产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
YAP1 Antibody - BSA Free
目录 :
NB110-58358
规格 :
0.1 ml (also 0.025 ml)
价格 :
459美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
异硫氰酸荧光素
克隆名称 :
6C5cc
反应物种 :
人类, 小鼠, , 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, ChIP-Seq
更多信息或购买 :
文章摘录数: 69
出版应用/物种/样本/稀释参考文献
  • 染色质免疫沉淀 ; 小鼠; 1:1000; 图 6a
Savorani C, Malinverno M, Seccia R, Maderna C, Giannotta M, Terreran L, et al. A dual role of YAP in driving TGFβ-mediated endothelial-to-mesenchymal transition. J Cell Sci. 2021;134: pubmed 出版商
  • ChIP-Seq; 小鼠; 图 5b
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed 出版商
Karatsai O, Lehka L, Wojton D, Grabowska A, Duda M, Lenartowski R, et al. Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166748 pubmed 出版商
Macfarlane E, Cavanagh L, Fong Yee C, Tuckermann J, Chen D, Little C, et al. Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis Cartilage. 2023;31:1189-1201 pubmed 出版商
Fetiva M, Liss F, Gertzmann D, Thomas J, Gantert B, Vogl M, et al. Oncogenic YAP mediates changes in chromatin accessibility and activity that drive cell cycle gene expression and cell migration. Nucleic Acids Res. 2023;51:4266-4283 pubmed 出版商
Meliambro K, Yang Y, de Cos M, Rodriguez Ballestas E, Malkin C, Haydak J, et al. KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression. JCI Insight. 2023;8: pubmed 出版商
Banerjee P, Kumaravel S, Roy S, Gaddam N, Odeh J, Bayless K, et al. Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway. Cells. 2023;12: pubmed 出版商
McCourt J, Stearns Reider K, Mamsa H, Kannan P, Afsharinia M, Shu C, et al. Multi-omics analysis of sarcospan overexpression in mdx skeletal muscle reveals compensatory remodeling of cytoskeleton-matrix interactions that promote mechanotransduction pathways. Skelet Muscle. 2023;13:1 pubmed 出版商
Sakabe M, Thompson M, Chen N, Verba M, Hassan A, Lu R, et al. Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis. elife. 2022;11: pubmed 出版商
Hazra R, Brine L, Garcia L, Benz B, Chirathivat N, Shen M, et al. Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment. Dev Cell. 2022;57:2450-2468.e7 pubmed 出版商
Zhao X, Tang L, Le T, Nguyen B, Chen W, Zheng M, et al. Yap and Taz promote osteogenesis and prevent chondrogenesis in neural crest cells in vitro and in vivo. Sci Signal. 2022;15:eabn9009 pubmed 出版商
Kokate S, Ciuba K, Tran V, Kumari R, Tojkander S, Engel U, et al. Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments. Nat Commun. 2022;13:6032 pubmed 出版商
De Chiara L, Conte C, Semeraro R, Diaz Bulnes P, Angelotti M, Mazzinghi B, et al. Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease. Nat Commun. 2022;13:5805 pubmed 出版商
Fang K, Du S, Shen D, Xiong Z, Jiang K, Liang D, et al. SUFU suppresses ferroptosis sensitivity in breast cancer cells via Hippo/YAP pathway. iScience. 2022;25:104618 pubmed 出版商
Das A, Adhikary S, Chowdhury A, Barui A. Leveraging Substrate Stiffness to Promote Stem Cell Asymmetric Division via Mechanotransduction-Polarity Protein Axis and Its Bayesian Regression Analysis. Rejuvenation Res. 2022;25:59-69 pubmed 出版商
Zhu M, Peng R, Liang X, Lan Z, Tang M, Hou P, et al. P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis. Oncogene. 2021;40:6049-6056 pubmed 出版商
Wolfe A, Zhou Q, Toska E, Galeas J, Ku A, Koche R, et al. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
Hicks Berthet J, Ning B, Federico A, Tilston Lunel A, Matschulat A, Ai X, et al. Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Rep. 2021;36:109347 pubmed 出版商
Chakravarti D, Lee R, Multani A, Santoni A, Keith Z, Hsu W, et al. Telomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021;118: pubmed 出版商
Liu S, Li K, Wagner Florencio L, Tang L, Heallen T, Leach J, et al. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med. 2021;13: pubmed 出版商
Kastan N, Gnedeva K, Alisch T, Petelski A, Huggins D, Chiaravalli J, et al. Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues. Nat Commun. 2021;12:3100 pubmed 出版商
Sun X, Malandraki Miller S, Kennedy T, Bassat E, Klaourakis K, Zhao J, et al. The extracellular matrix protein agrin is essential for epicardial epithelial-to-mesenchymal transition during heart development. Development. 2021;148: pubmed 出版商
Tang Q, Efe G, Chiarella A, Leung J, Chen M, Yamazoe T, et al. Mutant p53 regulates Survivin to foster lung metastasis. Genes Dev. 2021;35:528-541 pubmed 出版商
Li C, Peng Z, Wang Y, Lam G, Nissen N, Tang J, et al. Epithelial Cell Transforming 2 (ECT2) is regulated by Yes-associated protein 1 (YAP1) and mediates pancreatic cancer progression and metastasis. Am J Physiol Gastrointest Liver Physiol. 2021;: pubmed 出版商
Zhang H, Gui T, Liu R, Tong K, Wu C, Li Z, et al. Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1. Cell Death Dis. 2021;12:121 pubmed 出版商
Passaro F, De Martino I, Zambelli F, Di Benedetto G, Barbato M, D Erchia A, et al. YAP contributes to DNA methylation remodeling upon mouse embryonic stem cell differentiation. J Biol Chem. 2020;: pubmed 出版商
Imam Aliagan A, Madungwe N, Tombo N, Feng Y, Bopassa J. Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway. Front Endocrinol (Lausanne). 2020;11:579161 pubmed 出版商
Fomicheva M, Macara I. Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation. elife. 2020;9: pubmed 出版商
Aharonov A, Shakked A, Umansky K, Savidor A, Genzelinakh A, Kain D, et al. ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration. Nat Cell Biol. 2020;22:1346-1356 pubmed 出版商
Gao C, Hu W, Liu F, Zeng Z, Zhu Q, Fan J, et al. Aldo-keto reductase family 1 member B induces aortic valve calcification by activating hippo signaling in valvular interstitial cells. J Mol Cell Cardiol. 2020;150:54-64 pubmed 出版商
Lorenzo Martín L, Fernández Parejo N, Menacho Márquez M, Rodríguez Fdez S, Robles Valero J, Zumalave S, et al. VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma. Nat Commun. 2020;11:4788 pubmed 出版商
Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, et al. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020;11:4766 pubmed 出版商
Yamashita A, Yoshitomi H, Kihara S, Toguchida J, Tsumaki N. Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells. Stem Cells Transl Med. 2020;: pubmed 出版商
Wilson K, Ameen M, Guo H, Abilez O, Tian L, Mumbach M, et al. Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates. Dev Cell. 2020;54:694-709.e9 pubmed 出版商
Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, et al. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer. 2020;11:479-487 pubmed 出版商
Liu T, Zhou L, Yang K, Iwasawa K, Kadekaro A, Takebe T, et al. The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduct Target Ther. 2019;4:63 pubmed 出版商
Lefort S, Tan S, Balani S, Rafn B, Pellacani D, Hirst M, et al. Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation. Oncogene. 2020;39:1957-1968 pubmed 出版商
St Jean G, Tsoi M, Abedini A, Levasseur A, Rico C, Morin M, et al. Lats1 and Lats2 are required for the maintenance of multipotency in the Müllerian duct mesenchyme. Development. 2019;146: pubmed 出版商
Kattan W, Chen W, Ma X, Lan T, van der Hoeven D, van der Hoeven R, et al. Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function. Life Sci Alliance. 2019;2: pubmed 出版商
Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, et al. The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Rep. 2019;27:3533-3546.e7 pubmed 出版商
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed 出版商
Rueda E, Hall B, Hill M, Swinton P, Tong X, Martin J, et al. The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming. Cell Rep. 2019;27:1637-1649.e6 pubmed 出版商
He Q, Gao Y, Wang T, Zhou L, Zhou W, Yuan Z. Deficiency of Yes-Associated Protein Induces Cataract in Mice. Aging Dis. 2019;10:293-306 pubmed 出版商
Ma R, Ren J, Li P, Zhou Y, Zhou M, Hu Z, et al. Activated YAP causes renal damage of type 2 diabetic nephropathy. Eur Rev Med Pharmacol Sci. 2019;23:755-763 pubmed 出版商
Mueller K, Glajch K, Huizenga M, Wilson R, Granucci E, Dios A, et al. Hippo Signaling Pathway Dysregulation in Human Huntington's Disease Brain and Neuronal Stem Cells. Sci Rep. 2018;8:11355 pubmed 出版商
Liu M, Jiang K, Lin G, Liu P, Yan Y, Ye T, et al. Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation. J Exp Clin Cancer Res. 2018;37:165 pubmed 出版商
Frank S, Köllmann C, Luong P, Galli G, Zou L, Bernards A, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217:3183-3201 pubmed 出版商
Cai J, Song X, Wang W, Watnick T, Pei Y, Qian F, et al. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev. 2018;32:781-793 pubmed 出版商
Dehghanian F, Hojati Z, Esmaeili F, Masoudi Nejad A. Network-based expression analyses and experimental validations revealed high co-expression between Yap1 and stem cell markers compared to differentiated cells. Genomics. 2018;: pubmed 出版商
Artap S, Manderfield L, Smith C, Poleshko A, Aghajanian H, See K, et al. Endocardial Hippo signaling regulates myocardial growth and cardiogenesis. Dev Biol. 2018;440:22-30 pubmed 出版商
Xiao Y, Hill M, Zhang M, Martin T, Morikawa Y, Wang S, et al. Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development. Dev Cell. 2018;45:153-169.e6 pubmed 出版商
Zheng Y, Liu B, Wang L, Lei H, Pulgar Prieto K, Pan D. Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Dependent Recruitment of the STRIPAK PP2A Phosphatase Complex. Cell Rep. 2017;21:3612-3623 pubmed 出版商
Meliambro K, Wong J, Ray J, Calizo R, Towne S, Cole B, et al. The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics. J Biol Chem. 2017;292:21137-21148 pubmed 出版商
Leach J, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill M, et al. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017;550:260-264 pubmed 出版商
Sarkar S, Bristow C, Dey P, Rai K, Perets R, Ramirez Cardenas A, et al. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017;31:1109-1121 pubmed 出版商
Morikawa Y, Heallen T, Leach J, Xiao Y, Martin J. Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. Nature. 2017;547:227-231 pubmed 出版商
Bassat E, Mutlak Y, Genzelinakh A, Shadrin I, Baruch Umansky K, Yifa O, et al. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017;547:179-184 pubmed 出版商
Kim Y, Kim W, Song Y, Kim J, Cho K, Moon H, et al. Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability. Proc Natl Acad Sci U S A. 2017;114:4691-4696 pubmed 出版商
Hirata H, Samsonov M, Sokabe M. Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes. Sci Rep. 2017;7:46326 pubmed 出版商
Nakajima H, Yamamoto K, Agarwala S, Terai K, Fukui H, Fukuhara S, et al. Flow-Dependent Endothelial YAP Regulation Contributes to Vessel Maintenance. Dev Cell. 2017;40:523-536.e6 pubmed 出版商
Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed 出版商
Tao G, Kahr P, Morikawa Y, Zhang M, Rahmani M, Heallen T, et al. Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury. Nature. 2016;534:119-23 pubmed 出版商
Rizvi S, Yamada D, Hirsova P, Bronk S, Werneburg N, Krishnan A, et al. A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma. J Biol Chem. 2016;291:8031-47 pubmed 出版商
Jung K, McCarthy R, Zhou C, Uprety N, Barton M, Beretta L. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 2016;34:1284-96 pubmed 出版商
Brusgard J, Choe M, Chumsri S, Renoud K, MacKerell A, Sudol M, et al. RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget. 2015;6:28132-50 pubmed 出版商
Chen W, Lin H, Tang M. Matrix-Stiffness-Regulated Inverse Expression of Krüppel-Like Factor 5 and Krüppel-Like Factor 4 in the Pathogenesis of Renal Fibrosis. Am J Pathol. 2015;185:2468-81 pubmed 出版商
Cai J, Maitra A, Anders R, Taketo M, Pan D. β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev. 2015;29:1493-506 pubmed 出版商
Chen Q, Zhang N, Xie R, Wang W, Cai J, Choi K, et al. Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP. Genes Dev. 2015;29:1285-97 pubmed 出版商
Karystinou A, Roelofs A, Neve A, Cantatore F, Wackerhage H, De Bari C. Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells. Arthritis Res Ther. 2015;17:147 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB110-58358
SKU号 :
NB110-58358
产品名称 :
YAP1 Antibody - BSA Free
描述 :
The YAP1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to YAP1. This antibody reacts with human, mouse, rat, canine, zebrafish. The YAP1 Antibody - BSA Free has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Chromatin Immunoprecipitation (ChIP), Knockout Validated, Knockdown Validated.
靶标 :
YAP1
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
This YAP1 Antibody was developed against a partial recombinant human YAP1 protein expressed in bacteria. [Uniprot: P46937], N-terminal GST fusion protein
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 狗, 斑马鱼
特异性 :
Expected reactivity based on immunogen homology: Isoform 4 (100%), Isoform 6 (100%)
理论上的分子量 :
48 kDa
基因符号 :
YAP1
应用 :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Chromatin Immunoprecipitation (ChIP), Knockout Validated, Knockdown Validated
美元 :
459美元
别名 :
65 kDa Yes-associated protein, COB1, Protein Yorkie Homolog, Transcriptional Coactivator YAP1, YAP, YAP1-2gamma, YAP2, YAP2L, YAP65, YAP65yes-associated protein 2, Yes Associated Protein, Yes-Associated Protein, Yes-associated protein 1, Yes-associated protein 1, 65kDa, yes-associated protein beta, yes-associated protein delta, Yes-Associated Protein YAP65 Homolog, YKI, yorkie homolog
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。