产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Apolipoprotein E/ApoE Antibody (WUE-4) - BSA Free
目录 :
NB110-60531
规格 :
0.1 ml (also 0.025 ml)
价格 :
449美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
WUE-4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 77
出版应用/物种/样本/稀释参考文献
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类
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  • 酶联免疫吸附测定; 小鼠
Lee C, Tse W, Smith J, Landreth G. Apolipoprotein E promotes ?-amyloid trafficking and degradation by modulating microglial cholesterol levels. J Biol Chem. 2012;287:2032-44 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
  • 免疫印迹; 小鼠
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  • 酶联免疫吸附测定; 人类
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Wang G, Yin W, Shin H, Tian Q, Lu W, Hou S. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nat Aging. 2021;1:1024-1037 pubmed 出版商
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Konings S, Torres Garcia L, Martinsson I, Gouras G. Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability. Front Neurosci. 2021;15:734001 pubmed 出版商
Milich L, Choi J, Ryan C, Cerqueira S, Benavides S, Yahn S, et al. Single-cell analysis of the cellular heterogeneity and interactions in the injured mouse spinal cord. J Exp Med. 2021;218: pubmed 出版商
Gnanaguru G, Wagschal A, Oh J, Saez Torres K, Li T, Temel R, et al. Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration. Mol Ther. 2021;29:2281-2293 pubmed 出版商
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Xu Y, Li Y, Jadhav K, Pan X, Zhu Y, Hu S, et al. Hepatocyte ATF3 protects against atherosclerosis by regulating HDL and bile acid metabolism. Nat Metab. 2021;3:59-74 pubmed 出版商
Yamazaki Y, Liu C, Yamazaki A, Shue F, Martens Y, Chen Y, et al. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. 2021;109:438-447.e6 pubmed 出版商
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Qi F, Meng Q, Hayashi I, Kobayashi J. FXR1 is a novel MRE11-binding partner and participates in oxidative stress responses. J Radiat Res. 2020;61:368-375 pubmed 出版商
Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019;9:19110 pubmed 出版商
Mladenov E, Staudt C, Soni A, Murmann Konda T, Siemann Loekes M, Iliakis G. Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52. Nucleic Acids Res. 2020;48:1905-1924 pubmed 出版商
Hanlon K, Meltzer J, Buzhdygan T, Cheng M, Sena Esteves M, Bennett R, et al. Selection of an Efficient AAV Vector for Robust CNS Transgene Expression. Mol Ther Methods Clin Dev. 2019;15:320-332 pubmed 出版商
Scherthan H, Lee J, Maus E, Schumann S, Muhtadi R, Chojowski R, et al. Nanostructure of Clustered DNA Damage in Leukocytes after In-Solution Irradiation with the Alpha Emitter Ra-223. Cancers (Basel). 2019;11: pubmed 出版商
Fievet A, Bellanger D, Zahed L, Burglen L, Derrien A, Dubois d Enghien C, et al. DNA repair functional analyses of NBN hypomorphic variants associated with NBN-related infertility. Hum Mutat. 2020;41:608-618 pubmed 出版商
Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann Y, Kanekiyo T, et al. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arterioscler Thromb Vasc Biol. 2020;40:128-144 pubmed 出版商
Porebski B, Wild S, Kummer S, Scaglione S, Gaillard P, Gari K. WRNIP1 Protects Reversed DNA Replication Forks from SLX4-Dependent Nucleolytic Cleavage. iScience. 2019;21:31-41 pubmed 出版商
Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, et al. C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex. Mol Cell. 2019;: pubmed 出版商
Yoshimura Y. Increased error-free DNA repair gene expression through reprogramming in human iPS cells. Regen Ther. 2019;11:101-105 pubmed 出版商
Jung J, Volk C, Marga C, Navarrete Santos A, Jung M, Rujescu D, et al. Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. Cell Reprogram. 2019;21:187-199 pubmed 出版商
Velichko A, Petrova N, Luzhin A, Strelkova O, Ovsyannikova N, Kireev I, et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription. Nucleic Acids Res. 2019;: pubmed 出版商
Zimmerman K, Bentley M, Lever J, Li Z, Crossman D, Song C, et al. Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species. J Am Soc Nephrol. 2019;30:767-781 pubmed 出版商
Afzal S, Garg S, Ishida Y, Terao K, Kaul S, Wadhwa R. Rat Glioma Cell-Based Functional Characterization of Anti-Stress and Protein Deaggregation Activities in the Marine Carotenoids, Astaxanthin and Fucoxanthin. Mar Drugs. 2019;17: pubmed 出版商
Alfano L, Caporaso A, Altieri A, Dell Aquila M, Landi C, Bini L, et al. Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Nucleic Acids Res. 2019;47:4068-4085 pubmed 出版商
Li C, Mahon C, Sweeney N, Verschueren E, Kantamani V, Li D, et al. PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis. Cell Rep. 2019;26:1333-1343.e7 pubmed 出版商
Schmid B, Prehn K, Nimsanor N, Garcia B, Poulsen U, Jørring I, et al. Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Stem Cell Res. 2019;34:101349 pubmed 出版商
Jachimowicz R, Beleggia F, Isensee J, Velpula B, Goergens J, Bustos M, et al. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019;176:505-519.e22 pubmed 出版商
Zhao N, Liu C, Van Ingelgom A, Linares C, Kurti A, Knight J, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nat Commun. 2018;9:4388 pubmed 出版商
Gustafsson N, Färnegårdh K, Bonagas N, Ninou A, Groth P, Wiita E, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018;9:3872 pubmed 出版商
Hung P, Johnson B, Chen B, Byrum A, Bredemeyer A, Yewdell W, et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Mol Cell. 2018;71:332-342.e8 pubmed 出版商
Müncheberg S, Hay R, Ip W, Meyer T, Weis C, Brenke J, et al. E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression. J Virol. 2018;92: pubmed 出版商
Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, et al. GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1. Nat Commun. 2018;9:1418 pubmed 出版商
Pancholi N, Weitzman M. Serotype-specific restriction of wild-type adenoviruses by the cellular Mre11-Rad50-Nbs1 complex. Virology. 2018;518:221-231 pubmed 出版商
Liu C, Zhao N, Fu Y, Wang N, Linares C, Tsai C, et al. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron. 2017;96:1024-1032.e3 pubmed 出版商
Huynh T, Liao F, Francis C, Robinson G, Serrano J, Jiang H, et al. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. Neuron. 2017;96:1013-1023.e4 pubmed 出版商
Zhao N, Liu C, Van Ingelgom A, Martens Y, Linares C, Knight J, et al. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 2017;96:115-129.e5 pubmed 出版商
Zhou H, Kawamura K, Yanagihara H, Kobayashi J, Zhang Akiyama Q. NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle-dependent degradation of protein. J Radiat Res. 2017;58:487-494 pubmed 出版商
Morales A, Carrero J, Hung P, Tubbs A, Andrews J, Edelson B, et al. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. elife. 2017;6: pubmed 出版商
Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed 出版商
Speiseder T, Hofmann Sieber H, Rodriguez E, Schellenberg A, Akyüz N, Dierlamm J, et al. Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. J Virol. 2017;91: pubmed 出版商
Cirilli M, Bereshchenko O, Ermakova O, Nerlov C. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Biochim Biophys Acta Gen Subj. 2017;1861:467-476 pubmed 出版商
Alvarez P, Genre F, Iglesias M, Augustin J, Tamayo E, Escolà Gil J, et al. Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol. Clin Exp Immunol. 2016;186:292-303 pubmed 出版商
Xu Z, Song Z, Li G, Tu H, Liu W, Liu Y, et al. H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Nucleic Acids Res. 2016;44:9681-9697 pubmed
Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed 出版商
Chouinard Watkins R, Pinçon A, Coulombe J, Spencer R, Massenavette L, Plourde M. A Diet Rich in Docosahexaenoic Acid Restores Liver Arachidonic Acid and Docosahexaenoic Acid Concentrations in Mice Homozygous for the Human Apolipoprotein E ?4 Allele. J Nutr. 2016;146:1315-21 pubmed 出版商
Pinçon A, Coulombe J, Chouinard Watkins R, Plourde M. Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. J Nutr Biochem. 2016;34:83-8 pubmed 出版商
Jung B, Kim H, Park G, Luo G, Chang K. Roles of human apolipoprotein E in the infectivity and replication of hepatitis C virus genotype 2a. J Microbiol. 2016;54:451-8 pubmed 出版商
Sódar B, Kittel A, Pálóczi K, Vukman K, Osteikoetxea X, Szabó Taylor K, et al. Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sci Rep. 2016;6:24316 pubmed 出版商
Choi Y, Meghani K, Brault M, Leclerc L, He Y, Day T, et al. Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer. Cell Rep. 2016;14:429-439 pubmed 出版商
Mayer A, Baran V, Sakakibara Y, Brzakova A, Ferencova I, Motlik J, et al. DNA damage response during mouse oocyte maturation. Cell Cycle. 2016;15:546-58 pubmed 出版商
Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmüller L. Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients. Oncogene. 2016;35:3796-806 pubmed 出版商
Tambini M, Pera M, Kanter E, Yang H, Guardia Laguarta C, Holtzman D, et al. ApoE4 upregulates the activity of mitochondria-associated ER membranes. EMBO Rep. 2016;17:27-36 pubmed 出版商
Bürck C, Mund A, Berscheminski J, Kieweg L, Müncheberg S, Dobner T, et al. KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification. J Virol. 2016;90:930-46 pubmed 出版商
Liu X, Chandramouly G, Rass E, Guan Y, Wang G, Hobbs R, et al. LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair. Nat Commun. 2015;6:8325 pubmed 出版商
Iannascoli C, Palermo V, Murfuni I, Franchitto A, Pichierri P. The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation. Nucleic Acids Res. 2015;43:9788-803 pubmed 出版商
Kijas A, Lim Y, Bolderson E, Cerosaletti K, Gatei M, Jakob B, et al. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015;43:8352-67 pubmed 出版商
Lee K, Im J, Shibata E, Park J, Handa N, Kowalczykowski S, et al. MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex. Nat Commun. 2015;6:7744 pubmed 出版商
Muraki K, Han L, Miller D, Murnane J. Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks. Nucleic Acids Res. 2015;43:7911-30 pubmed 出版商
Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem. 2015;290:18545-58 pubmed 出版商
Kobayashi J, Saito Y, Okui M, Miwa N, Komatsu K. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses. Mutat Res Genet Toxicol Environ Mutagen. 2015;782:42-50 pubmed 出版商
Wimmer P, Berscheminski J, Blanchette P, Groitl P, Branton P, Hay R, et al. PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53. Oncogene. 2016;35:69-82 pubmed 出版商
Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, et al. DNA2 drives processing and restart of reversed replication forks in human cells. J Cell Biol. 2015;208:545-62 pubmed 出版商
Patel J, Puck J, Srinivasan R, Brown C, Sunderam U, Kundu K, et al. Nijmegen breakage syndrome detected by newborn screening for T cell receptor excision circles (TRECs). J Clin Immunol. 2015;35:227-33 pubmed 出版商
Kondratova A, Watanabe T, Marotta M, Cannon M, Segall A, Serre D, et al. Replication fork integrity and intra-S phase checkpoint suppress gene amplification. Nucleic Acids Res. 2015;43:2678-90 pubmed 出版商
Parameswaran B, Chiang H, Lu Y, Coates J, Deng C, Baer R, et al. Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle. 2015;14:437-48 pubmed 出版商
Badie S, Carlos A, Folio C, Okamoto K, Bouwman P, Jonkers J, et al. BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres. EMBO J. 2015;34:410-24 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB110-60531
SKU号 :
NB110-60531
产品名称 :
Apolipoprotein E/ApoE Antibody (WUE-4) - BSA Free
描述 :
The Apolipoprotein E/ApoE Antibody (WUE-4) - BSA Free from Novus is a mouse monoclonal antibody to Apolipoprotein E/ApoE. This antibody reacts with human, mouse, rat (negative). The Apolipoprotein E/ApoE Antibody (WUE-4) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Flow (Intracellular), CyTOF-ready.
靶标 :
载脂蛋白e/ApoE基因
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
WUE-4
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Purified human ApoE [UniProt# P02649]
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Rat (Negative)
特异性 :
This antibody detects ApoE2, ApoE3 and ApoE4 (PMID 2466929)
理论上的分子量 :
36 kDa
基因符号 :
ApoE基因
应用 :
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Flow (Intracellular), CyTOF-ready
美元 :
449美元
别名 :
Apo-E, apolipoprotein E, apolipoprotein E3, late onset), MGC1571
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。