产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
LRRK2 Antibody - BSA Free
目录 :
NB300-268
规格 :
0.1 ml (also 0.025 ml)
价格 :
399美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
HRP
克隆名称 :
6C5cc
反应物种 :
人类, 小鼠, 牛
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
Novus Biologicals 产品网页
文章摘录数: 14
参考文献
Pajarillo E, Kim S, Digman A, Dutton M, Son D, Aschner M, et al. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023;299:104879 pubmed 出版商
Pajarillo E, Kim S, Digman A, Dutton M, Son D, Aschner M, et al. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv. 2023;: pubmed 出版商
Wallings R, Hughes L, Staley H, Simon Z, McFarland N, Alcalay R, et al. WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes. Front Cell Neurosci. 2022;16:892899 pubmed 出版商
Bharat V, Hsieh C, Wang X. Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients. Front Cell Dev Biol. 2021;9:765408 pubmed 出版商
Chen S, Luo Z, Ward C, Ibáñez D, Liu H, Zhong X, et al. Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9. Stem Cell Res. 2020;45:101804 pubmed 出版商
Hsieh C, Li L, Vanhauwaert R, Nguyen K, Davis M, Bu G, et al. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab. 2019;30:1131-1140.e7 pubmed 出版商
Kim J, Pajarillo E, Rizor A, Son D, Lee J, Aschner M, et al. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS ONE. 2019;14:e0210248 pubmed 出版商
Bonello F, Hassoun S, Mouton Liger F, Shin Y, Muscat A, Tesson C, et al. LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease. Hum Mol Genet. 2019;28:1645-1660 pubmed 出版商
Takanashi M, Funayama M, Matsuura E, Yoshino H, Li Y, Tsuyama S, et al. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta Neuropathol Commun. 2018;6:105 pubmed 出版商
Lim J, Bang Y, Choi J, Han A, Kwon M, Liu K, et al. LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice. J Neurosci. 2018;38:1611-1621 pubmed 出版商
Chen Z, Zhang W, Chua L, Chai C, Li R, Lin L, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017;10: pubmed 出版商
Bliederhaeuser C, Zondler L, Grozdanov V, Ruf W, Brenner D, Melrose H, et al. LRRK2 contributes to monocyte dysregulation in Parkinson's disease. Acta Neuropathol Commun. 2016;4:123 pubmed
Nucifora F, Nucifora L, Ng C, Arbez N, Guo Y, Roby E, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun. 2016;7:11792 pubmed 出版商
Vitte J, Traver S, Maués De Paula A, Lesage S, Rovelli G, Corti O, et al. Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol. 2010;69:959-72 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB300-268
SKU号 :
NB300-268
产品名称 :
LRRK2 Antibody - BSA Free
描述 :
The LRRK2 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to LRRK2. This antibody reacts with human, mouse, bovine, c. elegans, insect, plant. The LRRK2 Antibody - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated.
靶标 :
LRRK2
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1毫克/毫升
共轭标签 :
未共轭
宿主 :
兔
免疫原 :
A C-terminal synthetic peptide made to the human LRRK2 protein sequence (between residues 2500-2527). [UniProt# Q5S007]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
Human, Mouse, Bovine, C. elegans, Insect, Plant
理论上的分子量 :
286 kDa
基因符号 :
LRRK2
accessionNumbers :
Q5S007
应用 :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated
美元 :
399美元
别名 :
augmented in rheumatoid arthritis 17, AURA17, Dardarin, DKFZp434H2111, EC 2.7.11.1, FLJ45829, leucine-rich repeat kinase 2, leucine-rich repeat serine/threonine-protein kinase 2, PARK8DARDARIN, Parkinson disease (autosomal dominant) 8, RIPK7, ROCO2
储存 :
Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
Novus Biologicals 产品网页
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工，Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外，Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂，Novus Biologicals扮演市场上重要的角色。