产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
xCT Antibody - BSA Free
目录 :
NB300-318
规格 :
0.1 ml (also 0.025 ml)
价格 :
459美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 55
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 1:200; 图 5a
Ku C, Wuputra K, Kato K, Pan J, Li C, Tsai M, et al. Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. Stem Cell Res Ther. 2021;12:369 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000
Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death Dis. 2021;12:426 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin Arbelet V, Holmseth S, et al. Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed. J Comp Neurol. 2016;524:1015-32 pubmed 出版商
Shi J, Wang Q, Wei X, Huo B, Ye J, Yi X, et al. Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis. Mol Med. 2023;29:91 pubmed 出版商
Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, et al. SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun. 2023;14:3673 pubmed 出版商
Ma Z, Fan Y, Peng Y, Bian L, Zhou J, Wang L, et al. miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway. Biosci Rep. 2023;43: pubmed 出版商
Bao X, Luo X, Bai X, Lv Y, Weng X, Zhang S, et al. Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. Free Radic Biol Med. 2023;201:76-88 pubmed 出版商
Xie Z, Wang X, Luo X, Yan J, Zhang J, Sun R, et al. Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. Biochem Pharmacol. 2023;207:115374 pubmed 出版商
Ishii T, Mimura I, Nagaoka K, Naito A, Sugasawa T, Kuroda R, et al. Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression. Cell Death Discov. 2022;8:480 pubmed 出版商
Sketriené D, Battista D, Lalert L, Kraiwattanapirom N, Thai H, Leeboonngam T, et al. Compulsive-like eating of high-fat high-sugar food is associated with 'addiction-like' glutamatergic dysfunction in obesity prone rats. Addict Biol. 2022;27:e13206 pubmed 出版商
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, et al. Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection. Int J Biol Sci. 2022;18:4118-4134 pubmed 出版商
Lee J, Chang Chien G, Lin S, Hsiao Y, Ke M, Chen A, et al. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. Oxid Med Cell Longev. 2022;2022:1792894 pubmed 出版商
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, et al. The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell Biosci. 2022;12:20 pubmed 出版商
Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Pharmacol Res. 2022;177:106122 pubmed 出版商
Akusjärvi S, Ambikan A, Krishnan S, Gupta S, Sperk M, Vegvari A, et al. Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling. iScience. 2022;25:103607 pubmed 出版商
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Xu Z, et al. HSP27 protects against ferroptosis of glioblastoma cells. Hum Cell. 2022;35:238-249 pubmed 出版商
Kim H, Choi Y, Kim S, Kim H, Jun D, Yoon K, et al. Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome. Commun Biol. 2021;4:824 pubmed 出版商
Sharbeen G, McCarroll J, Akerman A, Kopecky C, Youkhana J, Kokkinos J, et al. Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition. Cancer Res. 2021;81:3461-3479 pubmed 出版商
Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, et al. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Front Cell Dev Biol. 2021;9:639851 pubmed 出版商
Kim S, Kang S, Joo J, Han S, Shin H, Nam B, et al. Characterization of ferroptosis in kidney tubular cell death under diabetic conditions. Cell Death Dis. 2021;12:160 pubmed 出版商
Kazama M, Kato Y, Kakita A, Noguchi N, Urano Y, Masui K, et al. Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis. Neuropathology. 2020;40:587-598 pubmed 出版商
Healey K, Kibble S, Bell A, Hodges S, Swartzwelder H. Effects of adolescent intermittent ethanol on hippocampal expression of glutamate homeostasis and astrocyte-neuronal tethering proteins in male and female rats. J Neurosci Res. 2020;: pubmed 出版商
Krys D, Mattingly S, Glubrecht D, Wuest M, Wuest F. PET Imaging of L-Type Amino Acid Transporter (LAT1) and Cystine-Glutamate Antiporter (xc-) with [18F]FDOPA and [18F]FSPG in Breast Cancer Models. Mol Imaging Biol. 2020;22:1562-1571 pubmed 出版商
Park S, Na S, Kumar M, Mosci C, Wardak M, Koglin N, et al. Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-glutamate (18F-FSPG) for PET/CT Imaging in Patients with Newly Diagnosed and Recurrent Prostate Cancer. Clin Cancer Res. 2020;26:5380-5387 pubmed 出版商
Gao M, Liu H, Xiao Y, Guo Y, Wan X, Li X, et al. xCT regulates redox homeostasis and promotes photoreceptor survival after retinal detachment. Free Radic Biol Med. 2020;158:32-43 pubmed 出版商
Long Y, Tao H, Karachi A, Grippin A, Jin L, Chang Y, et al. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res. 2020;80:499-509 pubmed 出版商
Wu W, Sun H, Chen J, OuYang H, Yu X, Chen H, et al. Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer. Cancer Immunol Res. 2019;7:1605-1618 pubmed 出版商
Pitman K, Alluri S, Kristian A, Aarnes E, Lyng H, Riss P, et al. Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. Eur J Nucl Med Mol Imaging. 2019;46:2190-2198 pubmed 出版商
Isobe S, Kataoka M, Endo J, Moriyama H, Okazaki S, Tsuchihashi K, et al. Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019;: pubmed 出版商
Ungard R, Linher Melville K, Nashed M, Sharma M, Wen J, Singh G. xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain. Mol Pain. 2019;15:1744806918822185 pubmed 出版商
Li C, Chen H, Lan Z, He S, Chen R, Wang F, et al. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019;: pubmed 出版商
Greenwood H, McCormick P, Gendron T, Glaser M, Pereira R, Maddocks O, et al. Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography. Clin Cancer Res. 2019;25:2471-2482 pubmed 出版商
Mi D, Dixit S, Warner T, Kennard J, Scharf D, Kessler E, et al. Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging. 2018;71:241-254 pubmed 出版商
Miladinovic T, Ungard R, Linher Melville K, Popovic S, Singh G. Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain. Mol Pain. 2018;14:1744806918776467 pubmed 出版商
Logan C, Lacrosse A, Knackstedt L. Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology. 2018;135:297-307 pubmed 出版商
Hoehne A, James M, Alam I, Ronald J, Schneider B, D Souza A, et al. [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. J Neuroinflammation. 2018;15:55 pubmed 出版商
Bechard A, Hamor P, Schwendt M, Knackstedt L. The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens. Psychopharmacology (Berl). 2018;235:837-848 pubmed 出版商
Nasca C, Bigio B, Zelli D, De Angelis P, Lau T, Okamoto M, et al. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. 2017;96:402-413.e5 pubmed 出版商
Sayin V, LeBoeuf S, Singh S, Davidson S, Biancur D, Guzelhan B, et al. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. elife. 2017;6: pubmed 出版商
Bertaux Skeirik N, Wunderlich M, Teal E, Chakrabarti J, Biesiada J, Mahe M, et al. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. J Pathol. 2017;242:463-475 pubmed 出版商
Lacrosse A, O Donovan S, Sepulveda Orengo M, McCullumsmith R, Reissner K, Schwendt M, et al. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. J Neurosci. 2017;37:5809-5821 pubmed 出版商
Suárez Pozos E, Martínez Lozada Z, Méndez Flores O, Guillem A, Hernández Kelly L, Castelán F, et al. Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells. Neurochem Int. 2017;108:52-59 pubmed 出版商
Martin C, Patel M, Melendez Ferro M, Sims B. Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc. Exp Cell Res. 2017;352:202-206 pubmed 出版商
Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed 出版商
Kavanaugh G, Williams J, Morris A, Nickels M, Walker R, Koglin N, et al. Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population. Mol Imaging Biol. 2016;18:924-934 pubmed
Polewski M, Reveron Thornton R, Cherryholmes G, Marinov G, Cassady K, Aboody K. Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Mol Cancer Res. 2016;14:1229-1242 pubmed
Linher Melville K, Nashed M, Ungard R, Haftchenary S, Rosa D, Gunning P, et al. Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity. PLoS ONE. 2016;11:e0161202 pubmed 出版商
Slosky L, Bassirirad N, Symons A, Thompson M, Doyle T, Forte B, et al. The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. Pain. 2016;157:2605-2616 pubmed
Soria F, Zabala A, Pampliega O, Palomino A, Miguelez C, Ugedo L, et al. Cystine/glutamate antiporter blockage induces myelin degeneration. Glia. 2016;64:1381-95 pubmed 出版商
Pati D, Kelly K, Stennett B, Frazier C, Knackstedt L. Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release. Eur J Neurosci. 2016;44:1896-905 pubmed 出版商
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112:E4600-9 pubmed 出版商
Merckx E, Demuyser T, Bentea E, Van Liefferinge J, Albertini G, Deneyer L, et al. Lack of effect of Theiler's murine encephalomyelitis virus infection on system xc⁻. Neurosci Lett. 2015;593:124-8 pubmed 出版商
Rao P, Saternos H, Goodwani S, Sari Y. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Psychopharmacology (Berl). 2015;232:2333-42 pubmed 出版商
Aal Aaboda M, Alhaddad H, Osowik F, Nauli S, Sari Y. Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats. J Neurosci Res. 2015;93:930-7 pubmed 出版商
Martin L, Gardner L. Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11. Oncogene. 2015;34:4211-8 pubmed 出版商
产品信息
品牌 :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB300-318
SKU号 :
NB300-318
产品名称 :
xCT Antibody - BSA Free
描述 :
The xCT Antibody - BSA Free from Novus is a rabbit polyclonal antibody to xCT. This antibody reacts with human, mouse, rat. The xCT Antibody - BSA Free has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunoprecipitation (Negative), Dual RNAscope ISH-IHC.
靶标 :
xCT
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
This xCT Antibody was prepared from a synthetic peptide made to an N-terminal region of the human xCT protein (between residues 1-50) [UniProt Q9UPY5].
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠
基因符号 :
SLC7A11
accessionNumbers :
Q9UPY5, Q9WTR6
应用 :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunoprecipitation (Negative), Dual RNAscope ISH-IHC
美元 :
459美元
别名 :
Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, CCBR1, cystine/glutamate transporter, SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, Solute carrier family 7 member 11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, xCT
储存 :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
更多信息或购买 :
公司信息
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。