产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
HSPA8/HSC71/Hsc70抗体(13D3)
目录 :
NB120-2788
规格 :
100 ul (also 25 ul)
价格 :
449美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
13D3
反应物种 :
人类, 小鼠, 大鼠,
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 中和反应, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 38
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 5a
Caballero B, Bourdenx M, Luengo E, Díaz A, Sohn P, Chen X, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021;12:2238 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 6b
Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 2
Kaushik S, Cuervo A. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17:759-70 pubmed 出版商
Choi Y, Yun S, Yu J, Mun Y, Lee W, Park C, et al. Chaperone-mediated autophagy dysregulation during aging impairs hepatic fatty acid oxidation via accumulation of NCoR1. Mol Metab. 2023;76:101784 pubmed 出版商
Idera A, Sharkey L, Kurauchi Y, Kadoyama K, Paulson H, Katsuki H, et al. Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways. J Pharmacol Sci. 2023;152:182-192 pubmed 出版商
Ueda E, Ohta T, Konno A, Hirai H, Kurauchi Y, Katsuki H, et al. D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation. Cells. 2022;11: pubmed 出版商
Wang D, Tan K, Zeng W, Li S, Wang Y, Xu F, et al. Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription. Life Sci. 2022;293:120336 pubmed 出版商
Bourdenx M, Martín Segura A, Scrivo A, Rodriguez Navarro J, Kaushik S, Tasset I, et al. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021;184:2696-2714.e25 pubmed 出版商
Juste Y, Cuervo A. Analysis of Chaperone-Mediated Autophagy. Methods Mol Biol. 2019;1880:703-727 pubmed 出版商
Rodriguez Rodriguez J, Lewis C, McKinley K, Sikirzhytski V, Corona J, Maciejowski J, et al. Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion. Curr Biol. 2018;28:3422-3429.e5 pubmed 出版商
Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, et al. Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240. Neurobiol Dis. 2018;120:34-50 pubmed 出版商
Sikirzhytski V, Renda F, Tikhonenko I, Magidson V, McEwen B, Khodjakov A. Microtubules assemble near most kinetochores during early prometaphase in human cells. J Cell Biol. 2018;217:2647-2659 pubmed 出版商
Ciossani G, Overlack K, Petrovic A, Huis In t Veld P, Koerner C, Wohlgemuth S, et al. The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases. J Biol Chem. 2018;293:10084-10101 pubmed 出版商
Chong T, Sarac A, Yao C, Liao L, Lyttle N, Boutros P, et al. Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer. J Ovarian Res. 2018;11:27 pubmed 出版商
Gong Z, Tasset I, Díaz A, Anguiano J, Tas E, Cui L, et al. Humanin is an endogenous activator of chaperone-mediated autophagy. J Cell Biol. 2018;217:635-647 pubmed 出版商
Ueno M, Suzuki J, Hirose M, Sato S, Imagawa M, Zenimaru Y, et al. Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase. Am J Physiol Endocrinol Metab. 2017;313:E699-E709 pubmed 出版商
Yamauchi M, Shibata A, Suzuki K, Suzuki M, Niimi A, Kondo H, et al. Regulation of pairing between broken DNA-containing chromatin regions by Ku80, DNA-PKcs, ATM, and 53BP1. Sci Rep. 2017;7:41812 pubmed 出版商
Zhang S, Eitan E, Mattson M. Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal. J Neurochem. 2017;140:941-954 pubmed 出版商
Ganesan S, Reynolds C, Hollinger K, Pearce S, Gabler N, Baumgard L, et al. Twelve hours of heat stress induces inflammatory signaling in porcine skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1288-96 pubmed 出版商
Magidson V, He J, Ault J, O Connell C, Yang N, Tikhonenko I, et al. Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells. J Cell Biol. 2016;212:307-19 pubmed 出版商
Zhu L, Wang Z, Wang W, Wang C, Hua S, Su Z, et al. Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis. J Biol Chem. 2015;290:27053-66 pubmed 出版商
Kanfer G, Courtheoux T, Peterka M, Meier S, Soste M, Melnik A, et al. Mitotic redistribution of the mitochondrial network by Miro and Cenp-F. Nat Commun. 2015;6:8015 pubmed 出版商
Magidson V, Paul R, Yang N, Ault J, O Connell C, Tikhonenko I, et al. Adaptive changes in the kinetochore architecture facilitate proper spindle assembly. Nat Cell Biol. 2015;17:1134-44 pubmed 出版商
Guo Y, Zheng Y. Lamins position the nuclear pores and centrosomes by modulating dynein. Mol Biol Cell. 2015;26:3379-89 pubmed 出版商
Kaida A, Miura M. Unusual prolongation of radiation-induced G2 arrest in tumor xenografts derived from HeLa cells. Cancer Sci. 2015;106:1370-6 pubmed 出版商
Nishikawa R, Goto Y, Kurozumi A, Matsushita R, Enokida H, Kojima S, et al. MicroRNA-205 inhibits cancer cell migration and invasion via modulation of centromere protein F regulating pathways in prostate cancer. Int J Urol. 2015;22:867-77 pubmed 出版商
Park C, Suh Y, Cuervo A. Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat Commun. 2015;6:6823 pubmed 出版商
Bee L, Nasca A, Zanolini A, Cendron F, d Adamo P, Costa R, et al. A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy. EMBO Mol Med. 2015;7:918-29 pubmed 出版商
Kett L, Stiller B, Bernath M, Tasset I, Blesa J, Jackson Lewis V, et al. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015;35:5724-42 pubmed 出版商
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed 出版商
Lee I, Lee C, Lee J. CaMKKβ-AMPKα2 signaling contributes to mitotic Golgi fragmentation and the G2/M transition in mammalian cells. Cell Cycle. 2015;14:598-611 pubmed 出版商
Ferreira J, Fôfo H, Bejarano E, Bento C, Ramalho J, Girao H, et al. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy. 2013;9:1349-66 pubmed 出版商
Hubbi M, Hu H, Kshitiz -, Ahmed I, Levchenko A, Semenza G. Chaperone-mediated autophagy targets hypoxia-inducible factor-1? (HIF-1?) for lysosomal degradation. J Biol Chem. 2013;288:10703-14 pubmed 出版商
Orenstein S, Kuo S, Tasset I, Arias E, Koga H, Fernandez Carasa I, et al. Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci. 2013;16:394-406 pubmed 出版商
Chang A, Jeong J, Levine R. Iron regulatory protein 2 turnover through a nonproteasomal pathway. J Biol Chem. 2011;286:23698-707 pubmed 出版商
Koga H, Kaushik S, Cuervo A. Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 2010;24:3052-65 pubmed 出版商
Welsch T, Younsi A, Disanza A, Rodriguez J, Cuervo A, Scita G, et al. Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells. Exp Cell Res. 2010;316:1914-24 pubmed 出版商
Guerrero C, Bouyssounade D, Zárate S, Isa P, López T, Espinosa R, et al. Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol. 2002;76:4096-102 pubmed
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB120-2788
SKU号 :
NB120-2788
产品名称 :
HSPA8/HSC71/Hsc70抗体(13D3)
描述 :
The HSPA8/HSC71/Hsc70 Antibody (13D3) from Novus is a mouse monoclonal antibody to HSPA8/HSC71/Hsc70. This antibody reacts with human, mouse, rat, bovine, feline, fish, hamster, primate. The HSPA8/HSC71/Hsc70 Antibody (13D3) has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Block/Neutralize.
靶标 :
HSPA8/HSC71/Hsc70
类别 :
一抗
单位尺寸 :
100 ul (also 25 ul)
缓冲液 :
Ascites diluted with PBS
克隆性 :
单克隆
克隆 :
13D3
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Mouse spermatogenic cell protein.
抗体亚型 :
IgM
纯度 :
Unpurified
物种 :
人类, 小鼠, 大鼠, 牛, 猫, 鱼类, 仓鼠, 灵长类动物
特异性 :
This displays slight cross-reactivity to HSP 70
理论上的分子量 :
70 kDa
基因符号 :
HSPA8
accessionNumbers :
P08107
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Block/Neutralize
美元 :
449美元
别名 :
Heat shock 70 kDa protein 8, heat shock 70kD protein 8, heat shock 70kDa protein 8, heat shock cognate 71 kDa protein, heat shock cognate protein 54, heat shock cognate protein, 71-kDa, HSC54, HSC70heat shock 70kd protein 10, HSC71, HSP71, HSP73constitutive heat shock protein 70, HSPA10, LAP1, lipopolysaccharide-associated protein 1, LPS-associated protein 1, MGC131511, MGC29929, NIP71, N-myristoyltransferase inhibitor protein 71
储存 :
存放在-20C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。