| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 免疫印迹; 人类; 1:1000; 图 2a, 3b
| Siu M, Jiang Y, Wang J, Leung T, Ngu S, Cheung A, et al. PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling. Oncogenesis. 2020;9:24 pubmed 出版商 |
| Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed 出版商 |
| Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, et al. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016;7:12702 pubmed 出版商 |
| Rossi S, Matzkin M, Riviere E, Martinez G, Ponzio R, Levalle O, et al. Melatonin improves oxidative state and lactate metabolism in rodent Sertoli cells. Mol Cell Endocrinol. 2023;576:112034 pubmed 出版商 |
| Bekeova C, Han J, Xu H, Kerr E, Blackburne B, Lynch S, et al. Acyl-CoA thioesterase-2 facilitates β-oxidation in glycolytic skeletal muscle in a lipid supply dependent manner. bioRxiv. 2023;: pubmed 出版商 |
| Li J, Zhu X, Oberdier M, Lee C, Lin S, Fink S, et al. A cell-penetrating PHLPP peptide improves cardiac arrest survival in murine and swine models. J Clin Invest. 2023;133: pubmed 出版商 |
| HOLLOWAY C, Zhong G, Kim Y, Ye H, Sampath H, Hammerling U, et al. Retinoic acid regulates pyruvate dehydrogenase kinase 4 (Pdk4) to modulate fuel utilization in the adult heart: Insights from wild-type and β-carotene 9',10' oxygenase knockout mice. FASEB J. 2022;36:e22513 pubmed 出版商 |
| Ito N, Takatsu A, Ito H, Koike Y, Yoshioka K, Kamei Y, et al. Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging. Cell Rep. 2022;40:111131 pubmed 出版商 |
| Li J, Chang W, Qin G, Wojcik K, Li C, Hsu C, et al. Baicalein Preconditioning Cardioprotection Involves Pro-Oxidant Signaling and Activation of Pyruvate Dehydrogenase. Am J Chin Med. 2022;50:1255-1267 pubmed 出版商 |
| Martin A, Fernandez M, Cattaneo E, Schuster C, Venara M, Cl xe9 ment F, et al. Type 1 Insulin-Like Growth Factor Receptor Nuclear Localization in High-Grade Glioma Cells Enhances Motility, Metabolism, and In Vivo Tumorigenesis. Front Endocrinol (Lausanne). 2022;13:849279 pubmed 出版商 |
| Gatie M, Cooper T, Khazaee R, Lajoie G, Kelly G. Lactate Enhances Mouse ES Cell Differentiation Toward XEN Cells In Vitro. Stem Cells. 2022;40:239-259 pubmed 出版商 |
| Damerau A, Kirchner M, Pfeiffenberger M, Ehlers L, Do Nguyen D, Mertins P, et al. Metabolic reprogramming of synovial fibroblasts in osteoarthritis by inhibition of pathologically overexpressed pyruvate dehydrogenase kinases. Metab Eng. 2022;72:116-132 pubmed 出版商 |
| Kanan Y, Hackett S, Taneja K, Khan M, Campochiaro P. Oxidative stress-induced alterations in retinal glucose metabolism in Retinitis Pigmentosa. Free Radic Biol Med. 2022;181:143-153 pubmed 出版商 |
| Burns J, Hurst C, Knowles M, Phillips R, Allison S. The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. Cancer Sci. 2021;112:3822-3834 pubmed 出版商 |
| Vitvitsky V, Kumar R, Libiad M, Maebius A, Landry A, Banerjee R. The mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis. J Biol Chem. 2021;296:100736 pubmed 出版商 |
| Santiappillai N, Abuhammad S, Slater A, Kirby L, McArthur G, Sheppard K, et al. CDK4/6 Inhibition Reprograms Mitochondrial Metabolism in BRAFV600 Melanoma via a p53 Dependent Pathway. Cancers (Basel). 2021;13: pubmed 出版商 |
| Hjelholt A, Charidemou E, Griffin J, Pedersen S, Gudiksen A, Pilegaard H, et al. Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals. Diabetologia. 2020;63:2641-2653 pubmed 出版商 |
| Na Y, Jung D, Song J, Park J, Seok S. Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages. J Mol Cell Biol. 2020;: pubmed 出版商 |
| Jebessa Z, Shanmukha Kumar D, Dewenter M, Lehmann L, Xu C, Schreiter F, et al. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nat Metab. 2019;1:1157-1167 pubmed 出版商 |
| Lu H, Lu Y, Xie Y, Qiu S, Li X, Fan Z. Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI Insight. 2019;4: pubmed 出版商 |
| Jiang H, Jin J, Duan Y, Xie Z, Li Y, Gao A, et al. Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation. Diabetes. 2019;68:2197-2209 pubmed 出版商 |
| Li J, Zhu X, Wang H, Lee C, Chen S, Qian Y, et al. Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest. PLoS ONE. 2019;14:e0220604 pubmed 出版商 |
| Thapa D, Zhang M, Manning J, Guimaraes D, Stoner M, Lai Y, et al. Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions. Physiol Rep. 2019;7:e14054 pubmed 出版商 |
| Zhong W, Xu M, Li C, Zhu B, Cao X, Li D, et al. ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells. Cell Rep. 2019;26:2166-2177.e9 pubmed 出版商 |
| Zhuang Y, Ly R, Frazier C, Yu J, Qin S, Fan X, et al. The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer. Cancer Metab. 2019;7:1 pubmed 出版商 |
| Kwong J, Huo J, Bround M, Boyer J, Schwanekamp J, Ghazal N, et al. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI Insight. 2018;3: pubmed 出版商 |
| Deng Y, Deng Z, Hao H, Wu X, Gao H, Tang S, et al. MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4. Exp Cell Res. 2018;373:171-179 pubmed 出版商 |
| Thapa D, Wu K, Stoner M, Xie B, Zhang M, Manning J, et al. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA. J Biol Chem. 2018;293:17676-17684 pubmed 出版商 |
| Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, et al. MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes. Sci Rep. 2018;8:15096 pubmed 出版商 |
| Gao Y, Zhou Z, Ren T, Kim S, He Y, Seo W, et al. Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids. Gut. 2019;68:1311-1322 pubmed 出版商 |
| Menk A, Scharping N, Moreci R, Zeng X, Guy C, Salvatore S, et al. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell Rep. 2018;22:1509-1521 pubmed 出版商 |
| Xu S, Liu C, Xu W, Huang L, Zhao J, Zhao S. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduct Target Ther. 2017;2:16035 pubmed 出版商 |
| Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H. Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts. Sci Rep. 2017;7:8474 pubmed 出版商 |
| Gorga A, Rindone G, Regueira M, Pellizzari E, Camberos M, Cigorraga S, et al. PPARγ activation regulates lipid droplet formation and lactate production in rat Sertoli cells. Cell Tissue Res. 2017;369:611-624 pubmed 出版商 |
| Bhosale G, Sharpe J, Koh A, Kouli A, Szabadkai G, Duchen M. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics. Biochim Biophys Acta Mol Cell Res. 2017;1864:1009-1017 pubmed 出版商 |
| Jun J, Devera R, Unnikrishnan D, Shin M, Bevans Fonti S, Yao Q, et al. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. J Mol Med (Berl). 2017;95:287-297 pubmed 出版商 |
| Lu H, Li X, Lu Y, Qiu S, Fan Z. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Lett. 2016;381:23-30 pubmed 出版商 |
| Rossi S, Windschüttl S, Matzkin M, Rey Ares V, Terradas C, Ponzio R, et al. Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Mol Cell Endocrinol. 2016;434:154-65 pubmed 出版商 |
| Regueira M, Artagaveytia S, Galardo M, Pellizzari E, Cigorraga S, Meroni S, et al. Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells. Reproduction. 2015;150:311-21 pubmed 出版商 |
| Zuo R, Gu X, Qi Q, Wang T, Zhao X, Liu J, et al. Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy. J Biol Chem. 2015;290:21280-91 pubmed 出版商 |
| Hagopian K, Tomilov A, Kim K, Cortopassi G, Ramsey J. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS ONE. 2015;10:e0124204 pubmed 出版商 |
| Llorente Folch I, Rueda C, Pardo B, Szabadkai G, Duchen M, Satrustegui J. The regulation of neuronal mitochondrial metabolism by calcium. J Physiol. 2015;593:3447-62 pubmed 出版商 |
| Rellinger E, Romain C, Choi S, Qiao J, Chung D. Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells. Pediatr Blood Cancer. 2015;62:581-6 pubmed 出版商 |
| Ho N, Coomber B. Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Exp Cell Res. 2015;331:73-81 pubmed 出版商 |
| Delaney L, Ho N, Morrison J, Farias N, Mosser D, Coomber B. Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. Apoptosis. 2015;20:63-74 pubmed 出版商 |
