产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
ER乙/NR3A2抗体(14C8)
目录 :
NB200-305
规格 :
100微升
价格 :
429美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
14C8
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片, dot blot
更多信息或购买 :
文章摘录数: 75
参考文献
Liu M, Du Y, Li H, Wang L, Ponikwicka Tyszko D, Lebiedzinska W, et al. Cyanidin-3-o-Glucoside Pharmacologically Inhibits Tumorigenesis via Estrogen Receptor β in Melanoma Mice. Front Oncol. 2019;9:1110 pubmed 出版商
Voskuhl R, Itoh N, Tassoni A, Matsukawa M, Ren E, Tse V, et al. Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis. Proc Natl Acad Sci U S A. 2019;116:10130-10139 pubmed 出版商
Dubey N, Hoffman J, Schuebel K, Yuan Q, Martinez P, Nieman L, et al. The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Mol Psychiatry. 2017;22:1172-1184 pubmed 出版商
Castelán F, Xelhuantzi N, Hernández Aragón L, Rodríguez Antolín J, Cuevas E, Martínez Gómez M. Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;170:286-92 pubmed 出版商
Jardel P, Debiais C, Godet J, Irani J, Fromont G. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. Histopathology. 2013;63:57-63 pubmed 出版商
López García K, E Cuevas -, Corona Quintanilla D, Jiménez Estrada I, Martinez Gomez M, Castelán F. Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant?. Eur J Obstet Gynecol Reprod Biol. 2013;169:113-20 pubmed 出版商
Kauffman E, Robinson B, Downes M, Marcinkiewicz K, Vourganti S, Scherr D, et al. Estrogen receptor-β expression and pharmacological targeting in bladder cancer. Oncol Rep. 2013;30:131-8 pubmed 出版商
Verma M, Miki Y, Abe K, Nagasaki S, Niikawa H, Suzuki S, et al. Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome. Life Sci. 2012;91:800-8 pubmed 出版商
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Miki Y, et al. Aromatase in colon carcinoma. Anticancer Res. 2012;32:3069-75 pubmed
Cheng L, Li J, Han Y, Lin J, Niu C, Zhou Z, et al. PES1 promotes breast cancer by differentially regulating ER? and ER?. J Clin Invest. 2012;122:2857-70 pubmed 出版商
Karlsson C, Helenius G, Fernandes O, Karlsson M. Oestrogen receptor β in NSCLC - prevalence, proliferative influence, prognostic impact and smoking. APMIS. 2012;120:451-8 pubmed 出版商
Tonetti D, Gao W, Escarzaga D, Walters K, Szafran A, Coon J. PKC? and ER? Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients. Int J Breast Cancer. 2012;2012:740353 pubmed 出版商
Zuguchi M, Miki Y, Onodera Y, Fujishima F, Takeyama D, Okamoto H, et al. Estrogen receptor ? and ? in esophageal squamous cell carcinoma. Cancer Sci. 2012;103:1348-55 pubmed 出版商
Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, et al. Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. Int J Cancer. 2012;131:2284-93 pubmed 出版商
Verma M, Miki Y, Abe K, Niikawa H, Sasano H. Cytoplasmic estrogen receptor ? as a potential marker in human non-small cell lung carcinoma. Expert Opin Ther Targets. 2012;16 Suppl 1:S91-102 pubmed 出版商
Navaratnam S, Skliris G, Qing G, Banerji S, Badiani K, Tu D, et al. Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer. Horm Cancer. 2012;3:93-100 pubmed 出版商
Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, et al. CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor). Stem Cells. 2011;29:1485-95 pubmed 出版商
Honma N, Saji S, Hirose M, Horiguchi S, Kuroi K, Hayashi S, et al. Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol. Cancer Sci. 2011;102:1848-54 pubmed 出版商
Mehasseb M, Panchal R, Taylor A, Brown L, Bell S, Habiba M. Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis. Fertil Steril. 2011;95:2228-35, 2235.e1 pubmed 出版商
Vouk K, Smuc T, Guggenberger C, Ribic Pucelj M, Sinkovec J, Husen B, et al. Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. J Steroid Biochem Mol Biol. 2011;125:231-42 pubmed 出版商
Miki Y, Abe K, Suzuki S, Suzuki T, Sasano H. Suppression of estrogen actions in human lung cancer. Mol Cell Endocrinol. 2011;340:168-74 pubmed 出版商
Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman D. Estrogen receptor ? causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat. 2011;129:777-84 pubmed 出版商
Huang G, Gunter M, Arend R, Li M, Arias Pulido H, Prossnitz E, et al. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol. 2010;203:242.e1-5 pubmed 出版商
Vivar O, Zhao X, Saunier E, Griffin C, Mayba O, Tagliaferri M, et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem. 2010;285:22059-66 pubmed 出版商
Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti C, et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 2010;17:319-32 pubmed 出版商
Vivar O, Saunier E, Leitman D, Firestone G, Bjeldanes L. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology. 2010;151:1662-7 pubmed 出版商
Koyama S, Wada Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem Biophys Res Commun. 2010;392:357-62 pubmed 出版商
Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, et al. Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer. Hum Pathol. 2010;41:190-8 pubmed 出版商
Wong M, Dobbins T, Tseung J, Tran N, Lee C, O BRIEN C, et al. Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol. 2009;62:789-93 pubmed 出版商
Raso M, Behrens C, Herynk M, Liu S, Prudkin L, Ozburn N, et al. Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res. 2009;15:5359-68 pubmed 出版商
Maehle B, Collett K, Tretli S, Akslen L, Grotmol T. Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?. APMIS. 2009;117:644-50 pubmed 出版商
Chakravarty D, Gupta N, Goda J, Srinivasan R, Patel F, Dhaliwal L. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem. 2010;112:355-63 pubmed 出版商
Miki Y, Suzuki T, Nagasaki S, Hata S, Akahira J, Sasano H. Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009;113:281-9 pubmed 出版商
Huang G, Arend R, Li M, Gunter M, Chiu L, Horwitz S, et al. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol. 2009;200:457.e1-5 pubmed 出版商
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, et al. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res. 2009;69:914-22 pubmed 出版商
Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, et al. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. J Cell Physiol. 2009;219:392-401 pubmed 出版商
Belcher S, Ma X, Le H. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology. 2009;150:1112-21 pubmed 出版商
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed 出版商
Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed 出版商
Ohata C, Tadokoro T, Itami S. Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol. 2008;35:215-21 pubmed 出版商
Dohi O, Hatori M, Suzuki T, Ono K, Hosaka M, Akahira J, et al. Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. Cancer Sci. 2008;99:518-23 pubmed
Bukulmez O, Hardy D, Carr B, Word R, Mendelson C. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190-204 pubmed
Caiazza F, Galluzzo P, Lorenzetti S, Marino M. 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun. 2007;359:102-7 pubmed
Gruvberger Saal S, Bendahl P, Saal L, Laakso M, Hegardt C, Edén P, et al. Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res. 2007;13:1987-94 pubmed
Galluzzo P, Caiazza F, Moreno S, Marino M. Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer. 2007;14:153-67 pubmed
Cvoro A, Paruthiyil S, Jones J, Tzagarakis Foster C, Clegg N, Tatomer D, et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007;148:538-47 pubmed
Al Dhaheri M, Rowan B. Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation. Mol Endocrinol. 2007;21:439-56 pubmed
Skliris G, Lewis A, Emberley E, Peng B, Weebadda W, Kemp A, et al. Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res Treat. 2007;104:75-85 pubmed
Dietrich W, Haitel A, Holzer G, Huber J, Kolbus A, Tschugguel W. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig. 2006;13:512-7 pubmed
Skliris G, Leygue E, Curtis Snell L, Watson P, Murphy L. Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer. 2006;95:616-26 pubmed
Savinov A, Remacle A, Golubkov V, Krajewska M, Kennedy S, Duffy M, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res. 2006;66:2716-24 pubmed
Cvoro A, Tzagarakis Foster C, Tatomer D, Paruthiyil S, Fox M, Leitman D. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell. 2006;21:555-64 pubmed
Poola I, Fuqua S, De Witty R, Abraham J, Marshallack J, Liu A. Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention. Clin Cancer Res. 2005;11:7579-85 pubmed
Schwartz A, Prysak G, Murphy V, Lonardo F, Pass H, Schwartz J, et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005;11:7280-7 pubmed
Poola I, Abraham J, Baldwin K, Saunders A, Bhatnagar R. Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization. Endocrine. 2005;27:227-38 pubmed
Zheng F, Wu R, Smith C, O Malley B. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005;25:8273-84 pubmed
Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, et al. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res. 2005;65:6450-8 pubmed
Helguero L, Faulds M, Gustafsson J, Haldosén L. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene. 2005;24:6605-16 pubmed
Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, et al. Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005;220:197-210 pubmed
Jones L, Li M, Halama E, Ma Y, Lubet R, Grubbs C, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene. 2005;24:3554-62 pubmed
Hopp T, Weiss H, Parra I, Cui Y, Osborne C, Fuqua S. Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res. 2004;10:7490-9 pubmed
Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, et al. Estrogen receptor alpha and beta profiling in human breast cancer. Eur J Surg Oncol. 2004;30:469-74 pubmed
Speirs V, Carder P, Lane S, Dodwell D, Lansdown M, Hanby A. Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol. 2004;5:174-81 pubmed
Paruthiyil S, Parmar H, Kerekatte V, Cunha G, Firestone G, Leitman D. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res. 2004;64:423-8 pubmed
Tee M, Rogatsky I, Tzagarakis Foster C, Cvoro A, An J, Christy R, et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004;15:1262-72 pubmed
Tonetti D, Rubenstein R, DeLeon M, Zhao H, Pappas S, Bentrem D, et al. Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol. 2003;87:47-55 pubmed
Skliris G, Munot K, Bell S, Carder P, Lane S, Horgan K, et al. Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol. 2003;201:213-20 pubmed
Li X, Hisaoka M, Hashimoto H. Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis. Pathol Int. 2003;53:671-9 pubmed
Omoto Y, Eguchi H, Yamamoto Yamaguchi Y, Hayashi S. Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7. Oncogene. 2003;22:5011-20 pubmed
Fuqua S, Schiff R, Parra I, Moore J, Mohsin S, Osborne C, et al. Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res. 2003;63:2434-9 pubmed
Linja M, Savinainen K, Tammela T, Isola J, Visakorpi T. Expression of ERalpha and ERbeta in prostate cancer. Prostate. 2003;55:180-6 pubmed
Saji S, Omoto Y, Shimizu C, Warner M, Hayashi Y, Horiguchi S, et al. Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor. Cancer Res. 2002;62:4849-53 pubmed
Skliris G, Parkes A, Limer J, Burdall S, Carder P, Speirs V. Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. J Pathol. 2002;197:155-62 pubmed
Speirs V, Skliris G, Burdall S, Carder P. Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J Clin Pathol. 2002;55:371-4 pubmed
Skliris G, Carder P, Lansdown M, Speirs V. Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?. Br J Cancer. 2001;84:1095-8 pubmed
图像
图像 1 :
Novus Biologicals NB200-305 图像 1
Western Blot: ER beta/NR3A2 Antibody (14C8) [NB200-305] - Non-transfected (-) and transfected (+) 293T whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Estrogen Receptor beta antibody [14C8] diluted at 1:5000. The HRP-conjugated anti-mouse IgG antibody (NBP2-19382) was used to detect the primary antibody
产品信息
品牌 :
Novus
master code :
NB200-305
SKU号 :
NB200-305
产品名称 :
ER乙/NR3A2抗体(14C8)
描述 :
The ER beta/NR3A2 Antibody (14C8) from Novus is a mouse monoclonal antibody to ER beta/NR3A2. This antibody reacts with human, mouse, monkey, rabbit. The ER beta/NR3A2 Antibody (14C8) has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Dot Blot.
靶标 :
ER乙/NR3A2
类别 :
一抗
sizes available :
100微升
缓冲液 :
PBS
克隆性 :
单克隆
克隆 :
14C8
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
氨基酸1-153人的ER乙在大肠杆菌中表达
抗体亚型 :
IgG2b
纯度 :
蛋白质G纯化
物种 :
Human, Mouse, Monkey, Rabbit
特异性 :
Strong Erb staining in epithelial cell nuclei
理论上的分子量 :
59 kDa
基因符号 :
ESR2
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ER-beta-NR3A2-Antibody-(14C8)-Western-Blot-NB200-305-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ER-beta-NR3A2-Antibody-(14C8)-Immunohistochemistry-Paraffin-NB200-305-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Estrogen-Receptor-beta-Antibody-(14C8)-Immunohistochemistry-Paraffin-NB200-305-img0003.jpg
accessionNumbers :
Q92731
应用 :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Dot Blot
美元 :
429美元
别名 :
Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。