产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Caspase-11 Antibody (17D9) - BSA Free
目录 :
NB120-10454
规格 :
0.1 ml (also 0.025 ml)
价格 :
449美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
Alexa Fluor系列荧光染料594
克隆名称 :
17D9
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 67
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 3a
Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7a
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 6a
Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2d
Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s7d
Kayagaki N, Stowe I, Lee B, O Rourke K, Anderson K, Warming S, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-71 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s6b
Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660-5 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠
Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, et al. Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia. PLoS Pathog. 2015;11:e1004732 pubmed 出版商
  • 免疫印迹; 人类
Youm Y, Nguyen K, Grant R, Goldberg E, Bodogai M, Kim D, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21:263-9 pubmed 出版商
  • 免疫印迹; 小鼠
Yuan Z, Syed M, Panchal D, Joo M, Colonna M, Brantly M, et al. Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival. J Biol Chem. 2014;289:15118-29 pubmed 出版商
  • 免疫印迹; 小鼠
Gurung P, Anand P, Malireddi R, Vande Walle L, Van Opdenbosch N, Dillon C, et al. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol. 2014;192:1835-46 pubmed 出版商
  • 免疫印迹; 小鼠
Jin H, Oda H, Lai M, Skalsky R, Bethel K, Shepherd J, et al. MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J. 2013;32:2377-91 pubmed 出版商
  • 免疫印迹; 小鼠
Case C, Kohler L, Lima J, Strowig T, de Zoete M, Flavell R, et al. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A. 2013;110:1851-6 pubmed 出版商
  • 免疫印迹; 小鼠
Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, et al. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain. J Neurosci. 2012;32:11330-42 pubmed
  • 免疫印迹; 小鼠
Kenneth N, Younger J, Hughes E, Marcotte D, Barker P, Saunders T, et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J. 2012;443:355-9 pubmed 出版商
  • 免疫组化; 小鼠
Kang S, Wang S, Kuida K, Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 2002;9:1115-25 pubmed
  • 免疫沉淀; 小鼠
  • 免疫组化; 小鼠
  • 免疫印迹; 小鼠
Kang S, Wang S, Hara H, Peterson E, Namura S, Amin Hanjani S, et al. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol. 2000;149:613-22 pubmed
Daily K, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan M, et al. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease The Ohio State University College of Medicine. bioRxiv. 2023;: pubmed 出版商
Lin A, Guo Y, Zhang H, Lin P, Tao K, Jiang L, et al. GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166687 pubmed 出版商
Exconde P, Hernandez Chavez C, Bray M, Lopez J, Srivastava T, Egan M, et al. The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases. bioRxiv. 2023;: pubmed 出版商
Han J, Tweedell R, Kanneganti T. Evaluation of Caspase Activation to Assess Innate Immune Cell Death. J Vis Exp. 2023;: pubmed 出版商
Wu Y, Mo S, Chen I, Hsieh F, Hsieh S, Zhang J, et al. Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells. Sci Adv. 2022;8:eabn9912 pubmed 出版商
Gros M, Segura E, Rookhuizen D, Baudon B, Heurtebise Chr xe9 tien S, Burgdorf N, et al. Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Cell Rep. 2022;40:111205 pubmed 出版商
Jiang H, Niu C, Guo Y, Liu Z, Jiang Y. Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation. Int Immunopharmacol. 2022;111:108855 pubmed 出版商
Lin W, Li L, Hsiao Y, Wong W, Chiu H, Hsu H, et al. Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity. Front Immunol. 2022;13:870627 pubmed 出版商
Wang Z, Yang X, Wang X, Liang F, Tang Y. Glycyrrhizin attenuates caspase-11-dependent immune responses and coagulopathy by targeting high mobility group box 1. Int Immunopharmacol. 2022;107:108713 pubmed 出版商
Sundaram B, Karki R, Kanneganti T. NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis. Immunohorizons. 2022;6:243-252 pubmed 出版商
Huang D, Chen P, Huang G, Sun H, Luo X, He C, et al. Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury. Cell Death Dis. 2022;13:188 pubmed 出版商
Guo Y, Mao R, Xie Q, Cheng X, Xu T, Wang X, et al. Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection. Front Cell Dev Biol. 2021;9:743335 pubmed 出版商
Zheng M, Karki R, Kancharana B, Berns H, Pruett Miller S, Kanneganti T. Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections. J Biol Chem. 2021;297:101379 pubmed 出版商
Karki R, Sundaram B, Sharma B, Lee S, Malireddi R, Nguyen L, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep. 2021;37:109858 pubmed 出版商
Xiong S, Zhang L, Richner J, Class J, Rehman J, Malik A. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021;41:2773-2785 pubmed 出版商
Fan R, Sui J, Dong X, Jing B, Gao Z. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. Free Radic Biol Med. 2021;173:29-40 pubmed 出版商
Wang X, Li Z, Bai Y, Zhang R, Meng R, Chen F, et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis. 2021;12:402 pubmed 出版商
Chen Q, Zheng J, Wang D, Liu Q, Kang L, Gao X, et al. Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol. 2021;: pubmed 出版商
Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. bioRxiv. 2020;: pubmed 出版商
Finethy R, Dockterman J, Kutsch M, Orench Rivera N, Wallace G, Piro A, et al. Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020;21:e50830 pubmed 出版商
Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma J, et al. Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock. Front Immunol. 2020;11:561948 pubmed 出版商
Ma C, Yang D, Wang B, Wu C, Wu Y, Li S, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6:eaaz6717 pubmed 出版商
Selkrig J, Li N, Hausmann A, Mangan M, Zietek M, Mateus A, et al. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol. 2020;5:1119-1133 pubmed 出版商
Wang J, Li X, Liu Y, Peng C, Zhu H, Tu G, et al. CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis. Front Med (Lausanne). 2020;7:88 pubmed 出版商
Karki R, Lee E, Sharma B, Banoth B, Kanneganti T. IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death. J Immunol. 2020;204:2514-2522 pubmed 出版商
Huang L, Hong Z, Wu W, Xiong S, Zhong M, Gao X, et al. mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. Immunity. 2020;52:475-486.e5 pubmed 出版商
Wang C, Li Y, Wu X, Tian H, Jiang S, Xu T, et al. IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice. Eur J Immunol. 2020;: pubmed 出版商
Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, et al. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020;180:941-955.e20 pubmed 出版商
Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, et al. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med. 2019;216:2562-2581 pubmed 出版商
Wei Z, Wang J, Wang Y, Wang C, Liu X, Han Z, et al. Effects of Neutrophil Extracellular Traps on Bovine Mammary Epithelial Cells in vitro. Front Immunol. 2019;10:1003 pubmed 出版商
Kayagaki N, Lee B, Stowe I, Kornfeld O, O Rourke K, Mirrashidi K, et al. IRF2 transcriptionally induces GSDMD expression for pyroptosis. Sci Signal. 2019;12: pubmed 出版商
Pronin A, Pham D, An W, Dvoriantchikova G, Reshetnikova G, Qiao J, et al. Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Front Mol Neurosci. 2019;12:36 pubmed 出版商
Liu Q, Zhang S, Sun Z, Guo X, Zhou H. E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation. Cell Death Differ. 2019;: pubmed 出版商
Wang B, Lim J, Kajikawa T, Li X, Vallance B, Moutsopoulos N, et al. Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 2019;26:1614-1626.e5 pubmed 出版商
Quach J, Moreau F, Sandall C, Chadee K. Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D. Mucosal Immunol. 2019;12:323-339 pubmed 出版商
Chen J, Wang B, Lai J, Braunstein Z, He M, Ruan G, et al. Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration. Front Immunol. 2018;9:2015 pubmed 出版商
Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti T. Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. Cell Death Discov. 2018;4:3 pubmed 出版商
Deigendesch N, Zychlinsky A, Meissner F. Copper Regulates the Canonical NLRP3 Inflammasome. J Immunol. 2018;200:1607-1617 pubmed 出版商
Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, et al. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018;24:50-61 pubmed 出版商
Man S, Karki R, Briard B, Burton A, Gingras S, Pelletier S, et al. Differential roles of caspase-1 and caspase-11 in infection and inflammation. Sci Rep. 2017;7:45126 pubmed 出版商
Jin H, Oda H, Chen P, Yang C, Zhou X, Kang S, et al. Differential Sensitivity of Target Genes to Translational Repression by miR-17~92. PLoS Genet. 2017;13:e1006623 pubmed 出版商
Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski A, et al. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016;7:13007 pubmed 出版商
Man S, Karki R, Sasai M, Place D, Kesavardhana S, Temirov J, et al. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016;167:382-396.e17 pubmed 出版商
Kim M, Bae S, Ryu J, Kwon Y, Oh J, Kwon J, et al. SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 2016;12:1272-91 pubmed 出版商
Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi Simpson A, et al. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell Death Differ. 2016;23:1331-46 pubmed 出版商
Aachoui Y, Kajiwara Y, Leaf I, Mao D, Ting J, Coers J, et al. Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015;18:320-32 pubmed 出版商
Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed 出版商
Demon D, Kuchmiy A, Fossoul A, Zhu Q, Kanneganti T, Lamkanfi M. Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis. Mucosal Immunol. 2014;7:1480-91 pubmed 出版商
Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti T, Lamkanfi M. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209 pubmed 出版商
Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479:117-21 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB120-10454
SKU号 :
NB120-10454
产品名称 :
Caspase-11 Antibody (17D9) - BSA Free
描述 :
The Caspase-11 Antibody (17D9) - BSA Free from Novus is a rat monoclonal antibody to Caspase-11. This antibody reacts with human, mouse, rat, bovine. The Caspase-11 Antibody (17D9) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Microarray, Knockout Validated, Knockdown Validated.
靶标 :
胱氨酸-天冬氨酸蛋白酶11
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
17D9
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
大鼠
免疫原 :
A recombinant p30 subunit of mouse Caspase 11. [UniProt# P70343]
抗体亚型 :
IgG2a
纯度 :
蛋白质G纯化
物种 :
人类, 小鼠, 大鼠, 牛
理论上的分子量 :
35-43 kDa
基因符号 :
Casp4
accessionNumbers :
P70343
应用 :
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Microarray, Knockout Validated, Knockdown Validated
美元 :
449美元
别名 :
ich-3, CASP11, CASP-11, CASP4, CASP-4, caspase 4, apoptosis-related cysteine peptidase, Caspl
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。