| 出版应用/物种/样本/稀释 | 参考文献 |
|---|
- 免疫组化; 小鼠; 图 4d
- 免疫印迹; 小鼠; 图 4c
| Brampton C, Pomozi V, Chen L, Apana A, McCurdy S, Zoll J, et al. ABCC6 deficiency promotes dyslipidemia and atherosclerosis. Sci Rep. 2021;11:3881 pubmed 出版商 |
| Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, et al. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nat Commun. 2021;12:843 pubmed 出版商 |
- 免疫细胞化学; 小鼠; 图 7d
- 免疫印迹; 小鼠; 图 7b
| Lv J, Wang H, Cui H, Liu Z, Zhang R, Lu M, et al. Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis. Front Cell Dev Biol. 2020;8:609090 pubmed 出版商 |
| Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed 出版商 |
- 免疫印迹; 小鼠; 图 6d
- 免疫印迹; 人类; 图 5d
| Nelson J, Koenis D, Scheij S, Cook E, Moeton M, Santos A, et al. EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Arterioscler Thromb Vasc Biol. 2017;37:423-432 pubmed 出版商 |
| Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, et al. Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. Mol Nutr Food Res. 2017;61: pubmed 出版商 |
| Ontsouka C, Huang X, Aliyev E, Albrecht C. In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland. Mol Cell Endocrinol. 2017;439:35-45 pubmed 出版商 |
| Conlon D, Thomas T, Fedotova T, Hernandez Ono A, Di Paolo G, Chan R, et al. Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. J Clin Invest. 2016;126:3852-3867 pubmed 出版商 |
| Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed 出版商 |
| Hsieh J, Koseki M, Molusky M, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016;535:303-7 pubmed 出版商 |
- 免疫印迹; 小鼠; 1:1000; 图 3
- 免疫印迹; 人类; 1:1000; 图 3
| Fournier N, Tardivel S, Benoist J, Vedie B, Rousseau Ralliard D, Nowak M, et al. Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages. Biochim Biophys Acta. 2016;1861:331-41 pubmed 出版商 |
| Molina Gonzalez I, Holloway R, Jiwaji Z, Dando O, Kent S, Emelianova K, et al. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun. 2023;14:3372 pubmed 出版商 |
| Miyagawa S, Horie T, Nishino T, Koyama S, Watanabe T, Baba O, et al. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis. Life Sci Alliance. 2023;6: pubmed 出版商 |
| Cao D, Khan Z, Li X, Saito S, Bernstein E, Victor A, et al. Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism. Cardiovasc Res. 2023;119:1825-1841 pubmed 出版商 |
| Dragoljevic D, Lee M, Pernes G, Morgan P, Louis C, Shihata W, et al. Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis. Clin Transl Immunology. 2023;12:e1446 pubmed 出版商 |
| Cashikar A, Toral Rios D, Timm D, Romero J, Strickland M, Long J, et al. Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol. J Lipid Res. 2023;64:100350 pubmed 出版商 |
| Li Z, He M, Chen G, Worgall T, Jiang X. Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice. bioRxiv. 2023;: pubmed 出版商 |
| Yalcınkaya M, Fotakis P, Liu W, Endo Umeda K, Dou H, Abramowicz S, et al. Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion. Cardiovasc Res. 2023;119:969-981 pubmed 出版商 |
| Papotti B, Adorni M, Marchi C, Zimetti F, Ronda N, Panighel G, et al. PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer's Disease. Int J Mol Sci. 2022;23: pubmed 出版商 |
| Cassim Bawa F, Gopoju R, Xu Y, Hu S, Zhu Y, Chen S, et al. Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice. Cells. 2022;11: pubmed 出版商 |
| Cai Y, Wang Z, Li L, He L, Wu X, Zhang M, et al. Neuropeptide Y regulates cholesterol uptake and efflux in macrophages and promotes foam cell formation. J Cell Mol Med. 2022;26:5391-5402 pubmed 出版商 |
| Man B, Hu C, Yang G, Xiang J, Yang S, Ma C. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE-/- mice. Biochem Biophys Res Commun. 2022;624:59-67 pubmed 出版商 |
| Wang J, Li L, Hu A, Deng G, Wei J, Li Y, et al. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature. 2022;608:413-420 pubmed 出版商 |
| Perelroizen R, Philosof B, Budick Harmelin N, Chernobylsky T, Ron A, Katzir R, et al. Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Brain. 2022;145:3288-3307 pubmed 出版商 |
| Vaisar T, Wang S, Omer M, Irwin A, Storey C, Tang C, et al. 10,12-Conjugated linoleic acid supplementation improves HDL composition and function in mice. J Lipid Res. 2022;63:100241 pubmed 出版商 |
| Picataggi A, Rodrigues A, Cromley D, Wang H, Wiener J, Garliyev V, et al. Specificity of ABCA7-mediated cell lipid efflux. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159157 pubmed 出版商 |
| Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, et al. Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy. Cancer Sci. 2022;113:2129-2143 pubmed 出版商 |
| Peters F, Ebner L, Atac D, Maggi J, Berger W, den Hollander A, et al. Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE. Int J Mol Sci. 2022;23: pubmed 出版商 |
| Yıldırım Z, Baboo S, Hamid S, Dogan A, Tufanlı Ö, Robichaud S, et al. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med. 2022;14:e15344 pubmed 出版商 |
| Balamurugan K, Medishetti R, Kotha J, Behera P, Chandra K, Mavuduru V, et al. PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways. iScience. 2022;25:103766 pubmed 出版商 |
| Wang W, Lokman N, Noye T, Macpherson A, Oehler M, Ricciardelli C. ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome. Cancer Drug Resist. 2021;4:485-502 pubmed 出版商 |
| Toma L, Barbalata T, Sanda G, Niculescu L, Sima A, Stancu C. CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction. Biomolecules. 2021;11: pubmed 出版商 |
| Kane J, Jansen M, Hendrix S, Bosmans L, Beckers L, Tiel C, et al. Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity. Thromb Haemost. 2021;: pubmed 出版商 |
| Casado M, Huerta L, Marcos Díaz A, Ortiz A, Kraemer F, Lasunción M, et al. Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159043 pubmed 出版商 |
| Han Y, Onufer E, Huang L, Sprung R, Davidson W, Czepielewski R, et al. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science. 2021;373: pubmed 出版商 |
| Huang R, Hu Z, Chen X, Cao Y, Li H, Zhang H, et al. The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis. Adv Sci (Weinh). 2021;8:e2004162 pubmed 出版商 |
| Wright M, Varona Santos J, Kemmer C, Maugeais C, Carralot J, Roever S, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021;12:4662 pubmed 出版商 |
| Mota A, Dominguez M, Weigert A, Snodgrass R, Namgaladze D, Brüne B. Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages. Front Immunol. 2021;12:637778 pubmed 出版商 |
| Wang H, Lv J, Zhao Y, Wei H, Zhang T, Yang H, et al. Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease. CNS Neurosci Ther. 2021;: pubmed 出版商 |
| Zhang S, Li Z, Zhang Y, Chen J, Li Y, Wu F, et al. Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx. Adv Sci (Weinh). 2021;8:2003410 pubmed 出版商 |
| Navia Pelaez J, Choi S, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa Boyle C, et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med. 2021;218: pubmed 出版商 |
| Wang H, Arias E, Cartee G. Reduced membrane cholesterol content in skeletal muscle is not essential for greater insulin-stimulated glucose uptake after acute exercise by rats. Appl Physiol Nutr Metab. 2021;46:685-689 pubmed 出版商 |
| Alajbegovic A, Holmberg J, Daoud F, Rippe C, Kalliokoski G, Ekman M, et al. MRTFA overexpression promotes conversion of human coronary artery smooth muscle cells into lipid-laden foam cells. Vascul Pharmacol. 2021;:106837 pubmed 出版商 |
| Palafox Sánchez V, Ying Z, Royes L, Gomez Pinilla F. The interaction between brain and liver regulates lipid metabolism in the TBI pathology. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166078 pubmed 出版商 |
| . E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021;:ATVBAHA120314156 pubmed 出版商 |
| Ren Q, Xie X, Tang Y, Hu Q, Du Y. Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo. J Environ Sci (China). 2021;101:236-247 pubmed 出版商 |
| Mukherjee V, Ramakrishna P, Bora S, Kotteazeth S. Phytosteroid 28-homobrassinolide targets cholesterol and glucose homeostasis implicating ABCA1 and SREBP role in regulation. Steroids. 2021;165:108756 pubmed 出版商 |
| Ma C, Zhang J, Yang S, Hua Y, Su J, Shang Y, et al. Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE-/- Mice. Front Pharmacol. 2020;11:610550 pubmed 出版商 |
| Dodge J, Jensen E, Yu J, Sardi S, Bialas A, Taksir T, et al. Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis. J Neurosci. 2020;40:9137-9147 pubmed 出版商 |
| Munir M, Ponce C, Santos J, Sufian H, Al Harrasi A, Gollahon L, et al. VD3 and LXR agonist (T0901317) combination demonstrated greater potency in inhibiting cholesterol accumulation and inducing apoptosis via ABCA1-CHOP-BCL-2 cascade in MCF-7 breast cancer cells. Mol Biol Rep. 2020;47:7771-7782 pubmed 出版商 |
| Zhao Y, Zeng C, Li X, Yang T, Kuang X, Du J. Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease. Aging Cell. 2020;:e13239 pubmed 出版商 |
| Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, et al. TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. J Biol Chem. 2020;295:16314-16327 pubmed 出版商 |
| Shang Y, Ma C, Zhang J, Wang Z, Ren C, Luo X, et al. Bifunctional supramolecular nanofiber inhibits atherosclerosis by enhancing plaque stability and anti-inflammation in apoE-/- mice. Theranostics. 2020;10:10231-10244 pubmed 出版商 |
| Venkat P, Zacharek A, Landschoot Ward J, Wang F, Culmone L, Chen Z, et al. Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats. Exp Neurol. 2020;334:113456 pubmed 出版商 |
| Xia X, Xu Q, Liu M, Chen X, Liu X, He J, et al. Deubiquitination of CD36 by UCHL1 promotes foam cell formation. Cell Death Dis. 2020;11:636 pubmed 出版商 |
| Wu J, Yu X, Xue K, Wu J, Wang R, Xie X, et al. The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson's Disease. Oxid Med Cell Longev. 2020;2020:8735249 pubmed 出版商 |
| Gao Q, Wei A, Chen F, Chen X, Ding W, Ding Z, et al. Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020;160:105059 pubmed 出版商 |
| Werkman I, Kövilein J, de Jonge J, Baron W. Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination. J Neurochem. 2020;: pubmed 出版商 |
| Wang D, Hiebl V, Schachner D, Ladurner A, Heiss E, Atanasov A, et al. Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation. Biochem Pharmacol. 2020;177:114022 pubmed 出版商 |
| Marshall J, Courage E, Elliott R, Fitzpatrick M, Kim A, Lopez Clavijo A, et al. THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation. PLoS ONE. 2020;15:e0233180 pubmed 出版商 |
| Pathak P, Helsley R, Brown A, Buffa J, Choucair I, Nemet I, et al. Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism. Am J Physiol Heart Circ Physiol. 2020;318:H1474-H1486 pubmed 出版商 |
| Hiebl V, Schachner D, Ladurner A, Heiss E, Stangl H, Dirsch V. Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations. Biol Proced Online. 2020;22:7 pubmed 出版商 |
| Salonurmi T, Nabil H, Ronkainen J, Hyötyläinen T, Hautajärvi H, Savolainen M, et al. 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters. Front Pharmacol. 2020;11:361 pubmed 出版商 |
| He Q, Wang F, Honda T, Greis K, Redington A. Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation. Sci Rep. 2020;10:6127 pubmed 出版商 |
| Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A. Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages. J Pharmacol Sci. 2020;143:106-111 pubmed 出版商 |
| Bogie J, Grajchen E, Wouters E, Corrales A, Dierckx T, Vanherle S, et al. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med. 2020;217: pubmed 出版商 |
| Cipollari E, Szapary H, Picataggi A, Billheimer J, Lyssenko C, Ying G, et al. Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease. J Alzheimers Dis. 2020;74:563-578 pubmed 出版商 |
| Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, et al. Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. Autophagy. 2020;:1-16 pubmed 出版商 |
| Chen T, Yuan H, Sun Y, Song Y, Lü M, Ni X, et al. Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior. Biochem Biophys Res Commun. 2020;523:315-321 pubmed 出版商 |
| Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, et al. Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression. J Pharmacol Sci. 2020;142:9-15 pubmed 出版商 |
| Du Y, Li X, Su C, Xi M, Zhang X, Jiang Z, et al. Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice. Br J Pharmacol. 2020;177:1754-1772 pubmed 出版商 |
| Pagano S, Magenta A, D Agostino M, Martino F, Barilla F, Satta N, et al. Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation. J Clin Med. 2019;8: pubmed 出版商 |
| Kaymak I, Maier C, Schmitz W, Campbell A, Dankworth B, Ade C, et al. Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress. Cancer Res. 2020;80:189-203 pubmed 出版商 |
| Xiao L, Luo G, Guo X, Jiang C, Zeng H, Zhou F, et al. Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158531 pubmed 出版商 |
| Smith T, Kahiel Z, LeBlond N, Ghorbani P, Farah E, Al Awosi R, et al. Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages. Molecules. 2019;24: pubmed 出版商 |
| Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020;28:202-216 pubmed 出版商 |
| Hennessy E, van Solingen C, Scacalossi K, Ouimet M, Afonso M, Prins J, et al. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 2019;1:98-110 pubmed 出版商 |
| Zhou Y, Bazick H, Miles J, Fethiere A, Salihi M, Fazio S, et al. A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice. Exp Neurol. 2019;321:113031 pubmed 出版商 |
| Paul A, Lydic T, Hogan R, Goo Y. Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells. Int J Mol Sci. 2019;20: pubmed 出版商 |
| Mukhamedova N, Hoang A, Dragoljevic D, Dubrovsky L, Pushkarsky T, Low H, et al. Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. PLoS Pathog. 2019;15:e1007907 pubmed 出版商 |
| Koyama S, Horie T, Nishino T, Baba O, Sowa N, Miyasaka Y, et al. Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice. J Am Heart Assoc. 2019;8:e012609 pubmed 出版商 |
| Rege S, Royes L, Tsai B, Zhang G, Yang X, Gomez Pinilla F. Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?. Mol Nutr Food Res. 2019;63:e1801054 pubmed 出版商 |
| Zhou Y, Miles J, Tavori H, Lin M, Khoshbouei H, Borchelt D, et al. PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux. J Neurosci. 2019;: pubmed 出版商 |
| Tiwari P, Blank A, Cui C, Schoenfelt K, Zhou G, Xu Y, et al. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. J Exp Med. 2019;216:1345-1358 pubmed 出版商 |
| Liao S, Zhou Q, Zhang Y. Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs. J Diabetes Metab Disord. 2018;17:101-109 pubmed 出版商 |
| Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde Visser S, et al. Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration. elife. 2019;8: pubmed 出版商 |
| Margaryan N, Hazard Jenkins H, Salkeni M, Smolkin M, Coad J, Wen S, et al. The Stem Cell Phenotype of Aggressive Breast Cancer Cells. Cancers (Basel). 2019;11: pubmed 出版商 |
| Cabou C, Honorato P, Briceno L, Ghezali L, Duparc T, León M, et al. Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation. Acta Physiol (Oxf). 2019;226:e13268 pubmed 出版商 |
| Nakazeki F, Tsuge I, Horie T, Imamura K, Tsukita K, Hotta A, et al. MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons. Clin Sci (Lond). 2019;133:583-595 pubmed 出版商 |
| Tang S, Tabet F, Cochran B, Cuesta Torres L, Wu B, Barter P, et al. Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle. Sci Rep. 2019;9:1350 pubmed 出版商 |
| Vaidya M, Jentsch J, Peters S, Keul P, Weske S, Gräler M, et al. Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res. 2019;60:506-515 pubmed 出版商 |
| Ramón Vázquez A, de la Rosa J, Tabraue C, Lopez F, Díaz Chico B, Bosca L, et al. Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages. Mol Cell Biol. 2019;39: pubmed 出版商 |
| Moon S, Huang C, Houlihan S, Regunath K, Freed Pastor W, Morris J, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019;176:564-580.e19 pubmed 出版商 |
| Torres Adorno A, Vitrac H, Qi Y, Tan L, Levental K, Fan Y, et al. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019;38:2135-2150 pubmed 出版商 |
| Zinkhan E, Yu B, McKnight R. Uteroplacental Insufficiency Impairs Cholesterol Elimination in Adult Female Growth-Restricted Rat Offspring Fed a High-Fat Diet. Reprod Sci. 2019;26:1173-1180 pubmed 出版商 |
| Han Q, Yeung S, Ip M, Mak J. Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model. Lipids Health Dis. 2018;17:255 pubmed 出版商 |
| O Reilly M, Kajani S, Ralston J, Lenighan Y, Roche H, McGillicuddy F. Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages. Mol Nutr Food Res. 2019;63:e1800713 pubmed 出版商 |
| Jin P, Bian Y, Wang K, Cong G, Yan R, Sha Y, et al. Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages. Life Sci. 2018;214:41-50 pubmed 出版商 |
| Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865:161-180 pubmed 出版商 |
| Zhong S, Li L, Zhang Y, Zhang L, Lu J, Guo S, et al. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019;129:252-267 pubmed 出版商 |
| Nishino T, Horie T, Baba O, Sowa N, Hanada R, Kuwabara Y, et al. SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo. Arterioscler Thromb Vasc Biol. 2018;38:2460-2473 pubmed 出版商 |
| Liao S, Wu H, Chen R. Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT-/- mouse model of preeclampsia. Clin Hypertens. 2018;24:11 pubmed 出版商 |
| De Neergaard R, Nielsen J, Jørgensen A, Toft B, Goetze J, Jørgensen N. Positive association between cholesterol in human seminal plasma and sperm counts: results from a cross-sectional cohort study and immunohistochemical investigations. Andrology. 2018;6:817-828 pubmed 出版商 |
| Wang X, Luo J, Li N, Liu L, Han X, Liu C, et al. E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression. Biochem Biophys Res Commun. 2018;504:68-74 pubmed 出版商 |
| Qian K, Feng L, Sun Y, Xiong B, Ding Y, Han P, et al. Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model. Biomed Res Int. 2018;2018:8973986 pubmed 出版商 |
| Lyssenko N, Haider N, Picataggi A, Cipollari E, Jiao W, Phillips M, et al. Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium. J Lipid Res. 2018;59:1927-1939 pubmed 出版商 |
| Wang L, Eftekhari P, Schachner D, Ignatova I, Palme V, Schilcher N, et al. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Sci Rep. 2018;8:11061 pubmed 出版商 |
| Chernick D, Ortiz Valle S, Jeong A, Swaminathan S, Kandimalla K, Rebeck G, et al. High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia. J Neurochem. 2018;147:647-662 pubmed 出版商 |
| Sonett J, Goldklang M, Sklepkiewicz P, Gerber A, Trischler J, Zelonina T, et al. A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure. FASEB J. 2018;:fj201701381 pubmed 出版商 |
| Zinkhan E, Yu B, Schlegel A. Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1. Front Physiol. 2018;9:645 pubmed 出版商 |
| Wang D, Hiebl V, Ladurner A, Latkolik S, Bucar F, Heiß E, et al. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Mol Nutr Food Res. 2018;:e1800011 pubmed 出版商 |
| Feng T, Liu P, Wang X, Luo J, Zuo X, Jiang X, et al. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis. 2018;274:172-181 pubmed 出版商 |
| Ishigami M, Ogasawara F, Nagao K, Hashimoto H, Kimura Y, Kioka N, et al. Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation. Sci Rep. 2018;8:6170 pubmed 出版商 |
| Xie Z, Wang X, Liu X, Du H, Sun C, Shao X, et al. Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization. J Am Heart Assoc. 2018;7: pubmed 出版商 |
| Ahn S, Jun D, Jang K, Lee B, Shin K. Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease. Korean J Intern Med. 2019;34:777-784 pubmed 出版商 |
| Sallam T, Jones M, Thomas B, Wu X, Gilliland T, Qian K, et al. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018;24:304-312 pubmed 出版商 |
| Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, et al. Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function. Cell Death Dis. 2018;9:173 pubmed 出版商 |
| Li Y, Shen S, Ding S, Wang L. Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis. Exp Ther Med. 2018;15:198-204 pubmed 出版商 |
| Milligan S, Martin G, Landrock D, McIntosh A, Mackie J, Schroeder F, et al. Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:323-338 pubmed 出版商 |
| Widenmaier S, Snyder N, Nguyen T, Arduini A, Lee G, Arruda A, et al. NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017;171:1094-1109.e15 pubmed 出版商 |
| Doran A, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond C, et al. CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. J Clin Invest. 2017;127:4075-4089 pubmed 出版商 |
| Storti F, Raphael G, Griesser V, Klee K, Drawnel F, Willburger C, et al. Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells. Exp Eye Res. 2017;165:65-77 pubmed 出版商 |
| Pelletier R, Akpovi C, Chen L, Vitale M. Cholesterol metabolism and Cx43, Cx46, Cx50 gap junction protein expression and localisation in normal and diabetic and obese ob/ob and db/db mouse testes. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00215.2017 pubmed 出版商 |
| Liang Y, Li X, Zhang Y, Yeung S, Zhen Z, Ip M, et al. Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction. Front Pharmacol. 2017;8:501 pubmed 出版商 |
| Morizawa Y, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, et al. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017;8:28 pubmed 出版商 |
| Wang D, Tosevska A, Heiß E, Ladurner A, Mölzer C, Wallner M, et al. Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression. J Am Heart Assoc. 2017;6: pubmed 出版商 |
| Delgado Maroto V, Benitez R, Forte Lago I, Morell M, Maganto Garcia E, Souza Moreira L, et al. Cortistatin reduces atherosclerosis in hyperlipidemic ApoE-deficient mice and the formation of foam cells. Sci Rep. 2017;7:46444 pubmed 出版商 |
| Li J, Xiu Z, Wang R, Yu C, Chi Y, Qin J, et al. The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPAR?. Life Sci. 2017;177:27-40 pubmed 出版商 |
| Mailleux J, Vanmierlo T, Bogie J, Wouters E, Lutjohann D, Hendriks J, et al. Active liver X receptor signaling in phagocytes in multiple sclerosis lesions. Mult Scler. 2018;24:279-289 pubmed 出版商 |
| Pulakazhi Venu V, Adijiang A, Seibert T, Chen Y, Shi C, Batulan Z, et al. Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice. FASEB J. 2017;31:2364-2379 pubmed 出版商 |
| Cook E, Nelson J, Sorrentino V, Koenis D, Moeton M, Scheij S, et al. Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. PLoS ONE. 2017;12:e0172721 pubmed 出版商 |
| Mariani M, Malm T, Lamb R, Jay T, Neilson L, Casali B, et al. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. Sci Rep. 2017;7:42270 pubmed 出版商 |
| Hafiane A, Genest J. ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis. Atherosclerosis. 2017;257:90-99 pubmed 出版商 |
| Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed 出版商 |
| Cui X, Chopp M, Zhang Z, Li R, Zacharek A, Landschoot Ward J, et al. ABCA1/ApoE/HDL Pathway Mediates GW3965-Induced Neurorestoration After Stroke. Stroke. 2017;48:459-467 pubmed 出版商 |
| Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, et al. MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol. Circ Res. 2017;120:835-847 pubmed 出版商 |
| Cermak S, Kosicek M, Mladenovic Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S. Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins. PLoS ONE. 2016;11:e0167428 pubmed 出版商 |
| Jiang M, Li X. Activation of PPAR? does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. Biochem Biophys Res Commun. 2017;482:849-856 pubmed 出版商 |
| Luo L, Yang T. Triptolide inhibits the progression of atherosclerosis in apolipoprotein E-/- mice. Exp Ther Med. 2016;12:2307-2313 pubmed |
| de Gaetano M, Crean D, Barry M, Belton O. M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis. Front Immunol. 2016;7:275 pubmed 出版商 |
| Lai L, Azzam K, Lin W, Rai P, Lowe J, Gabor K, et al. MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains. J Biol Chem. 2016;291:19651-60 pubmed 出版商 |
| Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, et al. miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats. Stem Cells Transl Med. 2016;5:1656-1667 pubmed |
| Bechor S, Zolberg Relevy N, Harari A, Almog T, Kamari Y, Ben Amotz A, et al. 9-cis ?-Carotene Increased Cholesterol Efflux to HDL in Macrophages. Nutrients. 2016;8: pubmed 出版商 |
| Khan F, Ahmed F, Pushparaj P, Abuzenadah A, Kumosani T, Barbour E, et al. Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest. PLoS ONE. 2016;11:e0158963 pubmed 出版商 |
| Kim S, Lim E, Yoon Y, Ahn Y, Park E, Kim H, et al. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci Rep. 2016;6:29673 pubmed 出版商 |
| Hnatiuk A, Ong S, Olea F, Locatelli P, Riegler J, Lee W, et al. Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-? (HIF1-?) in an Ovine Model of Acute Myocardial Infarction. J Am Heart Assoc. 2016;5: pubmed 出版商 |
| Kemmerer M, Wittig I, Richter F, Brüne B, Namgaladze D. AMPK activates LXR? and ABCA1 expression in human macrophages. Int J Biochem Cell Biol. 2016;78:1-9 pubmed 出版商 |
| Ollikainen E, Tulamo R, Lehti S, Lee Rueckert M, Hernesniemi J, Niemela M, et al. Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture. J Neuropathol Exp Neurol. 2016;75:689-99 pubmed 出版商 |
| Westerterp M, Tsuchiya K, Tattersall I, Fotakis P, Bochem A, Molusky M, et al. Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Endothelial Cells Accelerates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2016;36:1328-37 pubmed 出版商 |
| Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu C, et al. Quercetin stabilizes apolipoprotein E and reduces brain A? levels in amyloid model mice. Neuropharmacology. 2016;108:179-92 pubmed 出版商 |
| Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, et al. Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. J Lipid Res. 2016;57:1006-16 pubmed 出版商 |
| Wolfe A, Bambhroliya A, Reddy J, Debeb B, Huo L, Larson R, et al. MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer. Int J Radiat Oncol Biol Phys. 2016;95:791-9 pubmed 出版商 |
| Shrestha E, Hussein M, Savas J, Ouimet M, Barrett T, Leone S, et al. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem. 2016;291:11172-84 pubmed 出版商 |
| Hong L, Xu X, Huang J, Lei M, Xu D, Zhao S, et al. Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency. Sci Rep. 2016;6:20503 pubmed 出版商 |
| Schäfer Somi S, Palme N. Seminal Plasma Characteristics and Expression of ATP-binding Cassette Transporter A1 (ABCA1) in Canine Spermatozoa from Ejaculates with Good and Bad Freezability. Reprod Domest Anim. 2016;51:232-9 pubmed 出版商 |
| Shi H, Mao X, Zhong Y, Liu Y, Zhao X, Yu K, et al. Lanatoside C Promotes Foam Cell Formation and Atherosclerosis. Sci Rep. 2016;6:20154 pubmed 出版商 |
| Merkl M, Ertl R, Handschuh S, Aurich C, Schäfer Somi S. The cholesterol transporter ABCA1 is expressed in stallion spermatozoa and reproductive tract tissues. Theriogenology. 2016;85:1080-9 pubmed 出版商 |
| Schreurs B, Sparks D. Dietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortex. J Alzheimers Dis. 2016;49:201-9 pubmed 出版商 |
| Hussein M, Shrestha E, Ouimet M, Barrett T, Leone S, Moore K, et al. LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS ONE. 2015;10:e0135218 pubmed 出版商 |
| Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado del Pozo C, et al. RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes. 2015;64:4046-60 pubmed 出版商 |
| Ito A, Hong C, Rong X, Zhu X, Tarling E, Hedde P, et al. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. elife. 2015;4:e08009 pubmed 出版商 |
| Ramezani A, Dubrovsky L, Pushkarsky T, Sviridov D, Karandish S, RAJ D, et al. Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection. J Pharmacol Exp Ther. 2015;354:376-83 pubmed 出版商 |
| Casali B, Corona A, Mariani M, Karlo J, Ghosal K, Landreth G. Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:9173-81 pubmed 出版商 |
| Fond A, Lee C, Schulman I, Kiss R, Ravichandran K. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest. 2015;125:2748-58 pubmed 出版商 |
| Baker A, Watt J, Huang C, Gerstenfeld L, Schlezinger J. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol. 2015;28:1156-66 pubmed 出版商 |
| Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, et al. Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation. Vascul Pharmacol. 2015;67-69:59-66 pubmed 出版商 |
| de Boussac H, Maqdasy S, Trousson A, Zelcer N, Volle D, Lobaccaro J, et al. Enolase is regulated by Liver X Receptors. Steroids. 2015;99:266-71 pubmed 出版商 |
| Park S, Paek J, Shin D, Lee J, Lim S, Kang Y. Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages. Int J Mol Med. 2015;35:957-65 pubmed 出版商 |
| Chou J, Huang R, Shay J, Chen L, Lin S, Yan P, et al. Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients. Clin Epigenetics. 2015;7:1 pubmed 出版商 |
