产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
p53 Antibody (PAb 240) - BSA Free
目录 :
NB200-103
规格 :
0.1 ml (also 0.025 ml)
价格 :
399美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
多克隆抗体240
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 人类; 图 s3a
  • 免疫组化-石蜡切片; 人类; 1:250; 图 1c
Li W, Gu X, Liu C, Shi Y, Wang P, Zhang N, et al. A synergetic effect of BARD1 mutations on tumorigenesis. Nat Commun. 2021;12:1243 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 4a
Khayati K, Bhatt V, Hu Z, Fahumy S, Luo X, Guo J. Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 图 af6e
Graham N, Minasyan A, Lomova A, Cass A, Balanis N, Friedman M, et al. Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol. 2017;13:914 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Biswas A, Mitchell D, Johnson D. E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res. 2014;74:3369-77 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠
Lange S, Bedford E, Reh S, Wittschieben J, Carbajal S, Kusewitt D, et al. Dual role for mammalian DNA polymerase ? in maintaining genome stability and proliferative responses. Proc Natl Acad Sci U S A. 2013;110:E687-96 pubmed 出版商
  • 免疫印迹; 小鼠
Jensen M, Factor V, Fantozzi A, Helin K, Huh C, Thorgeirsson S. Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology. 2003;37:862-70 pubmed
  • 免疫印迹; 小鼠
Asher G, Lotem J, Cohen B, Sachs L, Shaul Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc Natl Acad Sci U S A. 2001;98:1188-93 pubmed
  • 免疫沉淀; 人类
Jones N, Turner J, McIlwrath A, Brown R, Dive C. Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53. Mol Pharmacol. 1998;53:819-26 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Halazonetis T, Davis L, Kandil A. Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA. EMBO J. 1993;12:1021-8 pubmed
  • 免疫组化-冰冻切片; 人类
Rubio M, von Deimling A, Yandell D, Wiestler O, Gusella J, Louis D. Accumulation of wild type p53 protein in human astrocytomas. Cancer Res. 1993;53:3465-7 pubmed
  • 免疫印迹; 人类
Bargonetti J, Manfredi J, Chen X, Marshak D, Prives C. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein. Genes Dev. 1993;7:2565-74 pubmed
  • 免疫组化; 人类
Davidoff A, Humphrey P, Iglehart J, Marks J. Genetic basis for p53 overexpression in human breast cancer. Proc Natl Acad Sci U S A. 1991;88:5006-10 pubmed
  • 免疫细胞化学; 大鼠
Georgoff I, Martinez J, Levine A. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev. 1991;5:151-9 pubmed
  • 免疫沉淀; 人类
  • 免疫组化; 人类
  • 酶联免疫吸附测定; 人类
  • 免疫印迹; 人类
  • 免疫沉淀; 大鼠
  • 免疫组化; 大鼠
  • 酶联免疫吸附测定; 大鼠
  • 免疫印迹; 大鼠
  • 免疫沉淀; 小鼠
  • 免疫组化; 小鼠
  • 酶联免疫吸附测定; 小鼠
  • 免疫印迹; 小鼠
Gannon J, Greaves R, Iggo R, Lane D. Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J. 1990;9:1595-602 pubmed
  • 免疫组化; 人类
Cunningham J, Lust J, Schaid D, Bren G, Carpenter H, Rizza E, et al. Expression of p53 and 17p allelic loss in colorectal carcinoma. Cancer Res. 1992;52:1974-80 pubmed
  • 流式细胞仪; 人类
  • 酶联免疫吸附测定; 人类
Remvikos Y, Tominaga O, Hammel P, Laurent Puig P, Salmon R, Dutrillaux B, et al. Increased p53 protein content of colorectal tumours correlates with poor survival. Br J Cancer. 1992;66:758-64 pubmed
  • 免疫细胞化学; 人类
Somers K, Merrick M, Lopez M, Incognito L, Schechter G, Casey G. Frequent p53 mutations in head and neck cancer. Cancer Res. 1992;52:5997-6000 pubmed
  • 免疫组化-冰冻切片; 人类
Eccles D, Brett L, Lessells A, Gruber L, Lane D, Steel C, et al. Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma. Br J Cancer. 1992;65:40-4 pubmed
Mansky R, Greguske E, Yu D, Zarate N, Intihar T, Tsai W, et al. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease. Cell Rep. 2023;42:112198 pubmed 出版商
Anton P, Rutt L, Capper C, Orlicky D, McCullough R. Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress. Alcohol. 2023;107:119-135 pubmed 出版商
Reis Barbosa P, Marinho T, Matsuura C, Aguila M, de Carvalho J, Mandarim de Lacerda C. The obesity and nonalcoholic fatty liver disease mouse model revisited: Liver oxidative stress, hepatocyte apoptosis, and proliferation. Acta Histochem. 2022;124:151937 pubmed 出版商
Yue W, Ma J, Xiao Y, Wang P, Gu X, Xie B, et al. The Apoptotic Resistance of BRCA1-Deficient Ovarian Cancer Cells is Mediated by cAMP. Front Cell Dev Biol. 2022;10:889656 pubmed 出版商
Radtke A, Chu C, Yaniv Z, Yao L, MARR J, Beuschel R, et al. IBEX: an iterative immunolabeling and chemical bleaching method for high-content imaging of diverse tissues. Nat Protoc. 2022;17:378-401 pubmed 出版商
Kong N, Chen X, Feng J, Duan T, Liu S, Sun X, et al. Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1. Acta Pharm Sin B. 2021;11:4045-4054 pubmed 出版商
Fontana M, Nanni J, Ghelli Luserna Di Rorà A, Petracci E, Padella A, Ghetti M, et al. Pharmacological Inhibition of WIP1 Sensitizes Acute Myeloid Leukemia Cells to the MDM2 Inhibitor Nutlin-3a. Biomedicines. 2021;9: pubmed 出版商
Marks D, Heinen N, Bachmann L, Meermeyer S, Werner M, Gallego L, et al. Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load. Acta Neuropathol Commun. 2021;9:66 pubmed 出版商
Li L, Chen B, An T, Zhang H, Xia B, Li R, et al. BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2. J Ethnopharmacol. 2021;271:113810 pubmed 出版商
Wang C, Yuan W, Hu A, Lin J, Xia Z, Yang C, et al. Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury. Mol Med Rep. 2020;22:175-184 pubmed 出版商
Yang Y, Karsli Uzunbas G, Poillet Perez L, Sawant A, Hu Z, Zhao Y, et al. Autophagy promotes mammalian survival by suppressing oxidative stress and p53. Genes Dev. 2020;34:688-700 pubmed 出版商
Marinho T, Borges C, Aguila M, Mandarim de Lacerda C. Intermittent fasting benefits on alpha- and beta-cell arrangement in diet-induced obese mice pancreatic islet. J Diabetes Complications. 2020;34:107497 pubmed 出版商
Tran T, Guha R, Portugal S, Skinner J, Ongoiba A, Bhardwaj J, et al. A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity. 2019;51:750-765.e10 pubmed 出版商
Yang X, Zhao T, Feng L, Shi Y, Jiang J, Liang S, et al. PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3K/Akt pathway. Environ Int. 2019;127:601-614 pubmed 出版商
Sikorski K, Mehta A, Inngjerdingen M, Thakor F, Kling S, Kalina T, et al. A high-throughput pipeline for validation of antibodies. Nat Methods. 2018;15:909-912 pubmed 出版商
Kutwin M, Sawosz E, Jaworski S, Hinzmann M, Wierzbicki M, Hotowy A, et al. Investigation of platinum nanoparticle properties against U87 glioblastoma multiforme. Arch Med Sci. 2017;13:1322-1334 pubmed 出版商
Shi M, Ma L, Zhou L, Fu P. Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy. Molecules. 2016;21: pubmed
Ge X, Pettan Brewer C, Morton J, Carter K, Fatemi S, Rabinovitch P, et al. Mitochondrial catalase suppresses naturally occurring lung cancer in old mice. Pathobiol Aging Age Relat Dis. 2015;5:28776 pubmed 出版商
Jørgensen M, Bæk R, Varming K. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles. 2015;4:26048 pubmed 出版商
Blagosklonny M, Toretsky J, Bohen S, Neckers L. Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90. Proc Natl Acad Sci U S A. 1996;93:8379-83 pubmed
Farrell P, Allan G, Shanahan F, Vousden K, Crook T. p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J. 1991;10:2879-87 pubmed
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB200-103
SKU号 :
NB200-103
产品名称 :
p53 Antibody (PAb 240) - BSA Free
描述 :
The p53 Antibody (PAb 240) - BSA Free from Novus is a mouse monoclonal antibody to p53. This antibody reacts with human, mouse, rat, yeast, xenopus (negative). The p53 Antibody (PAb 240) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready.
靶标 :
p53
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
多克隆抗体240
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Gel-purified p53-beta-galactosidase fusion protein containing murine p53 from aa 14-389 (derived from pSV53C cDNA clone).
抗体亚型 :
IgG1 Kappa
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Rat, Yeast, Xenopus (Negative)
特异性 :
This monoclonal recognizes both mutant forms and wild-type human p53 under denaturing conditions
基因符号 :
TP53
应用 :
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready
美元 :
399美元
别名 :
Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。