产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
Ubiquitin Antibody (Ubi-1)
目录 :
NB300-130
规格 :
0.1 ml (also 0.025 ml)
价格 :
489美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Ubi-1
反应物种 :
fruit fly , green plants , 人类, 小鼠, 大鼠, , , 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 43
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 2d
Yoon Y, Go G, Yoon S, Lim J, Lee G, Lee J, et al. Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis. Cells. 2021;10: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4e
Swatek K, Usher J, Kueck A, Gladkova C, Mevissen T, Pruneda J, et al. Insights into ubiquitin chain architecture using Ub-clipping. Nature. 2019;572:533-537 pubmed 出版商
  • 免疫印迹; 人类; 图 7c
Li L, Guturi K, Gautreau B, Patel P, Saad A, Morii M, et al. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. J Clin Invest. 2018;128:4525-4542 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3
Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠
Begum G, Yan H, Li L, Singh A, Dixon C, Sun D. Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. J Neurosci. 2014;34:3743-55 pubmed 出版商
  • 免疫细胞化学; 大鼠
Ejlerskov P, Rasmussen I, Nielsen T, Bergström A, Tohyama Y, Jensen P, et al. Tubulin polymerization-promoting protein (TPPP/p25?) promotes unconventional secretion of ?-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem. 2013;288:17313-35 pubmed 出版商
  • 免疫印迹; 人类
Maroui M, Kheddache Atmane S, El Asmi F, Dianoux L, Aubry M, Chelbi Alix M. Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms. PLoS ONE. 2012;7:e44949 pubmed 出版商
  • 免疫组化; 小鼠
Rosenfeldt M, Nixon C, Liu E, Mah L, Ryan K. Analysis of macroautophagy by immunohistochemistry. Autophagy. 2012;8:963-9 pubmed 出版商
  • 免疫印迹; green plants
Stuttmann J, Lechner E, Guerois R, Parker J, Nussaume L, Genschik P, et al. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. J Biol Chem. 2009;284:7920-30 pubmed 出版商
  • 免疫印迹; 人类
Dayal S, Sparks A, Jacob J, Allende Vega N, Lane D, Saville M. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem. 2009;284:5030-41 pubmed 出版商
  • 免疫组化; fruit fly
Watson M, Lagow R, Xu K, Zhang B, Bonini N. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. J Biol Chem. 2008;283:24972-81 pubmed 出版商
  • 免疫印迹; 人类
Cripps D, Thomas S, Jeng Y, Yang F, Davies P, Yang A. Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J Biol Chem. 2006;281:10825-38 pubmed
  • 免疫印迹; 人类
Lichtenfels R, Kellner R, Atkins D, Bukur J, Ackermann A, Beck J, et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta. 2003;1646:21-31 pubmed
Hackerova L, Klusackova B, Zigo M, Zelenkova N, Havlikova K, Krejčířová R, et al. Modulatory effect of MG-132 proteasomal inhibition on boar sperm motility during in vitro capacitation. Front Vet Sci. 2023;10:1116891 pubmed 出版商
Yang S, Xiang J, Ma C, Yang G, Wang X, Liu H, et al. Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis. Cell Rep. 2023;42:112367 pubmed 出版商
Yonenobu Y, Beck G, Kido K, Maeda N, Yamashita R, Inoue K, et al. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology. 2023;: pubmed 出版商
Guo Y, Chomiak A, Hong Y, Lowe C, Kopsidas C, Chan W, et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. iScience. 2022;25:104519 pubmed 出版商
Chomiak A, Guo Y, Kopsidas C, McDaniel D, Lowe C, Pan H, et al. Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022;25:104354 pubmed 出版商
Kwon M, Oh T, Jang M, Kim G, Kim J, Ryu H, et al. Kurarinone induced p53-independent G0/G1 cell cycle arrest by degradation of K-RAS via WDR76 in human colorectal cancer cells. Eur J Pharmacol. 2022;923:174938 pubmed 出版商
Zhang C, Tang Q, Xia H, Xu H, Bi F. PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins. FASEB J. 2022;36:e22121 pubmed 出版商
Ito Y, Yamamoto T, Miyai K, Take J, Scherthan H, Rommel A, et al. Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model. Int J Radiat Biol. 2021;:1-16 pubmed 出版商
Jo J, Yang L, Tran H, Yu W, Sun A, Chang Y, et al. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. 2021;: pubmed 出版商
Schwertheim S, Kälsch J, Jastrow H, Schaefer C, Theurer S, Ting S, et al. Characterization of two types of intranuclear hepatocellular inclusions in NAFLD. Sci Rep. 2020;10:16533 pubmed 出版商
Thurner L, Hartmann S, Bewarder M, Fadle N, Regitz E, Schormann C, et al. Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell-type diffuse large B-cell lymphoma. Haematologica. 2020;: pubmed 出版商
Chen Z, Wasney G, Picaud S, Filippakopoulos P, Vedadi M, D Angiolella V, et al. Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. Open Biol. 2020;10:200041 pubmed 出版商
Yoon Y, Lee J, Song K, Noh H, Lee S. Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem/stromal cells via cellular prion proteins. J Pineal Res. 2020;68:e12632 pubmed 出版商
Schwertheim S, Theurer S, Jastrow H, Herold T, Ting S, Westerwick D, et al. New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation. PLoS ONE. 2019;14:e0226199 pubmed 出版商
Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, et al. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine. 2019;50:260-273 pubmed 出版商
Aalto A, Mohan A, Schwintzer L, Kupka S, Kietz C, Walczak H, et al. M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. Cell Death Differ. 2019;26:860-876 pubmed 出版商
Gladkova C, Maslen S, Skehel J, Komander D. Mechanism of parkin activation by PINK1. Nature. 2018;559:410-414 pubmed 出版商
Gogoi M, Ravikumar V, Dixit N, Chakravortty D. Salmonella escapes antigen presentation through K63 ubiquitination mediated endosomal proteolysis of MHC II via modulation of endosomal acidification in dendritic cells. Pathog Dis. 2018;76: pubmed 出版商
Deger S, Hung A, Gamboa J, Siew E, Ellis C, Booker C, et al. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight. 2017;2: pubmed 出版商
Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D. Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017;24:920-930 pubmed 出版商
Michel M, Swatek K, Hospenthal M, Komander D. Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Mol Cell. 2017;68:233-246.e5 pubmed 出版商
Kaul Z, Chakrabarti O. Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins. Mol Biol Cell. 2017;28:2106-2122 pubmed 出版商
Pruneda J, Durkin C, Geurink P, Ovaa H, Santhanam B, Holden D, et al. The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases. Mol Cell. 2016;63:261-276 pubmed 出版商
Ohmi K, Zhao H, Neufeld E. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS ONE. 2011;6:e27461 pubmed 出版商
Guo J, Chen H, Mathew R, Fan J, Strohecker A, Karsli Uzunbas G, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25:460-70 pubmed 出版商
Sun K, Johnson B, Gunn T. Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice. Neurobiol Aging. 2007;28:1840-52 pubmed
Ryazantsev S, Yu W, Zhao H, Neufeld E, Ohmi K. Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B. Mol Genet Metab. 2007;90:393-401 pubmed
Hawryluk M, Keyel P, Mishra S, Watkins S, Heuser J, Traub L. Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic. 2006;7:262-81 pubmed
Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-13 pubmed
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB300-130
SKU号 :
NB300-130
产品名称 :
Ubiquitin Antibody (Ubi-1)
描述 :
The Ubiquitin Antibody (Ubi-1) from Novus is a mouse monoclonal antibody to Ubiquitin. This antibody reacts with human, mouse, rat, porcine, bovine, c. elegans, chicken, drosophila, equine, plant, monkey, zebrafish. The Ubiquitin Antibody (Ubi-1) has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting.
靶标 :
泛肽
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
50% PBS, 50% 甘油
克隆性 :
单克隆
克隆 :
Ubi-1
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
Purified bovine erythrocyte ubiquitin cross-linked with glutaraldehyde to KLH
抗体亚型 :
IgG1
纯度 :
亲和纯化
物种 :
Human, Mouse, Rat, Porcine, Bovine, C. elegans, Chicken, Drosophila, Equine, Plant, Monkey, Zebrafish
特异性 :
Recognizes polyubiquitin chains much more strongly than monoubiquitinated molecules or free ubiquitin
理论上的分子量 :
8.5 kDa
基因符号 :
RPS27A
accessionNumbers :
P0CG48, P0CG47
应用 :
免疫印迹, 免疫组化, 免疫细胞化学/免疫荧光, 免疫组化石蜡, 免疫组化冷冻, 免疫印迹
美元 :
489美元
别名 :
RPS27A, 泛素蛋白A52残基核糖体蛋白融合产物1, UBB泛肽B, UBC
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。