产品简要
公司名称 :
Novus Biologicals
其他品牌 :
IMGENEX
产品类型 :
抗体
产品名称 :
LC3B抗体
目录 :
NB600-1384
规格 :
0.1 ml (also 0.025 ml)
价格 :
349美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
AF647
克隆名称 :
OTI2B3
反应物种 :
人类, 小鼠, 大鼠, , , 斑马鱼
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 165
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 5s2b
Lieberman O, Frier M, McGuirt A, Griffey C, Rafikian E, Yang M, et al. Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Zheng J, Croteau D, Bohr V, Akbari M. Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. Nucleic Acids Res. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 图 4b
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, et al. Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene. 2019;38:3458-3474 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s8d
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed 出版商
  • 免疫组化; 大鼠; 1:200; 图 3
  • 免疫印迹; 大鼠; 1:1000; 图 1a
Gao Y, Zhuang Z, Gao S, Li X, Zhang Z, Ye Z, et al. Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury. Am J Transl Res. 2017;9:887-899 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 3a
Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
  • 免疫印迹; 人类; 图 5
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:4000; 图 3
  • 免疫印迹; 人类; 图 1a
Adams O, Dislich B, Berezowska S, Schläfli A, Seiler C, Kröll D, et al. Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. Oncotarget. 2016;7:39241-39255 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed 出版商
Li Z, Zhu Y, Xiang M, Qiu J, Luo S, Lin F. Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells: reversed by artesunate. Acta Pharmacol Sin. 2020;: pubmed 出版商
Zhang Z, Qian Q, Li M, Shao F, Ding W, Lira V, et al. The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB. Autophagy. 2020;:1-15 pubmed 出版商
Cheung C, Hsu C, Lin T, Chen W, Wang Y, Huang H, et al. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. J Biomed Sci. 2020;27:75 pubmed 出版商
Deynoux M, Sunter N, Ducrocq E, Dakik H, Guibon R, Burlaud Gaillard J, et al. A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids. PLoS ONE. 2020;15:e0225485 pubmed 出版商
Bonam S, Bayry J, Tschan M, Muller S. Progress and Challenges in The Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo. Cells. 2020;9: pubmed 出版商
Eriksson I, Wäster P, Ollinger K. Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins. Cell Death Dis. 2020;11:370 pubmed 出版商
Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, et al. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin. Biochem Biophys Rep. 2020;22:100750 pubmed 出版商
Kim H, Lee G, Bhattarai K, Lee M, Back S, Kim H, et al. TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy. 2020;:1-18 pubmed 出版商
Wang C, Li Y, Wu X, Tian H, Jiang S, Xu T, et al. IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice. Eur J Immunol. 2020;: pubmed 出版商
Zheng J, Akbari M, Schirmer C, Reynaert M, Loyens A, Lefebvre B, et al. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:25 pubmed 出版商
Vincent G, Novak E, Siow V, Cunningham K, Griffith B, Comerford T, et al. Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation. Antioxid Redox Signal. 2020;33:1-19 pubmed 出版商
Zhou W, Fang C, Zhang L, Wang Q, Li D, Zhu D. Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma. Biochem Biophys Res Commun. 2020;524:582-588 pubmed 出版商
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier M, et al. Autophagy drives fibroblast senescence through MTORC2 regulation. Autophagy. 2020;:1-13 pubmed 出版商
Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V, et al. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta Neuropathol. 2020;139:773-789 pubmed 出版商
Wardman J, Henriksen E, Marthaler A, Nielsen J, Nielsen T. Enhancement of Autophagy and Solubilization of Ataxin-2 Alleviate Apoptosis in Spinocerebellar Ataxia Type 2 Patient Cells. Cerebellum. 2020;19:165-181 pubmed 出版商
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, et al. Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury. Exp Neurol. 2020;324:113138 pubmed 出版商
Codina Martínez H, Fernandez Garcia B, Díez Planelles C, Fernández A, Higarza S, Fernández Sanjurjo M, et al. Autophagy is required for performance adaptive response to resistance training and exercise-induced adult neurogenesis. Scand J Med Sci Sports. 2020;30:238-253 pubmed 出版商
Yoon J, Lee K, Seok J, Cheng W, Kwon H, Jeong C, et al. Zearalenone Induces Endoplasmic Reticulum Stress and Modulates the Expression of Phase I/II Enzymes in Human Liver Cells. Toxins (Basel). 2019;12: pubmed 出版商
Simon C, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson D, et al. Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy. Cell Rep. 2019;29:3885-3901.e5 pubmed 出版商
Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, et al. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. 2019;:1-16 pubmed 出版商
Yu Y, Xiang N, Lin M, Huang J, Zhang J, Cheng B, et al. miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways. Drug Des Devel Ther. 2019;13:3717-3726 pubmed 出版商
Wang R, Wang W, Li A, Wang Y, Jin J, Huang Z, et al. Lipopolysaccharide enhances DNA-induced IFN-β expression and autophagy by upregulating cGAS expression in A549 cells. Exp Ther Med. 2019;18:4157-4164 pubmed 出版商
Zhang Y, Pan N, Sheng Y, Zhou M, Wen Z, Chen Y, et al. Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes. Immunol Lett. 2019;216:36-42 pubmed 出版商
Frendo Cumbo S, Jaldin Fincati J, Coyaud E, Laurent E, Townsend L, Tan J, et al. Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation. J Biol Chem. 2019;294:16172-16185 pubmed 出版商
Hong J, Kim J, Kim H, Lee W, Hwang Y. SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells. Molecules. 2019;24: pubmed 出版商
Dhandapani P, Begines Moreno I, Brea Calvo G, Gärtner U, Graeber T, Javier Sanchez G, et al. Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy. Sci Rep. 2019;9:12741 pubmed 出版商
Sun C, Enkhjargal B, Reis C, Zhou K, Xie Z, Wu L, et al. Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther. 2019;25:1162-1172 pubmed 出版商
Schott M, Weller S, Schulze R, Krueger E, Drizyte Miller K, Casey C, et al. Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes. J Cell Biol. 2019;218:3320-3335 pubmed 出版商
Parejo S, Tschan M, Muraro M, Garattini E, Spagnoli G, Schläfli A. Assessing Autophagy During Retinoid Treatment of Breast Cancer Cells. Methods Mol Biol. 2019;2019:237-256 pubmed 出版商
Geng J, Liu J, Yuan X, Liu W, Guo W. Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice. Toxicol Appl Pharmacol. 2019;379:114688 pubmed 出版商
Kang S, Son S, Baik S, Yang J, Mook Jung I. Autophagy-mediated secretory pathway is responsible for both normal and pathological tau in neurons. J Alzheimers Dis. 2019;: pubmed 出版商
Cousin M, Conboy E, Wang J, Lenz D, Schwab T, Williams M, et al. RINT1 Bi-allelic Variations Cause Infantile-Onset Recurrent Acute Liver Failure and Skeletal Abnormalities. Am J Hum Genet. 2019;: pubmed 出版商
Malvin N, Kern J, Liu T, Brody S, Stappenbeck T. Autophagy proteins are required for club cell structure and function in airways. Am J Physiol Lung Cell Mol Physiol. 2019;317:L259-L270 pubmed 出版商
Capurro M, Greenfield L, Prashar A, Xia S, Abdullah M, Wong H, et al. VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1. Nat Microbiol. 2019;: pubmed 出版商
Ota K, Okuma T, Lorenzo A, Yokota A, Hino H, Kazama H, et al. Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest. Oncol Rep. 2019;42:231-242 pubmed 出版商
Lee D, Ahn J, Jang Y, Ha T, Jung C. Oleic acid-induced defective autolysosome shows impaired lipid degradation. Biochem Biophys Res Commun. 2019;513:553-559 pubmed 出版商
Audesse A, Dhakal S, Hassell L, Gardell Z, Nemtsova Y, Webb A. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. PLoS Genet. 2019;15:e1008097 pubmed 出版商
Im E, Lee C, Moon P, Rangaswamy G, Lee B, Lee J, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019;10:1387 pubmed 出版商
Bhatt V, Khayati K, Hu Z, Lee A, Kamran W, Su X, et al. Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis. Genes Dev. 2019;33:150-165 pubmed 出版商
van der Kant R, Langness V, Herrera C, Williams D, Fong L, Leestemaker Y, et al. Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019;24:363-375.e9 pubmed 出版商
Das L, Binko A, Traylor Z, Peng H, Lu K. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy. 2019;15:813-826 pubmed 出版商
Twomey J, Zhang B. Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model. Cancers (Basel). 2019;11: pubmed 出版商
Saladini S, Aventaggiato M, Barreca F, Morgante E, Sansone L, Russo M, et al. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells. Cells. 2019;8: pubmed 出版商
Abdullah M, Greenfield L, Bronte Tinkew D, Capurro M, Rizzuti D, Jones N. VacA promotes CagA accumulation in gastric epithelial cells during Helicobacter pylori infection. Sci Rep. 2019;9:38 pubmed 出版商
Ji E, Kim C, Kang H, Ahn S, Jung M, Hong Y, et al. RNA Binding Protein HuR Promotes Autophagosome Formation by Regulating Expression of Autophagy-Related Proteins 5, 12, and 16 in Human Hepatocellular Carcinoma Cells. Mol Cell Biol. 2019;39: pubmed 出版商
Spinello I, Saulle E, Quaranta M, Pasquini L, Pelosi E, Castelli G, et al. The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells. Haematologica. 2019;104:973-985 pubmed 出版商
Latre De Late P, Haidar M, Ansari H, Tajeri S, Szarka E, Alexa A, et al. Theileria highjacks JNK2 into a complex with the macroschizont GPI (GlycosylPhosphatidylInositol)-anchored surface protein p104. Cell Microbiol. 2019;21:e12973 pubmed 出版商
Wang C, Bauckman K, Ross A, Symington J, Ligon M, Scholtes G, et al. A non-canonical autophagy-dependent role of the ATG16L1T300A variant in urothelial vesicular trafficking and uropathogenic Escherichia coli persistence. Autophagy. 2019;15:527-542 pubmed 出版商
Li H, Ham A, Ma T, Kuo S, Kanter E, Kim D, et al. Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. Autophagy. 2019;15:113-130 pubmed 出版商
Aubert P, Oleynikova E, Rizvi H, Ndjim M, Le Berre Scoul C, Grohard P, et al. Maternal protein restriction induces gastrointestinal dysfunction and enteric nervous system remodeling in rat offspring. FASEB J. 2019;33:770-781 pubmed 出版商
Chou L, Cheng Y, Hsieh C, Lin C, Yang H, Chen Y, et al. Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease. Nutrients. 2018;11: pubmed 出版商
Giuliani A, Cirilli I, Prattichizzo F, Mensà E, Fulgenzi G, Sabbatinelli J, et al. The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells. Aging (Albany NY). 2018;10:2855-2873 pubmed 出版商
Nawas A, Mistry R, Narayanan S, Thomas Jardin S, Ramachandran J, Ravichandran J, et al. IL-1 induces p62/SQSTM1 and autophagy in ERα+ /PR+ BCa cell lines concomitant with ERα and PR repression, conferring an ERα- /PR- BCa-like phenotype. J Cell Biochem. 2018;: pubmed 出版商
Zhu Y, Fang J, Wang H, Fei M, Tang T, Liu K, et al. Baicalin suppresses proliferation, migration, and invasion in human glioblastoma cells via Ca2+-dependent pathway. Drug Des Devel Ther. 2018;12:3247-3261 pubmed 出版商
Janssen A, Katrukha E, van Straaten W, Verlhac P, Reggiori F, Kapitein L. Probing aggrephagy using chemically-induced protein aggregates. Nat Commun. 2018;9:4245 pubmed 出版商
Janser F, Adams O, Bütler V, Schläfli A, Dislich B, Seiler C, et al. Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells. Int J Mol Sci. 2018;19: pubmed 出版商
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed 出版商
Dias B, de Souza C, Almeida N, Lima J, Fukutani K, Dos Santos T, et al. Autophagic Induction Greatly Enhances Leishmania major Intracellular Survival Compared to Leishmania amazonensis in CBA/j-Infected Macrophages. Front Microbiol. 2018;9:1890 pubmed 出版商
Tsai Y, Wen Y, Wang J, Yang K, Sun H, Liou J, et al. Complement regulatory protein CD46 induces autophagy against oxidative stress-mediated apoptosis in normal and asthmatic airway epithelium. Sci Rep. 2018;8:12973 pubmed 出版商
Langer R, Neppl C, Keller M, Schmid R, Tschan M, Berezowska S. Expression Analysis of Autophagy Related Markers LC3B, p62 and HMGB1 Indicate an Autophagy-Independent Negative Prognostic Impact of High p62 Expression in Pulmonary Squamous Cell Carcinomas. Cancers (Basel). 2018;10: pubmed 出版商
Hutt D, Mishra S, Roth D, Larsen M, Anglès F, Frizzell R, et al. Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy. J Biol Chem. 2018;293:13682-13695 pubmed 出版商
Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema K, et al. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14:1435-1455 pubmed 出版商
Corona Velazquez A, Corona A, Klein K, Jackson W. Poliovirus induces autophagic signaling independent of the ULK1 complex. Autophagy. 2018;14:1201-1213 pubmed 出版商
Adams O, Janser F, Dislich B, Berezowska S, Humbert M, Seiler C, et al. A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE. 2018;13:e0197610 pubmed 出版商
Gao R, Ma J, Wen Z, Yang P, Zhao J, Xue M, et al. Tumor cell-released autophagosomes (TRAP) enhance apoptosis and immunosuppressive functions of neutrophils. Oncoimmunology. 2018;7:e1438108 pubmed 出版商
Lapierre J, Rodriguez M, Ojha C, El Hage N. Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse. J Neuroimmune Pharmacol. 2018;13:355-370 pubmed 出版商
Jin J, Britschgi A, Schläfli A, Humbert M, Shan Krauer D, Batliner J, et al. Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018;2018:1482795 pubmed 出版商
Lundquist M, Goncalves M, Loughran R, Possik E, Vijayaraghavan T, Yang A, et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell. 2018;70:531-544.e9 pubmed 出版商
Shukla S, Bachireddy P, Schilling B, Galonska C, Zhan Q, Bango C, et al. Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade. Cell. 2018;173:624-633.e8 pubmed 出版商
Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, et al. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Int J Oncol. 2018;52:1165-1177 pubmed 出版商
Yang J, Wang C, Su C, Ho H, Chang C, Chou C, et al. Eudesmin attenuates Helicobacter pylori-induced epithelial autophagy and apoptosis and leads to eradication of H. pylori infection. Exp Ther Med. 2018;15:2388-2396 pubmed 出版商
Santiago O Farrill J, Kleinerman E, Hollomon M, Livingston A, Wang W, Tsai J, et al. Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy. Oncotarget. 2018;9:1602-1616 pubmed 出版商
Chao T, Wang T, Lee C, Yiin S, Ho C, Wu S, et al. Anti-Cancerous Effect of Inonotus taiwanensis Polysaccharide Extract on Human Acute Monocytic Leukemia Cells through ROS-Independent Intrinsic Mitochondrial Pathway. Int J Mol Sci. 2018;19: pubmed 出版商
Li Y, Guo X, Hu C, Du Y, Guo C, Di Wang -, et al. Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection. Cell Death Differ. 2018;25:1304-1318 pubmed 出版商
Yang A, Herter Sprie G, Zhang H, Lin E, Biancur D, Wang X, et al. Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. Cancer Discov. 2018;8:276-287 pubmed 出版商
Magnaghi P, Salom B, Cozzi L, Amboldi N, Ballinari D, Tamborini E, et al. Afatinib Is a New Therapeutic Approach in Chordoma with a Unique Ability to Target EGFR and Brachyury. Mol Cancer Ther. 2018;17:603-613 pubmed 出版商
Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, et al. SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model. Neurobiol Dis. 2018;110:154-165 pubmed 出版商
Persaud A, Cormerais Y, Pouyssegur J, Rotin D. Dynamin inhibitors block activation of mTORC1 by amino acids independently of dynamin. J Cell Sci. 2018;131: pubmed 出版商
Parcon P, Balasubramaniam M, Ayyadevara S, Jones R, Liu L, Shmookler Reis R, et al. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018;14:230-242 pubmed 出版商
Tao L, Togarrati P, Choi K, Suknuntha K. StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells. J Stem Cells Regen Med. 2017;13:75-79 pubmed
Sanborn R, Ross H, Aung S, Acheson A, Moudgil T, Puri S, et al. A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer. J Immunother Cancer. 2017;5:103 pubmed 出版商
Garcia Peterson L, Ndiaye M, Singh C, Chhabra G, Huang W, Ahmad N. SIRT6 histone deacetylase functions as a potential oncogene in human melanoma. Genes Cancer. 2017;8:701-712 pubmed 出版商
Pascarella A, Terracciano C, Farina O, Lombardi L, Esposito T, Napolitano F, et al. Vacuolated PAS-positive lymphocytes as an hallmark of Pompe disease and other myopathies related to impaired autophagy. J Cell Physiol. 2017;: pubmed 出版商
Zhou H, Luo W, Zeng C, Zhang Y, Wang L, Yao W, et al. PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines. Oncotarget. 2017;8:80770-80789 pubmed 出版商
Liu Y, Wang L, Xu T, Guo X, Li Y, Yin T, et al. Whole-genome sequencing of African dogs provides insights into adaptations against tropical parasites. Mol Biol Evol. 2017;: pubmed 出版商
Humbert M, Federzoni E, Tschan M. Distinct TP73-DAPK2-ATG5 pathway involvement in ATO-mediated cell death versus ATRA-mediated autophagy responses in APL. J Leukoc Biol. 2017;: pubmed 出版商
Kemp V, Dautzenberg I, Limpens R, van den Wollenberg D, Hoeben R. Oncolytic Reovirus Infection Is Facilitated by the Autophagic Machinery. Viruses. 2017;9: pubmed 出版商
Muniz Feliciano L, Doggett T, Zhou Z, Ferguson T. RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye. Autophagy. 2017;13:2072-2085 pubmed 出版商
Niklaus M, Adams O, Berezowska S, Zlobec I, Graber F, Slotta Huspenina J, et al. Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer. Oncotarget. 2017;8:54604-54615 pubmed 出版商
Jiang P, Gan M, Yen S, McLean P, Dickson D. Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates. Sci Rep. 2017;7:7690 pubmed 出版商
Jia J, Werkmeister E, Gonzalez Hilarion S, Leroy C, Gruenert D, Lafont F, et al. Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017;130:3009-3022 pubmed 出版商
Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, et al. Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism. Mol Cancer Ther. 2017;16:2502-2515 pubmed 出版商
Germic N, Stojkov D, Oberson K, Yousefi S, Simon H. Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation. Immunology. 2017;152:517-525 pubmed 出版商
Cao B, Parnell L, Diamond M, Mysorekar I. Inhibition of autophagy limits vertical transmission of Zika virus in pregnant mice. J Exp Med. 2017;214:2303-2313 pubmed 出版商
Sun Q, Lin G, Li L, Jin X, Huang L, Zhang G, et al. Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem. 2017;60:6337-6352 pubmed 出版商
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, et al. Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio). PLoS ONE. 2017;12:e0180865 pubmed 出版商
Tuohetahuntila M, Molenaar M, Spee B, Brouwers J, Wubbolts R, Houweling M, et al. Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. J Biol Chem. 2017;292:12436-12448 pubmed 出版商
Pekow J, Hutchison A, Meckel K, Harrington K, Deng Z, Talasila N, et al. miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling. Inflamm Bowel Dis. 2017;23:1328-1337 pubmed 出版商
Saha S, Yin Y, Kim K, Yang G, Dayem A, Choi H, et al. Valproic Acid Induces Endocytosis-Mediated Doxorubicin Internalization and Shows Synergistic Cytotoxic Effects in Hepatocellular Carcinoma Cells. Int J Mol Sci. 2017;18: pubmed 出版商
Pagliassotti M, Estrada A, Hudson W, Wei Y, Wang D, Seals D, et al. Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice. J Nutr Biochem. 2017;45:15-23 pubmed 出版商
Zhang L, Wang H, Fan Y, Gao Y, Li X, Hu Z, et al. Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways. Sci Rep. 2017;7:46763 pubmed 出版商
Hung H, Kao L, Liu P, Huang C, Yang D, Pan C. Dopamine elevates intracellular zinc concentration in cultured rat embryonic cortical neurons through the cAMP-nitric oxide signaling cascade. Mol Cell Neurosci. 2017;82:35-45 pubmed 出版商
Zhu Y, Shui M, Liu X, Hu W, Wang Y. Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia/reperfusion injury. Metab Brain Dis. 2017;32:1449-1458 pubmed 出版商
Sioutas A, Vainikka L, Kentson M, Dam Larsen S, Wennerström U, Jacobson P, et al. Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron. J Inflamm Res. 2017;10:29-39 pubmed 出版商
Tang L, Chai W, Ye F, Yu Y, Cao L, Yang M, et al. HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells. Oncotarget. 2017;8:27314-27327 pubmed 出版商
Lu Y, Bradley J, McCoski S, Gonzalez J, Ealy A, Johnson S. Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. Am J Physiol Regul Integr Comp Physiol. 2017;312:R806-R815 pubmed 出版商
Wang J, Cao B, Han D, Sun M, Feng J. Long Non-coding RNA H19 Induces Cerebral Ischemia Reperfusion Injury via Activation of Autophagy. Aging Dis. 2017;8:71-84 pubmed 出版商
Liu X, Cao H, Li J, Wang B, Zhang P, Dong Zhang X, et al. Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination. Cell Death Differ. 2017;24:683-693 pubmed 出版商
Liu Y, Weng Y, Lin H, Tang S, Chen C, Liang C, et al. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci Rep. 2017;7:41437 pubmed 出版商
Kristensen L, Oppermann F, Rauen M, Hartmann Petersen R, Thirstrup K. Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites. Neurochem Int. 2017;105:42-50 pubmed 出版商
Kaur G, Pawlik M, Gandy S, Ehrlich M, Smiley J, Levy E. Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Mol Psychiatry. 2017;22:981-989 pubmed 出版商
Li Z, Schulze R, Weller S, Krueger E, Schott M, Zhang X, et al. A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Sci Adv. 2016;2:e1601470 pubmed 出版商
Hirasawa K, Moriya S, Miyahara K, Kazama H, Hirota A, Takemura J, et al. Macrolide Antibiotics Exhibit Cytotoxic Effect under Amino Acid-Depleted Culture Condition by Blocking Autophagy Flux in Head and Neck Squamous Cell Carcinoma Cell Lines. PLoS ONE. 2016;11:e0164529 pubmed 出版商
Liu H, Ferrington D, Baumann C, Thompson L. Denervation-Induced Activation of the Standard Proteasome and Immunoproteasome. PLoS ONE. 2016;11:e0166831 pubmed 出版商
Wang J, Han D, Sun M, Feng J. Cerebral ischemic post?conditioning induces autophagy inhibition and a HMGB1 secretion attenuation feedback loop to protect against ischemia reperfusion injury in an oxygen glucose deprivation cellular model. Mol Med Rep. 2016;14:4162-4172 pubmed 出版商
Zhou M, Wen Z, Cheng F, Ma J, Li W, Ren H, et al. Tumor-released autophagosomes induce IL-10-producing B cells with suppressive activity on T lymphocytes via TLR2-MyD88-NF-κB signal pathway. Oncoimmunology. 2016;5:e1180485 pubmed 出版商
Qi X, Man S, Malireddi R, Karki R, Lupfer C, Gurung P, et al. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016;213:2081-97 pubmed 出版商
Sousa C, Biancur D, Wang X, Halbrook C, Sherman M, Zhang L, et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016;536:479-83 pubmed 出版商
Shui M, Liu X, Zhu Y, Wang Y. Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice. Can J Physiol Pharmacol. 2016;94:1187-1192 pubmed 出版商
Bang Y, Kim K, Seol W, Choi H. LRRK2 interferes with aggresome formation for autophagic clearance. Mol Cell Neurosci. 2016;75:71-80 pubmed 出版商
Cemma M, Grinstein S, Brumell J. Autophagy proteins are not universally required for phagosome maturation. Autophagy. 2016;12:1440-6 pubmed 出版商
Yu Y, Xie Y, Cao L, Yang L, Yang M, Lotze M, et al. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol. 2015;2:e1054549 pubmed 出版商
Schläfli A, Adams O, Galvan J, Gugger M, Savic S, Bubendorf L, et al. Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer. Oncotarget. 2016;7:39544-39555 pubmed 出版商
Lee S, Du J, Stitham J, Atteya G, Lee S, Xiang Y, et al. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Mol Med. 2016;8:779-95 pubmed 出版商
Alán L, Spacek T, Pajuelo Reguera D, Jaburek M, Jezek P. Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress. Toxicol Appl Pharmacol. 2016;302:31-40 pubmed 出版商
Boman A, Svensson S, Boxer A, Rojas J, Seeley W, Karydas A, et al. Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. J Parkinsons Dis. 2016;6:307-15 pubmed 出版商
Bauckman K, Mysorekar I. Ferritinophagy drives uropathogenic Escherichia coli persistence in bladder epithelial cells. Autophagy. 2016;12:850-63 pubmed 出版商
Santanam U, Banach Petrosky W, Abate Shen C, Shen M, White E, DiPaola R. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016;30:399-407 pubmed 出版商
Myeku N, CLELLAND C, Emrani S, Kukushkin N, Yu W, Goldberg A, et al. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med. 2016;22:46-53 pubmed 出版商
Wang Y, Chen B, Longtine M, Nelson D. Punicalagin promotes autophagy to protect primary human syncytiotrophoblasts from apoptosis. Reproduction. 2016;151:97-104 pubmed 出版商
Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed 出版商
Koukourakis M, Kalamida D, Giatromanolaki A, Zois C, Sivridis E, Pouliliou S, et al. Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. PLoS ONE. 2015;10:e0137675 pubmed 出版商
Brigger D, Schläfli A, Garattini E, Tschan M. Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. Cell Death Dis. 2015;6:e1861 pubmed 出版商
Chourasia A, Tracy K, Frankenberger C, Boland M, Sharifi M, Drake L, et al. Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis. EMBO Rep. 2015;16:1145-63 pubmed 出版商
Dever S, Rodriguez M, Lapierre J, COSTIN B, El Hage N. Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. Front Microbiol. 2015;6:653 pubmed 出版商
Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed 出版商
Owczarczyk A, Schaller M, Reed M, Rasky A, Lombard D, Lukacs N. Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses. J Immunol. 2015;195:1637-46 pubmed 出版商
Schläfli A, Berezowska S, Adams O, Langer R, Tschan M. Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry. Eur J Histochem. 2015;59:2481 pubmed 出版商
Hu G, McQuiston T, Bernard A, Park Y, Qiu J, Vural A, et al. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. Nat Cell Biol. 2015;17:930-942 pubmed 出版商
Dickinson J, Alevy Y, Malvin N, Patel K, Gunsten S, Holtzman M, et al. IL13 activates autophagy to regulate secretion in airway epithelial cells. Autophagy. 2016;12:397-409 pubmed 出版商
Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun. 2015;6:7250 pubmed 出版商
Del Mar N, von Buttlar X, Yu A, Guley N, Reiner A, Honig M. A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments. Exp Neurol. 2015;271:53-71 pubmed 出版商
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed 出版商
Muñoz Sáez E, de Munck García E, Arahuetes Portero R, Martínez A, Solas Alados M, Miguel B. Analysis of β-N-methylamino-L-alanine (L-BMAA) neurotoxicity in rat cerebellum. Neurotoxicology. 2015;48:192-205 pubmed 出版商
Akizu N, Cantagrel V, Zaki M, Al Gazali L, Wang X, Rosti R, et al. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Nat Genet. 2015;47:528-34 pubmed 出版商
Sharifi M, Mowers E, Drake L, Macleod K. Measuring autophagy in stressed cells. Methods Mol Biol. 2015;1292:129-50 pubmed 出版商
Stander X, Stander B, Joubert A. Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways. Cell Physiol Biochem. 2015;35:1499-526 pubmed 出版商
Fjeld K, Weiss F, Lasher D, Rosendahl J, Chen J, Johansson B, et al. A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nat Genet. 2015;47:518-522 pubmed 出版商
Strohecker A, Joshi S, Possemato R, Abraham R, Sabatini D, White E. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening. Oncogene. 2015;34:5662-76 pubmed 出版商
Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner L. Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. Sci Signal. 2015;8:ra27 pubmed 出版商
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11:253-70 pubmed 出版商
Xie X, Koh J, Price S, White E, Mehnert J. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov. 2015;5:410-23 pubmed 出版商
Yang Q, Stevenson H, Scott M, Ismail N. Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae. Am J Pathol. 2015;185:446-61 pubmed 出版商
Toops K, Tan L, Jiang Z, Radu R, Lakkaraju A. Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium. Mol Biol Cell. 2015;26:1-14 pubmed 出版商
Brigger D, Proikas Cezanne T, Tschan M. WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells. Cell Death Dis. 2014;5:e1315 pubmed 出版商
图像
图像 1 :
Novus Biologicals NB600-1384 图像 1
Western Blot: LC3B Antibody [NB600-1384] - Analysis of LC3B in treated U87-MG (human glioblastoma astrocytoma) lysates using anti- [Catalog # NB600-1384].
产品信息
品牌 :
Novus
master code :
NB600-1384
SKU号 :
NB600-1384
产品名称 :
LC3B抗体
描述 :
The LC3B Antibody from Novus is a rabbit polyclonal antibody to LC3B. This antibody reacts with human, mouse, rat, porcine, bacteria, bovine, canine, primate, zebrafish. The LC3B Antibody has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Electron Microscopy, Immunohistochemistry Free-Floating, Knockout Validated, Knockdown Validated.
靶标 :
LC3B
类别 :
一抗
单位尺寸 :
0.1 ml (also 0.025 ml)
缓冲液 :
PBS
克隆性 :
多克隆
浓度 :
1.0毫克/毫升
共轭标签 :
未共轭
宿主 :
免疫原 :
Polyclonal LC3B Antibody was made to a synthetic peptide made to the N-terminal region of the human LC3B protein. [Uniprot: Q9GZQ8]
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠, 大鼠, 猪, 细菌, 牛, 狗, 灵长类动物, 斑马鱼
理论上的分子量 :
14.688 kDa
基因符号 :
MAP1LC3B
catalog number base :
NB600-1384
应用 :
Western Blot, Simple Western, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Electron Microscopy, Immunohistochemistry Free-Floating, Knockout Validated, Knockdown Validated
美元 :
349美元
别名 :
ATG8F, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, LC3B, lc3b autophagy marker, lc3-i, ii, MAP1 light chain 3-like protein 2, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, map1lc3b, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta, microtubule associated protein 3 b, microtubule associated protein 3 beta, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3B
储存 :
分成小份儿保存在-20C或-80C。 避免冻融循环
更多信息或购买 :
公司信息
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
technical@novusbio.com
https://www.novusbio.com
1-888-506-6887 303-730-1950
公司总部: 美国
Novus Biologicals的任务是开发最先进的新产品及市场行销来加速生物科研的新发现。藉由高效率的组织分工,Novus Biologicals建立了一个将生物学术团体的成果快速商品化的平台。我们的产品除了附有详细的产品资讯外,Novus Biologicals更提供完整的技术支援及服务。利用快速有效的市场通路以便迅速提供所有的科研学者最先进的研究试剂,Novus Biologicals扮演市场上重要的角色。