出版商
Chao M, Chang L, Tu H, Chang C, Lai M, Chen Y, et al. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status. Clin Epigenetics. 2019;11:85 pubmed 出版商
Jia R, Jia N, Yang F, Liu Z, Li R, Jiang Y, et al. Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. Cell Mol Neurobiol. 2019;39:857-869 pubmed 出版商
An W, Yao S, Sun X, Hou Z, Lin Y, Su L, et al. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019;38:181 pubmed 出版商
Owonikoko T, Zhang G, Lallani S, Chen Z, Martinson D, Khuri F, et al. Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models. PLoS ONE. 2019;14:e0206309 pubmed 出版商
Chou C, Huang H, Yang C, Dahms H, Liang S, Wang T, et al. Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019;34:401-414 pubmed 出版商
Jaworski S, Strojny B, Sawosz E, Wierzbicki M, Grodzik M, Kutwin M, et al. Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells. Int J Mol Sci. 2019;20: pubmed 出版商
Li X, Song H, Kong F, Guo Y, Chen Y, Zhang L, et al. Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells. Oncol Lett. 2019;17:1851-1858 pubmed 出版商
Ponandai Srinivasan S, Lalitkumar P, Garcia L, Varghese S, Carlson J, Gemzell Danielsson K, et al. Mifepristone mediates anti-proliferative effect on ovarian mesenchymal stem/stromal cells from female BRCA1-/2- carriers. Acta Obstet Gynecol Scand. 2019;98:250-261 pubmed 出版商
Fauzia E, Barbhuyan T, Shrivastava A, Kumar M, Garg P, Khan M, et al. Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism. Front Pharmacol. 2018;9:1034 pubmed 出版商
Chang Y, Fong Y, Tsai E, Chang Y, Chou H, Wu C, et al. Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018;19: pubmed 出版商
Lin W, Wang W, Lin Y, Leu J, Cheng S, Chen Y, et al. Synergistic effects of tetrandrine combined with ionizing radiation on a murine colorectal carcinoma‑bearing mouse model. Oncol Rep. 2018;40:1390-1400 pubmed 出版商
Chou C, Liu W, Hong Y, Dahms H, Chiu C, Chang W, et al. Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. Int J Mol Sci. 2018;19: pubmed 出版商
Camgoz A, Paszkowski Rogacz M, Satpathy S, Wermke M, Hamann M, von Bonin M, et al. STK3 is a therapeutic target for a subset of acute myeloid leukemias. Oncotarget. 2018;9:25458-25473 pubmed 出版商
Oldoni F, van Capelleveen J, Dalila N, Wolters J, Heeren J, Sinke R, et al. Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans. Arterioscler Thromb Vasc Biol. 2018;38:1440-1453 pubmed 出版商
Krishnamoorthy V, Khanna R, Parnaik V. E3 ubiquitin ligase HECW2 targets PCNA and lamin B1. Biochim Biophys Acta Mol Cell Res. 2018;1865:1088-1104 pubmed 出版商
Zhao L, Zhu Z, Yao C, Huang Y, Zhi E, Chen H, et al. VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2. Cell Cycle. 2018;17:225-239 pubmed 出版商
Qiu S, Wu X, Liao H, Zeng X, Zhang S, Lu X, et al. Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells. Oncol Lett. 2017;14:5540-5548 pubmed 出版商
Shi P, Oh Y, Deng L, Zhang G, Qian G, Zhang S, et al. Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation. Clin Cancer Res. 2017;23:6567-6579 pubmed 出版商
Schecher S, Walter B, Falkenstein M, Macher Goeppinger S, Stenzel P, Krümpelmann K, et al. Cyclin K dependent regulation of Aurora B affects apoptosis and proliferation by induction of mitotic catastrophe in prostate cancer. Int J Cancer. 2017;141:1643-1653 pubmed 出版商
Patel N, Garikapati K, Pandita R, Singh D, Pandita T, Bhadra U, et al. miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin. Sci Rep. 2017;7:4263 pubmed 出版商
Kao C, Chen W, Guo B, Feng C, Hung H, Yang W, et al. The 1-Tosylpentan-3-one Protects against 6-Hydroxydopamine-Induced Neurotoxicity. Int J Mol Sci. 2017;18: pubmed 出版商
Chang W, Liu W, Chiu Y, Chen B, Chuang S, Chen Y, et al. A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression. Molecules. 2017;22: pubmed 出版商
Wang Y, Chen Y, Hu S, Hsu Y, Tsai C, Chi T, et al. CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Cancer Chemother Pharmacol. 2017;79:1129-1140 pubmed 出版商
Chao M, Chen T, Huang H, Chang Y, HuangFu W, Lee Y, et al. Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells. Sci Rep. 2017;7:46134 pubmed 出版商
Velagapudi S, Yalcınkaya M, Piemontese A, Meier R, Nørrelykke S, Perisa D, et al. VEGF-A Regulates Cellular Localization of SR-BI as Well as Transendothelial Transport of HDL but Not LDL. Arterioscler Thromb Vasc Biol. 2017;37:794-803 pubmed 出版商
Sakchaisri K, Kim S, Hwang J, Soung N, Lee K, Choi T, et al. Anticancer activity of a novel small molecule tubulin inhibitor STK899704. PLoS ONE. 2017;12:e0173311 pubmed 出版商
Chao M, Huang H, HuangFu W, Hsu K, Liu Y, Wu Y, et al. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. Oncotarget. 2017;8:27772-27785 pubmed 出版商
Nepali K, Lee H, Lai M, Ojha R, Wu T, Wu G, et al. Ring-opened tetrahydro-?-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms. Eur J Med Chem. 2017;127:115-127 pubmed 出版商
Omar H, Tolba M, Hung J, Al Tel T. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKC?/p53. Front Pharmacol. 2016;7:463 pubmed
Huang Y, Lee C, Lee J, Liu Y, Chen Y, Tseng J, et al. Epigenetic silencing of miR-137 contributes to early colorectal carcinogenesis by impaired Aurora-A inhibition. Oncotarget. 2016;7:76852-76866 pubmed 出版商
Liu X, Lv Z, Zou J, Liu X, Ma J, Wang J, et al. Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma. Am J Cancer Res. 2016;6:1708-19 pubmed
Kwon J, Willy J, Quirin K, Wek R, Korc M, Yin X, et al. Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential. Oncotarget. 2016;7:71635-71650 pubmed 出版商
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图像
图像 1 :
Novus Biologicals NB100-56708 图像 1
Western Blot: Caspase-3 Antibody (31A1067) - (Pro and Active) [NB100-56708] - Image of Caspase-3 Antibody (31A1067) - (Pro and Active). Whole cell protein from Jurkat cells treated with and without 2 uM staurosporine as indicated was separated on a 4-15% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 5 ug/ml anti-Caspase 3 in 1% milk, and detected with an anti-mouse HRP secondary antibody using a Femto sensitivity chemiluminescence reagent. Note the detection of both pro-caspase 3 at 35 kDa and the cleaved active caspase 3 at 15-17 kDa.
产品信息
品牌 :
Novus
master code :
NB100-56708
SKU号 :
NB100-56708
产品名称 :
Caspase-3 Antibody (31A1067) - (Pro and Active)
描述 :
The Caspase-3 Antibody (31A1067) - (Pro and Active) from Novus Biologicals is a mouse monoclonal antibody to Caspase-3. This antibody reacts with human, mouse, rat, porcine, chicken, chinese hamster, mammal. The Caspase-3 Antibody (31A1067) - (Pro and Active) has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Hematoxylin Eosin Stain, Electron Microscopy, Immunohistochemistry Free-Floating, CyTOF-ready, Knockout Validated, Knockdown Validated.
靶标 :
胱氨酸-天冬氨酸蛋白酶3
类别 :
一抗
单位尺寸 :
0.1 mg (also 0.025 mg)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
31A1067
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
This Caspase-3 Antibody (31A1067) - (Pro and Active) was developed against full-length recombinant human caspase-3 protein.
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠, 猪, 鸡, 中国人仓鼠, 哺乳动物
特异性 :
The antibody detects both pro Caspase-3 (~32 kDa) and the large subunit of the active/cleaved form (~14-21 kDa) of Caspase-3. The large subunit of the cleaved form may appear as one or two or even as a stack of bands depending on the presence or absence of the Caspase-3 pro-domain. It is highly recommended that a maximum sensitivity ECL substrate (Femto sensitive) be used for efficient detection of this antibody in Western blot applications.
理论上的分子量 :
31.7 kDa
基因符号 :
CASP3
catalog number base :
NB100-56708
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Hematoxylin Eosin Stain, Electron Microscopy, Immunohistochemistry Free-Floating, CyTOF-ready, Knockout Validated, Knockdown Validated
2020美元 :
379
2021美元 :
379美元
别名 :
Apopain, apoptosis-related cysteine protease, CASP-3, caspase 3, apoptosis-related cysteine peptidase, caspase-3, CPP-32, CPP32B, CPP32SREBP cleavage activity 1, Cysteine protease CPP32, EC 3.4.22, EC 3.4.22.56, PARP cleavage protease, procaspase3, Protein Yama, SCA-1, Yama
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。