出版应用/物种/样本/稀释 | 参考文献 |
---|
| Hülser M, Luo Y, Frommer K, Hasseli R, Köhler K, Diller M, et al. Systemic versus local adipokine expression differs in a combined obesity and osteoarthritis mouse model. Sci Rep. 2021;11:17001 pubmed 出版商
|
- 免疫组化-冰冻切片; 小鼠; 1:100; 图 1c
| Wutschka J, Kast B, Sator Schmitt M, Appak Baskoy S, Hess J, Sinn H, et al. JUNB suppresses distant metastasis by influencing the initial metastatic stage. Clin Exp Metastasis. 2021;38:411-423 pubmed 出版商
|
- 免疫组化-冰冻切片; 小鼠; 1:100; 图 s9a
| Pommier A, Anaparthy N, Memos N, Kelley Z, Gouronnec A, Yan R, et al. Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases. Science. 2018;360: pubmed 出版商
|
| Klak M, Wszo x142 a M, Berman A, Filip A, Kosowska A, Olkowska Truchanowicz J, et al. Bioprinted 3D Bionic Scaffolds with Pancreatic Islets as a New Therapy for Type 1 Diabetes-Analysis of the Results of Preclinical Studies on a Mouse Model. J Funct Biomater. 2023;14: pubmed 出版商
|
| Reches G, Blondheim Shraga N, Carrette F, Malka A, Saleev N, Gubbay Y, et al. Resolving the conflicts around Par2 opposing roles in regeneration by comparing immune-mediated and toxic-induced injuries. Inflamm Regen. 2022;42:52 pubmed 出版商
|
| Wu M, Yu Z, Matar D, Karvar M, Chen Z, Ng B, et al. Human Amniotic Membrane Promotes Angiogenesis in an Oxidative Stress Chronic Diabetic Murine Wound Model. Adv Wound Care (New Rochelle). 2022;: pubmed 出版商
|
| George K, Heithoff B, Shandra O, Robel S. Mild Traumatic Brain Injury/Concussion Initiates an Atypical Astrocyte Response Caused by Blood-Brain Barrier Dysfunction. J Neurotrauma. 2022;39:211-226 pubmed 出版商
|
| Yusuf A, Qaisar R, Al Tamimi A, Jayakumar M, Woodgett J, Koch W, et al. Cardiomyocyte-GSK-3β deficiency induces cardiac progenitor cell proliferation in the ischemic heart through paracrine mechanisms. J Cell Physiol. 2021;: pubmed 出版商
|
| Everton E, Rizvi F, Smith A, Beattie M, Tam Y, Pardi N, et al. Transient yet Robust Expression of Proteins in the Mouse Liver via Intravenous Injection of Lipid Nanoparticle-encapsulated Nucleoside-modified mRNA. Bio Protoc. 2021;11:e4184 pubmed 出版商
|
| Wen S, Deng F, Li L, Xu L, Li X, Fan Q. VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation. J Diabetes Investig. 2021;: pubmed 出版商
|
| Wang J, Kural M, Wu J, Leiby K, Mishra V, Lysyy T, et al. An ex vivo physiologic and hyperplastic vessel culture model to study intra-arterial stent therapies. Biomaterials. 2021;275:120911 pubmed 出版商
|
| Jelínková S, Sleiman Y, Fojtik P, Aimond F, Finan A, Hugon G, et al. Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart. Int J Mol Sci. 2021;22: pubmed 出版商
|
| Gangoso E, Southgate B, Bradley L, Rus S, Gálvez Cancino F, McGivern N, et al. Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion. Cell. 2021;184:2454-2470.e26 pubmed 出版商
|
| Moiseenko A, Vazquez Armendariz A, Kheirollahi V, Chu X, Tata A, Rivetti S, et al. Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration. Cell Rep. 2020;33:108549 pubmed 出版商
|
| Samanta D, Huang T, Shah R, Yang Y, Pan F, Semenza G. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep. 2020;32:108073 pubmed 出版商
|
| Riopel M, Moon J, Bandyopadhyay G, You S, Lam K, Liu X, et al. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism. Mol Metab. 2020;41:101039 pubmed 出版商
|
| Ho J, Balukoff N, Theodoridis P, Wang M, Krieger J, Schatz J, et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism. Nat Commun. 2020;11:2677 pubmed 出版商
|
| Jakubowska M, Pyka J, Michalczyk Wetula D, Baczynski K, Ciesla M, Susz A, et al. Electron paramagnetic resonance spectroscopy reveals alterations in the redox state of endogenous copper and iron complexes in photodynamic stress-induced ischemic mouse liver. Redox Biol. 2020;34:101566 pubmed 出版商
|
| Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed 出版商
|
| Simanjuntak Y, Ko H, Lee Y, Yu G, Lin Y. Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice. PLoS Pathog. 2020;16:e1008521 pubmed 出版商
|
| Park K, Han J, Kim S, Lim Y. Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats. Biomolecules. 2020;10: pubmed 出版商
|
| Acosta Iborra B, Tiana M, Maeso Alonso L, Hernández Sierra R, Herranz G, Santamaria A, et al. Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis. FASEB J. 2020;34:6654-6674 pubmed 出版商
|
| Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, et al. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. Theranostics. 2020;10:3562-3578 pubmed 出版商
|
| Fabbri L, Dufies M, Lacas Gervais S, Gardie B, Gad Lapiteau S, Parola J, et al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients. Theranostics. 2020;10:2696-2713 pubmed 出版商
|
| Park J, Kim M, Kim W, Kwon K, Ha K, Choi B, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett. 2020;478:71-81 pubmed 出版商
|
| Sun X, Sun B, Babicheva A, Vanderpool R, Oita R, Casanova N, et al. Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α. Am J Respir Cell Mol Biol. 2020;63:92-103 pubmed 出版商
|
| Gojkovic M, Darmasaputra G, Veliça P, Rundqvist H, Johnson R. Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE). Acta Physiol (Oxf). 2020;229:e13461 pubmed 出版商
|
| Sadaghianloo N, Contenti J, Dufies M, Parola J, Rouleau M, Lee S, et al. Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia. J Cell Mol Med. 2020;24:2931-2941 pubmed 出版商
|
| Roelants C, Pillet C, Franquet Q, Sarrazin C, Peilleron N, Giacosa S, et al. Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma. Cancers (Basel). 2020;12: pubmed 出版商
|
| Sivaraj K, Dharmalingam B, Mohanakrishnan V, Jeong H, Kato K, Schröder S, et al. YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells. elife. 2020;9: pubmed 出版商
|
| Brown E, Rowan C, Strowitzki M, Fagundes R, Faber K, Güntsch A, et al. Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients. FASEB J. 2020;34:3732-3742 pubmed 出版商
|
| Senavirathna L, Huang C, Pushparaj S, Xu D, Liu L. Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts. Physiol Rep. 2020;8:e14343 pubmed 出版商
|
| Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, et al. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020;58:126442 pubmed 出版商
|
| Chen B, Ghezzi C, Villegas B, Quon A, Radu C, Witte O, et al. 18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis. J Nucl Med. 2020;61:757-763 pubmed 出版商
|
| Gao R, Wang M, Liu Q, Feng D, Wen Y, Xia Y, et al. Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6. Hepatology. 2020;71:2105-2117 pubmed 出版商
|
| David B, Curtin J, Goldberg D, Scorpio K, Kandaswamy V, Hill C. Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord. Eneuro. 2020;7: pubmed 出版商
|
| Jeon G, Sheldon R, Ferriero D. Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia. Korean J Pediatr. 2019;62:444-449 pubmed 出版商
|
| Yoo H, Park S, Nam M, Kang J, Kim K, Yeo J, et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Cell Metab. 2019;: pubmed 出版商
|
| Hart P, Kenny H, Grassl N, Watters K, Litchfield L, Coscia F, et al. Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep. 2019;29:4086-4098.e6 pubmed 出版商
|
| Cannito S, Foglia B, Villano G, Turato C, Delgado T, Morello E, et al. SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets. Cancers (Basel). 2019;11: pubmed 出版商
|
| Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, et al. The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension. Sci Signal. 2019;12: pubmed 出版商
|
| Tashiro N, Segawa R, Tobita R, Asakawa S, Mizuno N, Hiratsuka M, et al. Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes. PLoS ONE. 2019;14:e0224705 pubmed 出版商
|
| Zhang X, Zhang Y, Wang P, Zhang S, Dong Y, Zeng G, et al. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism. Cell Metab. 2019;30:937-951.e5 pubmed 出版商
|
| Han S, Huang T, Hou F, Yao L, Wang X, Wu X. The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis. Ther Adv Med Oncol. 2019;11:1758835919875851 pubmed 出版商
|
| Seo J, Riopel M, Cabrales P, Huh J, Bandyopadhyay G, Andreyev A, et al. Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity. Nat Metab. 2019;1:86-97 pubmed 出版商
|
| Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed 出版商
|
| Schwartz A, Converso Baran K, Michele D, Shah Y. A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling. J Biol Chem. 2019;294:14991-15002 pubmed 出版商
|
| Novianti T, Juniantito V, Jusuf A, Arida E, Jusman S, Sadikin M. Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration. Organogenesis. 2019;15:69-84 pubmed 出版商
|
| Chang C, Liao C, Liou A, Chang Y, Chang Y, Tzeng B, et al. Enterovirus 71 targets the cardiopulmonary system in a robust oral infection mouse model. Sci Rep. 2019;9:11108 pubmed 出版商
|
| Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis. 2019;10:544 pubmed 出版商
|
| Lee Y, Riopel M, Cabrales P, Bandyopadhyay G. Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv. 2019;5:eaaw4176 pubmed 出版商
|
| Aquino Galvez A, Gonzalez Avila G, Jiménez Sánchez L, Maldonado Martínez H, Cisneros J, Toscano Marquez F, et al. Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis. Respir Res. 2019;20:130 pubmed 出版商
|
| Maugeri G, D Amico A, Federico C, Saccone S, Giunta S, Cavallaro S, et al. Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway. J Mol Neurosci. 2019;: pubmed 出版商
|
| Yamamoto A, Hester J, Macklin P, Kawai K, Uchiyama M, Biggs D, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019;130:3640-3656 pubmed 出版商
|
| Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza G, et al. A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension. Nat Commun. 2019;10:2130 pubmed 出版商
|
| Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth P, et al. Sox17 is required for endothelial regeneration following inflammation-induced vascular injury. Nat Commun. 2019;10:2126 pubmed 出版商
|
| Muenchau S, Deutsch R, de Castro I, Hielscher T, Heber N, Niesler B, et al. Hypoxic environment promotes barrier formation in human intestinal epithelial cells through regulation of miRNA-320a expression. Mol Cell Biol. 2019;: pubmed 出版商
|
| Fujimoto T, Colbert L, Huang Y, Molkentine J, Deorukhkar A, Baseler L, et al. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res. 2019;79:2327-2338 pubmed 出版商
|
| Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, et al. Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells. Cancers (Basel). 2019;11: pubmed 出版商
|
| Chaurasia S, Kushwaha G, Kulkarni P, Mallick R, Latheef N, Mishra J, et al. Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release. Haematologica. 2019;: pubmed 出版商
|
| Sumi C, Matsuo Y, Kusunoki M, Shoji T, Uba T, Iwai T, et al. Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma. PLoS ONE. 2019;14:e0215072 pubmed 出版商
|
| Gkotinakou I, Befani C, Simos G, Liakos P. ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling. J Cell Sci. 2019;132: pubmed 出版商
|
| Chang S, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun. 2019;10:1442 pubmed 出版商
|
| Chachami G, Stankovic Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, et al. Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen. Mol Cell Proteomics. 2019;18:1197-1209 pubmed 出版商
|
| Arthur S, Blaydes J, Houghton F. Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs. Stem Cell Reports. 2019;12:728-742 pubmed 出版商
|
| Natarajan S, Foreman K, Soriano M, Rossen N, Shehade H, Fregoso D, et al. Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis. Cancer Res. 2019;79:2271-2284 pubmed 出版商
|
| Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al. A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Nat Commun. 2019;10:1152 pubmed 出版商
|
| Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson J. Putative role of NF-kB but not HIF-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic stem and progenitor cells. Antioxid Redox Signal. 2019;: pubmed 出版商
|
| Ndiaye P, Dufies M, Giuliano S, Douguet L, Grepin R, Durivault J, et al. VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness. Theranostics. 2019;9:661-675 pubmed 出版商
|
| Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, et al. Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease. Redox Biol. 2019;22:101145 pubmed 出版商
|
| Xiong Y, Liu L, Xia Y, Qi Y, Chen Y, Chen L, et al. Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma. Cancer Immunol Immunother. 2019;68:731-741 pubmed 出版商
|
| Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, et al. TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. Int J Biol Sci. 2019;15:587-597 pubmed 出版商
|
| Lee B, Jun H, Kim J, Kim J. Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina. FASEB J. 2019;33:6045-6054 pubmed 出版商
|
| Tian Z, Yao L, Shen Y, Guo X, Duan X. Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia. Int J Biochem Cell Biol. 2019;109:33-39 pubmed 出版商
|
| Jarman E, Ward C, Turnbull A, Martinez Perez C, Meehan J, Xintaropoulou C, et al. HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer. Breast Cancer Res. 2019;21:10 pubmed 出版商
|
| Ma X, Das N, Castillo C, Gourani A, Perekatt A, Verzi M, et al. SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes. J Biol Chem. 2019;294:3974-3986 pubmed 出版商
|
| Guo H, Ci X, Ahmed M, Hua J, Soares F, Lin D, et al. ONECUT2 is a driver of neuroendocrine prostate cancer. Nat Commun. 2019;10:278 pubmed 出版商
|
| Santana Codina N, Gableske S, Quiles Del Rey M, Małachowska B, Jedrychowski M, Biancur D, et al. NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms. Haematologica. 2019;: pubmed 出版商
|
| Olcina M, Balanis N, Kim R, Aksoy B, Kodysh J, Thompson M, et al. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018;25:3721-3732.e6 pubmed 出版商
|
| Sharifpanah F, Ali E, Wartenberg M, Sauer H. The milk thistle (Silybum marianum) compound Silibinin stimulates leukopoiesis from mouse embryonic stem cells. Phytother Res. 2019;33:452-460 pubmed 出版商
|
| Karagiota A, Kourti M, Simos G, Mylonis I. HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia. Cell Mol Life Sci. 2019;76:809-825 pubmed 出版商
|
| Choi S, Kim Y, Park Y, Yang H, Jeong P, Cha J, et al. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2018;: pubmed 出版商
|
| Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, et al. Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Sci Rep. 2018;8:16475 pubmed 出版商
|
| Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I. Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen. Nat Commun. 2018;9:4545 pubmed 出版商
|
| Liao L, Liu Z, Langbein L, Cai W, Cho E, Na J, et al. Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. elife. 2018;7: pubmed 出版商
|
| Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed 出版商
|
| Carolina E, Kato T, Khanh V, Moriguchi K, Yamashita T, Takeuchi K, et al. Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway. Front Med (Lausanne). 2018;5:276 pubmed 出版商
|
| Fortenbery G, Sarathy B, Carraway K, Mansfield K. Hypoxic stabilization of mRNA is HIF-independent but requires mtROS. Cell Mol Biol Lett. 2018;23:48 pubmed 出版商
|
| Sethuraman A, Brown M, Krutilina R, Wu Z, Seagroves T, Pfeffer L, et al. BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion. Breast Cancer Res. 2018;20:117 pubmed 出版商
|
| Xu M, Tan X, Li N, Wu H, Wang Y, Xie J, et al. Differential regulation of estrogen in iron metabolism in astrocytes and neurons. J Cell Physiol. 2019;234:4232-4242 pubmed 出版商
|
| Zaini M, Patel S, Syafruddin S, Rodrigues P, Vanharanta S. Endogenous HIF2A reporter systems for high-throughput functional screening. Sci Rep. 2018;8:12063 pubmed 出版商
|
| Anea C, Merloiu A, Fulton D, Patel V, Rudic R. Immunohistochemistry of the circadian clock in mouse and human vascular tissues. Vessel Plus. 2018;2: pubmed 出版商
|
| Regan Anderson T, Ma S, Perez Kerkvliet C, Peng Y, Helle T, Krutilina R, et al. Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res. 2018;16:1761-1772 pubmed 出版商
|
| Miess H, Dankworth B, Gouw A, Rosenfeldt M, Schmitz W, Jiang M, et al. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene. 2018;37:5435-5450 pubmed 出版商
|
| Kumar V, Biswas S, Sharma N, Stone S, Fam C, Cox G, et al. PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome. Health Phys. 2018;115:65-76 pubmed 出版商
|
| Landau D, London L, Bandach I, Segev Y. The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia. PLoS ONE. 2018;13:e0196684 pubmed 出版商
|
| Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider R, et al. Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis. JCI Insight. 2018;3: pubmed 出版商
|
| Thompson J, Alvarez A, Singha M, Pavesic M, Nguyen Q, Nelson L, et al. Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism. Mol Cancer Ther. 2018;17:1781-1792 pubmed 出版商
|
| Maugeri G, D Amico A, Rasà D, Saccone S, Federico C, Cavallaro S, et al. PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia. Neuropeptides. 2018;69:84-91 pubmed 出版商
|
| Schofield H, Tandon M, Park M, Halbrook C, Ramakrishnan S, Kim E, et al. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol. 2018;5:169-185.e2 pubmed 出版商
|
| Yang Q, Guo X, Yang L. Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). Med Sci Monit. 2018;24:2225-2234 pubmed
|
| Ferecatu I, Canal F, Fabbri L, Mazure N, Bouton C, Golinelli Cohen M. Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1? activation. PLoS ONE. 2018;13:e0194782 pubmed 出版商
|
| Xie L, Yin A, Nichenko A, Beedle A, Call J, Yin H. Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration. J Clin Invest. 2018;128:2339-2355 pubmed 出版商
|
| Kim H, Lin Q, Glazer P, Yun Z. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Res. 2018;20:16 pubmed 出版商
|
| Abdul Aziz A, Shafat M, Sun Y, Marlein C, Piddock R, Robinson S, et al. HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene. 2018;37:2676-2686 pubmed 出版商
|
| Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, et al. The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE. 2018;13:e0193477 pubmed 出版商
|
| Robinson C, Lefebvre F, Poon B, Bousard A, Fan X, Lathrop M, et al. Consequences of VHL Loss on Global DNA Methylome. Sci Rep. 2018;8:3313 pubmed 出版商
|
| Simanjuntak Y, Liang J, Chen S, Li J, Lee Y, Wu H, et al. Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission. PLoS Pathog. 2018;14:e1006854 pubmed 出版商
|
| Senavirathna L, Huang C, Yang X, Munteanu M, Sathiaseelan R, Xu D, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018;8:2709 pubmed 出版商
|
| Mira E, Carmona RodrÃguez L, Pérez Villamil B, Casas J, Fernández Aceñero M, MartÃnez Rey D, et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nat Commun. 2018;9:575 pubmed 出版商
|
| Frump A, Selej M, Wood J, Albrecht M, Yakubov B, Petrache I, et al. Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner. Am J Respir Cell Mol Biol. 2018;59:114-126 pubmed 出版商
|
| Liu S, Tetzlaff M, Wang T, Chen X, Yang R, Kumar S, et al. Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma. Oncotarget. 2017;8:115140-115152 pubmed 出版商
|
| Samanta D, Park Y, Ni X, Li H, Zahnow C, Gabrielson E, et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proc Natl Acad Sci U S A. 2018;115:E1239-E1248 pubmed 出版商
|
| Maybin J, Murray A, Saunders P, Hirani N, Carmeliet P, Critchley H. Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation. Nat Commun. 2018;9:295 pubmed 出版商
|
| Dopeso H, Jiao H, Cuesta A, Henze A, Jurida L, Kracht M, et al. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018;78:1805-1819 pubmed 出版商
|
| Bogurcu N, Seidel S, Garvalov B, Acker T. Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts. Methods Mol Biol. 2018;1742:283-300 pubmed 出版商
|
| Brooks D, Seagroves T. Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models. Methods Mol Biol. 2018;1742:67-79 pubmed 出版商
|
| Ho J, Balukoff N, Cervantes G, Malcolm P, Krieger J, Lee S. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B. Cell Rep. 2018;22:17-26 pubmed 出版商
|
| Bäcker V, Cheung F, Siveke J, Fandrey J, Winning S. Knockdown of myeloid cell hypoxia-inducible factor-1? ameliorates the acute pathology in DSS-induced colitis. PLoS ONE. 2017;12:e0190074 pubmed 出版商
|
| Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T. Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury. FASEB J. 2017;: pubmed 出版商
|
| Gastelum G, Poteshkina A, Veena M, Artiga E, Weckstein G, Frost P. Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2? expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis. PLoS ONE. 2017;12:e0188438 pubmed 出版商
|
| Shi M, Flores B, Li P, Gillings N, McMillan K, Ye J, et al. Effects of Erythropoietin Receptor Activity on Angiogenesis, Tubular Injury and Fibrosis in Acute Kidney Injury: A "U-Shaped" Relationship. Am J Physiol Renal Physiol. 2017;:ajprenal.00306.2017 pubmed 出版商
|
| Du W, Zhang L, Brett Morris A, Aguila B, Kerner J, Hoppel C, et al. HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism. Nat Commun. 2017;8:1769 pubmed 出版商
|
| Ho J, Abdullah L, Pang Q, Jha S, Chow E, Yang H, et al. Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway. PLoS ONE. 2017;12:e0188051 pubmed 出版商
|
| Bino L, Prochazkova J, Radaszkiewicz K, Kucera J, Kudová J, Pachernik J, et al. Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner. Oncotarget. 2017;8:83684-83697 pubmed 出版商
|
| Palazon A, Tyrakis P, Macías D, Veliça P, Rundqvist H, Fitzpatrick S, et al. An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression. Cancer Cell. 2017;32:669-683.e5 pubmed 出版商
|
| Fanelli G, Gonzalez Cordero A, Gardner P, Peng Q, Fernando M, Kloc M, et al. Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress. Sci Rep. 2017;7:14625 pubmed 出版商
|
| Hascoet P, Chesnel F, Jouan F, Le Goff C, Couturier A, Darrigrand E, et al. The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13. Oncotarget. 2017;8:75989-76002 pubmed 出版商
|
| Casillas A, Toth R, Sainz A, Singh N, Desai A, Kraft A, et al. Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents. Clin Cancer Res. 2018;24:169-180 pubmed 出版商
|
| Tang H, Babicheva A, McDermott K, Gu Y, Ayon R, Song S, et al. Endothelial HIF-2? Contributes to Severe Pulmonary Hypertension by Inducing Endothelial-to-Mesenchymal Transition. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00096.2017 pubmed 出版商
|
| Caballero S, Kent D, Sengupta N, Li Calzi S, Shaw L, Beli E, et al. Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy. Invest Ophthalmol Vis Sci. 2017;58:5164-5176 pubmed 出版商
|
| Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017;23:1298-1308 pubmed 出版商
|
| Strowitzki M, Ritter A, Radhakrishnan P, Harnoss J, Opitz V, Biller M, et al. Pharmacological HIF-inhibition attenuates postoperative adhesion formation. Sci Rep. 2017;7:13151 pubmed 出版商
|
| He X, Zeng H, Chen S, Roman R, Aschner J, Didion S, et al. Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction. J Mol Cell Cardiol. 2017;112:104-113 pubmed 出版商
|
| Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, et al. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017;8:584 pubmed 出版商
|
| Ariazi J, Duffy K, Adams D, Fitch D, Luo L, Pappalardi M, et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther. 2017;363:336-347 pubmed 出版商
|
| Kong K, Oh H, Lim B, Kim M, Han K, Choi Y, et al. Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis. Sci Rep. 2017;7:11351 pubmed 出版商
|
| Dobrynin G, McAllister T, Leszczynska K, Ramachandran S, Krieg A, Kawamura A, et al. KDM4A regulates HIF-1 levels through H3K9me3. Sci Rep. 2017;7:11094 pubmed 出版商
|
| Yao X, Tan J, Lim K, Koh J, Ooi W, Li Z, et al. VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2017;7:1284-1305 pubmed 出版商
|
| Ma X, Zhang H, Xue X, Shah Y. Hypoxia-inducible factor 2? (HIF-2?) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem. 2017;292:17046-17056 pubmed 出版商
|
| Shved N, Warsow G, Eichinger F, Hoogewijs D, Brandt S, Wild P, et al. Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts. Sci Rep. 2017;7:8576 pubmed 出版商
|
| McGinn O, Gupta V, Dauer P, Arora N, Sharma N, Nomura A, et al. Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer. Sci Rep. 2017;7:7872 pubmed 出版商
|
| Tsang K, Hyun J, Cheng K, Vargas M, Mehta D, Ushio Fukai M, et al. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1?. Stem Cell Reports. 2017;9:796-806 pubmed 出版商
|
| Sun W, Kato H, Kitajima S, Lee K, Gradin K, Okamoto T, et al. Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression. Sci Rep. 2017;7:7190 pubmed 出版商
|
| Bhan A, Deb P, Shihabeddin N, Ansari K, Brotto M, Mandal S. Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. Gene. 2017;629:16-28 pubmed 出版商
|
| Jain C, Jessmon P, Barrak C, Bolnick A, Kilburn B, Hertz M, et al. Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding. Cell Death Differ. 2017;24:1772-1783 pubmed 出版商
|
| Lim E, Kuo C, Tu H, Yang C. The prognosis outcome of oral squamous cell carcinoma using HIF-2α. J Chin Med Assoc. 2017;80:651-656 pubmed 出版商
|
| Okamoto A, Sumi C, Tanaka H, Kusunoki M, Iwai T, Nishi K, et al. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep. 2017;7:3816 pubmed 出版商
|
| Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed 出版商
|
| Wu D, Huang R, Hamanaka R, Krause M, Oh M, Kuo C, et al. HIF-1? is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. elife. 2017;6: pubmed 出版商
|
| Khoriaty R, Vogel N, Hoenerhoff M, Sans M, Zhu G, Everett L, et al. SEC23B is required for pancreatic acinar cell function in adult mice. Mol Biol Cell. 2017;28:2146-2154 pubmed 出版商
|
| Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, et al. Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells. Oncotarget. 2017;8:49451-49469 pubmed 出版商
|
| Harashima N, Takenaga K, Akimoto M, Harada M. HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression. Oncotarget. 2017;8:42887-42900 pubmed 出版商
|
| Sun L, Kong Y, Cao M, Zhou H, Li H, Cui Y, et al. Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma. Cancer Sci. 2017;108:1338-1346 pubmed 出版商
|
| Lee H, Liu S, Lin C, Lee S, Hsu C, Sytwu H, et al. A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke. Theranostics. 2017;7:855-875 pubmed 出版商
|
| Ambrosi T, Scialdone A, Graja A, Gohlke S, Jank A, Bocian C, et al. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell. 2017;20:771-784.e6 pubmed 出版商
|
| Wang S, Zeng H, Chen S, Zhou L, Xie X, He X, et al. Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice. J Cell Mol Med. 2017;21:1967-1978 pubmed 出版商
|
| Lu H, Chen I, Shimoda L, Park Y, Zhang C, Tran L, et al. Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep. 2017;18:1946-1957 pubmed 出版商
|
| Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, et al. Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene. 2017;36:3609-3617 pubmed 出版商
|
| Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, et al. EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Sci Rep. 2017;7:41852 pubmed 出版商
|
| Hoppe Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci U S A. 2017;114:E990-E998 pubmed 出版商
|
| Gardner P, Liyanage S, Cristante E, Sampson R, Dick A, Ali R, et al. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Sci Rep. 2017;7:40830 pubmed 出版商
|
| Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun. 2017;8:13946 pubmed 出版商
|
| Kozlova N, Wottawa M, Katschinski D, Kristiansen G, Kietzmann T. Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer. Oncotarget. 2017;8:9885-9898 pubmed 出版商
|
| Shneor D, Folberg R, Pe er J, Honigman A, Frenkel S. Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther. 2017;24:64-74 pubmed 出版商
|
| Nakayama T, Otsuka S, Kobayashi T, Okajima H, Matsumoto K, Hagiya Y, et al. Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy. Sci Rep. 2016;6:36478 pubmed 出版商
|
| Thompson J, Nguyen Q, Singh M, Pavesic M, Nesterenko I, Nelson L, et al. Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma. Oncogene. 2017;36:1080-1089 pubmed 出版商
|
| Zhang L, Du J, Justus S, Hsu C, Bonet Ponce L, Wu W, et al. Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration. J Clin Invest. 2016;126:4659-4673 pubmed 出版商
|
| Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, et al. Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas. Am J Cancer Res. 2016;6:2263-2276 pubmed
|
| Ke S, Chen S, Dong Z, Hong C, Zhang Q, Tang L, et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017;65:134-151 pubmed 出版商
|
| Ha J, Doguer C, Collins J. Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells. Metallomics. 2016;8:963-972 pubmed
|
| D Alessio A, Proietti G, Lama G, Biamonte F, Lauriola L, Moscato U, et al. Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells. Oncotarget. 2016;7:78541-78556 pubmed 出版商
|
| Pangou E, Befani C, Mylonis I, Samiotaki M, Panayotou G, Simos G, et al. HIF-2? phosphorylation by CK1? promotes erythropoietin secretion in liver cancer cells under hypoxia. J Cell Sci. 2016;129:4213-4226 pubmed
|
| Dehn S, DeBerge M, Yeap X, Yvan Charvet L, Fang D, Eltzschig H, et al. HIF-2? in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis. J Immunol. 2016;197:3639-3649 pubmed
|
| Wang S, Zeng H, Xie X, Tao Y, He X, Roman R, et al. Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling. Oncotarget. 2016;7:58848-58861 pubmed 出版商
|
| Görtz G, Horstmann M, Aniol B, Reyes B, Fandrey J, Eckstein A, et al. Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking. J Clin Endocrinol Metab. 2016;101:4834-4842 pubmed
|
| Zhang C, Zhi W, Lu H, Samanta D, Chen I, Gabrielson E, et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget. 2016;7:64527-64542 pubmed 出版商
|
| Prakash H, Nadella V, Singh S, Schmitz Winnenthal H. CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma. Sci Rep. 2016;6:31490 pubmed 出版商
|
| Gstalder C, Ader I, Cuvillier O. FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. Mol Cancer Ther. 2016;15:2465-2474 pubmed
|
| Nauta T, Duyndam M, Weijers E, van Hinsbergh V, Koolwijk P. HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells. PLoS ONE. 2016;11:e0160700 pubmed 出版商
|
| Mendes V, Bartholomeusz G, Ayres M, Gandhi V, Salvador J. Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells. Eur J Med Chem. 2016;123:317-331 pubmed 出版商
|
| Depner C, Zum Buttel H, Bogurcu N, Cuesta A, Aburto M, Seidel S, et al. EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance. Nat Commun. 2016;7:12329 pubmed 出版商
|
| Leinonen H, Rossi M, Salo A, Tiainen P, Hyvärinen J, Pitkänen M, et al. Lack of P4H-TM in mice results in age-related retinal and renal alterations. Hum Mol Genet. 2016;25:3810-3823 pubmed 出版商
|
| Cui J, Duan B, Zhao X, Chen Y, Sun S, Deng W, et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016;37:13455-13467 pubmed
|
| Pramono A, Zahabi A, Morishima T, Lan D, Welte K, Skokowa J. Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop. Ann N Y Acad Sci. 2016;1375:38-51 pubmed 出版商
|
| Chen H, Hong F, Chen Y, Li J, Yao Y, Zhang Y, et al. Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion. Eur J Pharmacol. 2016;789:354-361 pubmed 出版商
|
| Luo B, Wang J, Liu Z, Shen Z, Shi R, Liu Y, et al. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution. Nat Commun. 2016;7:12177 pubmed 出版商
|
| Nunomiya A, Shin J, Kitajima Y, Dan T, Miyata T, Nagatomi R. Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice. Acta Physiol (Oxf). 2017;220:99-112 pubmed 出版商
|
| Lee M, Huang H, Chang T, Huang H, Hsieh S, Chen Y, et al. Genome-wide analysis of HIF-2? chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions. Sci Rep. 2016;6:29311 pubmed 出版商
|
| Mandl M, Lieberum M, Depping R. A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT. Cell Death Dis. 2016;7:e2284 pubmed 出版商
|
| Diaz Trelles R, Scimia M, Bushway P, Tran D, Monosov A, Monosov E, et al. Notch-independent RBPJ controls angiogenesis in the adult heart. Nat Commun. 2016;7:12088 pubmed 出版商
|
| Kowitzke B, Cohrs G, Leuschner I, Koch A, Synowitz M, Mehdorn H, et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J Neuropathol Exp Neurol. 2016;75:827-42 pubmed 出版商
|
| Mao X, Wang C, Liu D, Zhang X, Wang L, Yan M, et al. Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma. Oncotarget. 2016;7:47808-47820 pubmed 出版商
|
| Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed 出版商
|
| Zhang X, Prasadam I, Fang W, Crawford R, Xiao Y. Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2? activity. Osteoarthritis Cartilage. 2016;24:1970-1980 pubmed 出版商
|
| Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed 出版商
|
| Mahara S, Lee P, Feng M, Tergaonkar V, Chng W, Yu Q. HIFI-? activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer. Proc Natl Acad Sci U S A. 2016;113:E3735-44 pubmed 出版商
|
| Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed 出版商
|
| Hoang N, Kadonosono T, Kuchimaru T, Kizaka Kondoh S. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016;107:1151-8 pubmed 出版商
|
| Mammadzada P, Gudmundsson J, Kvanta A, André H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol. 2016;94:805-814 pubmed 出版商
|
| Rodriguez S, Rudloff S, Koenig K, Karthik S, Hoogewijs D, Huynh Do U. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016;468:1433-48 pubmed 出版商
|
| Warfel N, Sainz A, Song J, Kraft A. PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Mol Cancer Ther. 2016;15:1637-47 pubmed 出版商
|
| Christinat Y, Pawłowski R, Krek W. jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data. Bioinformatics. 2016;32:2111-9 pubmed 出版商
|
| Dai Z, Li M, Wharton J, Zhu M, Zhao Y. Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2?. Circulation. 2016;133:2447-58 pubmed 出版商
|
| Celik M, Labuz D, Henning K, Busch Dienstfertig M, Gaveriaux Ruff C, Kieffer B, et al. Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides. Brain Behav Immun. 2016;57:227-242 pubmed 出版商
|
| Fitzpatrick S, Fabian Z, Schaible B, Lenihan C, Schwarzl T, Rodriguez J, et al. Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-?B-dependent manner. Biochem Biophys Res Commun. 2016;474:579-586 pubmed 出版商
|
| Selfridge A, Cavadas M, Scholz C, Campbell E, Welch L, Lecuona E, et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016;291:11800-8 pubmed 出版商
|
| Timpano S, Uniacke J. Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation. J Biol Chem. 2016;291:10772-82 pubmed 出版商
|
| Zhang C, Samanta D, Lu H, Bullen J, Zhang H, Chen I, et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m?A-demethylation of NANOG mRNA. Proc Natl Acad Sci U S A. 2016;113:E2047-56 pubmed 出版商
|
| Nam H, Jones D, Cooksey R, Gao Y, Sink S, Cox J, et al. Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver. Diabetes. 2016;65:1521-33 pubmed 出版商
|
| German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed 出版商
|
| You A, Cao M, Guo Z, Zuo B, Gao J, Zhou H, et al. Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models. J Hematol Oncol. 2016;9:20 pubmed 出版商
|
| Zeng H, He X, Tuo Q, Liao D, Zhang G, Chen J. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways. Sci Rep. 2016;6:20931 pubmed 出版商
|
| Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed 出版商
|
| Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed 出版商
|
| Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed 出版商
|
| Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed 出版商
|
| Regan Anderson T, Ma S, Raj G, Cidlowski J, Helle T, Knutson T, et al. Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res. 2016;76:1653-63 pubmed 出版商
|
| Kadam P, Chuan H. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016;27:505 pubmed 出版商
|
| Qian F, He M, Duan W, Mao L, Li Q, Yu Z, et al. Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis. Am J Transl Res. 2015;7:2364-78 pubmed
|
| Mysore V, Szablowski J, Dervan P, FROST P. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. 2016;14:253-66 pubmed 出版商
|
| Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed 出版商
|
| Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed 出版商
|
| Binó L, KuÄera J, Å tefková K, Å vihálková Å indlerová L, Lánová M, Kudová J, et al. The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. Chem Biol Interact. 2016;244:204-14 pubmed 出版商
|
| Messai Y, Gad S, Noman M, Le Teuff G, Couve S, Janji B, et al. Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status. Eur Urol. 2016;70:623-632 pubmed 出版商
|
| Laukka T, Mariani C, Ihantola T, Cao J, Hokkanen J, Kaelin W, et al. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016;291:4256-65 pubmed 出版商
|
| Cavadas M, Mesnieres M, Crifò B, Manresa M, Selfridge A, Scholz C, et al. REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia. Sci Rep. 2015;5:17851 pubmed 出版商
|
| Vukovic M, Guitart A, Sepúlveda C, Villacreces A, O Duibhir E, Panagopoulou T, et al. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. J Exp Med. 2015;212:2223-34 pubmed 出版商
|
| Bhanu N, Sidoli S, Garcia B. Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation. Proteomics. 2016;16:448-58 pubmed 出版商
|
| Sun W, Kosyna F, Jelkmann W, Depping R. Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression. Cell Physiol Biochem. 2015;37:2257-64 pubmed 出版商
|
| Mandl M, Lieberum M, Dunst J, Depping R. The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 2015;10:229 pubmed 出版商
|
| Cheng S, Xing W, Pourteymoor S, Schulte J, Mohan S. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. 2016;157:127-40 pubmed 出版商
|
| Aquino Gálvez A, González Ãvila G, Delgado Tello J, Castillejos López M, Mendoza Milla C, Zúñiga J, et al. Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia. Oncol Rep. 2016;35:577-83 pubmed 出版商
|
| Highet A, Khoda S, Buckberry S, Leemaqz S, Bianco Miotto T, Harrington E, et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur J Cell Biol. 2015;94:589-602 pubmed 出版商
|
| Huh Y, Lee G, Lee K, Koh J, Chun J, Ryu J. HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models. Arthritis Res Ther. 2015;17:302 pubmed 出版商
|
| Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, et al. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. EMBO J. 2015;34:2953-70 pubmed 出版商
|
| Saini Y, Proper S, Dornbos P, Greenwood K, Kopec A, Lynn S, et al. Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice. PLoS ONE. 2015;10:e0139270 pubmed 出版商
|
| Stengel C, Newman S, Leese M, Thomas M, Potter B, Reed M, et al. The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression. Anticancer Res. 2015;35:5249-61 pubmed
|
| Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112:E4600-9 pubmed 出版商
|
| Högel H, Miikkulainen P, Bino L, Jaakkola P. Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27. Mol Cancer. 2015;14:143 pubmed 出版商
|
| Ramakrishnan S, Anderson E, Martin A, Centofanti B, Shah Y. Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice. Proc Natl Acad Sci U S A. 2015;112:E3738-47 pubmed 出版商
|
| Otto T, Gellhaus A, Lüschen N, Scheidler J, Bendix I, Dunk C, et al. Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia?. J Cell Biochem. 2015;116:2924-37 pubmed 出版商
|
| Matsuyama T, Tanaka T, Tatsumi K, Daijo H, Kai S, Harada H, et al. Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system. Eur J Pharmacol. 2015;761:189-98 pubmed 出版商
|
| Lin A, Beasley F, Olson J, Keller N, Shalwitz R, Hannan T, et al. Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection. PLoS Pathog. 2015;11:e1004818 pubmed 出版商
|
| Forristal C, Brown A, Helwani F, Winkler I, Nowlan B, Barbier V, et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia. 2015;29:2075-85 pubmed 出版商
|
| Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol Cancer. 2015;14:77 pubmed 出版商
|
| Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell Dev Biol Anim. 2015;51:808-14 pubmed 出版商
|
| Rad E, Dodd K, Thomas L, Upadhyaya M, Tee A. STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors. Mol Cancer Res. 2015;13:1149-60 pubmed 出版商
|
| Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, et al. Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes. Curr Gene Ther. 2015;15:313-25 pubmed
|
| McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew D, et al. Pharmacological inhibition of FTO. PLoS ONE. 2015;10:e0121829 pubmed 出版商
|
| Qiu B, Ackerman D, Sanchez D, Li B, Ochocki J, Grazioli A, et al. HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov. 2015;5:652-67 pubmed 出版商
|
| Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed 出版商
|
| Zeng H, Vaka V, He X, Booz G, Chen J. High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss. J Cell Mol Med. 2015;19:1847-56 pubmed 出版商
|
| Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116:1680-90 pubmed 出版商
|
| Doonachar A, Gallo M, Doukas D, Pasricha R, Lantsberg I, Schoenfeld A. Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines. Cancer Cell Int. 2015;15:23 pubmed 出版商
|
| Jimenez K, Khare V, Evstatiev R, Kulnigg Dabsch S, Jambrich M, Strobl H, et al. Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation. J Thromb Haemost. 2015;13:1113-27 pubmed 出版商
|
| Matak P, Heinis M, Mathieu J, Corriden R, Cuvellier S, Delga S, et al. Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis. J Immunol. 2015;194:3259-66 pubmed 出版商
|
| Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed 出版商
|
| Nozawa Suzuki N, Nagasawa H, Ohnishi K, Morishige K. The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer. Biochem Biophys Res Commun. 2015;457:706-11 pubmed 出版商
|
| Gong H, Rehman J, Tang H, Wary K, Mittal M, Chaturvedi P, et al. HIF2α signaling inhibits adherens junctional disruption in acute lung injury. J Clin Invest. 2015;125:652-64 pubmed 出版商
|
| Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, et al. Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet. 2015;11:e1004898 pubmed 出版商
|
| Tsuboi I, Yamashita T, Nagano M, Kimura K, To a Salazar G, Ohneda O. Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia. J Cell Physiol. 2015;230:1534-48 pubmed 出版商
|
| Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, et al. Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells. Oncotarget. 2015;6:2206-21 pubmed
|
| Singleton D, Rouhi P, Zois C, Haider S, Li J, Kessler B, et al. Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis. Oncogene. 2015;34:4713-22 pubmed 出版商
|
| Koh M, Nguyen V, Lemos R, Darnay B, Kiriakova G, Abdelmelek M, et al. Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma. Cancer Res. 2015;75:316-29 pubmed 出版商
|
| Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong G, et al. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell Death Differ. 2015;22:875-84 pubmed 出版商
|
| El Assar M, Sánchez Puelles J, Royo I, López Hernández E, Sánchez Ferrer A, Aceña J, et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br J Pharmacol. 2015;172:1277-91 pubmed 出版商
|
| Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed 出版商
|
| De Ponti A, Wiechert L, Stojanovic A, Longerich T, Marhenke S, Hogg N, et al. Chronic liver inflammation and hepatocellular carcinogenesis are independent of S100A9. Int J Cancer. 2015;136:2458-63 pubmed 出版商
|
| Muz B, de la Puente P, Azab F, Ghobrial I, Azab A. Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia. Mol Cancer Res. 2015;13:263-72 pubmed 出版商
|
| Kurt B, Gerl K, Karger C, Schwarzensteiner I, Kurtz A. Chronic hypoxia-inducible transcription factor-2 activation stably transforms juxtaglomerular renin cells into fibroblast-like cells in vivo. J Am Soc Nephrol. 2015;26:587-96 pubmed 出版商
|
| Wong W, Richardson T, Seykora J, Cotsarelis G, Simon M. Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function. J Invest Dermatol. 2015;135:454-461 pubmed 出版商
|
| Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed 出版商
|