产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
p19ARF/CDKN2A Antibody (5-C3-1) - BSA Free
目录 :
NB200-174
规格 :
0.1 ml (also 0.025 ml)
价格 :
379美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
5-C3-1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 22
出版应用/物种/样本/稀释参考文献
  • 免疫印迹基因敲除验证; 小鼠; 1:250; 图 s3
Deland K, Starr B, Mercer J, Byemerwa J, Crabtree D, Williams N, et al. Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models. J Clin Invest. 2021;131: pubmed 出版商
Weidenhammer L, Liu H, Luo L, Williams N, Deland K, Kirsch D, et al. Inducing primary brainstem gliomas in genetically engineered mice using RCAS/TVA retroviruses and Cre/loxP recombination. STAR Protoc. 2023;4:102094 pubmed 出版商
Maru Y, Tanaka N, Tatsumi Y, Nakamura Y, Itami M, Hippo Y. Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition. Oncogenesis. 2021;10:46 pubmed 出版商
Suzuki T, Katada E, Mizuoka Y, Takagi S, Kazuki Y, Oshimura M, et al. A novel all-in-one conditional knockout system uncovered an essential role of DDX1 in ribosomal RNA processing. Nucleic Acids Res. 2021;: pubmed 出版商
Santelli A, Sun I, Eirin A, Abumoawad A, Woollard J, Lerman A, et al. Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles. J Am Heart Assoc. 2019;8:e012584 pubmed 出版商
Li F, Zeng Z, Xing S, Gullicksrud J, Shan Q, Choi J, et al. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun. 2018;9:5452 pubmed 出版商
Baek K, Ryeom S. Detection of Oncogene-Induced Senescence In Vivo. Methods Mol Biol. 2017;1534:185-198 pubmed
Moding E, Min H, Castle K, Ali M, Woodlief L, Williams N, et al. An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer. JCI Insight. 2016;1: pubmed
Li D, Fu J, Du M, Zhang H, Li L, Cen J, et al. Hepatocellular carcinoma repression by TNF?-mediated synergistic lethal effect of mitosis defect-induced senescence and cell death sensitization. Hepatology. 2016;64:1105-20 pubmed 出版商
Lee C, Castle K, Moding E, Blum J, Williams N, Luo L, et al. Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. Nat Commun. 2015;6:8477 pubmed 出版商
Hamilton G, Abraham A, Morton J, Sampson O, Pefani D, Khoronenkova S, et al. AKT regulates NPM dependent ARF localization and p53mut stability in tumors. Oncotarget. 2014;5:6142-67 pubmed
Olive V, SABIO E, Bennett M, De Jong C, Biton A, McGann J, et al. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. elife. 2013;2:e00822 pubmed 出版商
Shchors K, Persson A, Rostker F, Tihan T, Lyubynska N, Li N, et al. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013;110:E1480-9 pubmed 出版商
Kim H, Kim D, Li S, Lee K, Li X, Bode A, et al. Polycomb (PcG) proteins, BMI1 and SUZ12, regulate arsenic-induced cell transformation. J Biol Chem. 2012;287:31920-8 pubmed 出版商
Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak Zablocki E, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. PLoS Genet. 2011;7:e1002360 pubmed 出版商
Garcia D, Warr M, Martins C, Brown Swigart L, Passegue E, Evan G. Validation of MdmX as a therapeutic target for reactivating p53 in tumors. Genes Dev. 2011;25:1746-57 pubmed 出版商
Murphy D, Junttila M, Pouyet L, Karnezis A, Shchors K, Bui D, et al. Distinct thresholds govern Myc's biological output in vivo. Cancer Cell. 2008;14:447-57 pubmed 出版商
Bertwistle D, Sherr C. Regulation of the Arf tumor suppressor in Emicro-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis. Blood. 2007;109:792-4 pubmed
Williams R, Roussel M, Sherr C. Arf gene loss enhances oncogenicity and limits imatinib response in mouse models of Bcr-Abl-induced acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2006;103:6688-93 pubmed
Klochendler Yeivin A, Picarsky E, Yaniv M. Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex. Mol Cell Biol. 2006;26:2661-74 pubmed
Korgaonkar C, Hagen J, Tompkins V, Frazier A, Allamargot C, Quelle F, et al. Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function. Mol Cell Biol. 2005;25:1258-71 pubmed
Bertwistle D, Zindy F, Sherr C, Roussel M. Monoclonal antibodies to the mouse p19(Arf) tumor suppressor protein. Hybrid Hybridomics. 2004;23:293-300 pubmed
图像
图像 1 :
Novus Biologicals NB200-174 图像 1
Western Blot: p19ARF/CDKN2A Antibody (5-C3-1) [NB200-174] - Whole cell protein from mouse Neuro2A and MEF cells was separated on a 4-20% gel by SDS-PAGE, transferred to 0.2 um PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/mL anti-p19ARF in block buffer and detected with an anti-mouse HRP secondary antibody using chemiluminescence.
产品信息
品牌 :
Novus
master code :
NB200-174
SKU号 :
NB200-174
产品名称 :
p19ARF/CDKN2A Antibody (5-C3-1) - BSA Free
描述 :
The p19ARF/CDKN2A Antibody (5-C3-1) - BSA Free from Novus is a rat monoclonal antibody to p19ARF/CDKN2A. This antibody reacts with human, mouse, golden syrian hamster (negative). The p19ARF/CDKN2A Antibody (5-C3-1) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready, Knockout Validated.
靶标 :
p19ARF/CDKN2A
类别 :
一抗
sizes available :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
5-C3-1
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
大鼠
免疫原 :
A synthetic peptide containing amino acids 54-75 of the murine p19ARF/CDKN2A. [UniProt# Q64364]
抗体亚型 :
IgG2b
纯度 :
蛋白质A纯化
物种 :
Human, Mouse, Golden Syrian Hamster (Negative)
理论上的分子量 :
19 kDa
基因符号 :
Cdkn2a
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Immunohistochemistry-NB200-174-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Immunohistochemistry-NB200-174-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Flow-(Intracellular)-NB200-174-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Flow-(Intracellular)-NB200-174-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Western-Blot-NB200-174-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Knockout-Validated-NB200-174-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/p19ARF-CDKN2A-Antibody-(5-C3-1)-Knockout-Validated-NB200-174-img0009.jpg
应用 :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready, Knockout Validated
美元 :
379美元
别名 :
alternative reading frame, ARF, ARF-INK4a, CDK4I, CDKN2A, Cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4), cyclin-dependent kinase inhibitor 2A, isoform 3, cyclin-dependent kinase inhibitor 2A, isoforms 1/2, cyclin-dependent kinase inhibitor protein, INK4, INK4a, Ink4a/Arf, INK4a-ARF, mitochondrial smARF', MTS1, p14, p14ARF, P16, p16(INK4a), p16-INK4, p16INK4a, p16-INK4a, P19, p19 ARF , p19ARF, Pctr1
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。