产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Nox4 Antibody - BSA Free
目录 :
NB110-58849
规格 :
0.1 ml (also 0.025 ml)
价格 :
449美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
DyLight系列染料405
克隆名称 :
5B12
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 75
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 1b
Luckett K, Cracchiolo J, Krishnamoorthy G, Leandro García L, Nagarajah J, Saqcena M, et al. Co-inhibition of SMAD and MAPK signaling enhances 124I uptake in BRAF-mutant thyroid cancers. Endocr Relat Cancer. 2021;28:391-402 pubmed 出版商
  • 免疫印迹; 人类; 图 4m
Mota M, Metge B, Hinshaw D, Alsheikh H, Chen D, Samant R, et al. Merlin deficiency alters the redox management program in breast cancer. Mol Oncol. 2021;15:942-956 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s1
  • 免疫印迹; 人类; 图 s7
Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3
Dyikanov D, Vasiluev P, Rysenkova K, Aleksandrushkina N, Tyurin Kuzmin P, Kulebyakin K, et al. Optimization of CRISPR/Cas9 technology to knock-out genes of interest in aneuploid cell lines. Tissue Eng Part C Methods. 2019;: pubmed 出版商
  • 免疫印迹; 大鼠; 图 3f
Bitar M, Nader J, Al Ali W, Al Madhoun A, Arefanian H, Al Mulla F. Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. Oxid Med Cell Longev. 2018;2018:6825452 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 5
  • 免疫印迹; 人类; 图 2
Sato N, Takasaka N, Yoshida M, Tsubouchi K, Minagawa S, Araya J, et al. Metformin attenuates lung fibrosis development via NOX4 suppression. Respir Res. 2016;17:107 pubmed 出版商
Pandey J, Larson Casey J, Patil M, Joshi R, Jiang C, Zhou Y, et al. NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming. J Biol Chem. 2023;299:104695 pubmed 出版商
Jiang Z, Wu L, van der Leeden B, van Rossum A, Niessen H, Krijnen P. NOX2 and NOX5 are increased in cardiac microvascular endothelium of deceased COVID-19 patients. Int J Cardiol. 2023;370:454-462 pubmed 出版商
Milara J, Mart xed nez Exp xf3 sito F, Montero P, Roger I, Bayarri M, Ribera P, et al. N-acetylcysteine Reduces Inflammasome Activation Induced by SARS-CoV-2 Proteins In Vitro. Int J Mol Sci. 2022;23: pubmed 出版商
Jo J, Kim J, Leem J. Protective Effects of Orexin A in a Murine Model of Cisplatin-Induced Acute Kidney Injury. J Clin Med. 2022;11: pubmed 出版商
Piao S, Ding J, Lin X, Nan Q, Xuan M, Jiang Y, et al. Inhibition of RIP1-RIP3-mediated necroptosis attenuates renal fibrosis via Wnt3α/β-catenin/GSK-3β signaling in unilateral ureteral obstruction. PLoS ONE. 2022;17:e0274116 pubmed 出版商
Chen Y, Wu T, Ho C, Yeh T, Sun G, Tseng C, et al. Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2022;23: pubmed 出版商
Baylan U, Korn A, Emmens R, Schalkwijk C, Niessen H, Krijnen P, et al. Liraglutide treatment attenuates inflammation markers in the cardiac, cerebral and renal microvasculature in streptozotocin-induced diabetic rats. Eur J Clin Invest. 2022;52:e13807 pubmed 出版商
Fukatsu M, Ohkawara H, Wang X, Alkebsi L, Furukawa M, Mori H, et al. The suppressive effects of Mer inhibition on inflammatory responses in the pathogenesis of LPS-induced ALI/ARDS. Sci Signal. 2022;15:eabd2533 pubmed 出版商
Ding J, Jin J, Na Lei Y, Cui S, Ying Li H, Lan Zheng H, et al. Exogenous pancreatic kininogenase protects against tacrolimus-induced renal injury by inhibiting PI3K/AKT signaling: The role of bradykinin receptors. Int Immunopharmacol. 2022;105:108547 pubmed 出版商
Xuan M, Piao S, Ding J, Nan Q, Piao M, Jiang Y, et al. Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction. Front Pharmacol. 2021;12:798381 pubmed 出版商
Youn J, Zhang Y, Wu Y, Cannesson M, Cai H. Therapeutic application of estrogen for COVID-19: Attenuation of SARS-CoV-2 spike protein and IL-6 stimulated, ACE2-dependent NOX2 activation, ROS production and MCP-1 upregulation in endothelial cells. Redox Biol. 2021;46:102099 pubmed 出版商
Chiou J, Shi Y, Lee Y, Wang L, Chen Y, Chang L. Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis. Int J Biol Macromol. 2021;187:513-527 pubmed 出版商
Jaekel C, Thelen S, Oezel L, Wohltmann M, Wille J, Windolf J, et al. Illuminating the effect of beneficial blue light and ROS-modulating enzymes in Dupuytren's disease. PLoS ONE. 2021;16:e0253777 pubmed 出版商
Larson Casey J, Gu L, Kang J, Dhyani A, Carter A. NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression. J Biol Chem. 2021;297:100810 pubmed 出版商
Chiou J, Huang N, Huang C, Wang L, Lee Y, Shi Y, et al. NOXA-mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin-treated human acute myeloid leukemia cells. J Cell Physiol. 2021;236:7356-7375 pubmed 出版商
Chen H, Yan T, Song Z, Ying S, Wu B, Ju X, et al. MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4. Exp Mol Med. 2021;53:681-694 pubmed 出版商
Ammon J, Valls D, Eldemerdash M, Patel J, Tran P, Feng L, et al. G protein-coupled receptor kinase 2 modifies the cellular reaction to cisplatin through interactions with NADPH oxidase 4. Mol Cell Biochem. 2021;476:1505-1516 pubmed 出版商
Li X, Chen X, Liu Y, Zhang P, Zheng Y, Zeng W. The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase. Front Genet. 2020;11:997 pubmed 出版商
Huang K, Wang Y, Siu K, Zhang Y, Cai H. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biol. 2020;38:101757 pubmed 出版商
Jayachandran I, Sundararajan S, Venkatesan S, Paadukaana S, Balasubramanyam M, Mohan V, et al. Asymmetric dimethylarginine (ADMA) accelerates renal cell fibrosis under high glucose condition through NOX4/ROS/ERK signaling pathway. Sci Rep. 2020;10:16005 pubmed 出版商
Tsuji S, Nakamura S, Maoka T, Yamada T, Imai T, Ohba T, et al. Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma. Mar Drugs. 2020;18: pubmed 出版商
Pan L, Ren Z, Liu Y, Zhao Y, Li H, Pan X, et al. A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation. J Cell Mol Med. 2020;: pubmed 出版商
Jiang J, Huang K, Xu S, Garcia J, Wang C, Cai H. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biol. 2020;36:101638 pubmed 出版商
Wang C, Chao Y, Xu W, Liu Z, Wang H, Huang K. Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance. Redox Biol. 2020;37:101688 pubmed 出版商
Kim J, Leem J, Hong H. Protective Effects of SPA0355, a Thiourea Analogue, Against Lipopolysaccharide-Induced Acute Kidney Injury in Mice. Antioxidants (Basel). 2020;9: pubmed 出版商
Kaushik D, Ashcraft K, Wang H, Shanmugasundaram K, Shah P, Gonzalez G, et al. Nuclear NADPH oxidase-4 associated with disease progression in renal cell carcinoma. Transl Res. 2020;223:1-14 pubmed 出版商
Yu H, Kim Y, Cho M. Cytoplasm-localized SIRT1 downregulation attenuates apoptosis and cell cycle arrest in cisplatin-resistant lung cancer A549 cells. J Cancer. 2020;11:4495-4509 pubmed 出版商
Zhou S, Li Z, Liu P, Wang S, Zhao J, Zhang G. Donepezil Prevents ox-LDL-Induced Attachment of THP-1 Monocytes to Human Aortic Endothelial Cells (HAECs). Chem Res Toxicol. 2020;33:975-981 pubmed 出版商
Wang L, Chiou J, Lee Y, Huang C, Shi Y, Chang L. SIRT3, PP2A and TTP protein stability in the presence of TNF-α on vincristine-induced apoptosis of leukaemia cells. J Cell Mol Med. 2020;24:2552-2565 pubmed 出版商
Li L, Chen B, Zhu R, Li R, Tian Y, Liu C, et al. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). 2019;11:9348-9368 pubmed 出版商
Chen Y, Wu T, Ho C, Yeh T, Sun G, Kung Y, et al. Dapagliflozin Prevents NOX- and SGLT2-Dependent Oxidative Stress in Lens Cells Exposed to Fructose-Induced Diabetes Mellitus. Int J Mol Sci. 2019;20: pubmed 出版商
Rojas Morales P, Tapia E, León Contreras J, González Reyes S, Jiménez Osorio A, Trujillo J, et al. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules. 2019;9: pubmed 出版商
He C, Larson Casey J, Davis D, Hanumanthu V, Longhini A, Thannickal V, et al. NOX4 modulates macrophage phenotype and mitochondrial biogenesis in asbestosis. JCI Insight. 2019;4: pubmed 出版商
Wegner A, Campos N, Robbins M, Haddad A, Cunningham H, Yik J, et al. Acute Changes in NADPH Oxidase 4 in Early Post-Traumatic Osteoarthritis. J Orthop Res. 2019;37:2429-2436 pubmed 出版商
Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, et al. Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep. 2019;9:9850 pubmed 出版商
Chen Z, Tao S, Li X, Zeng X, Zhang M, Yao Q. Anagliptin protects neuronal cells against endogenous amyloid β (Aβ)-induced cytotoxicity and apoptosis. Artif Cells Nanomed Biotechnol. 2019;47:2213-2220 pubmed 出版商
Buck T, Hack C, Berg D, Berg U, Kunz L, Mayerhofer A. The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells. Sci Rep. 2019;9:3585 pubmed 出版商
Tang P, Dang H, Huang J, Xu T, Yuan P, Hu J, et al. NADPH oxidase NOX4 is a glycolytic regulator through mROS-HIF1α axis in thyroid carcinomas. Sci Rep. 2018;8:15897 pubmed 出版商
Lanza Jacoby S, Cheng G. 3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species. Pharm Biol. 2018;56:407-414 pubmed 出版商
Liu R, Yan X. Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway. Int J Mol Med. 2018;42:2315-2328 pubmed 出版商
Lindquist R, Bayat Sarmadi J, Leben R, Niesner R, Hauser A. NAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes. Int J Mol Sci. 2018;19: pubmed 出版商
Seo G, Hyun C, Koh D, Park S, Lim Y, Kim Y, et al. A Novel Synthetic Material, BMM, Accelerates Wound Repair by Stimulating Re-Epithelialization and Fibroblast Activation. Int J Mol Sci. 2018;19: pubmed 出版商
Dai Y, Zhang H, Zhang J, Yan M. Isoquercetin attenuates oxidative stress and neuronal apoptosis after ischemia/reperfusion injury via Nrf2-mediated inhibition of the NOX4/ROS/NF-κB pathway. Chem Biol Interact. 2018;284:32-40 pubmed 出版商
Moloney J, Jayavelu A, Stanicka J, Roche S, O Brien R, Scholl S, et al. Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML. Oncotarget. 2017;8:105440-105457 pubmed 出版商
Shanmugasundaram K, Nayak B, Friedrichs W, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun. 2017;8:997 pubmed 出版商
Tsubouchi K, Araya J, Minagawa S, Hara H, Ichikawa A, Saito N, et al. Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4. Autophagy. 2017;13:1420-1434 pubmed 出版商
Wang L, Ma R, Guo Y, Sun J, Liu H, Zhu R, et al. Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway. Front Pharmacol. 2017;8:266 pubmed 出版商
Kim Y, Kim S, Tatsunami R, Yamamura H, Fukai T, Ushio Fukai M. ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis. Am J Physiol Cell Physiol. 2017;312:C749-C764 pubmed 出版商
Sigala F, Efentakis P, Karageorgiadi D, Filis K, Zampas P, Iliodromitis E, et al. Reciprocal regulation of eNOS, H2S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin. Redox Biol. 2017;12:70-81 pubmed 出版商
Dickson B, Gatie M, Spice D, Kelly G. NOX1 and NOX4 are required for the differentiation of mouse F9 cells into extraembryonic endoderm. PLoS ONE. 2017;12:e0170812 pubmed 出版商
Sweetwyne M, Pippin J, Eng D, Hudkins K, Chiao Y, Campbell M, et al. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int. 2017;91:1126-1145 pubmed 出版商
Chen L, Zhao M, Li J, Wang Y, Bao Q, Wu S, et al. Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1. Cell Cycle. 2017;16:348-359 pubmed 出版商
Moloney J, Stanicka J, Cotter T. Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia. Leuk Res. 2017;52:34-42 pubmed 出版商
Liu X, Hao B, Ma A, He J, Liu X, Chen J. The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD. Biomed Res Int. 2016;2016:2891810 pubmed
Dosoki H, Stegemann A, Taha M, Schnittler H, Luger T, Schröder K, et al. Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis. Exp Dermatol. 2017;26:73-81 pubmed 出版商
Maraldi T, Resca E, Nicoli A, Beretti F, Zavatti M, Capodanno F, et al. NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging. Life Sci. 2016;162:108-14 pubmed 出版商
Min H, Cha J, Kim K, Kim J, Ghee J, Kim H, et al. Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy. J Korean Med Sci. 2016;31:1403-12 pubmed 出版商
Avin K, Chen N, Organ J, Zarse C, O Neill K, Conway R, et al. Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease. PLoS ONE. 2016;11:e0159411 pubmed 出版商
Dushpanova A, Agostini S, Ciofini E, Cabiati M, Casieri V, Matteucci M, et al. Gene silencing of endothelial von Willebrand Factor attenuates angiotensin II-induced endothelin-1 expression in porcine aortic endothelial cells. Sci Rep. 2016;6:30048 pubmed 出版商
Dalal S, Zha Q, Singh M, Singh K. Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK. Mol Cell Biochem. 2016;418:1-11 pubmed 出版商
Tyurin Kuzmin P, Zhdanovskaya N, Sukhova A, Sagaradze G, Albert E, Ageeva L, et al. Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF. PLoS ONE. 2016;11:e0154157 pubmed 出版商
Rajamanickam S, Panneerdoss S, Gorthi A, Timilsina S, Onyeagucha B, Kovalskyy D, et al. Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis. Clin Cancer Res. 2016;22:3524-36 pubmed 出版商
Shi Y, Sun X, Sun Y, Hou L, Yao M, Lian K, et al. Elevation of cortical C26:0 due to the decline of peroxisomal β-oxidation potentiates amyloid β generation and spatial memory deficits via oxidative stress in diabetic rats. Neuroscience. 2016;315:125-35 pubmed 出版商
Austin S, Santhanam A, d Uscio L, Katusic Z. Regional Heterogeneity of Cerebral Microvessels and Brain Susceptibility to Oxidative Stress. PLoS ONE. 2015;10:e0144062 pubmed 出版商
Cheng G, Lanza Jacoby S. Metformin decreases growth of pancreatic cancer cells by decreasing reactive oxygen species: Role of NOX4. Biochem Biophys Res Commun. 2015;465:41-6 pubmed 出版商
Youn J, Zhou J, Cai H. Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus. Mol Endocrinol. 2015;29:1123-33 pubmed 出版商
Yu C, Luo X, Duquette N, Thorin Trescases N, Thorin E. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol. 2015;308:H386-97 pubmed 出版商
Sanders Y, Liu H, Liu G, Thannickal V. Epigenetic mechanisms regulate NADPH oxidase-4 expression in cellular senescence. Free Radic Biol Med. 2015;79:197-205 pubmed 出版商
Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015;12:320-31 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB110-58849
SKU号 :
NB110-58849
产品名称 :
Nox4 Antibody - BSA Free
描述 :
The Nox4 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Nox4. This antibody reacts with human, mouse, rat, porcine, bovine, primate, rabbit, sheep. The Nox4 Antibody - BSA Free has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Knockdown Validated.
靶标 :
Nox4
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
A synthetic peptide made to an internal region of the human NOX4 protein (between residues 100-200) [UniProt Q9NPH5].
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 猪, 牛, 灵长类动物, 兔, 羊
基因符号 :
NOX4
应用 :
免疫印迹, 免疫组化, 免疫细胞化学/免疫荧光, 免疫组化石蜡, 免疫组化冷冻, 免疫印迹 , 基因敲减验证
美元 :
449美元
别名 :
EC 1.6.3, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX, KOX-1Renal NAD(P)H-oxidase, NADPH oxidase 4, RENOXEC 1.6.3.-
储存 :
存放在4C。 不冻结
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。